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Book ; Online ; Thesis: Clinical peptidomics for non-invasive diagnosis and prognosis of renal diseases

Pontillo, Claudia [Verfasser]

2017

Author's details	Claudia Pontillo
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Publisher	Medizinische Fakultät Charité - Universitätsmedizin Berlin
Publishing place	Berlin
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Urinary peptide-based classifier CKD273: towards clinical application in chronic kidney disease.

Pontillo, Claudia / Mischak, Harald

Clinical kidney journal

2017 Volume 10, Issue 2, Page(s) 192–201

Abstract: Capillary electrophoresis coupled with mass spectrometry (CE-MS) has been used as a platform for discovery and validation of urinary peptides associated with chronic kidney disease (CKD). CKD affects ∼ 10% of the population, with high associated costs ... ...

Abstract	Capillary electrophoresis coupled with mass spectrometry (CE-MS) has been used as a platform for discovery and validation of urinary peptides associated with chronic kidney disease (CKD). CKD affects ∼ 10% of the population, with high associated costs for treatments. A urinary proteome-based classifier (CKD273) has been discovered and validated in cross-sectional and longitudinal studies to assess and predict the progression of CKD. It has been implemented in studies employing cohorts of > 1000 patients. CKD273 is commercially available as an
Language	English
Publishing date	2017-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfx002
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Article ; Online: Urinary biomarkers to predict CKD: is the future in multi-marker panels?

Pontillo, Claudia / Mischak, Harald

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2016 Volume 31, Issue 9, Page(s) 1373–1375

Language	English
Publishing date	2016-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfv467
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Article ; Online: Genetic contribution and functional impairment of inflammasome in sickle cell disease.

de Freitas Dutra, Valéria / Leal, Vinícius Nunes Cordeiro / Fernandes, Fernanda Pereira / Souza, Cláudia Regina Lustosa / Figueiredo, Maria Stella / Pontillo, Alessandra

Cytokine

2021 Volume 149, Page(s) 155717

Abstract: Background: Sickle cell disease (SCD), one of the most common single-gene disorders, is caused by mutations in the hemoglobin ß-chain gene. Clinical presentation is heterogeneous, and inflammation is a common condition. Thereby, we hypothesized that ... ...

Abstract	Background: Sickle cell disease (SCD), one of the most common single-gene disorders, is caused by mutations in the hemoglobin ß-chain gene. Clinical presentation is heterogeneous, and inflammation is a common condition. Thereby, we hypothesized that inflammasome and related cytokine IL-1ß could represent significant SCD pathogenesis contributors. Material and methods: 161 SCD (SS/Sβ) patients were enrolled for the study. Seven single nucleotide polymorphisms (SNPs) in 5 inflammasome genes (NLRP1, NLRP3, NLRC4, CARD8, IL1B) were selected based on minor allele frequency. Total peripheral blood mononuclear cells (PBMC) and monocytes were isolated from 10 out of 161 SCD patients (HbSS) and 10 healthy donors (control group, Ctrl) for inflammasome analysis. Results: SCD patients presented a functional impairment of inflammasome, with monocytes and peripheral blood mononuclear cells (PBMC) exhibiting a different NLRP3 inflammasome activation rate. Gain-of-function variants in NLRP1 and IL1B genes resulted associated with a mild SCD clinical presentation. Discussion: Our results can contribute to the understanding of SCD inflammation. SCD patients showed possible exhaustion of monocytes due to chronic inflammation, moreover others cells in PBMC can contribute to the NLRP3 inflammasome activation. NLRP1 gain-of-function was associated with mild clinical presentation, suggesting that other inflammasome receptors can be involved in SCD. This is the first study reporting a significant contribution of inflammasome SNPs in SCD.
MeSH term(s)	Adult ; Anemia, Sickle Cell/genetics ; Anemia, Sickle Cell/pathology ; Apoptosis Regulatory Proteins/genetics ; Female ; Gain of Function Mutation/genetics ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Humans ; Inflammasomes/genetics ; Inflammation/genetics ; Interleukin-1beta/genetics ; Leukocytes, Mononuclear/pathology ; Male ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Proteins/genetics ; Polymorphism, Single Nucleotide/genetics
Chemical Substances	Apoptosis Regulatory Proteins ; Inflammasomes ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLR Proteins
Language	English
Publishing date	2021-10-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2021.155717
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Article ; Online: Visual Snow Syndrome Improves With Modulation of Resting-State Functional MRI Connectivity After Mindfulness-Based Cognitive Therapy: An Open-Label Feasibility Study.

