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Article ; Online: SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress.

Yang, Xue / Chung, Jin-Yong / Rai, Usha / Esumi, Noriko

Life science alliance

2023 Volume 6, Issue 7

Abstract: Retinal pigment epithelium (RPE) is essential for the survival of retinal photoreceptors. To study retinal degeneration, sodium iodate ( ... ...

Abstract	Retinal pigment epithelium (RPE) is essential for the survival of retinal photoreceptors. To study retinal degeneration, sodium iodate (NaIO
MeSH term(s)	Mice ; Animals ; Retinal Pigment Epithelium/metabolism ; DNA Helicases/metabolism ; Poly-ADP-Ribose Binding Proteins/metabolism ; RNA Helicases/metabolism ; RNA Recognition Motif Proteins/metabolism ; Retinal Degeneration/metabolism ; Oxidative Stress ; Sirtuins/genetics ; Sirtuins/adverse effects ; Sirtuins/metabolism
Chemical Substances	DNA Helicases (EC 3.6.4.-) ; Poly-ADP-Ribose Binding Proteins ; RNA Helicases (EC 3.6.4.13) ; RNA Recognition Motif Proteins ; Sirtuins (EC 3.5.1.-) ; Sirt6 protein, mouse (EC 2.4.2.31)
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2575-1077
ISSN (online)	2575-1077
DOI	10.26508/lsa.202201448
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sirt1 and Nrf2: regulation of Leydig cell oxidant/antioxidant intracellular environment and steroid formation†.

Chung, Jin-Yong / Chen, Haolin / Zirkin, Barry

Biology of reproduction

2021 Volume 105, Issue 5, Page(s) 1307–1316

Abstract: Previous studies reported that, with aging, Leydig cell intracellular antioxidants are reduced in concentration and intracellular ROS levels increase, suggesting that oxidant/antioxidant imbalance may contribute to the reduced testosterone production ... ...

Abstract	Previous studies reported that, with aging, Leydig cell intracellular antioxidants are reduced in concentration and intracellular ROS levels increase, suggesting that oxidant/antioxidant imbalance may contribute to the reduced testosterone production that characterizes the aging cells. As yet, little is known about how the Leydig cell oxidant/antioxidant environment is regulated. Sirt1, an enzyme that deacetylates transcription factors, and the transcription factor Nrf2, have been shown to be associated with cellular response to oxidative stress. We hypothesized that Sirt1 and/or Nrf2 might be involved in regulating the oxidant/antioxidant environment of Leydig cells, and therefore, the testosterone production. We found that Sirt1 and Nrf2 are present in the Leydig cells of Brown Norway rats, though reduced in aged cells. In MA-10 cells in which Sirt1 or Nrf2 were suppressed by nicotinamide (NAM) or ML385, respectively, or in which siRNAs were used for knockdown of Sirt1 or Nrf2, increased ROS levels and decreased progesterone production occurred. In rat Leydig cells, inhibition of Sirt1 by culturing the cells with NAM resulted in increased ROS and reduced testosterone production, and subsequent removal of NAM from the culture medium resulted in increased testosterone production. Activation of rat Leydig cells Sirt1 with honokiol or of Nrf2 with sulforaphane resulted in the maintenance of testosterone production despite the exposure of the cells to oxidizing agent. These results, taken together, suggest that Sirt1 and Nrf2 are involved in maintaining the Leydig cell oxidant/antioxidant environment, and thus in maintaining steroid production.
MeSH term(s)	Animals ; Male ; Rats ; Antioxidants/metabolism ; Leydig Cells/metabolism ; Oxidants/metabolism ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Testosterone/biosynthesis ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism
Chemical Substances	Antioxidants ; Oxidants ; Sirt1 protein, rat (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-) ; Testosterone (3XMK78S47O) ; Nfe2l2 protein, rat ; NF-E2-Related Factor 2
Language	English
Publishing date	2021-08-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1093/biolre/ioab150
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Fine Tuning of an Oxidative Stress Model with Sodium Iodate Revealed Protective Effect of NF-κB Inhibition and Sex-Specific Difference in Susceptibility of the Retinal Pigment Epithelium.

Yang, Xue / Rai, Usha / Chung, Jin-Yong / Esumi, Noriko

Antioxidants (Basel, Switzerland)

2021 Volume 11, Issue 1

Abstract: Oxidative stress of the retinal pigment epithelium (RPE) is a major risk factor for age-related macular degeneration (AMD). As a dry AMD model via oxidative stress, sodium iodate ( ... ...

