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Article ; Online: Rapidly progressive dementia with focal symptoms: when to suspect Creutzfeldt-Jakob disease?

Sánchez-Soblechero, Antonio / Grandas, Francisco / Olazarán, Javier

2023 Volume 124, Issue 1, Page(s) 351–354

MeSH term(s)	Humans ; Creutzfeldt-Jakob Syndrome/diagnosis ; Creutzfeldt-Jakob Syndrome/diagnostic imaging ; 14-3-3 Proteins/metabolism
Chemical Substances	14-3-3 Proteins
Language	English
Publishing date	2023-07-14
Publishing country	Italy
Document type	Letter
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-023-02332-9
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Article ; Online: Translating NIA-AA criteria into usual practice: Report from the ReDeMa Project.

Sánchez-Soblechero, Antonio / Berbel, Angel / Villarejo, Alberto / Palmí-Cortés, Itziar / Vieira, Alba / Gil-Moreno, María José / Fernández, Cristina / Martín-Montes, Ãngel / Carreras, María Teresa / Fernández, Yolanda / Puertas, Carolina / Blanco-Palmero, Victor / Llamas, Sara / González-Sánchez, Marta / Lapeña, Teresa / de Luis, Pilar / Manzano, Sagrario / Olazarán, Javier

Alzheimer's & dementia (New York, N. Y.)

2024 Volume 10, Issue 1, Page(s) e12451

Abstract: Introduction: Biomarker-informed criteria were proposed for the diagnosis of Alzheimer's disease (AD) by the National Institute on Aging and the Alzheimer's Association (NIA-AA) in 2011; however, the adequacy of this criteria has not been sufficiently ... ...

Abstract	Introduction: Biomarker-informed criteria were proposed for the diagnosis of Alzheimer's disease (AD) by the National Institute on Aging and the Alzheimer's Association (NIA-AA) in 2011; however, the adequacy of this criteria has not been sufficiently evaluated. Methods: ReDeMa ( Results: A total of 233 patients were analyzed (mean age 70 years, 50% women, 73% AD). The diagnostic language was modified significantly, with a majority assumption of NIA-AA definitions (69%). Confidence in diagnosis increased from 70% to 92% ( Discussion: The NIA-AA criteria are adequate and utile for usual practice in memory and neurology clinics, improving diagnostic confidence and significantly modifying patient management. Highlights: Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers increase diagnostic certainty regardless of the neurologist.AD CSF biomarkers lead to changes in disease management .Biomarker-enriched, 2011 NIA-AA diagnostic criteria are adequate for usual practice.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832891-7
ISSN	2352-8737 ; 2352-8737
ISSN (online)	2352-8737
ISSN	2352-8737
DOI	10.1002/trc2.12451
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Article ; Online: Where Should I Draw the Line: PET-Driven, Data-Driven, or Manufacturer Cut-Off?

Sánchez-Soblechero, Antonio / López-García, Sara / Lage, Carmen / Fernández-Matarrubia, Marta / Irure, Juan / López-Hoyos, Marcos / Jiménez-Bonilla, Julio / Quirce, Remedios / de Arcocha-Torres, María / Cuenca-Vera, Oriana / Martín-Arroyo, Juan / Martínez-Dubarbie, Francisco / Pozueta, Ana / García-Martínez, María / Infante, Jon / Sánchez-Juan, Pascual / Rodríguez-Rodríguez, Eloy

Journal of Alzheimer's disease : JAD

2024 Volume 98, Issue 3, Page(s) 957–967

Abstract: Background: The optimal cut-off for Alzheimer's disease (AD) CSF biomarkers remains controversial.: Objective: To analyze the performance of cut-off points standardized by three methods: one that optimized the agreement between 11C-Pittsburgh ... ...

