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Article ; Online: Resection of a giant mediastinal liposarcoma by median sternotomy with vascular reconstruction-a case report.

Benej, Michal / Klikovits, Thomas / Krajc, Tibor / Watzka, Stefan / Hochmair, Maximilian / Krenbek, Dagmar / Aigner, Clemens

Mediastinum (Hong Kong, China)

2023 Volume 7, Page(s) 39

Abstract: Background: Primary mediastinal liposarcoma is a rare malignancy of mesenchymal origin with local aggressive biological behavior which is often diagnosed as an incidental finding without any symptoms. Chemoresistance and low radiosensitivity of these ... ...

Abstract	Background: Primary mediastinal liposarcoma is a rare malignancy of mesenchymal origin with local aggressive biological behavior which is often diagnosed as an incidental finding without any symptoms. Chemoresistance and low radiosensitivity of these tumors favors surgical resection as the only option for radical treatment. The potential need for extended resections of adjacent structures is not uncommon and could be challenging. Only a limited number of cases with successful vascular reconstruction for the treatment of mediastinal liposarcoma has been reported so far. Case description: A 69-year-old female patient was admitted to our department with dry cough and a huge mediastinal mass for further investigation and treatment. Based on the results of preoperative examinations a mediastinal liposarcoma was suspected. The tumor was resected through median sternal incision with resection of the pericardium with subsequent mesh replacement and " Conclusions: Extended resection and vascular reconstruction for the surgical treatment of primary mediastinal liposarcoma is often necessary to ensure adequate radicality and to reduce the risk of local recurrence. Therefore, these patients should be treated in high-volume centers with sufficient experience.
Language	English
Publishing date	2023-08-10
Publishing country	China
Document type	Case Reports
ISSN	2522-6711
ISSN (online)	2522-6711
DOI	10.21037/med-23-20
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bayesian modelling suggests that the sterlet (Acipenser ruthenus, Linnaeus 1758) population is ageing in the middle Danube River

Kubala, Maroš / Farský, Martin / Krajč, Tibor / Pekárik, Ladislav

Aquatic conservation. 2021 Mar., v. 31, no. 3

2021

Abstract: In the past, sturgeons played an important role in commercial and recreational fisheries in the Danube River and its tributaries. Human impacts in the Danube River Basin coupled with exploitation of sturgeon stocks led to all species being either locally ...

Abstract	In the past, sturgeons played an important role in commercial and recreational fisheries in the Danube River and its tributaries. Human impacts in the Danube River Basin coupled with exploitation of sturgeon stocks led to all species being either locally extinct, critically endangered or of unknown status. Sterlet (Acipenser ruthenus, Linnaeus 1758) is the last known sturgeon species occurring in the upper and middle Danube; however, the population of this species is considered unbalanced and decreasing since the beginning of the twenty‐first century. The decline of sturgeon stocks has been noted before owing to their economic importance. With commercial fisheries being forbidden in the Slovak section of the Danube River, there is generally no information available about the status of what is considered a local population. Databases containing recreational catch of sterlet (2003–2018) and historical records of commercial harvest (1961–1990) were used to describe the trend in the weight and number of sterlet caught over the following years. Modelling indicated that the number of fish caught each year appears to be lower, while the average weight of each individual is increasing. This might suggest that the population is ageing. Although older individuals can contribute a great deal more to spawning because they produce a greater number of eggs, several problems are apparent. The number of spawners might be decreasing as a result of bycatch or fishing, their ability to spawn might be obstructed, or annual recruitment may fail owing to unpredictable events. Although restocking programmes are in place to help maintain the sterlet population in the Danube River, their efficiency seems to be drastically low. In fact, restocking could be of little value unless studies on the availability of key habitats are conducted and their protection and restoration are ensured.
Keywords	Acipenser ruthenus ; Bayesian theory ; bycatch ; humans ; sturgeon ; watersheds ; Danube River
Language	English
Dates of publication	2021-03
Size	p. 469-479.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	1146285-1
ISSN	1052-7613
ISSN	1052-7613
DOI	10.1002/aqc.3515
Database	NAL-Catalogue (AGRICOLA)

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Article: Prognostic factors of recurrence and disease-free survival in radically resected pulmonary carcinoids: a real-world analysis.

