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  1. Article ; Online: Prognostic value of low-voltage area burden in atrial fibrillation.

    Nery, Pablo B / Nair, Girish M / Birnie, David H

    Heart rhythm

    2024  Volume 21, Issue 4, Page(s) 387–388

    MeSH term(s) Humans ; Atrial Fibrillation ; Prognosis ; Heart Atria ; Catheter Ablation
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2024.01.036
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    Zs.A 6278: Show issues Location:
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  2. Article ; Online: Impact of a structured reporting template on the quality of HRCT radiology reports for interstitial lung disease.

    Ngo, Han G / Nair, Girish B / Al-Katib, Sayf

    Clinical imaging

    2023  Volume 97, Page(s) 78–83

    Abstract: Purpose: This QI study compared the completeness of HRCT radiology reports before and after the implementation of a disease-specific structured reporting template for suspected cases of interstitial lung disease (ILD).: Materials and methods: A pre- ... ...

    Abstract Purpose: This QI study compared the completeness of HRCT radiology reports before and after the implementation of a disease-specific structured reporting template for suspected cases of interstitial lung disease (ILD).
    Materials and methods: A pre-post study of radiology reports for HRCT of the thorax at a multicenter health system was performed. Data was collected in 6-month period intervals before (June 2019-November 2019) and after (January 2021-June 2021) the implementation of a disease-specific template. The use of the template was voluntary. The primary outcome measure was the completeness of HRCT reports graded based on the documentation of ten descriptors. The secondary outcome measure assessed which descriptor(s) improved after the intervention.
    Results: 521 HRCT reports before and 557 HRCT reports after the intervention were reviewed. Of the 557 reports, 118 reports (21%) were created using the structured reporting template. The mean completeness score of the pre-intervention group was 9.20 (SD = 1.08) and the post-intervention group was 9.36 (SD = 1.03) with a difference of -0.155, 95% CI [-0.2822, -0.0285, p < 0.0001]. Within the post-intervention group, the mean completeness score of the unstructured reports was 9.25 (SD = 1.07) and the template reports was 9.93 (SD = 0.25) with a difference of -0.677, 95% CI [-0.7871, -0.5671, p < 0.0001]. After the intervention, the use of two descriptors improved significantly: presence of honeycombing from 78.3% to 85.1% (p < 0.0039) and technique from 90% to 96.6% (p < 0.0001).
    Discussion: Shifting to disease-specific structured reporting for HRCT exams of suspected ILD is beneficial, as it improves the completeness of radiology reports. Further research on how to improve the voluntary uptake of a disease-specific template is needed to help increase the acceptance of structured reporting among radiologists.
    MeSH term(s) Research Report/standards ; Research Report/trends ; Radiology/methods ; Radiology/standards ; Radiology/trends ; Lung Diseases, Interstitial/diagnostic imaging ; Radiography, Thoracic/methods ; Radiography, Thoracic/standards ; Humans
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1028123-x
    ISSN 1873-4499 ; 0899-7071
    ISSN (online) 1873-4499
    ISSN 0899-7071
    DOI 10.1016/j.clinimag.2023.03.004
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    Zs.A 1469: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Complex Atrial Tachycardias: Is Technology the Answer or Should the Focus Be on Prevention?

    Nair, Girish M / Nery, Pablo B

    JACC. Clinical electrophysiology

    2020  Volume 6, Issue 7, Page(s) 827–829

    MeSH term(s) Heart Atria ; Humans ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/prevention & control
    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2020.04.018
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  4. Article ; Online: Reply to Hong and Glover-Catheter Ablation of Low-Voltage Areas for Persistent Atrial Fibrillation: Procedural Outcomes Using High-Density Voltage Mapping.

    Nery, Pablo B / Nair, Girish M / Birnie, David H

    The Canadian journal of cardiology

    2021  Volume 37, Issue 8, Page(s) 1297

    MeSH term(s) Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Catheter Ablation ; Humans ; Pulmonary Veins/surgery
    Language English
    Publishing date 2021-03-26
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2021.03.011
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    Zs.A 2150: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Longitudinal Lung Compliance Imaging in Idiopathic Pulmonary Fibrosis.

    Nair, Girish B / Castillo, Edward

    Radiology

    2019  Volume 293, Issue 2, Page(s) 272

    MeSH term(s) Aged ; Female ; Humans ; Idiopathic Pulmonary Fibrosis/diagnostic imaging ; Idiopathic Pulmonary Fibrosis/physiopathology ; Longitudinal Studies ; Lung/diagnostic imaging ; Lung Compliance/physiology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2019-09-17
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2019191115
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    Ue I Zs.106: Show issues Location:
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  6. Article ; Online: Updates on community acquired pneumonia management in the ICU.