Abstract	Background: The optimal cut-off for Alzheimer's disease (AD) CSF biomarkers remains controversial. Objective: To analyze the performance of cut-off points standardized by three methods: one that optimized the agreement between 11C-Pittsburgh compound B PET (a-PET) and CSF biomarkers (Aβ1-42, pTau, tTau, and Aβ1-42/Aβ1-40 ratio) in our population, called PET-driven; an unbiased cut-off using data from a healthy research cohort, called data-driven, and that provided by the manufacturer. We also compare changes in ATN classification. Methods: CSF biomarkers measured by the LUMIPULSE G600II platform and qualitative visualization of amyloid positron emission tomography (a-PET) were performed in all the patients. We established a cut-off for each single biomarker and Aβ1-42/Aβ1-40 ratio that optimized their agreement with a-PET using ROC curves. Sensitivity, Specificity, and Overall Percent of Agreement are assessed using a-PET or clinical diagnosis as gold standard for every cut-off. Also, we established a data-driven cut-off from our cognitively unimpaired cohort. We then analyzed changes in ATN classification. Results: One hundred and ten patients were recruited. Sixty-six (60%) were a-PET positive. PET-driven cut-offs were: pTau > 57, tTau > 362.62, Aβ1-42/Aβ1-40 < 0.069. For a single biomarker, pTau showed the highest accuracy (AUC 0.926). New PET-driven cut-offs classified patients similarly to manufacturer cut-offs (only two patients changed). However, 20 patients (18%) changed when data-driven cut-offs were used. Conclusions: We established our sample's best CSF biomarkers cut-offs using a-PET as the gold standard. These cut-offs categorize better symptomatic subjects than data-driven in ATN classification, but they are very similar to the manufacturer's.
MeSH term(s)	Humans ; Amyloid beta-Peptides ; tau Proteins ; Alzheimer Disease/diagnostic imaging ; Positron-Emission Tomography ; Biomarkers ; Peptide Fragments
Chemical Substances	Amyloid beta-Peptides ; tau Proteins ; Biomarkers ; Peptide Fragments
Language	English
Publishing date	2024-03-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-230678
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Article ; Online: Bilateral intracerebral hemorrhage as a presentation of central nervous system vasculitis in a patient with dermatomyositis.

Sánchez-Soblechero, Antonio / López-Anguita, Sergio / Díaz-Otero, Fernando / Vázquez Alen, Pilar

eNeurologicalSci

2019 Volume 15, Page(s) 100181

Language	English
Publishing date	2019-05-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2838045-9
ISSN	2405-6502 ; 2405-6502
ISSN (online)	2405-6502
ISSN	2405-6502
DOI	10.1016/j.ensci.2019.01.005
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Article ; Online: Upper trunk brachial plexopathy as a consequence of prone positioning due to SARS-CoV-2 acute respiratory distress syndrome.

Sánchez-Soblechero, Antonio / García, Cristina Ausín / Sáez Ansotegui, Aiala / Fernández-Lorente, José / Catalina-Álvarez, Irene / Grandas, Francisco / Muñoz-Blanco, José Luis

Muscle & nerve

2020 Volume 62, Issue 5, Page(s) E76–E78

MeSH term(s)	Aged ; Brachial Plexus Neuropathies/etiology ; COVID-19/complications ; Humans ; Male ; Muscle Weakness/etiology ; Patient Positioning/adverse effects ; Prone Position ; Treatment Outcome
Keywords	covid19
Language	English
Publishing date	2020-09-10
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	438353-9
ISSN	1097-4598 ; 0148-639X
ISSN (online)	1097-4598
ISSN	0148-639X
DOI	10.1002/mus.27055
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Zs.A 1449: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Evaluation of the concomitant use of prophylactic treatments in patients with migraine under anti-calcitonin gene-related peptide therapies: The PREVENAC study.

Gago-Veiga, Ana Beatriz / Lopez-Alcaide, Noelia / Quintas, Sonia / Fernández Lázaro, Iris / Casas-Limón, Javier / Calle, Carlos / Latorre, Germán / González-García, Nuria / Porta-Etessam, Jesús / Rodriguez-Vico, Jaime / Jaimes, Alex / Gómez García, Andrea / García-Azorín, David / Guerrero-Peral, Ángel Luis / Sierra, Álvaro / Lozano Ros, Alberto / Sánchez-Soblechero, Antonio / Díaz-de-Teran, Javier / Membrilla, Javier A /

Treviño, Cristina / Gonzalez-Martinez, Alicia

European journal of neurology

2024 Volume 31, Issue 5, Page(s) e16215

Abstract: Background and purpose: Anti-calcitonin gene-related peptide (CGRP) therapies are recent preventive therapies approved for both episodic and chronic migraine. One of the measures of effectiveness is the withdrawal of other preventive treatments. The ... ...

