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  1. Book: Endocrine-disrupting chemicals

    Vandenberg, Laura N.

    (Advances in pharmacology ; volume 92)

    2021  

    Author's details edited by Laura N. Vandenberg, Judith L. Turgeon
    Series title Advances in pharmacology ; volume 92
    Collection
    Language English
    Size xxiv, 553 Seiten, Illustrationen
    Edition First edition
    Publisher Elsevier Academic Press
    Publishing place Cambridge, MA
    Publishing country United States
    Document type Book
    HBZ-ID HT021071239
    ISBN 978-0-12-823466-2 ; 0-12-823466-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uf I Zs 171 -92- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Endocrine disrupting chemicals: strategies to protect present and future generations.

    Vandenberg, Laura N

    Expert review of endocrinology & metabolism

    2021  Volume 16, Issue 3, Page(s) 135–146

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Endocrine Disruptors/toxicity ; Hormones ; Humans ; Social Responsibility
    Chemical Substances Endocrine Disruptors ; Hormones
    Language English
    Publishing date 2021-05-11
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1080/17446651.2021.1917991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Toxicity testing and endocrine disrupting chemicals.

    Vandenberg, Laura N

    Advances in pharmacology (San Diego, Calif.)

    2021  Volume 92, Page(s) 35–71

    Abstract: Regulatory agencies around the world depend on standardized testing approaches to evaluate environmental chemicals for endocrine disrupting properties. The US Environmental Protection Agency (EPA) has developed a two-tiered testing approach within its ... ...

    Abstract Regulatory agencies around the world depend on standardized testing approaches to evaluate environmental chemicals for endocrine disrupting properties. The US Environmental Protection Agency (EPA) has developed a two-tiered testing approach within its Endocrine Disruptor Screening Program (EDSP). The eleven Tier 1 and three Tier 2 EDSP assays can be used to identify chemicals that act as agonists or antagonists of estrogen receptor, androgen receptor, or thyroid hormone receptor, or chemicals that interfere with steroidogenesis. Additional assays have been developed in the context of Tox21, and others have been validated by the OECD. In spite of the availability of validated toxicity tests, problems have been identified with the approaches and methods used to identify endocrine disrupting chemicals (EDCs). This chapter will provide an overview of several of these issues including: (1) The way an EDC is defined by an agency impacts whether a specific test can be used to determine if a chemical is an EDC. This is especially important when considering which assays examine outcomes that are considered "adverse effects." (2) Some assumptions about the validated studies used to identify EDCs may not be true (e.g., their reproducibility has been questioned). (3) Many of the validated assays are less sensitive than other methods that have not yet been validated. Ultimately, these and other problems contribute to the current landscape, where testing approaches have failed to protect the public from known EDCs. The chapter concludes with a review of approaches that have been taken to improve current guideline studies.
    MeSH term(s) Biological Assay ; Endocrine Disruptors/analysis ; Endocrine Disruptors/toxicity ; Humans ; Reproducibility of Results ; Toxicity Tests ; United States ; United States Environmental Protection Agency
    Chemical Substances Endocrine Disruptors
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1557-8925
    ISSN (online) 1557-8925
    DOI 10.1016/bs.apha.2021.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Endocrine disrupting chemicals and the mammary gland.

    Vandenberg, Laura N

    Advances in pharmacology (San Diego, Calif.)

    2021  Volume 92, Page(s) 237–277

    Abstract: Development of the mammary gland requires coordination of hormone signaling pathways including those mediated by estrogen, progesterone, androgen and prolactin receptors. These hormones play important roles at several distinct stages of life including ... ...

    Abstract Development of the mammary gland requires coordination of hormone signaling pathways including those mediated by estrogen, progesterone, androgen and prolactin receptors. These hormones play important roles at several distinct stages of life including embryonic/fetal development, puberty, pregnancy, lactation, and old age. This also makes the gland sensitive to perturbations from environmental agents including endocrine disrupting chemicals (EDCs). Although there is evidence from human populations of associations between EDCs and disruptions to breast development and lactation, these studies are often complicated by the timing of exposure assessments and the latency to develop breast diseases (e.g., years to decades). Rodents have been instrumental in providing insights-not only to the basic biology and endocrinology of the mammary gland, but to the effects of EDCs on this tissue at different stages of development. Studies, mostly but not exclusively, of estrogenic EDCs have shown that the mammary gland is a sensitive tissue, that exposures during perinatal development can produce abnormal mammary structures (e.g., alveolar buds, typically seen in pregnant females) in adulthood; that exposures during pregnancy can alter milk production; and that EDC exposures can enhance the response of the mammary tissue to hormones and chemical carcinogens. Other studies of persistent organic pollutants have shown that EDC exposures during critical windows of development can delay development of the gland, with lifelong consequences for the individual. Collectively, this work continues to support the conclusion that EDCs can harm the mammary gland, with effects that depend on the period of exposure and the period of evaluation.
    MeSH term(s) Adult ; Animals ; Endocrine Disruptors/toxicity ; Estrogens ; Female ; Humans ; Lactation ; Mammary Glands, Animal ; Mammary Glands, Human ; Pregnancy
    Chemical Substances Endocrine Disruptors ; Estrogens
    Language English
    Publishing date 2021-07-02
    Publishing country United States
    Document type Journal Article
    ISSN 1557-8925
    ISSN (online) 1557-8925
    DOI 10.1016/bs.apha.2021.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of a TAML catalyst on mice exposed during pregnancy and lactation.

