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Article ; Online: Allogeneic platelet-rich plasma for knee osteoarthritis in patients with primary immune thrombocytopenia: A randomized clinical trial.

Zhu, Xiaohang / Zhao, Lingying / Riva, Nicoletta / Yu, Ziqiang / Jiang, Miao / Zhou, Feng / Gatt, Alexander / Giannoudis, Peter V / Guo, Jiong Jiong

iScience

2024 Volume 27, Issue 5, Page(s) 109664

Abstract: The treatment of painful KOA in adult patients with ITP has not been well studied yet. We conducted a prospective, double-blind, randomized, placebo-controlled trial to evaluate the efficacy of intra-articular allogeneic PRP injections on symptoms and ... ...

Abstract	The treatment of painful KOA in adult patients with ITP has not been well studied yet. We conducted a prospective, double-blind, randomized, placebo-controlled trial to evaluate the efficacy of intra-articular allogeneic PRP injections on symptoms and joint structure in patients with KOA and ITP. 80 participants were randomly allocated in a 1:1 ratio to allogeneic PRP group or saline group. The primary outcome was the WOMAC total score at 12 months post-injection. The number of patients in each group who achieved MCID of primary outcome showed a statistically significant difference only at 3-month (27/39 vs. 5/39,
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109664
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Article: [Review of closed reduction techniques for femoral neck fracture].

Zhu, Xiao-Zhong / Zhu, Yi / Mei, Jiong

Zhongguo gu shang = China journal of orthopaedics and traumatology

2023 Volume 36, Issue 3, Page(s) 273–278

Abstract: For patients with femoral neck fractures who plan to undergo internal fixation, satisfied alignment of fracture ends is an important prerequisite for internal fixation stability and fracture healing. There are many reports on the reduction methods of ... ...

Abstract	For patients with femoral neck fractures who plan to undergo internal fixation, satisfied alignment of fracture ends is an important prerequisite for internal fixation stability and fracture healing. There are many reports on the reduction methods of displaced femoral neck fractures, which can be summarized into three categories:First, the solely longitudinal traction of lower limbs, supplemented by other manipulations such as rotation and compression; Second, the resultant force formed by the longitudinal traction of lower limbs and the lateral traction;the third is accomplished by vertical traction in the axis of femur with hip joint flexed. Each reduction method has its own advantages, but no single method can be applied to all fracture displacement. In this paper, some classical reduction techniques in the literatures are briefly reviewed. It is hoped that clinicians will not be limited to a certain reduction method, they should analyze the injury mechanism and fracture displacement process according to the morphology features and flexibly select targeted reduction methods to improve the success rate of closed reduction of femoral neck fracture.
MeSH term(s)	Humans ; Femoral Neck Fractures/surgery ; Femur ; Fracture Fixation, Internal ; Fracture Healing ; Traction ; Treatment Outcome
Language	Chinese
Publishing date	2023-02-03
Publishing country	China
Document type	English Abstract ; Journal Article ; Review
ISSN	1003-0034
ISSN	1003-0034
DOI	10.12200/j.issn.1003-0034.2023.03.016
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Article ; Online: Searching for Unconventional Superfluid in Excitons of Monolayer Semiconductors.

Chen, Wei / Huang, Chun-Jiong / Zhu, Qizhong

Physical review letters

2023 Volume 131, Issue 23, Page(s) 236004

Abstract: It is well known that two-dimensional (2D) bosons in homogeneous space cannot undergo real Bose-Einstein condensation, and the superfluid to normal phase transition is Berezinskii-Kosterlitz-Thouless (BKT) type, associated with vortex-antivortex pair ... ...

