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  1. Book ; Conference proceedings: New issues in skin and soft tissue infections

    Esposito, Silvano

    [includes papers presented at a Workshop on Skin and Soft Tissue Infections held in Naples, Italy on 28 January 2009]

    (International journal of antimicrobial agents ; 34, Suppl. 1)

    2009  

    Event/congress Workshop on Skin and Soft Tissue Infections (2009, Neapel)
    Author's details guest ed.: Silvano Esposito
    Series title International journal of antimicrobial agents ; 34, Suppl. 1
    Collection
    Language English
    Size S38 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT015996109
    Database Catalogue ZB MED Medicine, Health

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    Zs A 3368 -34,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Book: Appropriate use of antibiotics for intra abdominal infections

    Esposito, Silvano / Novelli, Andrea

    (Journal of chemotherapy ; 21, Suppl. 1)

    2009  

    Title variant Appropriate use of antibiotics for intra-abdominal infections
    Author's details [suppl. ed.: Silvano Esposito and Andrea Novelli]
    Series title Journal of chemotherapy ; 21, Suppl. 1
    Collection
    Language English
    Size 60 S. : graph. Darst.
    Publisher E.S.I.F.T. srl
    Publishing place Firenze
    Publishing country Italy
    Document type Book
    HBZ-ID HT017060005
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2701 -21,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: Broad Genome Sequencing of Environmental and Clinical Strains and Genotyping.

    Esposito, Alfonso / Piazza, Silvano

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2721, Page(s) 171–181

    Abstract: The Next-Generation Sequencing revolution had a great impact on the genomics of Pseudomonas aeruginosa. Since the first release of the P. aeruginosa PAO1 genome, there are more than 5700 genomes published. This wealth of information has been accompanied ... ...

    Abstract The Next-Generation Sequencing revolution had a great impact on the genomics of Pseudomonas aeruginosa. Since the first release of the P. aeruginosa PAO1 genome, there are more than 5700 genomes published. This wealth of information has been accompanied by the development of bioinformatic tools for handling genomic and phenotypic data. Bioinformatics, indeed, become de facto a big data science. In this chapter, we give a brief historical overview of the knowledge gained from P. aeruginosa genome sequencing, then we describe the wet-lab procedure to extract the DNA and prepare the library for broad genome sequencing using Illumina MiSeq technology. As last, we describe three user-friendly bioinformatics procedures to infer the P. aeruginosa genotype, starting from NGS data, with the Multi-Locus Sequence Typing method, and visualize it as a minimum spanning tree.
    MeSH term(s) Genotype ; Multilocus Sequence Typing ; Genomics/methods ; Computational Biology/methods ; Genome ; High-Throughput Nucleotide Sequencing/methods ; Pseudomonas aeruginosa/genetics ; Sequence Analysis, DNA/methods
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3473-8_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Update on treatment of COVID-19: ongoing studies between promising and disappointing results.

    Esposito, Silvano / Noviello, Silvana / Pagliano, Pasquale

    Le infezioni in medicina

    2020  Volume 28, Issue 2, Page(s) 198–211

    Abstract: The COVID-19 pandemic represents the greatest global public health crisis since the pandemic influenza outbreak of 1918. We are facing a new virus, so several antiviral agents previously used to treat other coronavirus infections such as SARS and MERS ... ...

    Abstract The COVID-19 pandemic represents the greatest global public health crisis since the pandemic influenza outbreak of 1918. We are facing a new virus, so several antiviral agents previously used to treat other coronavirus infections such as SARS and MERS are being considered as the first potential candidates to treat COVID-19. Thus, several agents have been used by the beginning of the current outbreak in China first and all over the word successively, as reported in several different guidelines and therapeutic recommendations. At the same time, a great number of clinical trials have been launched to investigate the potential efficacy therapies for COVID-19 highlighting the urgent need to get as quickly as possible high-quality evidence. Through PubMed, we explored the relevant articles published on treatment of COVID-19 and on trials ongoing up to April 15, 2020.
    MeSH term(s) Betacoronavirus ; Chloroquine/therapeutic use ; Clinical Trials as Topic ; Coronavirus Infections/drug therapy ; Drug Synergism ; Humans ; Hydroxychloroquine/therapeutic use ; Pandemics ; Pneumonia, Viral/drug therapy ; Zinc/therapeutic use
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF) ; Zinc (J41CSQ7QDS)
    Keywords covid19
    Language English
    Publishing date 2020-04-25
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2041081-5
    ISSN 1124-9390
    ISSN 1124-9390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5576: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Update on the main MDR pathogens: prevalence and treatment options.

