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  1. Article ; Online: Deciphering VITT's dangerous code.

    Bakchoul, Tamam / Zlamal, Jan

    Blood

    2024  Volume 143, Issue 4, Page(s) 301–303

    MeSH term(s) Humans ; Patients
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023023141
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  2. Article: Fomes fomentarius

    Cristini, Valentino / Nop, Patrik / Zlámal, Jan / Vand, Mojtaba Hassan / Šeda, Vít / Tippner, Jan

    Microorganisms

    2023  Volume 11, Issue 3

    Abstract: Wood-decaying fungi are responsible for the degradation of wood and the alteration in its material properties. ...

    Abstract Wood-decaying fungi are responsible for the degradation of wood and the alteration in its material properties.
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11030679
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  3. Article ; Online: Some New Aspects of Genetic Variability in Patients with Cutaneous T-Cell Lymphoma.

    Vašků, Vladimír / Máchal, Jan / Zlámal, Filip / Vašků, Anna

    Genes

    2022  Volume 13, Issue 12

    Abstract: Aim: Cutaneous T-cell lymphoma (CTCL) is a group of T-cell malignancies that develop in the skin. Though studied intensively, the etiology and pathogenesis of CTCL remain elusive. This study evaluated the survival of CTCL patients in the 1st Department ... ...

    Abstract Aim: Cutaneous T-cell lymphoma (CTCL) is a group of T-cell malignancies that develop in the skin. Though studied intensively, the etiology and pathogenesis of CTCL remain elusive. This study evaluated the survival of CTCL patients in the 1st Department of Dermatovenereology of St. Anne's University Hospital Brno. It included analysis of 19 polymorphic gene variants based on their expected involvement in CTCL severity.
    Material and methods: 75 patients with CTCL, evaluated and treated at the 1st Department of Dermatovenereology of St. Anne´s University Hospital Brno, Faculty of Medicine, Masaryk University, were recruited for the study over the last 28 years (44 men and 31 women, average age 58 years, range 20-82 years). All patients were genotyped for 19 chosen gene polymorphisms by the conventional PCR method with restriction analysis. A multivariate Cox regression model was calculated to reveal genetic polymorphisms and other risk factors for survival.
    Results: The model identified MDR Ex21 2677 (rs2032582) as a significant genetic factor influencing the survival of the patients, with the T-allele playing a protective role. A multivariate stepwise Cox regression model confirmed the following as significant independent risk factors for overall survival: increased age at admission, clinical staging of the tumor, and male sex.
    Conclusion: We showed that the TT genotype at position 2677 of the MDR1 gene exhibited statistically significant longer survival in CTCL patients. As such, the TT genotype of MDR1 confers a significant advantage for the CTCL patients who respond to treatment.
    Language English
    Publishing date 2022-12-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13122401
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  4. Article ; Online: Fomes fomentarius and F. inzengae —A Comparison of Their Decay Patterns on Beech Wood

    Valentino Cristini / Patrik Nop / Jan Zlámal / Mojtaba Hassan Vand / Vít Šeda / Jan Tippner

    Microorganisms, Vol 11, Iss 679, p

    2023  Volume 679

    Abstract: Wood-decaying fungi are responsible for the degradation of wood and the alteration in its material properties. Fomes fomentarius (L.) Fr. is one of the most common white-rot fungi colonising coarse wood and standing trees. In recent years, according to ... ...

    Abstract Wood-decaying fungi are responsible for the degradation of wood and the alteration in its material properties. Fomes fomentarius (L.) Fr. is one of the most common white-rot fungi colonising coarse wood and standing trees. In recent years, according to their genetic, physiological, and morphological differences, Fomes inzengae (Ces. and De Not.) Lécuru was identified as an independent species. This article aimed to compare the impact of the degradation caused by both species on the anatomical, physical, and mechanical properties of beech wood. When comparing the degradation caused by different strains of both species, no statistically significant difference was found in mass loss ( <semantics> M L </semantics> ) or moisture content ( <semantics> M C </semantics> ). A relevant correlation between <semantics> M L </semantics> and <semantics> M C </semantics> was confirmed for both species. Variabilities in the density distribution of the degraded and intact bending samples were found to be statistically different. No relevant difference was observed in the modulus of rupture ( <semantics> M O R </semantics> ) between the two species after each exposure period. A strong linear relationship between the <semantics> M O R </semantics> and the dynamic modulus of elasticity was revealed for both species. Both species showed decay patterns typical for simultaneous white rot and soft rot. According to the presented results, the impact of both species on the investigated material properties of wood cannot be considered significantly different.
    Keywords biodegradation ; nondestructive testing ; tree biomechanics ; tree stability ; white rot ; wood-decaying fungi ; Biology (General) ; QH301-705.5
    Subject code 511
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Platelet-neutrophil interaction in COVID-19 and vaccine-induced thrombotic thrombocytopenia.