Abstract	It is well known that two-dimensional (2D) bosons in homogeneous space cannot undergo real Bose-Einstein condensation, and the superfluid to normal phase transition is Berezinskii-Kosterlitz-Thouless (BKT) type, associated with vortex-antivortex pair unbinding. Here we point out a 2D bosonic system whose low energy physics goes beyond conventional paradigm of 2D homogeneous bosons, i.e., intralayer excitons in monolayer transition metal dichalcogenides. With intrinsic valley-orbit coupling and valley Zeeman energy, exciton dispersion becomes linear at small momentum, giving rise to a series of novel features. The critical temperature of Bose-Einstein condensation of these excitons is nonzero, suggesting true long-range order in 2D homogeneous system. The dispersion of Goldstone mode at long wavelength has the form ϵ(q)∼sqrt[q], in contrast to conventional linear phonon spectrum. The vortex energy deviates from the usual logarithmic form with respect to system size, but instead has an additional linear term. Superfluid to normal phase transition is no longer BKT type for system size beyond a characteristic scale, without discontinuous jump in superfluid density. With the recent experimental progress on exciton fluid at thermal equilibrium in monolayer semiconductors, our work points out an experimentally accessible system to search for unconventional 2D superfluids beyond BKT paradigm.
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.236004
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Article ; Online: Electrosynthesis of Hydrogen Peroxide Enabled by Exceptional Molecular Ni Sites in a Graphene-Supported Nickel Organic Framework.

Yu, Dongxue / Zhu, Peng / Hu, Chunfeng / Huang, Xiang / Tang, Kangjian / Wang, Jiong

The journal of physical chemistry letters

2023 Volume 14, Issue 49, Page(s) 10959–10966

Abstract: Electrosynthesis of hydrogen peroxide ( ... ...

Abstract	Electrosynthesis of hydrogen peroxide (H
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c02774
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Article: Investigation of Flexural Bearing Behavior of Corroded RC Strengthened with U-Type TRC.

Xie, Wei / Sheng, Jie / Yu, Zongjian / Zhu, Jiong / Zhou, Binbin / Chen, Ke

Materials (Basel, Switzerland)

2024 Volume 17, Issue 5

Abstract: In this study, the flexural bearing behavior of corroded reinforced concrete (RC) beams reinforced with U-type Textile Reinforced Concrete (TRC) was investigated using a four-point bending loading method. Nine test beams were produced: one original beam, ...

Abstract	In this study, the flexural bearing behavior of corroded reinforced concrete (RC) beams reinforced with U-type Textile Reinforced Concrete (TRC) was investigated using a four-point bending loading method. Nine test beams were produced: one original beam, three RC beams with corrosion alone, and five corroded beams strengthened with U-type TRC. The analysis focuses on assessing the impacts of the steel corrosion degree and the number of textile layers on various aspects of the bending behavior, such as failure modes, bearing capacity, and load displacement curves, in U-type TRC-strengthened corroded beams. The experimental results revealed three distinct failure modes in the U-type TRC-strengthened corroded beams. TRC effectively enhanced the bearing capacity. With sufficient textile layers, it can be restored to the level of the original RC beams. Moreover, in the cases of severe corrosion in RC beams, the bearing capacity increased more significantly. The TRC also enhanced the ductility. Finally, a calculation equation for the ultimate bearing capacity of U-type TRC-strengthened corroded beams was presented and validated, demonstrating consistent alignment with the experimental data.
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17051154
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Article ; Online: Traditional Chinese medicine Qingre Huoxue decoction enhances wound healing in through modulation of angiogenic and inflammatory pathways.

Li, Wen / Chen, Yongqi / Cai, Zhenguo / He, Xiang / Yang, Lili / Zhu, Jiong / Wang, Wuqing

International wound journal

2024 Volume 21, Issue 3, Page(s) e14724

Abstract: This study investigates the therapeutic potential of Qingre Huoxue Decoction (QHD), a traditional Chinese herbal formulation, in promoting wound healing in an imiquimod-induced murine model of psoriasis. The research was driven by the need for effective ... ...

Abstract	This study investigates the therapeutic potential of Qingre Huoxue Decoction (QHD), a traditional Chinese herbal formulation, in promoting wound healing in an imiquimod-induced murine model of psoriasis. The research was driven by the need for effective wound healing strategies in psoriatic conditions, where conventional treatments often fall short. Employing a combination of in vivo and in vitro methodologies, we assessed the effects of QHD on key factors associated with wound healing. Our results showed that QHD treatment significantly reduced the expression of angiogenic proteins HIF-1α, FLT-1, and VEGF, and mitigated inflammatory responses, as evidenced by the decreased levels of pro-inflammatory cytokines and increased expression of IL-10. Furthermore, QHD enhanced the expression of genes essential for wound repair. In vitro assays with HUVECs corroborated the anti-angiogenic effects of QHD. Conclusively, the study highlights QHD's efficacy in enhancing wound healing in psoriatic conditions by modulating angiogenic and inflammatory pathways, presenting a novel therapeutic avenue in psoriasis wound management.
MeSH term(s)	Humans ; Animals ; Mice ; Medicine, Chinese Traditional ; Cytokines ; Psoriasis/drug therapy ; Wound Healing ; Drugs, Chinese Herbal
Chemical Substances	qingre huoxue ; Cytokines ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14724
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Article ; Online: Pleural effusion caused by Trichinella spiralis infection: two case reports.

