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  1. Article ; Online: Investigation of accumulation of element contents in some wild and cultivated dried fruits.

    AlJuhaimi, Fahad / Kulluk, Duygu Akçay / Ahmed, Isam Ali Mohamed / Özcan, Mehmet Musa / Karrar, Emad

    Biological trace element research

    2024  

    Abstract: In this study, the moisture and biogenic element quantities of most wild and cultivated edible dried fruits were investigated. Macroelements found in highest amounts in fruits were K, P, Ca, and Mg. While K quantities of the fruits are recorded between ... ...

    Abstract In this study, the moisture and biogenic element quantities of most wild and cultivated edible dried fruits were investigated. Macroelements found in highest amounts in fruits were K, P, Ca, and Mg. While K quantities of the fruits are recorded between 5212.77 ("white myrtle") and 25550.60 mg/kg ("black nightshade"), P amounts of the fruits were characterized to be between 949.08 (black myrtle) and 4420.75 mg/kg ("black nightshade"). Ca and Mg amounts of the fruits were assessed to be between 359.83 (plum) and 4330.89 mg/kg ("yellow hawthorn") to 214.98 (plum) and 1852.04 mg/kg ("black nightshade"), respectively. Fe and B quantities of the fruitss were established to be between 2.69 ("black myrtle") and 60.13 mg/kg (cherry) to 3.76 ("black myrtle") and 76.25 mg/kg (sour cherry), respectively. In general, except for white and black myrtle fruits, it is thought that other fruits can be good sources of P, K, and Fe. P contents of "laurel cherry," "cherry," "black nightshade," and "Fragrant black grapes" were found partly high than those of other fruits. "Cherry laurel," "sour cherry," "cherry," "pear," "black nightshade," "black fig," and "hawthorn (yellow)" fruits contain more K than other fruits.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-024-04165-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Overexpression of Programmed Death-Ligand 2 in Uterine Adenosarcoma: Correlation with High-Grade Morphology, Mutant Type TP53 Expression and Clinical Outcomes.

    Ok Atılgan, Alev / Yılmaz Akçay, Eda / Özen, Özlem / Haberal Reyhan, A Nihan / Ayhan, Ali

    International journal of surgical pathology

    2022  Volume 31, Issue 4, Page(s) 352–364

    Abstract: Immunotherapy involving the programmed death-1 (PD-1)/the programmed death-ligand (PD-1/PD-L) blockade is an understudied tumor therapy approach in cases of adenosarcoma. PD-L1 and PD-L2, and tumor protein p53 (p53) were examined in 20 uterine ... ...

    Abstract Immunotherapy involving the programmed death-1 (PD-1)/the programmed death-ligand (PD-1/PD-L) blockade is an understudied tumor therapy approach in cases of adenosarcoma. PD-L1 and PD-L2, and tumor protein p53 (p53) were examined in 20 uterine adenosarcoma cases, and tumor-infiltrating lymphocytes and tumor-associated macrophages were counted in tumor tissue using immunohistochemistry. While CPS PD-L1 positivity with 1% and 10% cut-off values was observed in 40% and 10% of tumors, respectively, CPS PD-L2 positivity with 1%, 10% and 50% cut-off values was observed in 100%, 85% and 50% of the tumors, respectively. The CPS PD-L2 positivity with a 50% cut-off value was positively correlated with tumor grade and the presence of sarcomatous overgrowth and lymphovascular invasion (LVI) (p = 0.025, p = 0.025, and p = 0.025, respectively). Nine of 11 high-grade adenosarcomas and none of the low-grade adenosarcomas showed mutant type p53 expression (p = 0.000). However, PD-L1 expression and tumor-infiltrating immune cells did not correlate with clinicopathological parameters. The CPS PD-L2 positivity with a 50% cut-off value was also positively correlated with mutant type p53 expression (p = 0.024) and tumor-associated macrophages density (p = 0.024). The CPS PD-L2 positivity with a 50% cut-off value and mutant type p53 expression were associated with shorter disease-free survival and shorter overall survival. The high density of tumor-associated macrophages and low density of tumor-infiltrating lymphocytes were also associated with shorter disease-free survival and overall survival (p < 0.05).These results suggested that the CPS PD-L2 positivity with a 50% cut-off value, p53 mutation and tumor microenvironment played an essential role in the progression of uterine adenosarcomas.
    MeSH term(s) Female ; Humans ; Adenosarcoma ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Ligands ; Prognosis ; Tumor Microenvironment ; Tumor Suppressor Protein p53/genetics
    Chemical Substances B7-H1 Antigen ; Biomarkers, Tumor ; Ligands ; TP53 protein, human ; Tumor Suppressor Protein p53 ; PDCD1LG2 protein, human
    Language English
    Publishing date 2022-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969221095189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fertility comparison of frozen bull semen stored in cryogenic deep freezer (-152 °C) and LN

