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Article ; Online: Child with swollen fingers associated with recent SARS-CoV-2 infection.

Bosi, Isabelle / Singh-Grewal, Davinder

2023 Volume 60, Issue 1, Page(s) 32–33

MeSH term(s)	Child ; Humans ; COVID-19/diagnosis ; Edema/etiology ; SARS-CoV-2
Language	English
Publishing date	2023-01-31
Publishing country	Australia
Document type	Case Reports
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/jpc.16350
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Article ; Online: Vale Dr Christina Ann Boros (1966-2021).

Singh-Grewal, Davinder

International journal of rheumatic diseases

2021 Volume 24, Issue 8, Page(s) 1095–1096

MeSH term(s)	Biomedical Research/history ; History, 20th Century ; History, 21st Century ; Humans ; Paintings/history ; Pediatrics/history ; Rheumatology/history
Language	English
Publishing date	2021-07-19
Publishing country	England
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.14181
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Zs.A 6098: Show issues

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Article: Using Digital Health Technologies to Monitor Pain, Medication Adherence and Physical Activity in Young People with Juvenile Idiopathic Arthritis: A Feasibility Study.

Butler, Sonia / Sculley, Dean / Santos, Derek / Girones, Xavier / Singh-Grewal, Davinder / Coda, Andrea

Healthcare (Basel, Switzerland)

2024 Volume 12, Issue 3

Abstract: Juvenile idiopathic arthritis can be influenced by pain, medication adherence, and physical activity. A new digital health intervention, InteractiveClinics, aims to monitor these modifiable risk factors. Twelve children, aged 10 to 18 years, received ... ...

Abstract	Juvenile idiopathic arthritis can be influenced by pain, medication adherence, and physical activity. A new digital health intervention, InteractiveClinics, aims to monitor these modifiable risk factors. Twelve children, aged 10 to 18 years, received daily notifications on a smartwatch to record their pain levels and take their medications, using a customised mobile app synchronised to a secure web-based platform. Daily physical activity levels were automatically recorded by wearing a smartwatch. Using a quantitative descriptive research design, feasibility and user adoption were evaluated. The web-based data revealed the following: Pain: mean app usage: 68% (SD 30, range: 28.6% to 100%); pain score: 2.9 out of 10 (SD 1.8, range: 0.3 to 6.2 out of 10). Medication adherence: mean app usage: 20.7% (SD, range: 0% to 71.4%), recording 39% (71/182) of the expected daily and 37.5% (3/8) of the weekly medications. Pro-re-nata (PRN) medication monitoring: 33.3% (4/12), one to six additional medications (mean 3.5, SD 2.4) for 2-6 days. Physical activity: watch wearing behaviour: 69.7% (439/630), recording low levels of moderate-to-vigorous physical activity (mean: 11.8, SD: 13.5 min, range: 0-47 min). To conclude, remote monitoring of real-time data is feasible. However, further research is needed to increase adoption rates among children.
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12030392
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Article ; Online: Paediatric Rheumatology Fails to Meet Current Benchmarks, a Call for Health Equity for Children Living with Juvenile Idiopathic Arthritis, Using Digital Health Technologies.

Butler, Sonia / Sculley, Dean / Santos, Derek / Girones, Xavier / Singh-Grewal, Davinder / Coda, Andrea

Current rheumatology reports

2024

Abstract: Purpose of review: This critical review begins by presenting the history of Juvenile Idiopathic Arthritis (JIA) management. To move the conversation forward in addressing the current shortcomings that exist in the clinical management of children living ... ...