    Nair, Girish B / Niederman, Michael S

    Pharmacology & therapeutics

    2020  Volume 217, Page(s) 107663

    Abstract: While the world is grappling with the consequences of a global pandemic related to SARS-CoV-2 causing severe pneumonia, available evidence points to bacterial infection with Streptococcus pneumoniae as the most common cause of severe community acquired ... ...

    Abstract While the world is grappling with the consequences of a global pandemic related to SARS-CoV-2 causing severe pneumonia, available evidence points to bacterial infection with Streptococcus pneumoniae as the most common cause of severe community acquired pneumonia (SCAP). Rapid diagnostics and molecular testing have improved the identification of co-existent pathogens. However, mortality in patients admitted to ICU remains staggeringly high. The American Thoracic Society and Infectious Diseases Society of America have updated CAP guidelines to help streamline disease management. The common theme is use of timely, appropriate and adequate antibiotic coverage to decrease mortality and avoid drug resistance. Novel antibiotics have been studied for CAP and extend the choice of therapy, particularly for those who are intolerant of, or not responding to standard treatment, including those who harbor drug resistant pathogens. In this review, we focus on the risk factors, microbiology, site of care decisions and treatment of patients with SCAP.
    MeSH term(s) Community-Acquired Infections/drug therapy ; Community-Acquired Infections/microbiology ; Community-Acquired Infections/mortality ; Disease Management ; Drug Resistance, Multiple, Bacterial ; Guidelines as Topic ; Humans ; Intensive Care Units ; Pneumonia/drug therapy ; Pneumonia/microbiology ; Pneumonia/mortality
    Keywords covid19
    Language English
    Publishing date 2020-08-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2020.107663
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    Zs.A 1183: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Pulmonary Blood Mass and Quantitative Lung Function Imaging in Idiopathic Pulmonary Fibrosis.

    Nair, Girish B / Al-Katib, Sayf / Castillo, Edward

    Radiology. Cardiothoracic imaging

    2020  Volume 2, Issue 3, Page(s) e200003

    Language English
    Publishing date 2020-06-25
    Publishing country United States
    Document type Journal Article
    ISSN 2638-6135
    ISSN (online) 2638-6135
    DOI 10.1148/ryct.2020200003
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  8. Article: Update on Diagnosis and Treatment of Adult Pulmonary Alveolar Proteinosis.

    Iftikhar, Hira / Nair, Girish B / Kumar, Anupam

    Therapeutics and clinical risk management

    2021  Volume 17, Page(s) 701–710

    Abstract: Pulmonary alveolar proteinosis (PAP) is a rare pulmonary surfactant homeostasis disorder resulting in buildup of lipo-proteinaceous material within the alveoli. PAP is classified as primary (autoimmune and hereditary), secondary, congenital and ... ...

    Abstract Pulmonary alveolar proteinosis (PAP) is a rare pulmonary surfactant homeostasis disorder resulting in buildup of lipo-proteinaceous material within the alveoli. PAP is classified as primary (autoimmune and hereditary), secondary, congenital and unclassifiable type based on the underlying pathogenesis. PAP has an insidious onset and can, in some cases, progress to severe respiratory failure. Diagnosis is often secured with bronchoalveolar lavage in the setting of classic imaging findings. Recent insights into genetic alterations and autoimmune mechanisms have provided newer diagnostics and treatment options. In this review, we discuss the etiopathogenesis, diagnosis and treatment options available and emerging for PAP.
    Language English
    Publishing date 2021-08-10
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186560-7
    ISSN 1178-203X ; 1176-6336
    ISSN (online) 1178-203X
    ISSN 1176-6336
    DOI 10.2147/TCRM.S193884
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    Zs.A 6067: Show issues Location:
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  9. Article ; Online: Static Respiratory System Compliance as a Predictor of Extubation Failure in Patients with Acute Respiratory Failure.

    Abplanalp, Lauren A / Ionescu, Filip / Calvo-Ayala, Enrique / Yu, Limin / Nair, Girish B

    Lung

    2023  Volume 201, Issue 3, Page(s) 309–314

    Abstract: Purpose: Ventilator weaning protocols rely in part on objective indices to best predict extubation failure in the critically ill. We investigated static respiratory system compliance (RC) as a predictor of extubation failure, in comparison to extubation ...