Wong, Sui H / Pontillo, Giuseppe / Kanber, Baris / Prados, Ferran / Wingrove, Janet / Yiannakas, Marios / Davagnanam, Indran / Gandini Wheeler-Kingshott, Claudia A M / Toosy, Ahmed T

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

2023 Volume 44, Issue 1, Page(s) 112–118

Abstract: Background: Visual snow syndrome (VSS) is associated with functional connectivity (FC) dysregulation of visual networks (VNs). We hypothesized that mindfulness-based cognitive therapy, customized for visual symptoms (MBCT-vision), can treat VSS and ... ...

Abstract	Background: Visual snow syndrome (VSS) is associated with functional connectivity (FC) dysregulation of visual networks (VNs). We hypothesized that mindfulness-based cognitive therapy, customized for visual symptoms (MBCT-vision), can treat VSS and modulate dysfunctional VNs. Methods: An open-label feasibility study for an 8-week MBCT-vision treatment program was conducted. Primary (symptom severity; impact on daily life) and secondary (WHO-5; CORE-10) outcomes at Week 9 and Week 20 were compared with baseline. Secondary MRI outcomes in a subcohort compared resting-state functional and diffusion MRI between baseline and Week 20. Results: Twenty-one participants (14 male participants, median 30 years, range 22-56 years) recruited from January 2020 to October 2021. Two (9.5%) dropped out. Self-rated symptom severity (0-10) improved: baseline (median [interquartile range (IQR)] 7 [6-8]) vs Week 9 (5.5 [3-7], P = 0.015) and Week 20 (4 [3-6], P < 0.001), respectively. Self-rated impact of symptoms on daily life (0-10) improved: baseline (6 [5-8]) vs Week 9 (4 [2-5], P = 0.003) and Week 20 (2 [1-3], P < 0.001), respectively. WHO-5 Wellbeing (0-100) improved: baseline (median [IQR] 52 [36-56]) vs Week 9 (median 64 [47-80], P = 0.001) and Week 20 (68 [48-76], P < 0.001), respectively. CORE-10 Distress (0-40) improved: baseline (15 [12-20]) vs Week 9 (12.5 [11-16.5], P = 0.003) and Week 20 (11 [10-14], P = 0.003), respectively. Within-subject fMRI analysis found reductions between baseline and Week 20, within VN-related FC in the i) left lateral occipital cortex (size = 82 mL, familywise error [FWE]-corrected P value = 0.006) and ii) left cerebellar lobules VIIb/VIII (size = 65 mL, FWE-corrected P value = 0.02), and increases within VN-related FC in the precuneus/posterior cingulate cortex (size = 69 mL, cluster-level FWE-corrected P value = 0.02). Conclusions: MBCT-vision was a feasible treatment for VSS, improved symptoms and modulated FC of VNs. This study also showed proof-of-concept for intensive mindfulness interventions in the treatment of neurological conditions.
MeSH term(s)	Humans ; Male ; Mindfulness ; Feasibility Studies ; Cognitive Behavioral Therapy ; Magnetic Resonance Imaging ; Treatment Outcome ; Perceptual Disorders ; Vision Disorders
Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1189901-3
ISSN	1536-5166 ; 1070-8022
ISSN (online)	1536-5166
ISSN	1070-8022
DOI	10.1097/WNO.0000000000002013
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Article ; Online: Publisher Correction: Novel Urinary Biomarkers For Improved Prediction Of Progressive eGFR Loss In Early Chronic Kidney Disease Stages And In High Risk Individuals Without Chronic Kidney Disease.

