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  1. Article ; Online: Li

    Jiao, Jinmiao / Li, Conggang / She, Yuheng / Shi, Haiyan / Di, Wenhao / Ye, Ning / Hu, Zhanggui / Wu, Yicheng

    Inorganic chemistry

    2024  Volume 63, Issue 8, Page(s) 3986–3991

    Abstract: ... to its competitive optical transparency and robust stability. Herein, a novel lithium-rich rare-earth germanate, Li ...

    Abstract Germanate is garnering increasing attention in the field of optoelectronics owing to its competitive optical transparency and robust stability. Herein, a novel lithium-rich rare-earth germanate, Li
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c04635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Li

    Shi, Rui / Ning, Lixin / Huang, Yan / Tao, Ye / Zheng, Lirong / Li, Zhibing / Liang, Hongbin

    ACS applied materials & interfaces

    2019  Volume 11, Issue 10, Page(s) 9691–9695

    Abstract: Investigations on luminescence properties of lanthanide-activated phosphors are not only essential to understanding the fundamental structure-property relationship but also important to advancing the development and application of relevant research ... ...

    Abstract Investigations on luminescence properties of lanthanide-activated phosphors are not only essential to understanding the fundamental structure-property relationship but also important to advancing the development and application of relevant research techniques. We report herein a promising optical thermometric material Eu
    Language English
    Publishing date 2019-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.8b22754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; E-Book: Privileged scaffolds in drug discovery

    Yu, Bin / Li, Ning / Fu, Caiyun

    2023  

    Abstract: Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited experts ... ...

    Author's details edited by Bin Yu, Ning Li, Caiyun Fu
    Abstract Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited experts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable.
    MeSH term(s) Drug Discovery ; Chemistry, Pharmaceutical
    Keywords Drug development ; Pharmaceutical chemistry
    Subject code 615.19
    Language English
    Dates of publication 2023-2023
    Publisher Academic Press
    Publishing place London
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-18612-X ; 978-0-443-18612-7 ; 9780443186110 ; 0443186111
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: Optimization of deacidification for concentrated grape juice

    Li, Ning

    Food Science & Nutrition, 7(6):2050-2058

    2019  

    Abstract: Excessive organic acids in grape juice will not only result in poor taste but will also cause turbidity and sedimentation. Tartaric acid exerts the most significant acidity among all organic acids in grape juice. In this study, we used tartaric acid as ... ...

    Abstract Excessive organic acids in grape juice will not only result in poor taste but will also cause turbidity and sedimentation. Tartaric acid exerts the most significant acidity among all organic acids in grape juice. In this study, we used tartaric acid as the main target and anion‐exchange resin to remove tartaric acid from concentrated grape juice. Factors influencing the removal process were optimized by liquid chromatography with ultraviolet detection and statistical analysis for optimal deacidification of concentrated grape juice. Use of the anion‐exchange resin 335 treat the concentrated grape juice at a ratio of 1:6 (2:11.98) at 15.57°C for 4.35 hr. The tartaric acid removal rate reached 69.01%; the anion‐exchange resin 335 demonstrated the best removal effect.
    Keywords concentrated grape juice ; anion‐exchange resin ; optimized deacidification ; tartaric acid
    Language English
    Document type Article
    Database Repository for Life Sciences

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  5. Article: MicroRNAs from plants to animals, do they define a new messenger for communication?

    LI, Ning

    Nutrition & metabolism, 15:68

    2018  

    Abstract: MicroRNAs (miRNAs), a class of single-stranded non-coding RNA of about 22 nucleotides, are potent regulators of gene expression existing in both plants and animals. Recent studies showed that plant miRNAs could enter mammalian bloodstream via ... ...