Spils, Marc / Klikovits, Thomas / Krenbek, Dagmar / Hochmair, Maximilian Johannes / Jankovic, Igor / Schulte, Lisa / Krajc, Tibor / Benej, Michal / Getman, Vladyslav / Navarrete, José Ruiz / Akan, Ahmet / Mueller, Michael R / Aigner, Clemens / Watzka, Stefan B

Journal of thoracic disease

2024 Volume 16, Issue 3, Page(s) 1911–1922

Abstract: Background: Pulmonary carcinoids (PCs) are rare neuroendocrine lung tumors which may recur, thus worsening their otherwise favorable overall prognosis. Aiming to identify patients at risk for recurrence, we examined parameters affecting disease-free ... ...

Abstract	Background: Pulmonary carcinoids (PCs) are rare neuroendocrine lung tumors which may recur, thus worsening their otherwise favorable overall prognosis. Aiming to identify patients at risk for recurrence, we examined parameters affecting disease-free survival (DFS). Methods: A retrospective single-center analysis of 82 consecutive patients undergoing curative intent resection for primary PC tumors between 2010 and 2019 was carried out. Kaplan-Meier method was utilized for survival analysis. Independent prognostic factors were determined using multivariable Cox and logistic regression. Results: During the observation period 82 patients, 48 females (58.5%) and 34 males (41.5%) were operated, representing 84 cases of PCs, 56 typical (TCs) (66.7%) and 28 atypical (ACs) (33.3%) carcinoids. Five-year overall survival was 87.5% and 84.7%, 5-year DFS 97.5% and 74.9% (P=0.012) for TCs and ACs, respectively. Recurrences occurred in one patient (1.8%) with TCs and five patients (17.9%) with ACs (P=0.014). Using multivariable Cox regression, tumor size (cm) remained as an independent prognostic factor for reduced DFS (P=0.018). In logistic regression, nodal involvement (P=0.043) and tumor size (cm) (P=0.023) were independently associated with higher risk of recurrence. Age, sex, smoking, location, and Ki-67 index were not independently associated with recurrence or DFS. Conclusions: Recurrence in PCs after complete resection is relatively rare. However, DFS is reduced in ACs compared to TCs. Tumor size (cm) and nodal involvement appear as the most important prognostic factors associated with recurrence in PCs, independent of histologic type.
Language	English
Publishing date	2024-03-11
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-1681
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Lymph Node Log-Odds Ratio Accurately Defines Prognosis in Resectable Non-Small Cell Lung Cancer.

Benej, Michal / Klikovits, Thomas / Krajc, Tibor / Bohanes, Tomas / Schulte, Lisa / Hochmair, Maximilian Johannes / Watzka, Stefan / Mosleh, Berta / Hoetzenecker, Konrad / Aigner, Clemens / Hoda, Mir Alireza / Mueller, Michael Rolf

Cancers

2023 Volume 15, Issue 7

Abstract: Objectives: The ratio of positive and resected lymph nodes (LN ratio) has been shown to be prognostic in non-small cell lung cancer (NSCLC). Contrary to the LN ratio, calculating the LN log-odds ratio (LN-LOR) additionally considers the total number of ... ...

Abstract	Objectives: The ratio of positive and resected lymph nodes (LN ratio) has been shown to be prognostic in non-small cell lung cancer (NSCLC). Contrary to the LN ratio, calculating the LN log-odds ratio (LN-LOR) additionally considers the total number of resected lymph nodes. We aim to evaluate LN-LOR between positive and resected lymph nodes as a prognostic factor in operable NSCLC. Methods: Patients with NSCLC who underwent curative intent lobectomy treated at two high-volume centers were retrospectively studied. LN-LOR was dichotomized according to impact on OS and further combined with N descriptors and correlated with clinical variables and survival. Results: 944 patients were included. Cut-off analysis revealed that an LN-LOR of -0.34 significantly discriminated patients according to OS ( Conclusions: This retrospective two-center analysis shows that LN-LOR is significantly associated with OS in resectable NSCLC and might better reflect the biological behavior of the disease, regardless of anatomical lymph node locations. This finding may additionally support the value of extensive LN dissection.
Language	English
Publishing date	2023-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15072082
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Principles of lung cancer screening – low-dose computerized tomography