    Hirsch, Johannes / Uzun, Günalp / Zlamal, Jan / Singh, Anurag / Bakchoul, Tamam

    Frontiers in immunology

    2023  Volume 14, Page(s) 1186000

    Abstract: Coronavirus disease 2019 (COVID-19) is known to commonly induce a thrombotic diathesis, particularly in severely affected individuals. So far, this COVID-19-associated coagulopathy (CAC) has been partially explained by hyperactivated platelets as well as ...

    Abstract Coronavirus disease 2019 (COVID-19) is known to commonly induce a thrombotic diathesis, particularly in severely affected individuals. So far, this COVID-19-associated coagulopathy (CAC) has been partially explained by hyperactivated platelets as well as by the prothrombotic effects of neutrophil extracellular traps (NETs) released from neutrophils. However, precise insight into the bidirectional relationship between platelets and neutrophils in the pathophysiology of CAC still lags behind. Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare autoimmune disorder caused by auto-antibody formation in response to immunization with adenoviral vector vaccines. VITT is associated with life-threatening thromboembolic events and thus, high fatality rates. Our concept of the thrombophilia observed in VITT is relatively new, hence a better understanding could help in the management of such patients with the potential to also prevent VITT. In this review we aim to summarize the current knowledge on platelet-neutrophil interplay in COVID-19 and VITT.
    MeSH term(s) Humans ; Blood Platelets ; Neutrophils ; COVID-19/complications ; Thrombocytopenia/chemically induced ; Thrombosis/etiology ; Vaccines ; Rare Diseases
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1186000
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  6. Article ; Online: Diagnostic value of antibody-induced procoagulant platelets in heparin-induced thrombocytopenia: communication from the ISTH SSC Subcommittee on Platelet Immunology.

    Zlamal, Jan / Aliotta, Alessandro / Alberio, Lorenzo / Chen, Vivien / Bakchoul, Tamam

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 22, Issue 3, Page(s) 860–868

    Abstract: Heparin-induced thrombocytopenia (HIT) is an immune-mediated prothrombotic disorder characterized by a drop in platelet count and an increased risk of thromboembolic events. The accurate diagnosis of HIT involves clinical assessment and laboratory ... ...

    Abstract Heparin-induced thrombocytopenia (HIT) is an immune-mediated prothrombotic disorder characterized by a drop in platelet count and an increased risk of thromboembolic events. The accurate diagnosis of HIT involves clinical assessment and laboratory testing with well-characterized functional tests. Recent research has shown the potential of investigating procoagulant platelet formation induced by HIT antibodies. To successfully implement these assays in clinical laboratories, careful consideration of technical and preanalytical factors is crucial. In this communication from the SSC Platelet Immunology, we provide a consensus from experts on the use of flow cytometry in HIT diagnosis, highlighting the importance of standardized protocols.
    MeSH term(s) Humans ; Heparin/adverse effects ; Thrombocytopenia/chemically induced ; Thrombocytopenia/diagnosis ; Blood Platelets ; Platelet Count ; Antibodies ; Communication ; Platelet Factor 4
    Chemical Substances Heparin (9005-49-6) ; Antibodies ; Platelet Factor 4 (37270-94-3)
    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Practice Guideline
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.11.019
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  7. Article ; Online: The role of geometry precision in frequency-resonance method for non-destructive wood assessment – numerical case study on sugar maple

    Tippner, Jan / VojáČková, Barbora / Zlámal, Jan / Kolařĺk, Jaroslav / Paulic, Vinko / Funai, James

    Wood Material Science & Engineering. 2023 May 04, v. 18, no. 3 p.792-800

    2023  

    Abstract: The application of frequency-resonance method (FRM) for precise log bending testing is limited by complex geometry; usually the cone with variable cross. This case study presents the relationship among non-destructively tested material parameters of ... ...

    Abstract The application of frequency-resonance method (FRM) for precise log bending testing is limited by complex geometry; usually the cone with variable cross. This case study presents the relationship among non-destructively tested material parameters of sugar maples and the numerical analysis of effect of simplifications in FRM. Four standing stems were measured to find basic geometry parameters, 3D scanned for precise geometry description, tested by pulling test (PT) to obtain elastic parameters, and, finally, cut down to process the logs. Four logs were measured by stress wave propagation (SWP) using an acoustic tomography (AT) device to obtain longitudinal sound velocities and then evaluated by the FRM to obtain natural frequencies in bending and longitudinal vibrations. Comparison was made between the dynamic moduli of elasticity (MOE), calculated from SWP and the FRM, and the static MOE calculated from the PT. In-situ experimental evaluation was accompanied by modal analysis by finite element method (FEM) working at three levels of geometry simplification (beam model, simplified solid model, and scan-based solid model); the natural frequencies of bending and longitudinal mode shapes were analyzed. The influence of geometry precision on the resulting dynamic response of logs was found regarding comparison to the experimental values.
    Keywords Acer saccharum subsp. saccharum ; acoustics ; case studies ; finite element analysis ; geometry ; materials science ; models ; sugars ; tomography ; wood ; Non-destructive testing ; sugar maple ; sound propagation ; natural frequency ; finite element method ; modal analysis ; 3D scan ; cross section ; modulus of elasticity
    Language English
    Dates of publication 2023-0504
    Size p. 792-800.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ISSN 1748-0280
    DOI 10.1080/17480272.2022.2071166
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Some New Aspects of Genetic Variability in Patients with Cutaneous T-Cell Lymphoma