Rodríguez-Ortiz, María E / Pontillo, Claudia / Rodríguez, Mariano / Zürbig, Petra / Mischak, Harald / Ortiz, Alberto

Scientific reports

2018 Volume 8, Issue 1, Page(s) 17822

Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

Abstract	A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Language	English
Publishing date	2018-12-10
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-36919-7
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Article ; Online: Novel Urinary Biomarkers For Improved Prediction Of Progressive Egfr Loss In Early Chronic Kidney Disease Stages And In High Risk Individuals Without Chronic Kidney Disease.

Rodríguez-Ortiz, María E / Pontillo, Claudia / Rodríguez, Mariano / Zürbig, Petra / Mischak, Harald / Ortiz, Alberto

Scientific reports

2018 Volume 8, Issue 1, Page(s) 15940

Abstract: Chronic kidney disease is associated with increased risk of CKD progression and death. Therapeutic approaches to limit progression are limited. Developing tools for the early identification of those individuals most likely to progress will allow ... ...

Abstract	Chronic kidney disease is associated with increased risk of CKD progression and death. Therapeutic approaches to limit progression are limited. Developing tools for the early identification of those individuals most likely to progress will allow enriching clinical trials in high risk early CKD patients. The CKD273 classifier is a panel of 273 urinary peptides that enables early detection of CKD and prognosis of progression. We have generated urine capillary electrophoresis-mass spectrometry-based peptidomics CKD273 subclassifiers specific for CKD stages to allow the early identification of patients at high risk of CKD progression. In the validation cohort, the CKD273 subclassifiers outperformed albuminuria and CKD273 classifier for predicting rapid loss of eGFR in individuals with baseline eGFR > 60 ml/min/1.73 m
MeSH term(s)	Adult ; Aged ; Albuminuria/complications ; Albuminuria/diagnosis ; Area Under Curve ; Biomarkers/urine ; Disease Progression ; Early Diagnosis ; Female ; Glomerular Filtration Rate/physiology ; Humans ; Male ; Middle Aged ; Peptides/urine ; Prognosis ; ROC Curve ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/pathology ; Risk Factors ; Support Vector Machine
Chemical Substances	Biomarkers ; Peptides
Language	English
Publishing date	2018-10-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-34386-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparative Clinical Evaluation between Conventional Periodontal Treatment and Full Mouth Disinfection.

Pontillo, Viviane / Miziak, Debora Beckenkamp / Maller, Ana Claudia Piva Alegre / Nassar, Patricia Oehlmeyer / Nassar, Carlos Augusto

Journal of the International Academy of Periodontology

2018 Volume 20, Issue 4, Page(s) 123–130

Abstract: Periodontal disease is chronic and multifactorial, affecting protection and support tissues of the tooth. Its onset is due to the accumulation of bacterial plaque, in which are found microorganisms, mainly Gram-negative, which stimulate the host cells ... ...