Pan, Zhen-Zhen / Zhu, Miao-Juan / Rong, Yu-Qiong / Yang, Jiong

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 77

Abstract: Background: Trichinosis is a worldwide food-borne zoonotic parasitic disease, which is mainly obtained by ingesting undercooked meat containing infected larvae. The purpose of our article is to introduce and discuss two rare cases of pleural effusion ... ...

Abstract	Background: Trichinosis is a worldwide food-borne zoonotic parasitic disease, which is mainly obtained by ingesting undercooked meat containing infected larvae. The purpose of our article is to introduce and discuss two rare cases of pleural effusion caused by Trichinella spiralis. Case presentation: Here we described two male patients who presented to the respiratory department of our hospital with a massive unilateral pleural effusion, their serum eosinophils were in the normal range, laboratory serological tests revealed that Trichinella spiralis IgG antibody was positive. After the oral administration of antiparasitic drugs, the pleural effusion of two patients was completely absorbed. Conclusion: Both patients were diagnosed with Trichinosis complicated with pleural effusion, which is very rare in the clinic and easy to be misdiagnosed because of normal eosinophils.
MeSH term(s)	Animals ; Humans ; Male ; Trichinellosis/complications ; Trichinellosis/diagnosis ; Trichinellosis/drug therapy ; Trichinella spiralis ; Enzyme-Linked Immunosorbent Assay ; Meat/parasitology ; Pleural Effusion/diagnosis ; Pleural Effusion/etiology ; Antibodies, Helminth ; Larva
Chemical Substances	Antibodies, Helminth
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08047-9
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Article ; Online: Efficacy and safety of treatment with benralizumab for eosinophilic asthma.

Zhu, Miaojuan / Yang, Jiong / Chen, Yifei

International immunopharmacology

2022 Volume 111, Page(s) 109131

Abstract: Eosinophilic asthma accounts for 40% to 50% of asthmatic patients. However, 5% to 10% of patients with asthma need high-dose drug control, which is clinically referred to as severe asthma patients. Interleukin (IL)-5 plays an important role in the ... ...

Abstract	Eosinophilic asthma accounts for 40% to 50% of asthmatic patients. However, 5% to 10% of patients with asthma need high-dose drug control, which is clinically referred to as severe asthma patients. Interleukin (IL)-5 plays an important role in the proliferation, maturation, and migration of eosinophils. Benralizumab, as an antagonist of the IL-5 receptor, can treat eosinophilic asthma by promoting the apoptosis of eosinophils. The implications for efficacy and/or adverse events are unclear. This article reviews the findings about benralizumab in the treatment of severe eosinophilic asthma in recent years. Results indicated the effectiveness of benralizumab for the treatment of severe asthma.
MeSH term(s)	Anti-Asthmatic Agents/adverse effects ; Antibodies, Monoclonal, Humanized/adverse effects ; Asthma/chemically induced ; Asthma/drug therapy ; Eosinophils ; Humans
Chemical Substances	Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized ; benralizumab (71492GE1FX)
Language	English
Publishing date	2022-08-20
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2022.109131
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Article ; Online: Comparative outcomes of patient-specific instrumentation, the conventional method and navigation assistance in open-wedge high tibial osteotomy: A prospective comparative study with a two-year follow up.

Zhu, Xiaohang / Qian, Yufan / Liu, An / Xu, Pingcheng / Guo, Jiong Jiong

The Knee

2022 Volume 39, Page(s) 18–28

Abstract: Background: To compare and analyze the correction precision, clinical outcomes and complications among the three methods of performing open-wedge high tibial osteotomy (HTO), including patient-specific instrumentation (PSI), conventional method and ... ...