    Vašků, Vladimír / Máchal, Jan / Zlámal, Filip / Vašků, Anna

    Genes (Basel). 2022 Dec. 18, v. 13, no. 12

    2022  

    Abstract: Aim: Cutaneous T-cell lymphoma (CTCL) is a group of T-cell malignancies that develop in the skin. Though studied intensively, the etiology and pathogenesis of CTCL remain elusive. This study evaluated the survival of CTCL patients in the 1st Department ... ...

    Abstract Aim: Cutaneous T-cell lymphoma (CTCL) is a group of T-cell malignancies that develop in the skin. Though studied intensively, the etiology and pathogenesis of CTCL remain elusive. This study evaluated the survival of CTCL patients in the 1st Department of Dermatovenereology of St. Anne’s University Hospital Brno. It included analysis of 19 polymorphic gene variants based on their expected involvement in CTCL severity. Material and methods: 75 patients with CTCL, evaluated and treated at the 1st Department of Dermatovenereology of St. Anne´s University Hospital Brno, Faculty of Medicine, Masaryk University, were recruited for the study over the last 28 years (44 men and 31 women, average age 58 years, range 20–82 years). All patients were genotyped for 19 chosen gene polymorphisms by the conventional PCR method with restriction analysis. A multivariate Cox regression model was calculated to reveal genetic polymorphisms and other risk factors for survival. Results: The model identified MDR Ex21 2677 (rs2032582) as a significant genetic factor influencing the survival of the patients, with the T-allele playing a protective role. A multivariate stepwise Cox regression model confirmed the following as significant independent risk factors for overall survival: increased age at admission, clinical staging of the tumor, and male sex. Conclusion: We showed that the TT genotype at position 2677 of the MDR1 gene exhibited statistically significant longer survival in CTCL patients. As such, the TT genotype of MDR1 confers a significant advantage for the CTCL patients who respond to treatment.
    Keywords T-cell lymphoma ; T-lymphocytes ; etiology ; genes ; genetic factors ; genetic variation ; genotype ; genotyping ; hospitals ; males ; medicine ; models ; pathogenesis ; protective effect ; regression analysis ; risk
    Language English
    Dates of publication 2022-1218
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13122401
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Antibody-mediated platelet activation in COVID-19: A coincidence or a new mechanism of the dysregulated coagulation system?

    Althaus, Karina / Zlamal, Jan / Bakchoul, Tamam

    Journal of thrombosis and haemostasis : JTH

    2021  Volume 19, Issue 5, Page(s) 1171–1173

    MeSH term(s) Antigen-Antibody Complex ; Blood Platelets ; COVID-19 ; Critical Illness ; Humans ; Platelet Activation ; SARS-CoV-2 ; Thrombocytopenia
    Chemical Substances Antigen-Antibody Complex
    Language English
    Publishing date 2021-04-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15275
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5805: Show issues Location:
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  10. Article: Strain Rate-Dependent Compressive Properties of Bulk Cylindrical 3D-Printed Samples from 316L Stainless Steel.

    Neuhäuserová, Michaela / Koudelka, Petr / Fíla, Tomáš / Falta, Jan / Rada, Václav / Šleichrt, Jan / Zlámal, Petr / Mauko, Anja / Jiroušek, Ondřej

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 3

    Abstract: The main aim of the study was to analyse the strain rate sensitivity of the compressive deformation response in bulk 3D-printed samples from 316L stainless steel according to the printing orientation. The laser powder bed fusion (LPBF) method of metal ... ...

    Abstract The main aim of the study was to analyse the strain rate sensitivity of the compressive deformation response in bulk 3D-printed samples from 316L stainless steel according to the printing orientation. The laser powder bed fusion (LPBF) method of metal additive manufacturing was utilised for the production of the samples with three different printing orientations: 0∘, 45∘, and 90∘. The specimens were experimentally investigated during uni-axial quasi-static and dynamic loading. A split Hopkinson pressure bar (SHPB) apparatus was used for the dynamic experiments. The experiments were observed using a high-resolution (quasi-static loading) or a high-speed visible-light camera and a high-speed thermographic camera (dynamic loading) to allow for the quantitative and qualitative analysis of the deformation processes. Digital image correlation (DIC) software was used for the evaluation of displacement fields. To assess the deformation behaviour of the 3D-printed bulk samples and strain rate related properties, an analysis of the true stress-true strain diagrams from quasi-static and dynamic experiments as well as the thermograms captured during the dynamic loading was performed. The results revealed a strong strain rate effect on the mechanical response of the investigated material. Furthermore, a dependency of the strain-rate sensitivity on the printing orientation was identified.
    Language English
    Publishing date 2022-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15030941
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