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  1. Article ; Online: COVID-19 in children and the importance of COVID-19 vaccination.

    Xue, Feng-Xia / Shen, Kun-Ling

    World journal of pediatrics : WJP

    2021  Volume 17, Issue 5, Page(s) 462–466

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Child ; Humans
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-09-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2236681-7
    ISSN 1867-0687 ; 1708-8569
    ISSN (online) 1867-0687
    ISSN 1708-8569
    DOI 10.1007/s12519-021-00466-5
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    Zs.A 6309: Show issues Location:
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  2. Article ; Online: Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue.

    Shen, Kun-Ling / Yang, Yong-Hong

    World journal of pediatrics : WJP

    2020  Volume 16, Issue 3, Page(s) 219–221

    MeSH term(s) Adolescent ; Age Factors ; Antiviral Agents/therapeutic use ; COVID-19 ; COVID-19 Testing ; Child ; Child, Preschool ; China/epidemiology ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Disease Outbreaks/statistics & numerical data ; Female ; Humans ; Incidence ; Infant ; Interferons/therapeutic use ; Male ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Severe Acute Respiratory Syndrome/diagnosis ; Severe Acute Respiratory Syndrome/therapy ; Severity of Illness Index ; Sex Factors
    Chemical Substances Antiviral Agents ; Interferons (9008-11-1)
    Keywords covid19
    Language English
    Publishing date 2020-02-05
    Publishing country Switzerland
    Document type Editorial ; Review
    ZDB-ID 2236681-7
    ISSN 1867-0687 ; 1708-8569
    ISSN (online) 1867-0687
    ISSN 1708-8569
    DOI 10.1007/s12519-020-00344-6
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    Zs.A 6309: Show issues Location:
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  3. Article ; Online: Ellagic acid protects against angiotensin II-induced hypertrophic responses through ROS-mediated MAPK pathway in H9c2 cells.

    Lee, Ya-Che / Jou, Yeong-Chin / Chou, Wan-Ching / Tsai, Kun-Ling / Shen, Cheng-Huang / Lee, Shin-Da

    Environmental toxicology

    2024  Volume 39, Issue 5, Page(s) 3253–3263

    Abstract: The early myocardial response of hypertension is an elevation of angiotensin-II (Ang-II) concentration, leading to heart failure and cardiac hypertrophy. This hypertrophic event of the heart is mediated by the interaction of Ang type 1 receptors (AT-R1), ...

    Abstract The early myocardial response of hypertension is an elevation of angiotensin-II (Ang-II) concentration, leading to heart failure and cardiac hypertrophy. This hypertrophic event of the heart is mediated by the interaction of Ang type 1 receptors (AT-R1), thereby modulating NADPH oxidase activity in cardiomyocytes, which alters redox status in cardiomyocytes. Ellagic acid (EA) has anti-inflammatory and anti-oxidative capacities. Thus, EA has potential preventive effects on cardiovascular diseases and diabetes. In the last decades, because the protective effect of EA on Ang-II-induced hypertrophic responses is unclear, this study aims to investigate the protective effect of EA in cardiomyocytes. H9c2 cells were treated to Ang-II 1 μM for 24 h to induce cellular damage. We found that EA protected against Ang-II-increased cell surface area and pro-hypertrophic gene expression in H9c2. EA reduced Ang-II-caused AT-R1 upregulation, thereby inhibiting oxidative stress NADPH oxidase activation. EA mitigated Ang-II-enhanced p38 and extracellular-signal-regulated kinase (ERK) phosphorylation. Moreover, EA treatment under Ang-II stimulation also reversed NF-κB activity and iNOS expression. This study shows that EA protects against Ang-II-induced myocardial hypertrophy and attenuates oxidative stress through reactive oxygen species-mediated mitogen-activated protein kinase signaling pathways in H9c2 cells. Thus, EA may be an effective compound for preventing Ang-II-induced myocardial hypertrophy.
    MeSH term(s) Humans ; Reactive Oxygen Species/metabolism ; Angiotensin II/pharmacology ; Angiotensin II/metabolism ; Ellagic Acid/pharmacology ; Myocytes, Cardiac ; Cardiomegaly ; NADPH Oxidases/metabolism ; NADPH Oxidases/pharmacology
    Chemical Substances Reactive Oxygen Species ; Angiotensin II (11128-99-7) ; Ellagic Acid (19YRN3ZS9P) ; NADPH Oxidases (EC 1.6.3.-)
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.24170
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    Zs.A 2676: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: [Pay more attention to the diagnosis and treatment of bronchiolitis obliterans in children].