Abstract	Background: To compare and analyze the correction precision, clinical outcomes and complications among the three methods of performing open-wedge high tibial osteotomy (HTO), including patient-specific instrumentation (PSI), conventional method and navigation assistance. Methods: In this prospective, single-center study, we randomly assigned patients with knee osteoarthritis in a 1:1:1 ratio to undergo Open-wedge high tibial osteotomy (OWHTO) with conventional method, navigation assistance or PSI. The primary outcome was the target/observed hip-knee-ankle (HKA) angle difference at 1 month postoperatively. Secondary outcomes were changes in the postoperative posterior tibial slope (PTS) at 1 month and clinical outcomes including knee pain on a visual analogue scale (ranging from 0 to 100, with higher scores indicating more severe pain), Lysholm and Western Ontario and McMaster Universities Osteoarthritis Index (ranging from 0 to 240) scores at 1 month, 6 months, 12 months, and 24 months. Results: From 2017 through 2019, a total of 608 patients were screened; of those patients, 144 were enrolled, with 48 in each group. The primary outcome of the HKA difference was 2.6 ± 2.0° in the conventional group, 2.3 ± 1.5° in the navigation group and 0.6 ± 1.0° in the PSI group (P < 0.001). Secondary outcomes including changes in the postoperative PTS and clinical outcomes at 1 month, 6 months, and 12 months were in the same direction as the primary outcome. There were no significant differences in the complications among the three groups. Conclusions: In the present study, none of the three methods showed superiority in objective correction precision and clinical outcomes at 2 years.
Language	English
Publishing date	2022-09-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200476-5
ISSN	1873-5800 ; 0968-0160
ISSN (online)	1873-5800
ISSN	0968-0160
DOI	10.1016/j.knee.2022.08.013
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Article ; Online: Efficacy of intra-articular injection of allogeneic platelet-rich plasma for knee osteoarthritis combined with hematologic blood dyscrasias with platelet dysfunction: protocol of a randomized, double-blind, placebo-controlled trial.

Zhu, Xiaohang / Zhao, Lingying / Liu, An / Yu, Ziqiang / Guo, Jiong Jiong

BMC musculoskeletal disorders

2022 Volume 23, Issue 1, Page(s) 1095

Abstract: Background: Autologous platelet-rich plasma (PRP) has been shown to alleviate the symptoms of patients suffering from knee osteoarthritis (KOA), but for certain patients with hematologic diseases with platelet dysfunction and patients receiving anti- ... ...

Abstract	Background: Autologous platelet-rich plasma (PRP) has been shown to alleviate the symptoms of patients suffering from knee osteoarthritis (KOA), but for certain patients with hematologic diseases with platelet dysfunction and patients receiving anti-platelet medications, autologous PRP is not an optimum solution. Allogeneic PRP has been proven to be safe and effective in the treatment of osteoarthritis, rotator cuff disease, refractory wounds and other medical fields. However, a well-designed and long-term follow-up prospective randomized controlled trial (RCT) to evaluate the effect of allogeneic PRP intra-articular injections for KOA combined with hematologic blood dyscrasias has not yet been performed. Methods/ design: We will conduct an allogeneic PRP injection for KOA combined with hematologic blood dyscrasias with platelet dysfunction study: a prospective, randomized, double-blind, placebo-controlled trial. One hundred participants with KOA combined with hematologic blood dyscrasias with platelet dysfunction will be randomly allocated to receive either one allogeneic PRP injection or one saline injection into the knee joint. The primary outcome will be a 12-month change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. Secondary outcomes will be the 36-Item Short-Form General Health Survey (SF-36) score, Lysholm score, overall knee pain score and MRI assessment at 1-, 3-, 6- and 12-month. Discussion: The results of this study will help determine whether allogeneic PRP could be used as a non-surgical intervention to treat patients with knee OA combined with hematologic blood dyscrasias with platelet dysfunction. Trial registration: Chinese Clinical Trials Registry reference: ChiCTR2100048624. Prospectively registered 11th of July 2021.
MeSH term(s)	Humans ; Osteoarthritis, Knee/therapy ; Osteoarthritis, Knee/drug therapy ; Treatment Outcome ; Injections, Intra-Articular ; Platelet-Rich Plasma ; Hematologic Diseases/drug therapy ; Hematopoietic Stem Cell Transplantation ; Hyaluronic Acid ; Randomized Controlled Trials as Topic
Chemical Substances	Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2022-12-14
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-022-06073-3
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