    Abstract Purpose: Ventilator weaning protocols rely in part on objective indices to best predict extubation failure in the critically ill. We investigated static respiratory system compliance (RC) as a predictor of extubation failure, in comparison to extubation readiness using rapid shallow breathing index (RSBI).
    Material and methods: This was a cross-sectional, multi-institutional study of mechanically ventilated patients admitted between 12/01/2017 and 12/01/2019. All patients older than 18 years with a documented spontaneous breathing trial and extubation trial were included. RC and RSBI were calculated prior to the extubation trial. The primary outcome was extubation failure-defined as need for reintubation within 72 h from time of extubation.
    Results: Of the 2263 patients, 55.8% were males with a mean age of 68 years. The population consisted mostly of Caucasians (73%) and African Americans (20.4%). 274 (12.1%) patients required reintubation within 72 h. On multivariate logistic regression after adjusting for age, sex, body mass index (BMI), admission Sequential Organ Failure Assessment (SOFA) score, number of ventilator days, and the P/F ratio on the day of extubation, RC remained the strongest predictor for extubation failure at 24 h (aOR 1.45; 95% CI 1.00-2.10) and 72 h (aOR 1.58; 95% CI 1.15-2.17). There was no significant association between RSBI and extubation failure at 24 (aOR 1.00; 95% CI 0.99-1.01) or at 72 h (aOR 1.00; 95% CI 0.99-1.01).
    Conclusion: RC measured on the day of extubation is a promising physiological discriminant to potentially risk stratify patients with acute respiratory failure for extubation readiness. We recommend further validation studies in prospective cohorts.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Airway Extubation/methods ; Cross-Sectional Studies ; Prospective Studies ; Respiration, Artificial ; Respiratory Insufficiency/therapy ; Respiratory System ; Ventilator Weaning/methods
    Language English
    Publishing date 2023-06-10
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 6165-7
    ISSN 1432-1750 ; 0341-2040
    ISSN (online) 1432-1750
    ISSN 0341-2040
    DOI 10.1007/s00408-023-00625-7
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  10. Article ; Online: RISK OF THROMBOEMBOLISM AFTER COVID-19 VACCINATION AND COVID-19 INFECTION

    Tran, Huong / Risk, Malcolm / Lee, Yung-Chun / Nair.B, Girish / Zhao, Lili

    medRxiv

    Abstract: Background: Vaccine safety monitoring systems worldwide have reported cases of venous thromboembolism and arterial thromboembolism following a COVID-19 vaccination. However, evidence shows that the association between thromboembolism and SARS-CoV-2 ... ...

    Abstract Background: Vaccine safety monitoring systems worldwide have reported cases of venous thromboembolism and arterial thromboembolism following a COVID-19 vaccination. However, evidence shows that the association between thromboembolism and SARS-CoV-2 infection is stronger, compared to SARS-CoV-2 vaccination. Hence, weighing the risks and benefits of vaccination should also encounter the roles of vaccination in reducing infection rate, and potentially indirectly lowering the risk of thromboembolism caused by infection. Methods: We conducted a self-controlled case series study (SCCS) from Dec 1st 2020 to 31st August 2022 (before the bivalent vaccine was available) to examinate the association between the first two doses Pfizer/Moderna vaccination and thrombotic events among patients in Corewell Health East (CHE, formerly known as Beaumont Health) healthcare system. We also investigated the effect SARS-CoV-2 infection on the risk of thrombosis events and observed a significant increased risk using the SCCS design. However, because of misclassification bias, SCCS indeed overestimated incidence rate ratio (IRR) of acute event after infection, we then proposed a case-control study addressing this misclassification issues and obtained odd ratio comparing effect of exposure on thrombosis and a subset of controls group. Finally, we analyzed the risk of thromboembolism between vaccinated and unvaccinated groups by a simple diagram, explaining possible factors that affects the probability of experiencing an acute thromboembolism event after a COVID-19 vaccination. Results: Using EHR data at Corewell East, we found an increased risk of thrombosis after the first two doses of COVID-19 vaccination, with incidence rate ratios after the first dose is 1.16 (CI: [1.04, 1.29]), and after the second dose of 1.19 (CI: [1.07,1.32]). The association between thromboembolism and SARS-Cov-2 infection depends on prior vaccination status, as the conditional OR among unvaccinated and vaccinated groups are 1.77 (CI: [1.48,\ 2.1]) and 1.34 (CI: [1.09,\ 1.66]) respectively. Encountering the vaccine efficacy (VE), receiving the COVID-19 vaccine decreases the risk of thromboembolism, and the benefits of COVID-19 vaccines are much stronger in the period of high infection rate.
    Keywords covid19
    Language English
    Publishing date 2024-02-18
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2024.02.12.24302535
    Database COVID19

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