    Tırpan, Mehmet Borga / Olğaç, Kemal Tuna / Korkmaz, Fırat / Sonat, Ali / Kaya, Ufuk / Akçay, Ergun

    Theriogenology

    2022  Volume 185, Page(s) 1–5

    Abstract: The present study aimed to use cryogenic deep freezers that could be a feasible alternative for cryopreserved semen storage. A total of 284 straws from three Simmental bulls and 272 Simmental cows were used. The experimental group consisted of 151 semen ... ...

    Abstract The present study aimed to use cryogenic deep freezers that could be a feasible alternative for cryopreserved semen storage. A total of 284 straws from three Simmental bulls and 272 Simmental cows were used. The experimental group consisted of 151 semen straws that were stored at -152 °C for a week. Moreover, the control group consisted of 133 semen straws that were stored at -196 °C. Firstly, two samples per bull (n = 6) were examined in terms of sperm kinetic parameters by CASA. Furthermore, plasma membrane, acrosome integrity (PMAI) and high mitochondrial membrane potential (HMMP) were analyzed by flow cytometry. Then, artificial inseminations were performed on Simmental cows with 272 straws belonging to two groups. Then, 56th-day Non-return Rate (NRR56) was determined. All spermatological data were subjected to a linear mixed model. Chi-Square test was performed to NRR56 between storage temperature groups. Also, logistic regression analysis was used to examine the effect of bull, storage temperature and age of cows on pregnancy status. While age of cows was included in the final logistic regression model, effect of bull x storage temperature was not included because it was found as non-significant. The post-thaw PMOT and STR of cryopreserved bull semen, which was stored at -152 °C, had lower and statistically significant values (p < 0.05). However, frozen bull semen, which were stored at -152 °C, kept its fertility ability as which stored at -196 °C. Besides, NRR56 of semen stored at -152 °C and -196 °C were detected as 57.24% (83/145) and 55.91% (71/127), respectively (p > 0.05). Nevertheless, these results should be supplemented with more pre-freezing and post-thaw sperm quality analyses and more fertility data for increasing the accuracy of the method.
    MeSH term(s) Animals ; Cattle ; Cryopreservation/methods ; Cryopreservation/veterinary ; Female ; Fertility ; Male ; Pregnancy ; Semen ; Semen Analysis/veterinary ; Semen Preservation/methods ; Semen Preservation/veterinary ; Sperm Motility ; Spermatozoa
    Language English
    Publishing date 2022-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189232-0
    ISSN 1879-3231 ; 0093-691X
    ISSN (online) 1879-3231
    ISSN 0093-691X
    DOI 10.1016/j.theriogenology.2022.03.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of magnetic resonance imaging to differentiate between borderline and malignant serous epithelial ovarian tumors.

    Akçay, Ahmet / Peker, Abdusselim Adil / Oran, Zeynep / Toprak, Hüseyin / Toluk, Özlem / Balsak, Serdar / Badur, Bahar Atasoy / Gültekin, Mehmet Ali

    Abdominal radiology (New York)

    2023  Volume 49, Issue 1, Page(s) 229–236

    Abstract: Purpose: We aimed to differentiate serous borderline ovarian tumors (SBOT) from serous epithelial ovarian carcinomas (SEOC) using morphological and functional MRI findings, to improve the patient management.: Method: We retrospectively investigated ... ...

