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Article ; Online: Achieving global surgical excellence: an evidence-based framework to guide surgical quality improvement programs in low and middle income countries.

Henry, Jaymie Claire / Wong, Lye-Yeng / Reyes, Ana M / Jin, James Z / Ferguson, Mark K / Yip, Cheng Har / Hill, Andrew

Frontiers in health services

2023 Volume 3, Page(s) 1096144

Abstract: Objectives: There is a lack of evidence-based guidelines for enhancing global surgical care delivery. We propose a set of recommendations to serve as a framework to guide surgical quality improvement and scale-up initiatives in low and middle income ... ...

Abstract	Objectives: There is a lack of evidence-based guidelines for enhancing global surgical care delivery. We propose a set of recommendations to serve as a framework to guide surgical quality improvement and scale-up initiatives in low and middle income countries (LMICs). Methods: From January-December 2019, we reviewed the available literature and their application toward LMIC settings. The first initiative was the establishment of Best Practices Recommendations intended to summarize best-level evidence around quality improvement processes that have shown to decrease morbidity and mortality in LMICs. The GRADE level of evidence and strength of the recommendation were assigned in accordance with the Results: Recommendations for three topic areas were established: reducing surgical site infections, improving quality of trauma systems, and interventions to reduce maternal and perinatal mortality. 27 studies were included in a quantitative synthesis and meta-analysis for interventions reducing surgical site infections, 27 studies for interventions improving the quality of trauma systems, and 14 studies for interventions reducing maternal and perinatal mortality. Using Delphi methodology, an international expert panel established consensus that district hospitals should place the highest priority on developing surgical services for low complexity, high volume conditions. At the national level, emergency and essential surgical care should be integrated within national Universal Health Coverage frameworks. Conclusions: This project fills a critical cap in the rapidly developing field of global surgery: gathering evidence-based, practical, and cost-effective solutions that will serve as a guide for the efficient planning and allocation of resources necessary to promote quality and safe essential surgical services in LMICs.
Language	English
Publishing date	2023-08-07
Publishing country	Switzerland
Document type	Journal Article
ISSN	2813-0146
ISSN (online)	2813-0146
DOI	10.3389/frhs.2023.1096144
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Article ; Online: Embryo-scale epithelial buckling forms a propagating furrow that initiates gastrulation.

Fierling, Julien / John, Alphy / Delorme, Barthélémy / Torzynski, Alexandre / Blanchard, Guy B / Lye, Claire M / Popkova, Anna / Malandain, Grégoire / Sanson, Bénédicte / Étienne, Jocelyn / Marmottant, Philippe / Quilliet, Catherine / Rauzi, Matteo

Nature communications

2022 Volume 13, Issue 1, Page(s) 3348

Abstract: Cell apical constriction driven by actomyosin contraction forces is a conserved mechanism during tissue folding in embryo development. While much is now understood of the molecular mechanism responsible for apical constriction and of the tissue-scale ... ...

Abstract	Cell apical constriction driven by actomyosin contraction forces is a conserved mechanism during tissue folding in embryo development. While much is now understood of the molecular mechanism responsible for apical constriction and of the tissue-scale integration of the ensuing in-plane deformations, it is still not clear if apical actomyosin contraction forces are necessary or sufficient per se to drive tissue folding. To tackle this question, we use the Drosophila embryo model system that forms a furrow on the ventral side, initiating mesoderm internalization. Past computational models support the idea that cell apical contraction forces may not be sufficient and that active or passive cell apico-basal forces may be necessary to drive cell wedging leading to tissue furrowing. By using 3D computational modelling and in toto embryo image analysis and manipulation, we now challenge this idea and show that embryo-scale force balance at the tissue surface, rather than cell-autonomous shape changes, is necessary and sufficient to drive a buckling of the epithelial surface forming a furrow which propagates and initiates embryo gastrulation.
MeSH term(s)	Actomyosin/metabolism ; Animals ; Cell Shape ; Drosophila ; Drosophila melanogaster ; Embryo, Nonmammalian/metabolism ; Embryonic Development ; Gastrulation ; Morphogenesis
Chemical Substances	Actomyosin (9013-26-7)
Language	English
Publishing date	2022-06-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-30493-3
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Article ; Online: Embryo-scale epithelial buckling forms a propagating furrow that initiates gastrulation

Julien Fierling / Alphy John / Barthélémy Delorme / Alexandre Torzynski / Guy B. Blanchard / Claire M. Lye / Anna Popkova / Grégoire Malandain / Bénédicte Sanson / Jocelyn Étienne / Philippe Marmottant / Catherine Quilliet / Matteo Rauzi

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 14

Abstract: Drosophila mesoderm invagination begins with the formation of a furrow. Here they show that a long-range mechanism, powered by actomyosin contraction between the embryo polar caps, works like a ‘cheese-cutter wire’ indenting the tissue surface and ... ...