    Abstract MicroRNAs (miRNAs), a class of single-stranded non-coding RNA of about 22 nucleotides, are potent regulators of gene expression existing in both plants and animals. Recent studies showed that plant miRNAs could enter mammalian bloodstream via gastrointestinal tract, through which access a variety of tissues and cells of recipients to exert therapeutic effects. This intriguing phenomenon indicates that miRNAs of diet/plant origin may act as a new class of bioactive ingredients communicating with mammalian systems. In this review, in order to pinpoint the reason underlying discrepancies of miRNAs transmission from diet/plant to animals, the pathways that generate miRNAs and machineries involved in the functions of miRNAs in both kingdoms were outlined and compared. Then, the current controversies concerning cross-kingdom regulations and the potential mechanisms responsible for absorption and transfer of diet/plant-derived miRNAs were interpreted. Furthermore, the hormone-like action of miRNAs and the intricate interplay between miRNAs and hormones were implicated. Finally, how these findings may impact nutrition and medicine were briefly discussed.
    Keywords Cross-kingdom communication ; Gene regulation ; Hormones ; Herbal medicines ; Oral delivery ; MicroRNAs (miRNAs) ; Small RNAs (sRNAs)
    Language English
    Document type Article
    Database Repository for Life Sciences

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  6. Book ; Online: Groundwater overexploitation in the North China Plain: A path to sustainability

    Kinzelbach, Wolfgang / Wang, Haijing / Li, Yu / Wang, Lu / Li, Ning

    2022  

    Keywords Hydrology & the hydrosphere ; Sustainability ; Environmental monitoring ; Analytical chemistry ; Agricultural science ; Groundwater management ; Groundwater depletion ; Groundwater modelling ; Monitoring of groundwater levels ; Pumping tests for monitoring of pumping rates of wells ; Subsidized land fallowing ; Groundwater game app ; Smart metering of pumping wells ; Smart metering of electricity consumption ; Surface water diversion ; Decision support system ; Open Access
    Size 1 electronic resource (157 pages)
    Publisher Springer Nature
    Publishing place Bern
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231048
    ISBN 9789811658433 ; 9811658439
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: SLE disease activity stabilizes over time: a hypothesis stimulated by a model reported a few years ago and recently re-tested.

    Li, Ning

    Rheumatology (Oxford, England)

    2023  Volume 62, Issue 7, Page(s) 2338–2340

    MeSH term(s) Humans ; Lupus Erythematosus, Systemic
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead029
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 240: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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  8. Article: Development and validation of a nomogram predictive model for cerebral small vessel disease: a comprehensive retrospective analysis.

    Li, Ning / Li, Ying-Lei / Li, Li-Tao

    Frontiers in neurology

    2024  Volume 14, Page(s) 1340492

    Abstract: Background: Cerebral small vessel disease (CSVD) is a significant contributor to stroke, intracerebral hemorrhages, and vascular dementia, particularly in the elderly. Early diagnosis remains challenging. This study aimed to develop and validate a novel ...

    Abstract Background: Cerebral small vessel disease (CSVD) is a significant contributor to stroke, intracerebral hemorrhages, and vascular dementia, particularly in the elderly. Early diagnosis remains challenging. This study aimed to develop and validate a novel nomogram for the early diagnosis of cerebral small vessel disease (CSVD). We focused on integrating cerebrovascular risk factors and blood biochemical markers to identify individuals at high risk of CSVD, thus enabling early intervention.
    Methods: In a retrospective study conducted at the neurology department of the Affiliated Hospital of Hebei University from January 2020 to June 2022, 587 patients were enrolled. The patients were randomly divided into a training set (70%,
    Results: Out of 88 analyzed biomarkers, 32 showed significant differences between the CSVD and non-CSVD groups. The LASSO regression identified 12 significant indicators, with nine being independent clinical predictors of CSVD. The AUC-ROC values of the nomogram were 0.849 (95% CI: 0.821-0.894) in the training set and 0.863 (95% CI: 0.810-0.917) in the validation set, indicating excellent discriminative ability. Calibration plots demonstrated good agreement between predicted and observed probabilities in both sets. DCA showed that the nomogram had significant clinical utility.
    Conclusions: The study successfully developed a nomogram predictive model for CSVD, incorporating nine clinical predictive factors. This model offers a valuable tool for early identification and risk assessment of CSVD, potentially enhancing clinical decision-making and patient outcomes.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1340492
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  9. Article ; Online: Global research trends of uranium-containing wastewater treatment based on bibliometric review.