Abstract	Oxidative stress of the retinal pigment epithelium (RPE) is a major risk factor for age-related macular degeneration (AMD). As a dry AMD model via oxidative stress, sodium iodate (NaIO
Language	English
Publishing date	2021-12-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11010103
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Styrene Cytotoxicity in Testicular Leydig Cells

Chung, Jin-Yong / Park, Ji-Eun / Kim, Yoon-Jae / Lee, Seung-Jin / Yu, Wook-Joon / Kim, Jong-Min

Development & reproduction

2022 Volume 26, Issue 3, Page(s) 99–105

Abstract: Styrene is the precursor of polystyrene. Human exposure to styrene could occur in occupational and residential settings and via food intake. Styrene is metabolized to styrene-7,8-oxide by cytochrome P450 enzyme. In the present study, we investigated the ... ...

Abstract	Styrene is the precursor of polystyrene. Human exposure to styrene could occur in occupational and residential settings and via food intake. Styrene is metabolized to styrene-7,8-oxide by cytochrome P450 enzyme. In the present study, we investigated the cytotoxicity mediated by styrene and styrene-7,8-oxide in TM3 testicular Leydig cells
Language	English
Publishing date	2022-09-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3018107-0
ISSN	2465-9541 ; 2465-9525
ISSN (online)	2465-9541
ISSN	2465-9525
DOI	10.12717/DR.2022.26.3.99
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Suprascapular nerve entrapment caused by a large hematoma of the scapula: a case report.

Joo, Yong Bum / Lee, Woo Yong / Chung, Hyung Jin

BMC musculoskeletal disorders

2023 Volume 24, Issue 1, Page(s) 589

Abstract: Background: Suprascapular nerve entrapment is a rare disorder that is frequently misdiagnosed as another disease. The suprascapular nerve is commonly entrapped at the following two sites: the suprascapular and spinoglenoid notches. Nerve entrapment at ... ...

Abstract	Background: Suprascapular nerve entrapment is a rare disorder that is frequently misdiagnosed as another disease. The suprascapular nerve is commonly entrapped at the following two sites: the suprascapular and spinoglenoid notches. Nerve entrapment at the spinoglenoid notch causes infraspinatus muscle weakness and atrophy. Patients present with posterior shoulder pain and weakness. Magnetic resonance imaging is used to confirm the diagnosis of a spinoglenoid cyst and nerve compression. Open or arthroscopic aspiration or decompression is indicated for patients with cysts in whom conservative treatment has failed and those with cysts associated with suprascapular nerve compression. Case presentation: Herein, we describe the case of a 49-year-old man with suprascapular nerve entrapment caused by a large cyst, namely, a hematoma, in the superior scapular and spinoglenoid notches. Open surgical decompression of the suprascapular nerve was performed owing to an intact rotator cuff and glenoid labrum. Conclusion: Posterior shoulder pain promptly resolved without complications.
MeSH term(s)	Male ; Humans ; Middle Aged ; Shoulder Pain/diagnostic imaging ; Shoulder Pain/etiology ; Shoulder Pain/surgery ; Scapula/diagnostic imaging ; Scapula/surgery ; Shoulder/diagnostic imaging ; Shoulder/surgery ; Nerve Compression Syndromes/diagnostic imaging ; Nerve Compression Syndromes/etiology ; Nerve Compression Syndromes/surgery ; Cysts ; Paralysis
Language	English
Publishing date	2023-07-19
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-023-06723-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Fatty Liver Index's Association with Incident Chronic Kidney Disease in Korean Middle-Aged Adults: A Community-Based Cohort Study.

Lee, Hyun Hee / Ro, Han / Jung, Ji Yong / Chang, Jae Hyun / Chung, Wookyung / Kim, Ae Jin

Journal of clinical medicine

2024 Volume 13, Issue 6

Abstract: 1) ...

Abstract	(1)
Language	English
Publishing date	2024-03-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13061616
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Risk Factors Associated with Intraoperative Iatrogenic Fracture in Patients Undergoing Intramedullary Nailing for Atypical Femoral Fractures with Marked Anterior and Lateral Bowing.

Joo, Yong Bum / Jeon, Yoo Sun / Lee, Woo Yong / Chung, Hyung Jin

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 4

Abstract: Background and ... ...

Abstract	Background and objectives
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Aged, 80 and over ; Femoral Fractures/etiology ; Femoral Fractures/surgery ; Fracture Fixation, Intramedullary/adverse effects ; Retrospective Studies ; Cross-Sectional Studies ; Femur ; Risk Factors ; Bone Nails/adverse effects ; Iatrogenic Disease/epidemiology
Language	English
Publishing date	2023-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59040735
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 6270: Show issues

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Article: Fine Tuning of an Oxidative Stress Model with Sodium Iodate Revealed Protective Effect of NF-κB Inhibition and Sex-Specific Difference in Susceptibility of the Retinal Pigment Epithelium

Yang, Xue / Rai, Usha / Chung, Jin-Yong / Esumi, Noriko

Antioxidants. 2021 Dec. 31, v. 11, no. 1

2021

Abstract: Oxidative stress of the retinal pigment epithelium (RPE) is a major risk factor for age-related macular degeneration (AMD). As a dry AMD model via oxidative stress, sodium iodate (NaIO₃), which is primarily toxic to the RPE, has often been used at a high ...