    Abstract Purpose: We aimed to differentiate serous borderline ovarian tumors (SBOT) from serous epithelial ovarian carcinomas (SEOC) using morphological and functional MRI findings, to improve the patient management.
    Method: We retrospectively investigated 24 ovarian lesions diagnosed with SBOT and 64 ovarian lesions diagnosed with SEOC. Additional to the demographic and morphological findings T2W signal intensity ratio, mean apparent diffusion coefficient (ADC
    Results: Bilaterality, pelvic free fluid presence, serum CA-125 level (U/mL), presence of pelvic peritoneal implant were in favor of SEOC. Lower maximum size of solid component and solid size to maximum size ratio, dominantly cystic and solid-cystic appearance, exophytic growth pattern, presence of papiller projection and papillary architecture and internal branching pattern, higher T2W signal intensity ratio, ADC
    Conclusion: Our study revealed that morphological and functional imaging findings were valuable in differentiating BSOT from SEOC.
    MeSH term(s) Female ; Humans ; Ovarian Neoplasms/diagnostic imaging ; Ovarian Neoplasms/pathology ; Retrospective Studies ; Ovarian Cysts ; Magnetic Resonance Imaging/methods ; Diffusion Magnetic Resonance Imaging/methods ; Carcinoma, Ovarian Epithelial/diagnostic imaging ; Cystadenocarcinoma, Serous/pathology
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-023-04076-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intestinal obstruction due to phytobezoar induced in the Meckel's diverticulum-report of two cases.

    Firat, Necattin / Mantoglu, Baris / Altintoprak, Fatih / Muhtaroglu, Ali / Akcay, Mertcan

    Northern clinics of Istanbul

    2022  Volume 9, Issue 2, Page(s) 180–182

    Abstract: Meckel's diverticulum is generally asymptomatic, but it may become symptomatic due to various reasons and maybe the etiology of the acute abdominal syndrome. Bezoars are formed by the combination of non-digestible substances in the gastrointestinal tract, ...

    Abstract Meckel's diverticulum is generally asymptomatic, but it may become symptomatic due to various reasons and maybe the etiology of the acute abdominal syndrome. Bezoars are formed by the combination of non-digestible substances in the gastrointestinal tract, and which are among the rare causes of intestinal obstruction. The formation of bezoars in Meckel's diverticulum and subsequent intestinal obstruction is a rare condition. In this article, two cases with intestinal obstruction due to bezoar in Meckel's diverticulum and their surgical treatment had presented.
    Language English
    Publishing date 2022-04-01
    Publishing country Turkey
    Document type Case Reports
    ZDB-ID 3031921-3
    ISSN 2536-4553 ; 2148-4902
    ISSN (online) 2536-4553
    ISSN 2148-4902
    DOI 10.14744/nci.2020.89656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pneumococcal and Influenza Vaccines in Dialysis Patients

    Sibel Kara / Dilek Torun / Ebru Oruç / Mehmet Ali Habeşoğlu / Müşerref Şule Akçay

    Turkish Journal of Nephrology, Vol 31, Iss 2, Pp 165-

    Vaccination Information, Rates, and Patient Awareness

    2022  Volume 170

    Keywords Internal medicine ; RC31-1245 ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher AVES
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A novel missense mutation in the UBE2A gene causes intellectual disability in the large X-linked family.

    Arslan Satılmış, Saide Betül / Kurt, Emin Emre / Akçay, Ebru Perim / Sazci, Ali / Ceylan, Ahmet Cevdet

    The journal of gene medicine

    2021  Volume 23, Issue 2, Page(s) e3307

    Abstract: Background: X-linked intellectual disability type Nascimento (XIDTN) is a disorder of the ubiquitin-proteasome pathway of protein degradation controlled by the UBE2A gene. The disease is characterized by intellectual disability, speech impairment, ... ...