Abstract	Purpose of review: This critical review begins by presenting the history of Juvenile Idiopathic Arthritis (JIA) management. To move the conversation forward in addressing the current shortcomings that exist in the clinical management of children living with JIA, we argue that to date, the advancement of successful treatments for JIA has been historically slow. Factors implicated in this situation include a lack of rigorous research, JIA being considered a rare disease, and JIA's idiopathic and complex pathophysiology. Recent findings: Despite the well-intended legislative changes to increase paediatric research, and the major advancements seen in molecular medicine over the last 30 years, globally, paediatric rheumatology services are still failing to meet the current benchmarks of best practice. Provoking questions on how the longstanding health care disparities of poor access and delayed treatment for children living with JIA can be improved, to improve healthcare outcomes. Globally, paediatric rheumatology services are failing to meet the current benchmarks of best practice. Raising awareness of the barriers hindering JIA management is the first step in reducing the current health inequalities experienced by children living with JIA. Action must be taken now, to train and well-equip the paediatric rheumatology interdisciplinary workforce. We propose, a resource-efficient way to improve the quality of care provided could be achieved by embedding digital health into clinical practice, to create an integrative care model between the children, general practice and the paediatric rheumatology team. To improve fragmented service delivery and the coordination of interdisciplinary care, across the healthcare system.
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057357-1
ISSN	1534-6307 ; 1523-3774
ISSN (online)	1534-6307
ISSN	1523-3774
DOI	10.1007/s11926-024-01145-w
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Zs.A 5531: Show issues

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Article ; Online: Multidisciplinary paediatric rheumatology services in Australia and New Zealand.

Singh-Grewal, Davinder

The Medical journal of Australia

2017 Volume 206, Issue 2, Page(s) 96–97

MeSH term(s)	Australia ; Child ; Health Services Accessibility/statistics & numerical data ; Health Services Needs and Demand/statistics & numerical data ; Health Services Research ; Humans ; Interdisciplinary Communication ; Intersectoral Collaboration ; New Zealand ; Patient Care Team/statistics & numerical data ; Pediatrics ; Rheumatic Diseases/therapy ; Rheumatology ; Workforce
Language	English
Publishing date	2017-09-01
Publishing country	Australia
Document type	Letter
ZDB-ID	186082-3
ISSN	1326-5377 ; 0025-729X
ISSN (online)	1326-5377
ISSN	0025-729X
DOI	10.5694/mja16.00710
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Ua VI Zs.398: Show issues

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Article ; Online: Neonatal lupus erythematosus presenting as a non-bullous histiocytoid neutrophilic dermatosis.

Kozera, Emily K / Langan, Rinky / Singh-Grewal, Davinder / Sun, Helen Y / Sebaratnam, Deshan F / Henderson, Christopher J A

Journal of cutaneous pathology

2023 Volume 50, Issue 6, Page(s) 524–529

Abstract: Histopathologic findings in neonatal lupus erythematosus (NLE) are usually congruent with those of subacute cutaneous lupus erythematosus. However, neutrophilic dermatosis-type histopathologic features are being increasingly recognized in the literature ... ...

Abstract	Histopathologic findings in neonatal lupus erythematosus (NLE) are usually congruent with those of subacute cutaneous lupus erythematosus. However, neutrophilic dermatosis-type histopathologic features are being increasingly recognized in the literature including rare cases with variant histiocytoid morphology. We report the case of a 7-week-old male presenting with figurate erythema. His mother was found to have elevated anti-nuclear antibodies and was positive for anti-SSA/Ro, anti-SSB/La antibodies and Ro52 autoantibodies. The infant had a similar serological profile. Skin biopsy showed a histiocytoid interstitial infiltrate with mild lichenoid features, sparse neutrophils and mild leukocytoclasis. The histiocytoid infiltrate showed prominent CD68, CD163, and myeloperoxidase expression. Isolated clusters of CD123
MeSH term(s)	Infant ; Infant, Newborn ; Humans ; Male ; Erythema/pathology ; Dermatitis/pathology ; Lupus Erythematosus, Systemic/pathology ; Lupus Erythematosus, Cutaneous/pathology ; Antibodies, Antinuclear
Chemical Substances	Antibodies, Antinuclear
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Case Reports
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1111/cup.14387
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Zs.A 1043: Show issues

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Article: Range and consistency of outcome measures reported in randomised trials in dermatomyositis: a systematic review.

Kelly, Amy H / Singh-Grewal, Davinder / Sumpton, Daniel / Hasset, Geraldine / Manera, Karine E / Tong, Allison

Clinical and experimental rheumatology

2022 Volume 40, Issue 2, Page(s) 358–365

Abstract: Objectives: Dermatomyositis (DM) and juvenile dermatomyositis (JDM) are idiopathic inflammatory myopathies, which can be resistant and unresponsive to initial treatments, leading to severe complications and impaired quality of life. There are few ... ...