Tibor Krajc / Beatrice Alexandra Marzluf / Michael Rolf Mueller

Hamdan Medical Journal, Vol 9, Iss 1, Pp 3-

2016 Volume 16

Abstract: Screening for early-stage lung cancer has the potential to significantly increase cure rate, lower case fatality rate and even reduce cancer-specific and overall mortality in the screened population. Lung cancer screening is not a single test, but a ... ...

Abstract	Screening for early-stage lung cancer has the potential to significantly increase cure rate, lower case fatality rate and even reduce cancer-specific and overall mortality in the screened population. Lung cancer screening is not a single test, but a process. It begins with the selection of subjects at high risk and proceeds to baseline low-dose computerized tomography (LDCT), followed by regular additional rounds of LDCT accompanied by constant decision-making and risk re-evaluation, and continuing to eventual identification and timely adequate treatment of early-stage lung cancer, ultimately preventing death from lung cancer in a particular patient. There are conflicting interpretations of data from randomized trials and large cohort studies. This review attempts to summarize the basic principles of screening methodology and provide concise information on effectiveness of LDCT in detecting early lung cancer.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Surgical treatment of non-small-cell lung cancer

Stefan B Watzka / Tibor Krajc / Michael Rolf Mueller

Hamdan Medical Journal, Vol 9, Iss 1, Pp 57-

2016 Volume 67

Abstract: The current treatment of lung cancer is characterized by a broader interpretation of the term ‘targeted therapy’, which actually refers to the selective manipulation of molecular targets by neoadjuvant and/or adjuvant chemotherapy. The concept of ... ...

Abstract	The current treatment of lung cancer is characterized by a broader interpretation of the term ‘targeted therapy’, which actually refers to the selective manipulation of molecular targets by neoadjuvant and/or adjuvant chemotherapy. The concept of targeted therapy may, however, also be translated to thoracic surgery in the sense that – despite greatly reduced invasiveness – treatment options with increased effectiveness and selectivity can be offered. In this paper, the current surgical treatment of all stages of non-small-cell lung cancer will be reviewed. The presented literature will show that – thanks to constantly renewing technology – radical and oncologically correct surgical treatment of bronchial carcinoma of the highest quality is possible for almost all stages. Thus, even locally advanced tumours can no longer be considered as an obstacle to cure. On the other hand – in tune with the overall trend of reduced invasiveness and enhanced effectiveness – sublobar resection for T1a tumours is gaining increasing acceptance amongst thoracic surgeons worldwide. The oncological radicality of limited lung resection can be further increased by innovative minimally invasive approaches to mediastinal lymphadenectomy. In conclusion, the paramount importance of radical mediastinal lymphadenectomy for patients' survival is emphasized once more by the current literature.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Principles of lung cancer screening – exhaled breath analysis

Beatrice Alexandra Marzluf / Tibor Krajc / Michael Rolf Mueller

Hamdan Medical Journal, Vol 9, Iss 1, Pp 17-

2016 Volume 37

Abstract: This review considers exhaled breath analysis, a non-invasive, widely applicable and cost-effective technique that holds great potential for evolving into a future screening tool for lung cancer and other diseases. Exhaled human breath contains thousands ...

Abstract	This review considers exhaled breath analysis, a non-invasive, widely applicable and cost-effective technique that holds great potential for evolving into a future screening tool for lung cancer and other diseases. Exhaled human breath contains thousands of volatile and non-volatile chemical compounds, which are products of metabolic processes and subject to changes in composition and concentration as a result of carcinogenesis. In the last decade, the analysis of volatile organic compounds (VOCs) has gained increasing interest because of the development of new technologies that might allow for detection of certain VOC biomarkers or patterns indicative of lung cancer. We provide an overview of the chemical analytical and sensor array technologies currently available for VOC analysis, including statistical methods implemented for the analysis of complex VOC patterns, and discuss issues of exhaled breath sampling and storage. Furthermore, we summarize the literature on exhaled breath analysis in lung cancer and discuss the results, limitations and future perspectives. We also briefly review the literature on sniffer dogs trained to detect lung cancer from human breath samples. In conclusion, even though certain issues have yet to be addressed and large randomized blinded studies are still lacking, there is evidence that exhaled breath analysis may be a promising tool for lung cancer screening.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Global dataset of species-specific inland recreational fisheries harvest for consumption.