    Abstract Background: X-linked intellectual disability type Nascimento (XIDTN) is a disorder of the ubiquitin-proteasome pathway of protein degradation controlled by the UBE2A gene. The disease is characterized by intellectual disability, speech impairment, dysmorphic facial features, skin and nail anomalies, and, frequently, seizures. Eight affected males from a four-generation family who have intellectual disability and speech disorders were examined within an extended family of 57 individuals. Methods A number of methods were used for the molecular diagnosis. Conventional karyotype analyses, array-based comparative genomic hybridization (aCGH), whole exome swquencing (WES), sanger sequencing were performed. Results First, the conventional karyotype analyses were normal, and the results of the aCGH analyses were normal. Then, WES revealed a novel missense mutation of the UBE2A gene at exon 4 NM_003336.3: c.182A>G (p.Glu61Gly). Seven affected individuals and nine carriers in the multigenerational, large family were diagnosed through Sanger sequencing.
    Conclusions: We identified the mutation causing intellectual disability in the large family and demonstrated its phenotypic effects. Our cases showed that dysmorphic features could be considered mild, whereas intellectual disability and speech disorders are common features in XIDTN. The structure and function of the gene will be better understood in the novel UBE2A mutation. The genotype-phenotype correlation and phenotypic variations in XIDTN were identified through a literature review. Accordingly, XIDTN should be considered in individuals who exhibit an X-linked pedigree pattern and have intellectual disability and speech disorders.
    MeSH term(s) Abnormalities, Multiple/genetics ; Adult ; Exome ; Genetic Association Studies ; Genetic Diseases, X-Linked/diagnosis ; Genetic Diseases, X-Linked/genetics ; Genetic Predisposition to Disease ; Humans ; Intellectual Disability/genetics ; Male ; Microarray Analysis ; Middle Aged ; Molecular Diagnostic Techniques/methods ; Mutation, Missense ; Pedigree ; Ubiquitin-Conjugating Enzymes/genetics ; Whole Exome Sequencing ; Young Adult
    Chemical Substances UBE2A protein, human (EC 2.3.2.23) ; Ubiquitin-Conjugating Enzymes (EC 2.3.2.23)
    Language English
    Publishing date 2021-01-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1458024-x
    ISSN 1521-2254 ; 1099-498X
    ISSN (online) 1521-2254
    ISSN 1099-498X
    DOI 10.1002/jgm.3307
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  8. Article: Fertility comparison of frozen bull semen stored in cryogenic deep freezer (−152 °C) and LN2 container

    Tırpan, Mehmet Borga / Olğaç, Kemal Tuna / Korkmaz, Fırat / Sonat, Ali / Kaya, Ufuk / Akçay, Ergun

    Theriogenology. 2022 June, v. 185

    2022  

    Abstract: The present study aimed to use cryogenic deep freezers that could be a feasible alternative for cryopreserved semen storage. A total of 284 straws from three Simmental bulls and 272 Simmental cows were used. The experimental group consisted of 151 semen ... ...

    Abstract The present study aimed to use cryogenic deep freezers that could be a feasible alternative for cryopreserved semen storage. A total of 284 straws from three Simmental bulls and 272 Simmental cows were used. The experimental group consisted of 151 semen straws that were stored at −152 °C for a week. Moreover, the control group consisted of 133 semen straws that were stored at −196 °C. Firstly, two samples per bull (n = 6) were examined in terms of sperm kinetic parameters by CASA. Furthermore, plasma membrane, acrosome integrity (PMAI) and high mitochondrial membrane potential (HMMP) were analyzed by flow cytometry. Then, artificial inseminations were performed on Simmental cows with 272 straws belonging to two groups. Then, 56th-day Non-return Rate (NRR56) was determined. All spermatological data were subjected to a linear mixed model. Chi-Square test was performed to NRR56 between storage temperature groups. Also, logistic regression analysis was used to examine the effect of bull, storage temperature and age of cows on pregnancy status. While age of cows was included in the final logistic regression model, effect of bull x storage temperature was not included because it was found as non-significant. The post-thaw PMOT and STR of cryopreserved bull semen, which was stored at −152 °C, had lower and statistically significant values (p < 0.05). However, frozen bull semen, which were stored at −152 °C, kept its fertility ability as which stored at −196 °C. Besides, NRR56 of semen stored at −152 °C and −196 °C were detected as 57.24% (83/145) and 55.91% (71/127), respectively (p > 0.05). Nevertheless, these results should be supplemented with more pre-freezing and post-thaw sperm quality analyses and more fertility data for increasing the accuracy of the method.
    Keywords Simmental ; acrosome ; bulls ; chi-square distribution ; cryopreservation ; flow cytometry ; freezers ; membrane potential ; mitochondrial membrane ; plasma membrane ; pregnancy ; regression analysis ; semen ; sperm quality ; statistical models ; storage temperature
    Language English
    Dates of publication 2022-06
    Size p. 1-5.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 189232-0
    ISSN 1879-3231 ; 0093-691X
    ISSN (online) 1879-3231
    ISSN 0093-691X
    DOI 10.1016/j.theriogenology.2022.03.017
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Horner's Syndrome and Vertebral Artery Occlusion Concomitant With Brachial Plexus Injury in a Patient With Anterior Approach Cervical Disc Herniation Surgery.