    Vandenberg, Laura N / Mogus, Joshua P / Szabo, Gillian K

    Reproductive toxicology (Elmsford, N.Y.)

    2024  Volume 125, Page(s) 108557

    Abstract: Tetra-amido macrocyclic ligands (TAMLs) are catalysts designed to mimic endogenous peroxidases that can degrade pollutants. Before TAMLs gain widespread use, it is first important to determine if they have endocrine disrupting properties. In this study, ... ...

    Abstract Tetra-amido macrocyclic ligands (TAMLs) are catalysts designed to mimic endogenous peroxidases that can degrade pollutants. Before TAMLs gain widespread use, it is first important to determine if they have endocrine disrupting properties. In this study, we evaluated the effects of the iron TAML, NT7, on hormone-sensitive outcomes in mice exposed during pregnancy and lactation, and on their litters prior to weaning. We administered NT7 at one of three doses to mice via drinking water prior to and then throughout pregnancy and lactation. Two hormonally active pharmaceuticals, ethinyl estradiol (EE2) and flutamide (FLUT), a known estrogen receptor agonist and androgen receptor antagonist, respectively, were also included. In the females, we measured pre- and post-parturition weight, length of pregnancy, organ weights at necropsy, and morphology of the mammary gland at the end of the lactational period. We also quantified maternal behaviors at three stages of lactation. For the offspring, we measured litter size, litter weights, and the achievement of other developmental milestones. We observed only one statistically significant effect of NT7, a decrease in the percentage of pups with ear opening at postnatal day 5. This contrasts with the numerous effects of EE2 on both the mother and the litter, as well as several modest effects of FLUT. The approach taken in this study could provide guidance for future studies that aim to evaluate novel compounds for endocrine disrupting properties.
    MeSH term(s) Pregnancy ; Female ; Animals ; Mice ; Lactation ; Estrogens/pharmacology ; Flutamide ; Litter Size ; Ethinyl Estradiol/toxicity
    Chemical Substances Estrogens ; Flutamide (76W6J0943E) ; Ethinyl Estradiol (423D2T571U)
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639342-1
    ISSN 1873-1708 ; 0890-6238
    ISSN (online) 1873-1708
    ISSN 0890-6238
    DOI 10.1016/j.reprotox.2024.108557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2316: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Failure to Launch: The Endocrine Disruptor Screening Program at the U.S. Environmental Protection Agency.

    Maffini, Maricel V / Vandenberg, Laura N

    Frontiers in toxicology

    2022  Volume 4, Page(s) 908439

    Abstract: It has been 25 years since the U.S. Congress passed the Food Quality Protection Act of 1996, an amendment to the Food Drug and Cosmetic Act, which mandated that the US Environmental Protection Agency (EPA) test all pesticide chemicals used in food for ... ...

    Abstract It has been 25 years since the U.S. Congress passed the Food Quality Protection Act of 1996, an amendment to the Food Drug and Cosmetic Act, which mandated that the US Environmental Protection Agency (EPA) test all pesticide chemicals used in food for endocrine disruption. Soon after the law passed, EPA established the Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) to provide recommendations to the agency on how its Endocrine Disruptor Screening Program (EDSP) should work. Among them, the committee recommended that EDSP screening should 1) evaluate both human and ecological effects; 2) test for disruption of the estrogen, androgen, and thyroid systems; 3) evaluate pesticide and non-pesticide chemicals; and 4) implement a tiered approach. EPA adopted the recommendations and the EDSP was created in 1998. To date, the EPA has yet to fully implement the law; in other words, it has failed to test all pesticide chemicals for endocrine disruption. Of the small number that have been tested, not a single pesticide chemical has been determined to be an endocrine disruptor, and no regulatory actions have been taken. Here, we review the missed opportunities EPA had to make the EDSP a functional and effective program aimed at protecting human health and the environment. Two reports by the EPA's Office of Inspector General from 2011 to 2021 provide the framework for our discussion.
    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2022.908439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Towards a paradigm shift in environmental health decision-making: a case study of oxybenzone.

    Matouskova, Klara / Vandenberg, Laura N

    Environmental health : a global access science source

    2022  Volume 21, Issue 1, Page(s) 6

    Abstract: Background: Technological advancements make lives safer and more convenient. Unfortunately, many of these advances come with costs to susceptible individuals and public health, the environment, and other species and ecosystems. Synthetic chemicals in ... ...