    Esposito, Silvano / De Simone, Giuseppe

    Le infezioni in medicina

    2018  Volume 25, Issue 4, Page(s) 301–310

    Abstract: In recent years the proportion of multi-drug resistance (MDR) among the bacterial pathogens causing infections, particularly those acquired in healthcare settings, has risen worryingly worldwide. It poses a serious public health threat as the multiple ... ...

    Abstract In recent years the proportion of multi-drug resistance (MDR) among the bacterial pathogens causing infections, particularly those acquired in healthcare settings, has risen worryingly worldwide. It poses a serious public health threat as the multiple patterns of resistance limit the effective treatment options for such infections. Although many bacterial species have developed reduced susceptibility to a wide array of antimicrobial molecules, a particular group of pathogens acronymically referred to as ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) plays a clinically relevant role in the aetiology of life-threatening nosocomial infections. In this review, we represent the rise of MDR among the ESKAPE pathogens over the decades and report studies from each continent showing the current prevalence and burden of such infections worldwide.
    MeSH term(s) Acinetobacter Infections/drug therapy ; Acinetobacter Infections/epidemiology ; Acinetobacter baumannii/drug effects ; Acinetobacter baumannii/isolation & purification ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Drug Resistance, Multiple, Bacterial ; Enterobacter/drug effects ; Enterobacter/isolation & purification ; Enterococcus faecium/drug effects ; Enterococcus faecium/isolation & purification ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/epidemiology ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Klebsiella Infections/drug therapy ; Klebsiella Infections/epidemiology ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/isolation & purification ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/isolation & purification ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/isolation & purification
    Language English
    Publishing date 2018-01-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2041081-5
    ISSN 1124-9390
    ISSN 1124-9390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5576: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: An evidence based narrative review on treatment of diabetic foot osteomyelitis.

    Aicale, Rocco / Cipollaro, Lucio / Esposito, Silvano / Maffulli, Nicola

    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

    2020  Volume 18, Issue 5, Page(s) 311–320

    Abstract: Objective: The diagnosis of diabetic food infection is usually clinical, and its severity is related to location and depth of the lesion, and the presence of necrosis or gangrene. Osteomyelitis of the foot and ankle can be extremely debilitating, and, ... ...

    Abstract Objective: The diagnosis of diabetic food infection is usually clinical, and its severity is related to location and depth of the lesion, and the presence of necrosis or gangrene. Osteomyelitis of the foot and ankle can be extremely debilitating, and, in the preantibiotic era acute staphylococcal osteomyelitis carried a mortality rate of 50%. The microbiology of diabetic foot osteomyelitis (DFO) is usually polymicrobial. Indeed, gram-negative and gram-positive bacilli can be identified using molecular techniques applied to bone biopsies compared to conventional techniques. The aim of the present study is to report a complete overview regarding medical and surgical management of diabetic foot osteomyelitis (DFO) in combination or alone.
    Materials and methods: We performed a search in PubMed and Scopus electronic databases (up to January 2019) of articles assessing the epidemiology, diagnostic strategy and pharmacological treatment of diabetic foot infection. In the search strategy, we used various combinations of the following key terms: infection, orthopaedic, diabetic foot, management, DFO.
    Results: This article discusses the definition, epidemiology, microbiological assessment, clinical evaluation, pharmacological and surgical management and a comparison between them, of DFO. After the initial literature search and removal of duplicate records, a total of 756 potentially relevant citations were identified. After a further screening and according to the inclusion criteria, a total of 65 articles were included in the present review.
    Conclusion: The association of antibiotic and surgical therapy seems to be more effective compared to each one alone. The lack of comparison studies and randomized controlled trials makes it difficult to give information about the efficacy of the different management therapies.
    MeSH term(s) Diabetic Foot/complications ; Diabetic Foot/therapy ; Humans ; Osteomyelitis/diagnosis ; Osteomyelitis/etiology ; Osteomyelitis/therapy
    Language English
    Publishing date 2020-02-17
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 2102927-1
    ISSN 1479-666X
    ISSN 1479-666X
    DOI 10.1016/j.surge.2020.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Characteristics of viral pneumonia in the COVID-19 era: an update.

    Pagliano, P / Sellitto, C / Conti, V / Ascione, T / Esposito, Silvano

    Infection

    2021  Volume 49, Issue 4, Page(s) 607–616

    Abstract: Influenza virus, rhinovirus, and adenovirus frequently cause viral pneumonia, an important cause of morbidity and mortality especially in the extreme ages of life. During the last two decades, three outbreaks of coronavirus-associated pneumonia, namely ... ...

