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  1. Article ; Online: Targeting ferroptosis for treating kidney disease.

    Mishima, Eikan

    Clinical and experimental nephrology

    2024  

    Abstract: Ferroptosis is a type of regulated cell death hallmarked by iron-mediated excessive lipid oxidation. Over the past decade since the coining of the term ferroptosis, advances in research have led to the identification of intracellular processes that ... ...

    Abstract Ferroptosis is a type of regulated cell death hallmarked by iron-mediated excessive lipid oxidation. Over the past decade since the coining of the term ferroptosis, advances in research have led to the identification of intracellular processes that regulate ferroptosis such as GSH-GPX4 pathway and FSP1-coenzyme Q
    Language English
    Publishing date 2024-04-22
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-024-02491-w
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    Zs.A 4922: Show issues Location:
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  2. Article ; Online: Constipation and high blood pressure variability.

    Mishima, Eikan

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 47, Issue 2, Page(s) 562–563

    MeSH term(s) Humans ; Blood Pressure/physiology ; Defecation ; Hypertension/physiopathology ; Constipation/etiology ; Constipation/physiopathology
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01514-5
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    Zs.A 3898: Show issues Location:
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  3. Article ; Online: Membrane Dynamics and Cation Handling in Ferroptosis.

    Hirata, Yusuke / Mishima, Eikan

    Physiology (Bethesda, Md.)

    2024  Volume 39, Issue 2, Page(s) 73–87

    Abstract: Ferroptosis, a regulated cell death hallmarked by excessive lipid peroxidation, is implicated in various (patho)physiological contexts. During ferroptosis, lipid peroxidation leads to a diverse change in membrane properties and the dysregulation of ion ... ...

    Abstract Ferroptosis, a regulated cell death hallmarked by excessive lipid peroxidation, is implicated in various (patho)physiological contexts. During ferroptosis, lipid peroxidation leads to a diverse change in membrane properties and the dysregulation of ion homeostasis via the cation channels, ultimately resulting in plasma membrane rupture. This review illuminates cellular membrane dynamics and cation handling in ferroptosis regulation.
    MeSH term(s) Humans ; Ferroptosis ; Lipid Peroxidation
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2158667-6
    ISSN 1548-9221 ; 1548-9213
    ISSN (online) 1548-9221
    ISSN 1548-9213
    DOI 10.1152/physiol.00029.2023
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  4. Article ; Online: The E2F1-IREB2 axis regulates neuronal ferroptosis in cerebral ischemia.

    Mishima, Eikan

    Hypertension research : official journal of the Japanese Society of Hypertension

    2021  Volume 45, Issue 6, Page(s) 1085–1086

    MeSH term(s) Brain Ischemia ; E2F1 Transcription Factor ; Ferroptosis ; Humans ; Neurons
    Chemical Substances E2F1 Transcription Factor ; E2F1 protein, human
    Language English
    Publishing date 2021-12-24
    Publishing country England
    Document type Editorial
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-021-00837-5
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  5. Article ; Online: Nonmetabolic role for CKB in ferroptosis.

    Mishima, Eikan / Conrad, Marcus

    Nature cell biology

    2023  Volume 25, Issue 5, Page(s) 633–634

    MeSH term(s) Brain ; Ferroptosis/genetics ; Gene Expression Regulation, Enzymologic
    Language English
    Publishing date 2023-05-06
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-023-01104-0
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  6. Article ; Online: Gut Microbiota Dynamics and Uremic Toxins

    Eikan Mishima / Takaaki Abe

    Toxins, Vol 14, Iss 146, p

    2022  Volume 146

    Abstract: Recent evidence has highlighted the importance of the gut microbiota in the pathophysiology of kidney diseases [.] ...

    Abstract Recent evidence has highlighted the importance of the gut microbiota in the pathophysiology of kidney diseases [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Nutritional and Metabolic Control of Ferroptosis.

    Mishima, Eikan / Conrad, Marcus

    Annual review of nutrition

    2022  Volume 42, Page(s) 275–309

    Abstract: Ferroptosis is a type of regulated cell death characterized by an excessive lipid peroxidation of cellular membranes caused by the disruption of the antioxidant defense system and/or an imbalanced cellular metabolism. Ferroptosis differentiates from ... ...

    Abstract Ferroptosis is a type of regulated cell death characterized by an excessive lipid peroxidation of cellular membranes caused by the disruption of the antioxidant defense system and/or an imbalanced cellular metabolism. Ferroptosis differentiates from other forms of regulated cell death in that several metabolic pathways and nutritional aspects, including endogenous antioxidants (such as coenzyme Q
    MeSH term(s) Antioxidants/metabolism ; Ferroptosis ; Humans ; Iron/metabolism ; Lipid Peroxidation
    Chemical Substances Antioxidants ; Iron (E1UOL152H7)
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 406980-8
    ISSN 1545-4312 ; 0199-9885
    ISSN (online) 1545-4312
    ISSN 0199-9885
    DOI 10.1146/annurev-nutr-062320-114541
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    Zs.A 1786: Show issues Location:
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  8. Article ; Online: Gut Microbiota Dynamics and Uremic Toxins.

