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  1. Article ; Online: Reversing Anticancer Drug Resistance by Synergistic Combination of Chemotherapeutics and Membranolytic Antitumor β-Peptide Polymer.

    Shao, Ning / Yuan, Ling / Liu, Longqiang / Cong, Zihao / Wang, Jiangzhou / Wu, Yueming / Liu, Runhui

    Journal of the American Chemical Society

    2024  

    Abstract: Multidrug resistance is the main obstacle to cancer chemotherapy. Overexpression of drug efflux pumps causes excessive drug efflux from cancer cells, ultimately leading to drug resistance. Hereby, we raise an effective strategy to overcome multidrug ... ...

    Abstract Multidrug resistance is the main obstacle to cancer chemotherapy. Overexpression of drug efflux pumps causes excessive drug efflux from cancer cells, ultimately leading to drug resistance. Hereby, we raise an effective strategy to overcome multidrug resistance using a synergistic combination of membranolytic antitumor β-peptide polymer and chemotherapy drugs. This membrane-active β-peptide polymer promotes the transmembrane transport of chemotherapeutic drugs by increasing membrane permeability and enhances the activity of chemotherapy drugs against multidrug-resistant cancer cells. As a proof-of-concept demonstration, the synergistic combination of β-peptide polymer and doxorubicin (DOX) is substantially more effective than DOX alone against drug-resistant cancer both
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.4c00434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  2. Article: Efficacy evaluation of pulmonary hypertension therapy in patients with portal pulmonary hypertension: A systematic review and meta-analysis.

    Zhang, Ruihua / Li, Tengfei / Shao, Yueming / Bai, Wei / Wen, Xiaoyu

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 991568

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2022-11-16
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.991568
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  3. Article: Significance of initiating antiretroviral therapy in the early stage of HIV infection.

    Shao, Yueming / Xun, Jingna / Chen, Jun / Lu, Hongzhou

    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

    2022  Volume 51, Issue 3, Page(s) 373–379

    Abstract: A growing number of guidelines now recommend that human immunodeficiency virus (HIV) infected patients should be given early antiretroviral therapy (ART), especially in acute HIV infection. ART during early infection can limit viral reservoirs and ... ...

    Abstract A growing number of guidelines now recommend that human immunodeficiency virus (HIV) infected patients should be given early antiretroviral therapy (ART), especially in acute HIV infection. ART during early infection can limit viral reservoirs and improve immune cell function. From a societal prospect, early-infected individuals who achieve a state of viral suppression through ART can reduce the chance of HIV transmission and reduce the acquired immunodeficiency syndrome (AIDS)-related disease burden. However, there are many problems in the early diagnosis and treatment of HIV infection, including personal and social factors, which hinder the implementation and development of early treatment. It is recommended that initiating ART in the early stage of HIV infection, combined with other treatment strategies, so as to achieve functional cure.
    MeSH term(s) Acquired Immunodeficiency Syndrome/drug therapy ; Anti-Retroviral Agents/therapeutic use ; HIV Infections/drug therapy ; Humans ; Viral Load
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2022-10-04
    Publishing country China
    Document type Journal Article
    ISSN 1008-9292
    ISSN 1008-9292
    DOI 10.3724/zdxbyxb-2022-0052
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  4. Article ; Online: Exploring the complex trade-offs and synergies of global ecosystem services.

    Wang, Jinnan / Wu, Wenjun / Yang, Meng / Gao, Yueming / Shao, Jiacheng / Yang, Weishan / Ma, Guoxia / Yu, Fang / Yao, Nan / Jiang, Hongqiang

    Environmental science and ecotechnology

    2024  Volume 21, Page(s) 100391

    Abstract: The trade-off and synergy relationship of ecosystem services is an important topic in the current assessment. The value of each service provided by the ecosystem is substantially affected by human activities, and conversely, its changes will also affect ... ...