Abstract	Background and purpose: Anti-calcitonin gene-related peptide (CGRP) therapies are recent preventive therapies approved for both episodic and chronic migraine. One of the measures of effectiveness is the withdrawal of other preventive treatments. The objective of this study is to quantify the impact of anti-CGRP drugs in concomitant preventive treatment in patients with migraine. Methods: This was an observational, retrospective, multicenter cohort study with patients from nine national headache units. Patients with migraine undergoing treatment for at least 6 months with anti-CGRP antibodies, who were initially associated with some preventive treatment (oral and/or onabotulinumtoxinA) were included. Demographic and clinical variables were collected, as well as variables related to headache. Differences according to withdrawal or nonwithdrawal were evaluated. Results: A total of 408 patients were included, 86.52% women, 48.79 (SD = 1.46) years old. Preventive treatment was withdrawn in 43.87% (179/408), 20.83% partially and 23.04% totally. In 27.45% (112/408), it was maintained exclusively due to comorbidity and in 28.6% (117/408) due to partial efficacy. The most frequent time of withdrawal was between 3 and 5 months after the start of treatment. The baseline characteristics associated with nonwithdrawal were comorbidities: insomnia, hypertension and obesity, chronic migraine, and medication overuse. In the multivariate analysis, the absence of high blood pressure, a greater number of preventive treatments at the start, and a lower number of migraine days/month after anti-CGRP treatment were independently associated with withdrawal of the treatment (p < 0.05). Conclusions: Anti-CGRP antibodies allow the withdrawal of associated preventive treatment in a significant percentage of patients, which supports its effectiveness in real-life conditions.
MeSH term(s)	Humans ; Female ; Infant ; Male ; Calcitonin Gene-Related Peptide/therapeutic use ; Retrospective Studies ; Cohort Studies ; Migraine Disorders/drug therapy ; Migraine Disorders/prevention & control ; Headache
Chemical Substances	Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.16215
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Zs.A 4738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Pathological Correlations of Neuropsychiatric Symptoms in Institutionalized People with Dementia.

Esteban de Antonio, Ester / López-Álvarez, Jorge / Rábano, Alberto / Agüera-Ortiz, Luis / Sánchez-Soblechero, Antonio / Amaya, Laura / Portela, Sofía / Cátedra, Carlos / Olazarán, Javier

Journal of Alzheimer's disease : JAD

2020 Volume 78, Issue 4, Page(s) 1731–1741

Abstract: Background: Comprehensive clinicopathological studies of neuropsychiatric symptoms (NPS) in dementia are lacking.: Objective: To describe the pathological correlations of NPS in a sample of institutionalized people with dementia.: Methods: We ... ...

Abstract	Background: Comprehensive clinicopathological studies of neuropsychiatric symptoms (NPS) in dementia are lacking. Objective: To describe the pathological correlations of NPS in a sample of institutionalized people with dementia. Methods: We studied 59 people who were consecutively admitted to a nursing home and donated their brain. Correlations between pathological variables and NPS upon admission (n = 59) and at one-year follow-up assessment (n = 46) were explored and confirmed using bivariate and multivariate statistical methods. Results: Mean (SD) age at admission was 83.2 (6.4) years and mean (SD) age at demise was 85.4 (6.6); 73% of the subjects were female and 98% presented advanced dementia. The most frequent etiological diagnosis was Alzheimer's disease (AD; 74.6% clinical diagnosis, 67.8% pathological diagnosis). The pathological diagnosis of AD was associated with aggression (β est 0.31), depression (β est 0.31), anxiety (β est 0.38), and irritability (β est 0.28). Tau stage correlated with aggressive symptoms (β est 0.32) and anxiety (βest 0.33). Coexistence of AD and Lewy body pathology was associated with depression (β est 0.32), while argyrophilic grains were associated with eating symptoms (β est 0.29). Predictive models were achieved for apathy, including cognitive performance, basal ganglia ischemic lesions, and sex as predictors (R2 0.38) and for sleep disorders, including pathological diagnosis of AD and age at demise (R2 0.18) (all p-values <0.05, unadjusted). Conclusion: AD was the main pathological substrate of NPS in our sample of very elderly people with advanced dementia. However, correlations were mild, supporting a model of focal/asymmetric rather than diffuse brain damage, along with relevance of environmental and other personal factors, in the genesis of those symptoms.
MeSH term(s)	Aged ; Aged, 80 and over ; Aggression ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Alzheimer Disease/psychology ; Anxiety/pathology ; Anxiety/psychology ; Apathy ; Brain/pathology ; Delusions/pathology ; Delusions/psychology ; Dementia/pathology ; Dementia/physiopathology ; Dementia/psychology ; Dementia, Vascular/pathology ; Dementia, Vascular/physiopathology ; Dementia, Vascular/psychology ; Depression/pathology ; Depression/psychology ; Female ; Hallucinations/pathology ; Hallucinations/psychology ; Humans ; Irritable Mood ; Lewy Body Disease/pathology ; Lewy Body Disease/physiopathology ; Lewy Body Disease/psychology ; Male ; Plaque, Amyloid/pathology
Language	English
Publishing date	2020-11-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-200600
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Article ; Online: Acute Stroke Care during the COVID-19 Pandemic: Reduction in the Number of Admissions of Elderly Patients and Increase in Prehospital Delays.