Abstract	Drosophila mesoderm invagination begins with the formation of a furrow. Here they show that a long-range mechanism, powered by actomyosin contraction between the embryo polar caps, works like a ‘cheese-cutter wire’ indenting the tissue surface and folding it into a propagating furrow.
Keywords	Science ; Q
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Tension and epithelial morphogenesis in Drosophila early embryos.

Lye, Claire M / Sanson, Bénédicte

Current topics in developmental biology

2011 Volume 95, Page(s) 145–187

Abstract: During morphogenesis, tissues are shaped by cell behaviors such as apical cell constriction and cell intercalation, which are the result of cell intrinsic forces, but are also shaped passively by forces acting on the cells. The latter extrinsic forces ... ...

Abstract	During morphogenesis, tissues are shaped by cell behaviors such as apical cell constriction and cell intercalation, which are the result of cell intrinsic forces, but are also shaped passively by forces acting on the cells. The latter extrinsic forces can be produced either within the deforming tissue by the tissue-scale integration of intrinsic forces, or outside the tissue by other tissue movements or by fluid flows. Here we review the intrinsic and extrinsic forces that sculpt the epithelium of early Drosophila embryos, focusing on three conserved morphogenetic processes: tissue internalization, axis extension, and segment boundary formation. Finally, we look at how the actomyosin cytoskeleton forms force-generating structures that power these three morphogenetic events at the cell and the tissue scales.
MeSH term(s)	Actomyosin/metabolism ; Animals ; Biomechanical Phenomena ; Cytoskeleton/physiology ; Drosophila/embryology ; Embryonic Development/physiology ; Epithelium/physiology ; Mesoderm/physiology ; Morphogenesis/physiology ; Myosin Type II/physiology
Chemical Substances	Actomyosin (9013-26-7) ; Myosin Type II (EC 3.6.1.-)
Language	English
Publishing date	2011
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1557-8933 ; 0070-2153
ISSN (online)	1557-8933
ISSN	0070-2153
DOI	10.1016/B978-0-12-385065-2.00005-0
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Article ; Online: Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos.

Lye, Claire M / Naylor, Huw W / Sanson, Bénédicte

Development (Cambridge, England)

2014 Volume 141, Issue 20, Page(s) 4006–4017

Abstract: A key challenge in the post-genomic area is to identify the function of the genes discovered, with many still uncharacterised in all metazoans. A first step is transcription pattern characterisation, for which we now have near whole-genome coverage in ... ...

Abstract	A key challenge in the post-genomic area is to identify the function of the genes discovered, with many still uncharacterised in all metazoans. A first step is transcription pattern characterisation, for which we now have near whole-genome coverage in Drosophila. However, we have much more limited information about the expression and subcellular localisation of the corresponding proteins. The Cambridge Protein Trap Consortium generated, via piggyBac transposition, over 600 novel YFP-trap proteins tagging just under 400 Drosophila loci. Here, we characterise the subcellular localisations and expression patterns of these insertions, called the CPTI lines, in Drosophila embryos. We have systematically analysed subcellular localisations at cellularisation (stage 5) and recorded expression patterns at stage 5, at mid-embryogenesis (stage 11) and at late embryogenesis (stages 15-17). At stage 5, 31% of the nuclear lines (41) and 26% of the cytoplasmic lines (67) show discrete localisations that provide clues on the function of the protein and markers for organelles or regions, including nucleoli, the nuclear envelope, nuclear speckles, centrosomes, mitochondria, the endoplasmic reticulum, Golgi, lysosomes and peroxisomes. We characterised the membranous/cortical lines (102) throughout stage 5 to 10 during epithelial morphogenesis, documenting their apico-basal position and identifying those secreted in the extracellular space. We identified the tricellular vertices as a specialized membrane domain marked by the integral membrane protein Sidekick. Finally, we categorised the localisation of the membranous/cortical proteins during cytokinesis.
MeSH term(s)	Animals ; Bacterial Proteins/chemistry ; Cell Nucleus/metabolism ; Centrosome/metabolism ; Cytokinesis ; Cytoplasm/metabolism ; Drosophila Proteins/metabolism ; Drosophila melanogaster/physiology ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Genetic Techniques ; Green Fluorescent Proteins/chemistry ; Luminescent Proteins/chemistry ; Mitochondria/metabolism
Chemical Substances	Bacterial Proteins ; Drosophila Proteins ; Luminescent Proteins ; yellow fluorescent protein, Bacteria ; Green Fluorescent Proteins (147336-22-9)
Language	English
Publishing date	2014-10-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.111310
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Ub I Zs.183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Geometry can provide long-range mechanical guidance for embryogenesis.