    Abstract The trade-off and synergy relationship of ecosystem services is an important topic in the current assessment. The value of each service provided by the ecosystem is substantially affected by human activities, and conversely, its changes will also affect the relevant human decisions. Due to varying trade-offs among ecosystem services and synergies between them that can either increase or decrease, it is difficult to optimize multiple ecosystem services simultaneously, making it a huge challenge for ecosystem management. This study firstly develops a global Gross Ecosystem Product (GEP) accounting framework. It uses remote sensing data with a spatial resolution of 1 km to estimate the ecosystem services of forests, wetlands, grasslands, deserts, and farmlands in 179 major countries in 2018. The results show that the range of global GEP values is USD 112-197 trillion, with an average value of USD 155 trillion (the constant price), and the ratio of GEP to gross domestic product (GDP) is 1.85. The trade-offs and the synergies among different ecosystem services in each continent and income group have been further explored. We found a correspondence between the income levels and the synergy among ecosystem services within each nation. Among specific ecosystem services, there are strong synergies between oxygen release, climate regulation, and carbon sequestration services. A trade-off relationship has been observed between flood regulation and other services, such as water conservation and soil retention services in low-income countries. The results will help clarify the roles and the feedback mechanisms between different stakeholders and provide a scientific basis for optimizing ecosystem management and implementing ecological compensation schemes to enhance human well-being.
    Language English
    Publishing date 2024-01-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-4984
    ISSN (online) 2666-4984
    DOI 10.1016/j.ese.2024.100391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Author Correction: A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens.

    Zhou, Min / Liu, Longqiang / Cong, Zihao / Jiang, Weinan / Xiao, Ximian / Xie, Jiayang / Luo, Zhengjie / Chen, Sheng / Wu, Yueming / Xue, Xinying / Shao, Ning / Liu, Runhui

    Nature microbiology

    2024  

    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Published Erratum
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-024-01709-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intelligent carboxymethyl cellulose composite films containing Garcinia mangostana shell anthocyanin with improved antioxidant and antibacterial properties.

    Guo, Hao / Yue, Zhen / Shao, Chun / Han, Yingsheng / Li, Sijia / Miao, Zhikun / Gao, Shan / Li, Juan / Li, Yueming / Mi, Lufan / Lu, Panfang

    International journal of biological macromolecules

    2024  Volume 263, Issue Pt 2, Page(s) 130362

    Abstract: In this study, anthocyanin from Garcinia mangostana shell extract (Mse) was used as pH indicator to prepare intelligent carboxymethyl cellulose (CMC) based composite films. The structure and properties of the CMC-based composite films were characterized ... ...

    Abstract In this study, anthocyanin from Garcinia mangostana shell extract (Mse) was used as pH indicator to prepare intelligent carboxymethyl cellulose (CMC) based composite films. The structure and properties of the CMC-based composite films were characterized and discussed in detail. Results showed that the CMC-based composite films with Mse had excellent mechanical, antibacterial and antioxidant abilities. Especially, the carboxymethyl cellulose/corn starch/Garcinia mangostana shell extract (CMC/Cst/Mse) composite film had best mechanical properties (20.62 MPa, 4.06 % EB), lowest water vapor permeability (1.80 × 10
    MeSH term(s) Animals ; Antioxidants/chemistry ; Anthocyanins/pharmacology ; Carboxymethylcellulose Sodium/chemistry ; Garcinia mangostana ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Food Packaging/methods ; Plant Extracts/pharmacology
    Chemical Substances Antioxidants ; Anthocyanins ; Carboxymethylcellulose Sodium (K679OBS311) ; Anti-Bacterial Agents ; Plant Extracts
    Language English
    Publishing date 2024-02-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.130362
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Update: Drug treatment options for coronavirus disease 2019 (COVID-19).

    Shao, Yueming / Chen, Jun / Lu, Hongzhou

    Bioscience trends

    2021  Volume 15, Issue 5, Page(s) 345–349

    Abstract: Coronavirus disease 19 (COVID-19) continues to rage as a global pandemic. A number of potential therapeutic agents have been explored over the past year or two. However, numerous drugs that were expected to prove highly effective, such as lopinavir/ ... ...