    Mishima, Eikan / Abe, Takaaki

    Toxins

    2022  Volume 14, Issue 2

    Abstract: Recent evidence has highlighted the importance of the gut microbiota in the pathophysiology of kidney diseases [ ... ]. ...

    Abstract Recent evidence has highlighted the importance of the gut microbiota in the pathophysiology of kidney diseases [...].
    MeSH term(s) Bacterial Toxins/toxicity ; Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/physiopathology ; Gastrointestinal Microbiome/drug effects ; Humans ; Kidney Diseases/chemically induced ; Kidney Diseases/physiopathology ; Uremic Toxins/toxicity
    Chemical Substances Bacterial Toxins ; Uremic Toxins
    Language English
    Publishing date 2022-02-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins14020146
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  9. Article ; Online: Diverse biological functions of vitamin K: from coagulation to ferroptosis.

    Mishima, Eikan / Wahida, Adam / Seibt, Tobias / Conrad, Marcus

    Nature metabolism

    2023  Volume 5, Issue 6, Page(s) 924–932

    Abstract: Vitamin K is essential for several physiological processes, such as blood coagulation, in which it serves as a cofactor for the conversion of peptide-bound glutamate to γ-carboxyglutamate in vitamin K-dependent proteins. This process is driven by the ... ...

    Abstract Vitamin K is essential for several physiological processes, such as blood coagulation, in which it serves as a cofactor for the conversion of peptide-bound glutamate to γ-carboxyglutamate in vitamin K-dependent proteins. This process is driven by the vitamin K cycle facilitated by γ-carboxyglutamyl carboxylase, vitamin K epoxide reductase and ferroptosis suppressor protein-1, the latter of which was recently identified as the long-sought-after warfarin-resistant vitamin K reductase. In addition, vitamin K has carboxylation-independent functions. Akin to ubiquinone, vitamin K acts as an electron carrier for ATP production in some organisms and prevents ferroptosis, a type of cell death hallmarked by lipid peroxidation. In this Perspective, we provide an overview of the diverse functions of vitamin K in physiology and metabolism and, at the same time, offer a perspective on its role in ferroptosis together with ferroptosis suppressor protein-1. A comparison between vitamin K and ubiquinone, from an evolutionary perspective, may offer further insights into the manifold roles of vitamin K in biology.
    MeSH term(s) Vitamin K/metabolism ; Ubiquinone ; Ferroptosis ; Vitamin K Epoxide Reductases/genetics ; Vitamin K Epoxide Reductases/metabolism ; Blood Coagulation
    Chemical Substances Vitamin K (12001-79-5) ; Ubiquinone (1339-63-5) ; Vitamin K Epoxide Reductases (EC 1.17.4.4)
    Language English
    Publishing date 2023-06-19
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00821-y
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  10. Article ; Online: Role of the microbiota in hypertension and antihypertensive drug metabolism.

    Mishima, Eikan / Abe, Takaaki

    Hypertension research : official journal of the Japanese Society of Hypertension

    2021  Volume 45, Issue 2, Page(s) 246–253

    Abstract: Recent evidence suggests that the gut microbiota plays an important role in the development and pathogenesis of hypertension. Dysbiosis, an imbalance in the composition and function of the gut microbiota, was shown to be associated with hypertension in ... ...

    Abstract Recent evidence suggests that the gut microbiota plays an important role in the development and pathogenesis of hypertension. Dysbiosis, an imbalance in the composition and function of the gut microbiota, was shown to be associated with hypertension in both animal models and humans. In this review, we provide insights into host-microbiota interactions and summarize the evidence supporting the importance of the microbiota in blood pressure (BP) regulation. Metabolites produced by the gut microbiota, especially short-chain fatty acids (SCFAs), modulate BP and vascular responses. Harmful gut-derived metabolites, such as trimethylamine N-oxide and several uremic toxins, exert proatherosclerotic, prothrombotic, and proinflammatory effects. High-salt intake alters the composition of the microbiota, and this microbial alteration contributes to the pathogenesis of salt-sensitive hypertension. In addition, the microbiota may impact the metabolism of drugs and steroid hormones in the host. The drug-metabolizing activities of the microbiota affect the pharmacokinetic parameters of antihypertensive drugs and contribute to the pathogenesis of licorice-induced pseudohyperaldosteronism. Furthermore, the oral microbiota plays a role in BP regulation by producing nitric oxide, which lowers BP via its vasodilatory effects. Thus, antihypertensive intervention strategies targeting the microbiota, such as the use of prebiotics, probiotics, and postbiotics (e.g., SCFAs), are considered new therapeutic options for the treatment of hypertension.
    MeSH term(s) Animals ; Antihypertensive Agents/therapeutic use ; Dysbiosis ; Humans ; Hypertension ; Microbiota ; Uremic Toxins
    Chemical Substances Antihypertensive Agents ; Uremic Toxins
    Language English
    Publishing date 2021-12-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-021-00804-0
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