Dicko, Mahamar / Saramito, Pierre / Blanchard, Guy B / Lye, Claire M / Sanson, Bénédicte / Étienne, Jocelyn

PLoS computational biology

2017 Volume 13, Issue 3, Page(s) e1005443

Abstract: Downstream of gene expression, effectors such as the actomyosin contractile machinery drive embryo morphogenesis. During Drosophila embryonic axis extension, actomyosin has a specific planar-polarised organisation, which is responsible for oriented cell ... ...

Abstract	Downstream of gene expression, effectors such as the actomyosin contractile machinery drive embryo morphogenesis. During Drosophila embryonic axis extension, actomyosin has a specific planar-polarised organisation, which is responsible for oriented cell intercalation. In addition to these cell rearrangements, cell shape changes also contribute to tissue deformation. While cell-autonomous dynamics are well described, understanding the tissue-scale behaviour challenges us to solve the corresponding mechanical problem at the scale of the whole embryo, since mechanical resistance of all neighbouring epithelia will feedback on individual cells. Here we propose a novel numerical approach to compute the whole-embryo dynamics of the actomyosin-rich apical epithelial surface. We input in the model specific patterns of actomyosin contractility, such as the planar-polarisation of actomyosin in defined ventro-lateral regions of the embryo. Tissue strain rates and displacements are then predicted over the whole embryo surface according to the global balance of stresses and the material behaviour of the epithelium. Epithelia are modelled using a rheological law that relates the rate of deformation to the local stresses and actomyosin anisotropic contractility. Predicted flow patterns are consistent with the cell flows observed when imaging Drosophila axis extension in toto, using light sheet microscopy. The agreement between model and experimental data indicates that the anisotropic contractility of planar-polarised actomyosin in the ventro-lateral germband tissue can directly cause the tissue-scale deformations of the whole embryo. The three-dimensional mechanical balance is dependent on the geometry of the embryo, whose curved surface is taken into account in the simulations. Importantly, we find that to reproduce experimental flows, the model requires the presence of the cephalic furrow, a fold located anteriorly of the extending tissues. The presence of this geometric feature, through the global mechanical balance, guides the flow and orients extension towards the posterior end.
MeSH term(s)	Actomyosin/physiology ; Animals ; Body Patterning/physiology ; Computer Simulation ; Drosophila/embryology ; Drosophila/physiology ; Embryo, Nonmammalian/embryology ; Embryo, Nonmammalian/physiology ; Embryonic Development/physiology ; Mechanotransduction, Cellular/physiology ; Models, Biological ; Molecular Motor Proteins/physiology ; Stress, Mechanical
Chemical Substances	Molecular Motor Proteins ; Actomyosin (9013-26-7)
Language	English
Publishing date	2017-03-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1005443
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Article: A pilot randomised controlled trial of dressing and securement methods to prevent arterial catheter failure in intensive care.

Larsen, Emily N / Corley, Amanda / Mitchell, Marion / Lye, India / Powell, Madeleine / Tom, Sheena / Mihala, Gabor / Ullman, Amanda J / Gibson, Victoria / Marsh, Nicole / Kleidon, Tricia M / Rapchuk, Ivan L / Rickard, Claire M

Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

2020 Volume 34, Issue 1, Page(s) 38–46

Abstract: Background: Critically ill patients in an intensive care setting often require arterial catheters for blood pressure monitoring and arterial blood collection. Arterial catheter failure, which manifests in both mechanical and infective forms, remains ... ...