Abstract	Periodontal disease is chronic and multifactorial, affecting protection and support tissues of the tooth. Its onset is due to the accumulation of bacterial plaque, in which are found microorganisms, mainly Gram-negative, which stimulate the host cells and the production of immune-inflammatory molecules. Thus, the objective of this research was to evaluate the effectiveness of two techniques of periodontal treatment through clinical parameters and laboratory tests. For this, 42 patients were randomly evaluated and divided into three groups of 14 patients each: Group 1 (control) - periodontally healthy patients; Group 2 - patients with moderate to severe chronic periodontitis treated with conventional periodontal treatment [quadrant scaling and root planing (Q-SRP)]; and Group 3 - patients with moderate to severe chronic periodontitis treated with full-mouth scaling and root planing (FM-SRP). All of these patients received periodontal treatment and were evaluated using the plaque and gingival indices, probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), analysis of prostaglandin E2 (PGE2) isoform expression and analysis of gingival crevicular fluid (GCF), for a total period of 180 days. The results of the periodontal and laboratory parameters did not show significant differences statistically (p > 0.05) when comparing the treatments at 180 days. Therefore, it can be affirmed that both periodontal treatments were effective, but without differences between them. Both treatments improved periodontal and laboratorial clinical parameters significantly. Thus, the professional should evaluate the case and choose the treatment that best suits the needs of the patient and availability.
Language	English
Publishing date	2018-10-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2146303-7
ISSN	2518-3745 ; 1466-2094
ISSN (online)	2518-3745
ISSN	1466-2094
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Article ; Online: Impact of endocrine disruptor hexachlorobenzene on the mammary gland and breast cancer: The story thus far.

Miret, Noelia V / Pontillo, Carolina A / Zárate, Lorena V / Kleiman de Pisarev, Diana / Cocca, Claudia / Randi, Andrea S

Environmental research

2019 Volume 173, Page(s) 330–341

Abstract: Breast cancer incidence is increasing globally and exposure to endocrine disruptors has gained importance as a potential risk factor. Hexachlorobenzene (HCB) was once used as a fungicide and, despite being banned, considerable amounts are still released ... ...

Abstract	Breast cancer incidence is increasing globally and exposure to endocrine disruptors has gained importance as a potential risk factor. Hexachlorobenzene (HCB) was once used as a fungicide and, despite being banned, considerable amounts are still released into the environment. HCB acts as an endocrine disruptor in thyroid, uterus and mammary gland and was classified as possibly carcinogenic to human. This review provides a thorough analysis of results obtained in the last 15 years of research and evaluates data from assays in mammary gland and breast cancer in diverse animal models. We discuss the effects of environmentally relevant HCB concentrations on the normal mammary gland and different stages of carcinogenesis, and attempt to elucidate its mechanisms of action at molecular level. HCB weakly binds to the aryl hydrocarbon receptor (AhR), activating both membrane (c-Src) and nuclear pathways. Through c-Src stimulation, AhR signaling interacts with other membrane receptors including estrogen receptor-α, insulin-like growth factor-1 receptor, epidermal growth factor receptor and transforming growth factor beta 1 receptors. In this way, several pathways involved in mammary morphogenesis and breast cancer development are modified, inducing tumor progression. HCB thus stimulates epithelial cell proliferation, preneoplastic lesions and alterations in mammary gland development as well as neoplastic cell migration and invasion, metastasis and angiogenesis in breast cancer. In conclusion, our findings support the hypothesis that the presence and bioaccumulation of HCB in high-fat tissues and during highly sensitive time windows such as pregnancy, childhood and adolescence make exposure a risk factor for breast tumor development.
MeSH term(s)	Animals ; Breast Neoplasms ; Child ; Endocrine Disruptors ; Female ; Fungicides, Industrial ; Hexachlorobenzene ; Humans ; Mammary Glands, Animal ; Signal Transduction
Chemical Substances	Endocrine Disruptors ; Fungicides, Industrial ; Hexachlorobenzene (4Z87H0LKUY)
Language	English
Publishing date	2019-03-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2019.03.054
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Article ; Online: Publisher Correction

María E. Rodríguez-Ortiz / Claudia Pontillo / Mariano Rodríguez / Petra Zürbig / Harald Mischak / Alberto Ortiz

Scientific Reports, Vol 8, Iss 1, Pp 1-

Novel Urinary Biomarkers For Improved Prediction Of Progressive eGFR Loss In Early Chronic Kidney Disease Stages And In High Risk Individuals Without Chronic Kidney Disease

2018 Volume 1

Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

Abstract	A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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