Abstract	Objectives: Dermatomyositis (DM) and juvenile dermatomyositis (JDM) are idiopathic inflammatory myopathies, which can be resistant and unresponsive to initial treatments, leading to severe complications and impaired quality of life. There are few randomised trials in dermatomyositis and the outcomes reported may not be consistent, which can limit decision-making. The aim of this study is to assess the scope and consistency of outcomes reported in randomised trials in dermatomyositis. Methods: MEDLINE, Embase, PsycINFO and clinicaltrials.gov were searched from 1993-2020 for randomised trials in children and adults with dermatomyositis. The frequency and characteristics of the outcomes reported were analysed and classified. Results: 20 trials were included. Across these trials, a total of 743 outcome measures were reported, which were grouped into 34 outcome domains; of which 17 were clinical, 13 were surrogate/biochemical, and 4 were patient-reported outcomes. The top five most frequently reported outcome domains were muscle inflammation (15 trials, 46 outcome measures), physical function (14 trials, 16 outcome measures), muscle strength (13 trials, 30 outcome measures), global health (12 trials, 33 outcome measures) and immunologic marker (11 trials, 91 outcomes). Conclusions: The majority of outcomes reported in trials in people with dermatomyositis and JDM are clinical and surrogate outcomes rather than patient-reported outcomes. The outcomes reported are very inconsistent across trials, with wide heterogeneity in the measures used. Standardised reporting of critically important outcomes is needed to strengthen the value of trials for decision-making.
MeSH term(s)	Adult ; Child ; Dermatomyositis/diagnosis ; Dermatomyositis/therapy ; Humans ; Outcome Assessment, Health Care ; Patient Reported Outcome Measures ; Quality of Life ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-02-08
Publishing country	Italy
Document type	Journal Article ; Systematic Review
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/3izscd
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Zs.A 2002: Show issues

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Article ; Online: 18F-FDG PET/CT in Pediatric Immunoglobulin G4-Related Disease.

Singh, Karan / Bennett, Olivia / Wegner, Eva Alina / Marsden, Amanda / Grewal, Davinder Singh

Clinical nuclear medicine

2024

Abstract: Abstract: A 14-year-old boy presented with severe, nonintentional weight loss, fatigue, and cough. Investigations were notable for raised inflammatory markers and significantly elevated serum immunoglobulin G4 (IgG4). 18F-FDG PET/CT was obtained for ... ...

Abstract	Abstract: A 14-year-old boy presented with severe, nonintentional weight loss, fatigue, and cough. Investigations were notable for raised inflammatory markers and significantly elevated serum immunoglobulin G4 (IgG4). 18F-FDG PET/CT was obtained for assessment of disease involvement and extent, to exclude differential diagnoses and to guide biopsy. The study demonstrated extensive FDG-avid nodal disease and multisystem organ involvement. Excisional biopsy of a right inguinal lymph node demonstrated reactive changes with numerous IgG4-positive plasma cells consistent with IgG4-related disease. He was commenced on immunosuppressive therapy with consequent weight restoration and symptom resolution.
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000005151
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Zs.A 1276: Show issues

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Article ; Online: Effect of customised preformed foot orthoses on gait parameters in children with juvenile idiopathic arthritis: A multicentre randomised clinical trial.

Fellas, Antoni / Singh-Grewal, Davinder / Chaitow, Jeffrey / Santos, Derek / Clapham, Matthew / Coda, Andrea

Gait & posture

2022 Volume 95, Page(s) 93–99

Abstract: Background: Children with juvenile idiopathic arthritis (JIA) can experience significant physical impairment of the lower extremity. Prolonged joint disease and symptoms may cause gait alterations such as reduced walking speed and increased plantar ... ...