    Shen, Kun-ling

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2012  Volume 50, Issue 10, Page(s) 721

    MeSH term(s) Bronchiolitis Obliterans/diagnosis ; Bronchiolitis Obliterans/etiology ; Bronchiolitis Obliterans/therapy ; Child ; Humans
    Language Chinese
    Publishing date 2012-10
    Publishing country China
    Document type Editorial
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
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    Zs.B 3292: Show issues Location:
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  6. Article ; Online: Community-acquired Pneumonia and its Complications.

    Qin, Qiang / Shen, Kun-ling

    Indian journal of pediatrics

    2015  Volume 82, Issue 8, Page(s) 745–751

    Abstract: Community-acquired pneumonia (CAP) remains a major cause of morbidity and mortality worldwide in developing and developed countries, and its incidence is highest among children less than 5-y-old. Over the last five years, several international and local ... ...

    Abstract Community-acquired pneumonia (CAP) remains a major cause of morbidity and mortality worldwide in developing and developed countries, and its incidence is highest among children less than 5-y-old. Over the last five years, several international and local guidelines have been updated with new evidence concerning the epidemiology, etiology, pathogenesis, treatment and prevention of pediatric CAP, but there are still several major problems that need to be standardised. The aim of this review is to consider the available data concerning the termination, epidemiology, microbiology and pathogenesis, clinical features, diagnosis and differential diagnosis, treatment, and complications of pediatric CAP. There still are many unanswered questions concerning the management of CAP, including its definition, the difficulty to identify its etiological agents, the emergence of drug, and the lack of introduction of vaccines against respiratory pathogens in developing countries. More research is required in various areas (including therapy of atypical agents), and further efforts are needed to increase vaccination in order to reduce the incidence of the disease.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Child ; Child, Preschool ; Community-Acquired Infections/complications ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/drug therapy ; Diagnosis, Differential ; Humans ; Pneumonia, Bacterial/complications ; Pneumonia, Bacterial/diagnosis ; Pneumonia, Bacterial/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2015-08
    Publishing country India
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-015-1785-4
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    Zs.A 826: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Pseudo-Bartter Syndrome in a Chinese Infant with Cystic Fibrosis Caused by c.532G>A Mutation in

    Yao, Yao / Feng, Xue-Li / Xu, Bao-Ping / Shen, Kun-Ling

    Chinese medical journal

    2018  Volume 130, Issue 22, Page(s) 2771–2772

    MeSH term(s) Asian Continental Ancestry Group ; Bartter Syndrome/genetics ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Female ; Humans ; Infant ; Mutation/genetics
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2018-01-04
    Publishing country China
    Document type Case Reports ; Letter
    ZDB-ID 127089-8
    ISSN 0366-6999 ; 1002-0187
    ISSN 0366-6999 ; 1002-0187
    DOI 10.4103/0366-6999.218015
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    Zs.B 1207: Show issues Location:
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    Ua VI Zs.425: Show issues Location:
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  8. Article ; Online: Lactate-buffered solutions in patients with citrin deficiency.

    Tao, Kun-Ming / Shen, Ling / Sun, Yu-Ming

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2022  Volume 69, Issue 6, Page(s) 786–787

    MeSH term(s) Citrullinemia ; Humans ; Isotonic Solutions ; Lactic Acid
    Chemical Substances Isotonic Solutions ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Letter
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-022-02212-5
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    Zs.A 109: Show issues Location:
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  9. Article ; Online: Etiology and clinical features of children with bronchiectasis in China: A 10-year multicenter retrospective study.