    Akcay, Seniz / Koc, Ali Murat / Eskut, Neslihan / Koskderelioglu, Asli

    Cureus

    2021  Volume 13, Issue 9, Page(s) e17810

    Abstract: Horner's syndrome is one of the rare complications after anterior approach intervertebral disc herniation surgery. Here, we described a 35-year-old male patient with Horner's syndrome accompanied by brachial plexus injury at the upper trunk level and ... ...

    Abstract Horner's syndrome is one of the rare complications after anterior approach intervertebral disc herniation surgery. Here, we described a 35-year-old male patient with Horner's syndrome accompanied by brachial plexus injury at the upper trunk level and vertebral artery occlusion after anterior ipsilateral approach cervical discectomy and cervical disc prosthesis operation. We are not aware of a similar case of these complications after this operation in the literature. After the six-month follow-up period the patient's Horner's syndrome slightly improved and he partially gained right upper extremity muscle strength.
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.17810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Microsatellite Instability Status and the Expression of p16 and Cyclin D1 Proteins in Uterine Adenosarcoma and Their Clinicopathological Significance.

    Atilgan, Alev Ok / Akcay, Eda Yilmaz / Ozen, Ozlem / Haberal Reyhan, A Nihan / Ayhan, Ali

    Turk patoloji dergisi

    2022  Volume 39, Issue 1, Page(s) 31–41

    Abstract: Objective: Uterine adenosarcoma has low malignant potential, except in cases with sarcomatous overgrowth (SOG) and a high-grade morphology. We here point out the prognostic clinicopathological and immunohistochemical features as well as the ... ...

    Title translation Microsatellite Instability Status and the Expression of p16 and Cyclin D1 Proteins in Uterine Adenosarcoma and Their Clinicopathological Significance.
    Abstract Objective: Uterine adenosarcoma has low malignant potential, except in cases with sarcomatous overgrowth (SOG) and a high-grade morphology. We here point out the prognostic clinicopathological and immunohistochemical features as well as the microsatellite instability (MSI) status of high- and low-grade adenosarcomas.
    Material and method: In this study, DNA mismatch repair proteins, p16, cyclin D1, ER, PR, and CD10 were examined in uterine adenosarcoma cases using immunohistochemistry. The association between these proteins and clinicopathological parameters was also evaluated.
    Results: ER, PR and CD10 expressions were lower and weaker in high-grade adenosarcomas with SOG compared to low-grade adenosarcomas without SOG (p < 0.05). p16 positivity was more frequent in high-grade adenosarcomas than low-grade adenosarcomas (p < 0.05). There was no statistically significant difference between cyclin D1 positivity, MSI, and other clinicopathological parameters (p ≥ 0.05). Cyclin D1 positivity and loss of CD10 expression were associated with shorter disease-free survival (DFS). Loss of ER and CD10 expression was associated with shorter overall survival (OS) (p < 0.05). MSI was not associated with DFS or OS (p ≥ 0.05).
    Conclusion: These results suggested that p16 positivity, and loss of ER, PR, and CD10 expression were predictors of high-grade morphology. Additionally, the current study showed that cyclin D1-positive tumors had high recurrence rates; however, no significant relationships were found between MSI and DFS or OS in patients with uterine adenosarcoma. Further investigations are required to determine the importance of p16, cyclin D1, and MSI in uterine adenosarcomas.
    MeSH term(s) Female ; Humans ; Adenosarcoma/genetics ; Adenosarcoma/metabolism ; Cyclin D1/genetics ; Microsatellite Instability ; Uterine Neoplasms/genetics ; Sarcoma
    Chemical Substances Cyclin D1 (136601-57-5)
    Language English
    Publishing date 2022-07-26
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2515899-5
    ISSN 1309-5730 ; 1309-5730
    ISSN (online) 1309-5730
    ISSN 1309-5730
    DOI 10.5146/tjpath.2022.01580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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