Abstract	Background: Critically ill patients in an intensive care setting often require arterial catheters for blood pressure monitoring and arterial blood collection. Arterial catheter failure, which manifests in both mechanical and infective forms, remains common. Dressing and securement inadequacies may impact this failure; however, the best method for dressing and securing arterial catheters is yet to be determined. Objectives: The objective of this study was to establish the feasibility of a definitive randomised controlled trial comparing methods for dressing and securing arterial catheters and to prevent device failure in an adult intensive care setting. Methods: A pilot, parallel-group, randomised controlled trial was conducted between April 2017 and June 2018. Patients receiving treatment in two adult intensive care units (Queensland, Australia) were eligible for inclusion and were allocated to receive either (i) an integrated securement dressing or (ii) a simple polyurethane dressing (with gauze/foam), applied to their newly inserted arterial catheters. Main outcome measures: Primary outcomes were (i) feasibility (defined by pre-established criteria: patient eligibility, consent, protocol adherence, retention, and staff acceptability) and (ii) all-cause arterial catheter failure (a composite of local and bloodstream infection, occlusion, dislodgement, infiltration/extravasation, arterial inflammation, thrombosis, and/or inaccurate trace). Secondary outcomes included: failure type, dwell time, dressing adhesion, adverse event profiles, and staff acceptability. Results: In total, 109 patients were studied (n = 53 integrated securement dressing; n = 56 simple polyurethane). The feasibility criterion was met by most patients (including rates of consent [86%], protocol adherence [93%], and retention [100%]); however, the criteria for patient eligibility were not met (73%). All-cause device failure did not differ significantly between the integrated securement device group (n = 12/53, 23%) and the simple polyurethane group (n = 6/56, 11%) (hazard ratio = 2.39, 95% confidence interval = 0.89-6.37, p = 0.083). Conclusions: Findings indicate a larger study is feasible, with minor alterations to recruitment methods required. Arterial catheter failure remains unacceptably common; further research to determine optimal dressing/securement practices is urgently needed.
MeSH term(s)	Adult ; Bandages ; Catheter-Related Infections/prevention & control ; Catheters, Indwelling ; Critical Care ; Humans ; Pilot Projects
Language	English
Publishing date	2020-07-19
Publishing country	Australia
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1159493-7
ISSN	1878-1721 ; 1036-7314
ISSN (online)	1878-1721
ISSN	1036-7314
DOI	10.1016/j.aucc.2020.05.004
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Article ; Online: Geometry can provide long-range mechanical guidance for embryogenesis.

Mahamar Dicko / Pierre Saramito / Guy B Blanchard / Claire M Lye / Bénédicte Sanson / Jocelyn Étienne

PLoS Computational Biology, Vol 13, Iss 3, p e

2017 Volume 1005443

Abstract	Downstream of gene expression, effectors such as the actomyosin contractile machinery drive embryo morphogenesis. During Drosophila embryonic axis extension, actomyosin has a specific planar-polarised organisation, which is responsible for oriented cell intercalation. In addition to these cell rearrangements, cell shape changes also contribute to tissue deformation. While cell-autonomous dynamics are well described, understanding the tissue-scale behaviour challenges us to solve the corresponding mechanical problem at the scale of the whole embryo, since mechanical resistance of all neighbouring epithelia will feedback on individual cells. Here we propose a novel numerical approach to compute the whole-embryo dynamics of the actomyosin-rich apical epithelial surface. We input in the model specific patterns of actomyosin contractility, such as the planar-polarisation of actomyosin in defined ventro-lateral regions of the embryo. Tissue strain rates and displacements are then predicted over the whole embryo surface according to the global balance of stresses and the material behaviour of the epithelium. Epithelia are modelled using a rheological law that relates the rate of deformation to the local stresses and actomyosin anisotropic contractility. Predicted flow patterns are consistent with the cell flows observed when imaging Drosophila axis extension in toto, using light sheet microscopy. The agreement between model and experimental data indicates that the anisotropic contractility of planar-polarised actomyosin in the ventro-lateral germband tissue can directly cause the tissue-scale deformations of the whole embryo. The three-dimensional mechanical balance is dependent on the geometry of the embryo, whose curved surface is taken into account in the simulations. Importantly, we find that to reproduce experimental flows, the model requires the presence of the cephalic furrow, a fold located anteriorly of the extending tissues. The presence of this geometric feature, through the global mechanical balance, guides ...
Keywords	Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2017-03-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ureter myogenesis: putting Teashirt into context.

Lye, Claire M / Fasano, Laurent / Woolf, Adrian S

Journal of the American Society of Nephrology : JASN

2010 Volume 21, Issue 1, Page(s) 24–30

Abstract: After the basic shape of the mammalian ureter is established, its epithelia mature and a coat of smooth muscle cells differentiate around nascent urothelia. The ureter actively propels tubular fluid from the renal pelvis to the bladder, and this ... ...