    Abstract Coronavirus disease 19 (COVID-19) continues to rage as a global pandemic. A number of potential therapeutic agents have been explored over the past year or two. However, numerous drugs that were expected to prove highly effective, such as lopinavir/ritonavir and remdesivir, have been found to have little benefit in large clinical trials. Interleukin-6 receptor antagonists, glucocorticoids, Janus kinase inhibitors, and some antivirals have been found to provide significant benefits in terms of reducing viral load, reducing the time of nucleic acid conversion, or improving survival. For example, bamlanivimab and etesevimab, which are newly designed monoclonal antibodies against the surface spike protein S1 subunit receptor-binding domain (RBD) of SARS-CoV-2, have a significant effect on reducing the viral load and the hospitalization rate of patients with mild COVID-19. Several vaccines against SARS-CoV-2 have been widely administered worldwide and have provided good protection. Nevertheless, the increasingly hardy variants of the virus have raised the requirements for vaccine design. Perhaps RBD-based vaccines are a viable way to defend against variants, but this still needs to be verified in a large sample. Therefore, this paper provides an update on the treatment options for COVID-19 based on three previously proposed dimensions of drug screening: standard assays of existing broad-spectrum antivirals, screening of chemical libraries, and redevelopment of new, specific drugs.
    MeSH term(s) Animals ; Antibodies, Monoclonal/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19 Vaccines ; Drug Repositioning ; Humans ; Randomized Controlled Trials as Topic
    Chemical Substances Antibodies, Monoclonal ; Antiviral Agents ; COVID-19 Vaccines
    Language English
    Publishing date 2021-08-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2543899-2
    ISSN 1881-7823 ; 1881-7815
    ISSN (online) 1881-7823
    ISSN 1881-7815
    DOI 10.5582/bst.2021.01346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens.

    Zhou, Min / Liu, Longqiang / Cong, Zihao / Jiang, Weinan / Xiao, Ximian / Xie, Jiayang / Luo, Zhengjie / Chen, Sheng / Wu, Yueming / Xue, Xinying / Shao, Ning / Liu, Runhui

    Nature microbiology

    2024  

    Abstract: Drug-resistant fungal infections pose a significant threat to human health. Dual-targeting compounds, which have multiple targets on a single pathogen, offer an effective approach to combat drug-resistant pathogens, although ensuring potent activity and ... ...

    Abstract Drug-resistant fungal infections pose a significant threat to human health. Dual-targeting compounds, which have multiple targets on a single pathogen, offer an effective approach to combat drug-resistant pathogens, although ensuring potent activity and high selectivity remains a challenge. Here we propose a dual-targeting strategy for designing antifungal compounds. We incorporate DNA-binding naphthalene groups as the hydrophobic moieties into the host defence peptide-mimicking poly(2-oxazoline)s. This resulted in a compound, (Gly
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-024-01662-5
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  9. Article ; Online: Integration of photothermal water evaporation with photocatalytic microplastics upcycling via nanofluidic thermal management.

    Meng, Xiangyu / Wang, Xin / Yin, Kuibo / Jing, Yao / Gu, Liuning / Tao, Zequan / Ren, Xinchuan / Tang, Mingyu / Shao, Xinxing / Sun, Litao / Sun, Yueming / Dai, Yunqian / Xiong, Yujie

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 13, Page(s) e2317192121

    Abstract: Photothermal heating and photocatalytic treatment are two solar-driven water processing approaches by harnessing NIR and UV-vis light, respectively, which can fully utilize solar energy if integrated. However, it remains a challenge to achieve high ... ...

    Abstract Photothermal heating and photocatalytic treatment are two solar-driven water processing approaches by harnessing NIR and UV-vis light, respectively, which can fully utilize solar energy if integrated. However, it remains a challenge to achieve high performance in both approaches when integrated in a material due to uncontrollable heat diffusion. Here, we report a demonstration of heat confinement on photothermal sites and fluid cooling on photocatalysis sites at the nanoscale, within a well-designed heat and fluid confinement nanofiber reactor. Photothermal and photocatalytic nanostructures were alternatively aligned in electrospun nanofibers for on-demand nanofluidic thermal management as well as easy folding into 3D structures with enhanced light utilization and mass transfer. Such a design showed simultaneously high photothermal evaporation rate (2.59 kg m
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2317192121
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  10. Article ; Online: Corrigendum to "Activated low-grade phosphate rocks for simultaneously reducing the phosphorus loss and cadmium uptake by rice in paddy soil" [Sci. Total Environ., 780 (2021) 146550/STOTEN-D-21-02113].

    Shao, Xiangqing / Yao, Huanli / Cui, Shihao / Peng, Yutao / Gao, Xing / Yuan, Chengpeng / Chen, Xian / Hu, Yueming / Mao, Xiaoyun

    The Science of the total environment

    2021  Volume 789, Page(s) 148432

    Language English
    Publishing date 2021-06-18
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.148432
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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