    Abstract Influenza virus, rhinovirus, and adenovirus frequently cause viral pneumonia, an important cause of morbidity and mortality especially in the extreme ages of life. During the last two decades, three outbreaks of coronavirus-associated pneumonia, namely Severe Acute Respiratory Syndrome, Middle-East Respiratory Syndrome, and the ongoing Coronavirus Infectious Disease-2019 (COVID-19) were reported. The rate of diagnosis of viral pneumonia is increasingly approaching 60% among children identified as having community-acquired pneumonia (CAP). Clinical presentation ranges from mild to severe pneumonitis complicated by respiratory failure in severe cases. The most vulnerable patients, the elderly and those living with cancer, report a relevant mortality rate. No clinical characteristics can be useful to conclusively distinguish the different etiology of viral pneumonia. However, accessory symptoms, such as anosmia or ageusia together with respiratory symptoms suggest COVID-19. An etiologic-based treatment of viral pneumonia is possible in a small percentage of cases only. Neuraminidase inhibitors have been proven to reduce the need for ventilatory support and mortality rate while only a few data support the large-scale use of other antivirals. A low-middle dose of dexamethasone and heparin seems to be effective in COVID-19 patients, but data regarding their possible efficacy in viral pneumonia caused by other viruses are conflicting. In conclusion, viral pneumonia is a relevant cause of CAP, whose interest is increasing due to the current COVID-19 outbreak. To set up a therapeutic approach is difficult because of the low number of active molecules and the conflicting data bearing supportive treatments such as steroids.
    MeSH term(s) Age Factors ; COVID-19/complications ; Humans ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology
    Language English
    Publishing date 2021-03-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-021-01603-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 528: Show issues

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  8. Article: Could SARS-CoV-2/COVID-19 simply fade away?

    Rosselli, Diego / Yucumá, Daniela / Rodríguez-Morales, Alfonso J / Esposito, Silvano

    Le infezioni in medicina

    2020  Volume 28, Issue suppl 1, Page(s) 1–3

    Abstract: not available. ...

    Abstract not available.
    MeSH term(s) Betacoronavirus/genetics ; Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/epidemiology ; Global Health ; Humans ; Incidence ; Latin America/epidemiology ; Morbidity/trends ; Mutation ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2041081-5
    ISSN 1124-9390
    ISSN 1124-9390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5576: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Burden of fungal meningitis.

    Pagliano, Pasquale / Esposito, Silvano / Ascione, Tiziana / Spera, Anna M

    Future microbiology

    2020  Volume 15, Page(s) 469–472

    MeSH term(s) Candida albicans/genetics ; Candida albicans/isolation & purification ; Candida albicans/physiology ; Candidiasis/diagnosis ; Candidiasis/economics ; Candidiasis/microbiology ; Candidiasis/mortality ; Cost of Illness ; Cryptococcosis/diagnosis ; Cryptococcosis/economics ; Cryptococcosis/microbiology ; Cryptococcosis/mortality ; Cryptococcus neoformans/genetics ; Cryptococcus neoformans/isolation & purification ; Cryptococcus neoformans/physiology ; Humans ; Meningitis, Fungal/diagnosis ; Meningitis, Fungal/economics ; Meningitis, Fungal/microbiology ; Meningitis, Fungal/mortality
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Editorial
    ISSN 1746-0921
    ISSN (online) 1746-0921
    DOI 10.2217/fmb-2020-0006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Visceral leishmaniosis in immunocompromised host: an update and literature review.

    Pagliano, Pasquale / Esposito, Silvano

    Journal of chemotherapy (Florence, Italy)

    2017  Volume 29, Issue 5, Page(s) 261–266

    Abstract: Visceral leishmaniasis (VL) is a chronic infectious disease endemic in tropical and sub-tropical areas including the Mediterranean basin, caused by a group of protozoan parasites of the genus Leishmania and transmitted by phlebotomine sandflies. ... ...

    Abstract Visceral leishmaniasis (VL) is a chronic infectious disease endemic in tropical and sub-tropical areas including the Mediterranean basin, caused by a group of protozoan parasites of the genus Leishmania and transmitted by phlebotomine sandflies. Immunocompromised patients, in particular HIV positive, are considered at risk of VL. They report atypical signs and poor response to treatment due to impairment of T-helper and regulatory cells activity. Laboratory diagnosis is based on microscopy on bone marrow or spleen aspirates. Value of serology remains high in term of sensibility, but a positive test must be confirmed by microscopy or molecular tests. Treatment is based on Liposomal amphotericin B whose administration is associated to lower incidence of side effects, in respect to antimonials and other formulations of AmB. Use of Miltefosine needs further investigation when L. infantum is the causative agent. Frequent relapses are observed in co-infected HIV who can benefit of a second cycle.
    Language English
    Publishing date 2017-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036294-0
    ISSN 1973-9478 ; 1120-009X
    ISSN (online) 1973-9478
    ISSN 1120-009X
    DOI 10.1080/1120009X.2017.1323150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 387: Show issues

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