Abstract	After the basic shape of the mammalian ureter is established, its epithelia mature and a coat of smooth muscle cells differentiate around nascent urothelia. The ureter actively propels tubular fluid from the renal pelvis to the bladder, and this peristalsis, which starts in the fetal period, requires coordinated smooth muscle contraction. Teashirt-3 (Tshz3) is expressed in smooth muscle cell precursors that form the wall of the forming mammalian ureter. The Teashirt gene family was first identified in Drosophila where Teashirt (Tsh) protein acts as a transcription factor directing embryonic anterior-posterior patterning and leg and eye development. In fly embryonic renal tubules, Tsh is expressed in mesodermally derived stellate cells intercalating between principal cells, and a paralogue, tiptop, is expressed in forming tubules. Teashirt is a component of several gene networks in flies and it is notable that similar networks control mammalian renal tract development. Null mutation of Tshz3 in mice leads to failure of functional muscularization in the top of the ureter and this is followed by congenital hydronephrosis. A signaling pathway can be envisaged, starting with sonic hedgehog secreted by the nascent ureteric urothelium and ending with ureteric smooth muscle cell differentiation, with Tshz3 downstream of bone morphogenetic protein 4 and upstream of myocardin and smooth muscle cell contractile protein synthesis. The phenotype of Tshz3 mutant mice resembles that of human congenital pelviureteric junction obstruction, and we suggest these individuals may have mutations of genes encoding molecules in the differentiation pathway mediated by Tshz3.
MeSH term(s)	Animals ; Disease Models, Animal ; Drosophila ; Drosophila Proteins/physiology ; Humans ; Hydronephrosis/physiopathology ; Mice ; Mice, Knockout ; Muscle Development/physiology ; Muscle, Smooth/physiology ; Repressor Proteins/physiology ; Transcription Factors/genetics ; Transcription Factors/physiology ; Ureter/physiology ; Ureteral Obstruction/physiopathology
Chemical Substances	Drosophila Proteins ; Repressor Proteins ; Teashirt 3 protein, mouse ; Transcription Factors ; tsh protein, Drosophila (135315-85-4)
Language	English
Publishing date	2010-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2008111206
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Book ; Online: Aircraft-engine particulate matter emissions from conventional and sustainable aviation fuel combustion

Corbin, Joel C. / Schripp, Tobias / Anderson, Bruce E. / Smallwood, Greg J. / LeClercq, Patrick / Crosbie, Ewan C. / Achterberg, Steven / Whitefield, Philip D. / Miake-Lye, Richard C. / Yu, Zhenhong / Freedman, Andrew / Trueblood, Max / Satterfield, David / Liu, Wenyan / Oßwald, Patrick / Robinson, Claire / Shook, Michael A. / Moore, Richard H. / Lobo, Prem

eISSN: 1867-8548

comparison of measurement techniques for mass, number, and size

2022

Abstract: ... EI m ) reported by these techniques were similar, falling within 30 % of their geometric mean for EI ... m above 100 mg per kg fuel (approximately 10 µ g PM m −3 at the instrument); this geometric mean was ... applications, such as on board research aircraft to determine particulate matter (PM) emissions at cruise. EI m ...

Abstract	Sustainable aviation fuels (SAFs) have different compositions compared to conventional petroleum jet fuels, particularly in terms of fuel sulfur and hydrocarbon content. These differences may change the amount and physicochemical properties of volatile and non-volatile particulate matter (nvPM) emitted by aircraft engines. In this study, we evaluate whether comparable nvPM measurement techniques respond similarly to nvPM produced by three blends of SAFs compared to three conventional fuels. Multiple SAF blends and conventional (Jet A-1) jet fuels were combusted in a V2527-A5 engine, while an additional conventional fuel (JP-8) was combusted in a CFM56-2C1 engine. We evaluated nvPM mass concentration measured by three real-time measurement techniques: photoacoustic spectroscopy, laser-induced incandescence, and the extinction-minus-scattering technique. Various commercial instruments were tested, including three laser-induced incandescence (LII) 300s, one photoacoustic extinctiometer (PAX), one micro soot sensor (MSS+), and two cavity-attenuated phase shift PM SSA (CAPS PM SSA ) instruments. Mass-based emission indices (EI m ) reported by these techniques were similar, falling within 30 % of their geometric mean for EI m above 100 mg per kg fuel (approximately 10 µ g PM m −3 at the instrument); this geometric mean was therefore used as a reference value. Additionally, two integrative measurement techniques were evaluated: filter photometry and particle size distribution (PSD) integration. The commercial instruments used were one tricolor absorption photometer (TAP), one particle soot absorption photometer (PSAP), and two scanning mobility particle sizers (SMPSs). The TAP and PSAP were operated at 5 % and 10 % of their nominal flow rates, respectively, to extend the life of their filters. These techniques are used in specific applications, such as on board research aircraft to determine particulate matter (PM) emissions at cruise. EI m reported by the alternative techniques fell within approximately 50 % of the ...
Subject code	333
Language	English
Publishing date	2022-05-30
Publishing country	de
Document type	Book ; Online
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