    Li, Xianhong / Ning, Xiaolin / Li, Zhonghong

    Journal of environmental management

    2024  Volume 354, Page(s) 120310

    Abstract: The generation of uranium-containing wastewater (UCW) during different stages of uranium mining, processing, and utilization presents a significant ecological and biospheric threat. Consequently, it is crucial for both sustainable development and the ... ...

    Abstract The generation of uranium-containing wastewater (UCW) during different stages of uranium mining, processing, and utilization presents a significant ecological and biospheric threat. Consequently, it is crucial for both sustainable development and the protection of human health to adopt appropriate methods for the treatment of UCW as well as the separation and enrichment of uranium. This study conducted a comprehensive search of the Web of Science Core Collection (WOSCC) database for publications related to UCW treatment between 1990 and 2022 to gain insight into current trends in the field. Subsequently, the annual publications, WOSCC categories, geographical distribution, major collaborations, prolific authors, influential journals, and highly cited publications were the subjects of a biliometric analysis that was subsequently carried out. The study findings indicate a significant rise in the overall number of publications in the research field between 1990 and 2022. China, India, and the USA emerged as the primary contributors in terms of publication count. The Chinese Academy of Sciences, the East China University of Technology, and the University of South China were identified as the key research institutions in this field. Furthermore, a majority of the publications in this field were distributed through prestigious journals with high impact factors, such as the Journal of Radioanalytical and Nuclear Chemistry. The top 3 journals were Radioanalytical and Nuclear Chemistry, Chemical Engineering Journal, and Journal of Hazardous Materials. The keyword co-occurrence and burst analysis revealed that the current research on UCW treatment mainly focuses on adsorption-based treatment methods, environmentally functional materials, uranium recovery, etc. Furthermore, the study of the adsorption efficiency of different adsorbent materials, as well as the strengthening and improvement of adsorbent material selectivity and capacity for the recovery of uranium, represents a research hotspot in the field of UCW treatment in the future. This study conducts a comprehensive overview of the current status and prospects of the UCW treatment, which can provide a valuable reference for gaining insights into the development trajectory of the UCW treatment.
    MeSH term(s) Humans ; Uranium ; Adsorption ; Bibliometrics ; China ; Wastewater ; Water Purification
    Chemical Substances Uranium (4OC371KSTK) ; Wastewater
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120310
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  10. Article ; Online: Addressing subject heterogeneity in time-dependent discrimination for biomarker evaluation.

    Jiang, Xinyang / Li, Wen / Li, Ruosha / Ning, Jing

    Statistics in medicine

    2024  Volume 43, Issue 7, Page(s) 1341–1353

    Abstract: Accurate discrimination has been the central goal in identifying biomarkers for monitoring disease progression and early detection. Acknowledging the fact that discrimination accuracy of biomarkers for a time-to-event outcome often changes over time, ... ...

    Abstract Accurate discrimination has been the central goal in identifying biomarkers for monitoring disease progression and early detection. Acknowledging the fact that discrimination accuracy of biomarkers for a time-to-event outcome often changes over time, local measures such as the time-dependent receiver operating characteristic curve and its area under the curve (AUC) are used to assess time-dependent predictive discrimination. However, such measures do not address subject heterogeneity, although the impact of covariates including demographics, disease-related characteristics, and other clinical information on the discriminatory performance of biomarkers needs to be investigated before their clinical use. We propose the covariate-specific time-dependent AUC, a measure for covariate-adjusted discrimination. We develop a regression model on the covariate-specific time-dependent AUC to understand how and in what magnitude the covariates influence biomarker performance. Then we construct a pseudo partial-likelihood for estimation and inference. This is followed by our establishing the asymptotic properties of the proposed estimators and provide variance estimation. The simulation studies and application to the AIDS Clinical Trials Group 175 data demonstrate that the proposed method offers an informative tool for inferring covariate-specific and time-dependent predictive discrimination.
    MeSH term(s) Humans ; Computer Simulation ; Biomarkers ; ROC Curve ; Probability ; Time Factors ; Area Under Curve
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.10024
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