    Abstract Background: Technological advancements make lives safer and more convenient. Unfortunately, many of these advances come with costs to susceptible individuals and public health, the environment, and other species and ecosystems. Synthetic chemicals in consumer products represent a quintessential example of the complexity of both the benefits and burdens of modern living. How we navigate this complexity is a matter of a society's values and corresponding principles.
    Objectives: We aimed to develop a series of ethical principles to guide decision-making within the landscape of environmental health, and then apply these principles to a specific environmental chemical, oxybenzone. Oxybenzone is a widely used ultraviolet (UV) filter added to personal care products and other consumer goods to prevent UV damage, but potentially poses harm to humans, wildlife, and ecosystems. It provides an excellent example of a chemical that is widely used for the alleged purpose of protecting human health and product safety, but with costs to human health and the environment that are often ignored by stakeholders.
    Discussion: We propose six ethical principles to guide environmental health decision-making: principles of sustainability, beneficence, non-maleficence, justice, community, and precautionary substitution. We apply these principles to the case of oxybenzone to demonstrate the complex but imperative decision-making required if we are to address the limits of the biosphere's regenerative rates. We conclude that both ethical and practical considerations should be included in decisions about the commercial, pervasive application of synthetic compounds and that the current flawed practice of cost-benefit analysis be recognized for what it is: a technocratic approach to support corporate interests.
    MeSH term(s) Benzophenones ; Ecosystem ; Environmental Health ; Humans ; Social Justice
    Chemical Substances Benzophenones ; oxybenzone (95OOS7VE0Y)
    Language English
    Publishing date 2022-01-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2092232-2
    ISSN 1476-069X ; 1476-069X
    ISSN (online) 1476-069X
    ISSN 1476-069X
    DOI 10.1186/s12940-021-00806-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Endocrine disrupting chemicals: Understanding what matters.

    Vandenberg, Laura N / Turgeon, Judith L

    Advances in pharmacology (San Diego, Calif.)

    2021  Volume 92, Page(s) xiii–xxiv

    MeSH term(s) Endocrine Disruptors/toxicity ; Humans
    Chemical Substances Endocrine Disruptors
    Language English
    Publishing date 2021-05-10
    Publishing country United States
    Document type Editorial
    ISSN 1557-8925
    ISSN (online) 1557-8925
    DOI 10.1016/S1054-3589(21)00051-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effects of perinatal exposures to a TAML catalyst on the mammary gland and hormone-sensitive outcomes in male mice.

    Szabo, Gillian K / Mogus, Joshua P / Vandenberg, Laura N

    Reproductive toxicology (Elmsford, N.Y.)

    2023  Volume 123, Page(s) 108517

    Abstract: Estrogenic chemicals are common pollutants in wastewater and current effluent treatment processes are not typically effective in removing these compounds. Tetra-amido macrocyclic ligands (TAMLs) are catalysts that mimic endogenous peroxidases that may ... ...

    Abstract Estrogenic chemicals are common pollutants in wastewater and current effluent treatment processes are not typically effective in removing these compounds. Tetra-amido macrocyclic ligands (TAMLs) are catalysts that mimic endogenous peroxidases that may provide a solution to remove environmental pollutants including low concentrations of estrogenic compounds. Yet relatively little is known about the toxicity of TAMLs, and few studies have evaluated whether they may have endocrine disrupting properties. We administered one of three doses of a TAML, NT7, to mice via drinking water throughout pregnancy and lactation. Two pharmacologically active compounds, ethinyl estradiol (EE2) and flutamide were also included to give comparator data for estrogen receptor agonist and androgen receptor antagonist activities. Male pups were evaluated for several outcomes at weaning, puberty, and early adulthood. We found that EE2 exposures during gestation and the perinatal period induced numerous effects that were observed across the three ages including changes to spleen and testis weight and drastic effects on the morphology of the mammary gland. Flutamide had fewer effects but altered anogenital distance at weaning as well as spleen, liver, and kidney weight. In contrast, relatively few effects of NT7 were observed, but included alterations to spleen weight and modest changes to adult testis weight and morphology of the mammary gland at weaning. Collectively, these results provide some of the first evidence suggesting that NT7 may alter some hormone-sensitive outcomes, but that the effects were distinct from either EE2 or flutamide. Additional studies are needed to characterize the biological activity of this and other TAML catalysts.
    MeSH term(s) Pregnancy ; Female ; Mice ; Animals ; Male ; Flutamide/toxicity ; Sexual Maturation ; Estrogens/toxicity ; Ethinyl Estradiol/toxicity ; Lactation
    Chemical Substances Flutamide (76W6J0943E) ; Estrogens ; Ethinyl Estradiol (423D2T571U)
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639342-1
    ISSN 1873-1708 ; 0890-6238
    ISSN (online) 1873-1708
    ISSN 0890-6238
    DOI 10.1016/j.reprotox.2023.108517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2316: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Editorial: Endocrine-Disrupting Compounds in Plastics and Their Effects on Reproduction, Fertility, and Development.

    Maradonna, Francesca / Vandenberg, Laura N / Meccariello, Rosaria

    Frontiers in toxicology

    2022  Volume 4, Page(s) 886628

    Language English
    Publishing date 2022-03-25
    Publishing country Switzerland
    Document type Editorial
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2022.886628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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