Abstract	Oxidative stress of the retinal pigment epithelium (RPE) is a major risk factor for age-related macular degeneration (AMD). As a dry AMD model via oxidative stress, sodium iodate (NaIO₃), which is primarily toxic to the RPE, has often been used at a high dose to cause RPE death for studying photoreceptor degeneration. Thus, characterization of RPE damage by a low dose of NaIO₃ is still limited. To quantify RPE damage caused by NaIO₃ in mice, we recently developed a morphometric method using RPE flat-mounts. Here, we report that NaIO₃ has a narrow range of dose–effect correlation at 11–18 mg/kg body weight in male C57BL/6J mice. We evaluated the usefulness of our quantification method in two experimental settings. First, we tested the effect of NF-κB inhibition on NaIO₃-induced RPE damage in male C57BL/6J mice. IKKβ inhibitor BAY 651942 suppressed upregulation of NF-κB targets and protected the RPE from oxidative stress. Second, we tested sex-specific differences in NaIO₃-induced RPE damage in C57BL/6J mice using a low dose near the threshold. NaIO₃ caused more severe RPE damage in female mice than in male mice. These results demonstrate the usefulness of the quantification method and the importance of fine-tuning of the NaIO₃ dose. The results also show the therapeutic potential of IKKβ inhibition for oxidative stress-related RPE diseases, and reveal previously-unrecognized sex-specific differences in RPE susceptibility to oxidative stress.
Keywords	body weight ; death ; epithelium ; females ; iodates ; macular degeneration ; males ; models ; morphometry ; oxidative stress ; photoreceptors ; protective effect ; risk factors ; sodium ; therapeutics ; toxicity
Language	English
Dates of publication	2021-1231
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11010103
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Pancreatic islet cell type–specific transcriptomic changes during pregnancy and postpartum

Jin-Yong Chung / Yongjie Ma / Dingguo Zhang / Hayden H. Bickerton / Eric Stokes / Sweta B. Patel / Hubert M. Tse / Joseph Feduska / Rob S. Welner / Ronadip R. Banerjee

iScience, Vol 26, Iss 4, Pp 106439- (2023)

2023

Abstract: Summary: Pancreatic β-cell mass expands during pregnancy and regresses in the postpartum period in conjunction with dynamic metabolic demands on maternal glucose homeostasis. To understand transcriptional changes driving these adaptations in β-cells and ... ...

Abstract	Summary: Pancreatic β-cell mass expands during pregnancy and regresses in the postpartum period in conjunction with dynamic metabolic demands on maternal glucose homeostasis. To understand transcriptional changes driving these adaptations in β-cells and other islet cell types, we performed single-cell RNA sequencing on islets from virgin, late gestation, and early postpartum mice. We identified transcriptional signatures unique to gestation and the postpartum in β-cells, including induction of the AP-1 transcription factor subunits and other genes involved in the immediate-early response (IEGs). In addition, we found pregnancy and postpartum-induced changes differed within each endocrine cell type, and in endothelial cells and antigen-presenting cells within islets. Together, our data reveal insights into cell type–specific transcriptional changes responsible for adaptations by islet cells to pregnancy and their resolution postpartum.
Keywords	Pregnancy ; Molecular physiology ; Transcriptomics ; Science ; Q
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pancreatic islet cell type-specific transcriptomic changes during pregnancy and postpartum.

Chung, Jin-Yong / Ma, Yongjie / Zhang, Dingguo / Bickerton, Hayden H / Stokes, Eric / Patel, Sweta B / Tse, Hubert M / Feduska, Joseph / Welner, Rob S / Banerjee, Ronadip R

iScience

2023 Volume 26, Issue 4, Page(s) 106439

Abstract: Pancreatic β-cell mass expands during pregnancy and regresses in the postpartum period in conjunction with dynamic metabolic demands on maternal glucose homeostasis. To understand transcriptional changes driving these adaptations in β-cells and other ... ...

Abstract	Pancreatic β-cell mass expands during pregnancy and regresses in the postpartum period in conjunction with dynamic metabolic demands on maternal glucose homeostasis. To understand transcriptional changes driving these adaptations in β-cells and other islet cell types, we performed single-cell RNA sequencing on islets from virgin, late gestation, and early postpartum mice. We identified transcriptional signatures unique to gestation and the postpartum in β-cells, including induction of the AP-1 transcription factor subunits and other genes involved in the immediate-early response (IEGs). In addition, we found pregnancy and postpartum-induced changes differed within each endocrine cell type, and in endothelial cells and antigen-presenting cells within islets. Together, our data reveal insights into cell type-specific transcriptional changes responsible for adaptations by islet cells to pregnancy and their resolution postpartum.
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.106439
Database	MEDical Literature Analysis and Retrieval System OnLINE

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