Embke, Holly S / Nyboer, Elizabeth A / Robertson, Ashley M / Arlinghaus, Robert / Akintola, Shehu L / Atessahin, Tuncay / Badr, Laamiri Mohamed / Baigun, Claudio / Basher, Zeenatul / Beard, T Douglas / Boros, Gergely / Bower, Shannon D / Cooke, Steven J / Cowx, Ian G / Franco, Adolfo / Gaspar-Dillanes, Ma Teresa / Granada, Vladimir Puentes / Hart, Robert John / Heinsohn, Carlos R /

Scientific data

2022 Volume 9, Issue 1, Page(s) 488

Abstract: Inland recreational fisheries, found in lakes, rivers, and other landlocked waters, are important to livelihoods, nutrition, leisure, and other societal ecosystem services worldwide. Although recreationally-caught fish are frequently harvested and ... ...

Abstract	Inland recreational fisheries, found in lakes, rivers, and other landlocked waters, are important to livelihoods, nutrition, leisure, and other societal ecosystem services worldwide. Although recreationally-caught fish are frequently harvested and consumed by fishers, their contribution to food and nutrition has not been adequately quantified due to lack of data, poor monitoring, and under-reporting, especially in developing countries. Beyond limited global harvest estimates, few have explored species-specific harvest patterns, although this variability has implications for fisheries management and food security. Given the continued growth of the recreational fishery sector, understanding inland recreational fish harvest and consumption rates represents a critical knowledge gap. Based on a comprehensive literature search and expert knowledge review, we quantified multiple aspects of global inland recreational fisheries for 81 countries spanning ~192 species. For each country, we assembled recreational fishing participation rate and estimated species-specific harvest and consumption rate. This dataset provides a foundation for future assessments, including understanding nutritional and economic contributions of inland recreational fisheries.
MeSH term(s)	Animals ; Conservation of Natural Resources ; Ecosystem ; Fisheries ; Fishes ; Species Specificity
Language	English
Publishing date	2022-08-10
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-022-01604-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Global dataset of species-specific inland recreational fisheries harvest for consumption

Holly S. Embke / Elizabeth A. Nyboer / Ashley M. Robertson / Robert Arlinghaus / Shehu L. Akintola / Tuncay Atessahin / Laamiri Mohamed Badr / Claudio Baigun / Zeenatul Basher / T. Douglas Beard / Gergely Boros / Shannon D. Bower / Steven J. Cooke / Ian G. Cowx / Adolfo Franco / Ma. Teresa Gaspar-Dillanes / Vladimir Puentes Granada / Robert John Hart / Carlos R. Heinsohn /

Scientific Data, Vol 9, Iss 1, Pp 1-

2022 Volume 10

Abstract: Measurement(s) inland recreational fisheries harvest Technology Type(s) Module 4: Literature References Sample Characteristic - Organism Osteichthyes Sample Characteristic - Environment inland waters Sample Characteristic - Location ... ...

Abstract	Measurement(s) inland recreational fisheries harvest Technology Type(s) Module 4: Literature References Sample Characteristic - Organism Osteichthyes Sample Characteristic - Environment inland waters Sample Characteristic - Location Global
Keywords	Science ; Q
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Conference proceedings: Tracheoesophageal fistula – possibilites of treatment. 15 years of single-centre experience

Krajc, Tibor / Harustiak, Svetozar / Benej, Roman / Janik, Miroslav / Lucenic, Martin

2009 , Page(s) PO1.1

Event/congress	18. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie; Augsburg; Deutsche Gesellschaft für Thoraxchirurgie; 2009
Keywords	Medizin, Gesundheit
Publishing date	2009-11-20
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/09dgt60
Database	German Medical Science

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