Abstract	Background: Children with juvenile idiopathic arthritis (JIA) can experience significant physical impairment of the lower extremity. Prolonged joint disease and symptoms may cause gait alterations such as reduced walking speed and increased plantar pressures in diseased areas of their feet. There is limited robust clinical trials investigating the effect of non-invasive mechanical therapies such as foot orthoses (FOs) on improving gait parameters in children with JIA. Research question: Are customised preformed FOs effective in improving gait parameters in children with JIA? Methods: A multicentre, parallel design, single-blinded randomised clinical trial was used to assess the gait impacts of customised preformed FOs on children with JIA. Children with a diagnosis of JIA, exhibiting lower limb symptoms and aged 5-18 were eligible. The trial group received a low-density full length, Slimflex Simple device which was customised chair side and the control group received a sham device. Peak pressure and pressure time integrals were used as the main gait outcomes and were measured using portable Tekscan gait analysis technology at baseline, 3 and 6 months. Differences at each follow-up were assessed using the Wilcoxon rank sum test. Results: 66 participants were recruited. Customised preformed FOs were effective in altering plantar pressures in children with JIA versus a control device. Reductions of peak pressures and pressure time integrals in the heel, forefoot and 5th metatarsophalangeal joint were statistically significant in favour of the trial group. This was associated with statistically significant increased midfoot contact with the trial device at baseline, 3 and 6-month data collections. The trial intervention was safe and well accepted by participants, which is reflected in the high retention rate (92%). Significance: Clinicians may prescribe customised preformed FOs in children with JIA to deflect pressure from painful joints and redistribute from high pressure areas such as the rearfoot and forefoot.
MeSH term(s)	Arthritis, Juvenile/complications ; Arthritis, Juvenile/therapy ; Child ; Foot ; Foot Orthoses ; Gait ; Gait Analysis ; Humans
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1162323-8
ISSN	1879-2219 ; 0966-6362
ISSN (online)	1879-2219
ISSN	0966-6362
DOI	10.1016/j.gaitpost.2022.04.017
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Zs.A 3804: Show issues

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Article ; Online: Live vaccines following intravenous immunoglobulin for Kawasaki disease: Are we vaccinating appropriately?

Cardenas-Brown, Cassandra / Lucas, Ryan D / Buttery, Jim / Britton, Philip N / Wood, Nicholas / Singh-Grewal, Davinder / Burgner, David

Journal of paediatrics and child health

2023 Volume 59, Issue 11, Page(s) 1217–1222

Abstract: Aim: Australian and New Zealand guidelines recommend that live vaccines be postponed for 11 months after treatment of Kawasaki disease (KD) with intravenous immunoglobulin (IVIG). We aimed to describe patterns of live-vaccine administration after KD ... ...

Abstract	Aim: Australian and New Zealand guidelines recommend that live vaccines be postponed for 11 months after treatment of Kawasaki disease (KD) with intravenous immunoglobulin (IVIG). We aimed to describe patterns of live-vaccine administration after KD treatment, focusing on the measles-mumps-rubella/measles-mumps-rubella-varicella (MMR/MMRV) vaccines, and to compare real-world practice with current recommendations. Methods: We combined data from inpatient Electronic Health Records and the Australian Immunisation Register for all children who received IVIG for the treatment of KD under the age of 5 years at two Australian tertiary children's hospitals over a 12-year period. Children who received IVIG <11 months before a scheduled MMR/MMRV were deemed 'at risk' of breaching the guidelines, and those whose subsequent vaccination occurred <11 months after the IVIG were deemed to have 'breached' the guidelines. Results: Of those at risk, three-quarters (76%) breached the guidelines for their first MMR/MMRV. Findings were similar (50%-80%) for the second MMR/MMRV dose. Conclusions: The majority of Australian children treated for KD with IVIG may not be optimally protected by MMRV vaccination. Immunisation systems should address this avoidable risk.
MeSH term(s)	Child ; Humans ; Infant ; Child, Preschool ; Immunoglobulins, Intravenous/therapeutic use ; Mumps/prevention & control ; Mucocutaneous Lymph Node Syndrome/drug therapy ; Australia ; Chickenpox Vaccine ; Measles-Mumps-Rubella Vaccine ; Chickenpox/prevention & control ; Herpesvirus 3, Human ; Measles/prevention & control ; Rubella/prevention & control
Chemical Substances	Immunoglobulins, Intravenous ; Chickenpox Vaccine ; Measles-Mumps-Rubella Vaccine
Language	English
Publishing date	2023-09-04
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/jpc.16484
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