    Wang, Hao / Xu, Bao-Ping / Bao, Yan-Min / Yang, Yungang / Qian, Li-Ling / Zhang, Hai-Lin / Zhu, Chun-Mei / Yin, Yong / Jiang, Min / Dai, Ji-Hong / Xu, Yong-Sheng / Zhu, Xiao-Hua / Zhu, Xiao-Ping / Shen, Kun-Ling

    The clinical respiratory journal

    2023  Volume 17, Issue 9, Page(s) 841–850

    Abstract: Introduction: The current study aims to investigate the etiology spectrum and the clinical characteristics of bronchiectasis in Chinese children.: Methods: The study is designed as a multicenter retrospective study. 193 cases were enrolled in 13 ... ...

    Abstract Introduction: The current study aims to investigate the etiology spectrum and the clinical characteristics of bronchiectasis in Chinese children.
    Methods: The study is designed as a multicenter retrospective study. 193 cases were enrolled in 13 centers in China between 2008 and 2017. The inclusive cases must meet the clinical as well as the HRCT criteria. Only if both two radiologists confirmed the diagnosis, the case could be enrolled. The cases that could not provide clinical and imageology data were excluded. The data were entered into the specialized system and then analyzed.
    Results: One hundred sixty-nine cases (87%) were found to have the underlying etiology. Post-infective (46%), primary immunodeficiency (14%), and PCD (13%) were the common causes. All cases came from 28 provinces in Mainland China. The median age of symptom onset was 5.8 (2.0, 8.9) years. The median age of diagnosis was 8.4 (4.5, 11.6) years. The main symptoms were cough, sputum expectoration, and fever during the exacerbation. Nineteen percent of patients suffered from limited exercise tolerance. Clubbing was found in 17% of cases. Nearly 30% of patients presented growth limitations. On the HRCT findings, 126 cases had diffused bronchiectasis, and bilateral involvement was found in 94 cases. The lower lobes and right middle lobes were most commonly involved. Approximately 30% of cultures of sputum and bronchoalveolar lavage were positive.
    Conclusion: A majority of cases could be found the underlying etiology. Post-infective, primary immunodeficiency, and PCD were the most common causes. Some clinical figures might indicate a specific etiology.
    MeSH term(s) Child ; Humans ; Retrospective Studies ; Bronchiectasis/diagnostic imaging ; Bronchiectasis/epidemiology ; Lung ; Cough/etiology ; Cough/complications ; China/epidemiology
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2442214-9
    ISSN 1752-699X ; 1752-6981
    ISSN (online) 1752-699X
    ISSN 1752-6981
    DOI 10.1111/crj.13630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A pilot study: effectiveness of local injection of autologous platelet-rich plasma in treating women with stress urinary incontinence.

    Long, Cheng-Yu / Lin, Kun-Ling / Shen, Chin-Ru / Ker, Chin-Ru / Liu, Yi-Yin / Loo, Zi-Xi / Hsiao, Hui-Hua / Lee, Yung-Chin

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 1584

    Abstract: The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering ... ...

    Abstract The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering from SUI were treated with A-PRP injection at anterior vaginal wall where mid-urethra locates. Self-reported questionnaires were used to measure pre-treatment, 1 month and 6 months post-treatment symptom severity. Secondary outcomes of sexual function and treatment effect sorted by age were analyzed with valid statistical methods. A-PRP is effective in relieving SUI symptoms at both 1 month and 6 months post-treatment without significant adverse reactions reported. It seems to have a trend that treatment success rate with cured and improved symptoms was slightly higher in the younger group, although it did not reach statistical significance (P = 0.07). No significant changes in sexual function before and after the treatment were reported by the patients. This pilot study is the first to report A-PRP treatment effect for SUI in women. The result suggested that A-PRP is a considerable treatment option for mild to moderate SUI cases. It also opens up further research opportunities for A-PRP's clinical applications.
    MeSH term(s) Adult ; Female ; Humans ; Middle Aged ; Pilot Projects ; Platelet Transfusion ; Platelet-Rich Plasma/chemistry ; Prospective Studies ; Severity of Illness Index ; Transplantation, Autologous ; Treatment Outcome ; Urethra/pathology ; Urinary Incontinence, Stress/pathology ; Urinary Incontinence, Stress/therapy ; Urodynamics ; Vagina/pathology
    Language English
    Publishing date 2021-01-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-80598-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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