Velilla-Alonso, Gabriel / García-Pastor, Andrés / Rodríguez-López, Ángela / Gómez-Roldós, Ana / Sánchez-Soblechero, Antonio / Amaya-Pascasio, Laura / Díaz-Otero, Fernando / Fernández-Bullido, Yolanda / Iglesias-Mohedano, Ana María / Vázquez-Alén, Pilar / Vales-Montero, Marta / Gil-Núñez, Antonio-Carmelo

Cerebrovascular diseases (Basel, Switzerland)

2021 Volume 50, Issue 3, Page(s) 310–316

Abstract: Introduction: We analyzed whether the coronavirus disease 2019 (COVID-19) crisis affected acute stroke care in our center during the first 2 months of lockdown in Spain.: Methods: This is a single-center, retrospective study. We collected demographic, ...

Abstract	Introduction: We analyzed whether the coronavirus disease 2019 (COVID-19) crisis affected acute stroke care in our center during the first 2 months of lockdown in Spain. Methods: This is a single-center, retrospective study. We collected demographic, clinical, and radiological data; time course; and treatment of patients meeting the stroke unit admission criteria from March 14 to May 14, 2020 (COVID-19 period group). Data were compared with the same period in 2019 (pre-COVID-19 period group). Results: 195 patients were analyzed; 83 in the COVID-19 period group, resulting in a 26% decline of acute strokes and transient ischemic attacks (TIAs) admitted to our center compared with the previous year (p = 0.038). Ten patients (12%) tested positive for PCR SARS-CoV-2. The proportion of patients aged 65 years and over was lower in the COVID-19 period group (53 vs. 68.8%, p = 0.025). During the pandemic period, analyzed patients were more frequently smokers (27.7 vs. 10.7%, p = 0.002) and had less frequently history of prior stroke (13.3 vs. 25%, p = 0.043) or atrial fibrillation (9.6 vs. 25%, p = 0.006). ASPECTS score was lower (9 [7-10] vs. 10 [8-10], p = 0.032), NIHSS score was slightly higher (5 [2-14] vs. 4 [2-8], p = 0.122), onset-to-door time was higher (304 [93-760] vs. 197 [91.25-645] min, p = 0.104), and a lower proportion arrived within 4.5 h from onset of symptoms (43.4 vs. 58%, p = 0.043) during the CO-VID-19 period. There were no differences between proportion of patients receiving recanalization treatment (intravenous thrombolysis and/or mechanical thrombectomy) and in-hospital delays. Conclusion: We observed a reduction in the number of acute strokes and TIAs admitted during the COVID-19 period. This drop affected especially elderly patients, and despite a delay in their arrival to the emergency department, the proportion of patients treated with recanalization therapies was preserved.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging ; Brain Ischemia/diagnosis ; COVID-19/complications ; COVID-19/prevention & control ; Emergency Service, Hospital/statistics & numerical data ; Female ; Humans ; Ischemic Attack, Transient/therapy ; Male ; Middle Aged ; SARS-CoV-2/pathogenicity ; Stroke/diagnosis ; Stroke/etiology ; Stroke/therapy ; Thrombolytic Therapy/methods ; Time-to-Treatment
Language	English
Publishing date	2021-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000514140
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Article: Upper trunk brachial plexopathy as a consequence of prone positioning due to SARS-CoV-2 acute respiratory distress syndrome

Sánchez-Soblechero, Antonio / García, Cristina Ausín / Sáez Ansotegui, Aiala / Fernández-Lorente, José / Catalina-Álvarez, Irene / Grandas, Francisco / Muñoz-Blanco, José Luis

Muscle nerve

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #739633
Database	COVID19

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Article ; Online: Upper trunk brachial plexopathy as a consequence of prone positioning due to SARS‐CoV ‐2 acute respiratory distress syndrome

Sánchez‐Soblechero, Antonio / García, Cristina Ausín / Sáez Ansotegui, Aiala / Fernández‐Lorente, José / Catalina‐Álvarez, Irene / Grandas, Francisco / Muñoz‐Blanco, José Luis

Muscle & Nerve ; ISSN 0148-639X 1097-4598

2020

Keywords	Physiology (medical) ; Physiology ; Cellular and Molecular Neuroscience ; Clinical Neurology ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1002/mus.27055
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