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  1. Article ; Online: Renal Cell Carcinoma with Testicular Metastases: A Case Report and Review of the Literature.

    Yoshitake, Sho / Shinder, Brian M / Dazen, Kevin / Smith, Colton / Mayer, Tina M / Sadimin, Evita / Singer, Eric A

    Journal of kidney cancer and VHL

    2022  Volume 9, Issue 2, Page(s) 22–26

    Abstract: Renal cell carcinoma (RCC) metastases to the testicle are an extremely rare clinical entity. Here, we describe the case of a man with metastatic RCC who developed a new testicular mass. Pathologic analysis after surgical removal of this testicle ... ...

    Abstract Renal cell carcinoma (RCC) metastases to the testicle are an extremely rare clinical entity. Here, we describe the case of a man with metastatic RCC who developed a new testicular mass. Pathologic analysis after surgical removal of this testicle confirmed the diagnosis of metastatic RCC. This report highlights the unique diagnostic and therapeutic challenges associated with such a disease process.
    Language English
    Publishing date 2022-05-06
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 2803342-5
    ISSN 2203-5826 ; 2203-5826
    ISSN (online) 2203-5826
    ISSN 2203-5826
    DOI 10.15586/jkcvhl.v9i2.212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Renal Cell Carcinoma with Cardiac Metastases: A Case Report and Review of the Literature.

    Cahill, Ellen M / Tabakin, Alexandra / Shinder, Brian / Bramwit, Mark / Saraiya, Biren / Xu, Xinyang / Salazar, Cristo G / Zhou, Zhongren / Singer, Eric A

    Journal of kidney cancer and VHL

    2022  Volume 9, Issue 2, Page(s) 32–38

    Abstract: Cardiac metastases from renal cell carcinoma (RCC) are very rare. We describe the case of a woman with RCC with cardiac metastases involving the entire right atrium, penetrating through the myocardium, with extension into the tricuspid valve and right ... ...

    Abstract Cardiac metastases from renal cell carcinoma (RCC) are very rare. We describe the case of a woman with RCC with cardiac metastases involving the entire right atrium, penetrating through the myocardium, with extension into the tricuspid valve and right ventricle. This report highlights the unique challenge of the diagnosis and treatment of cardiac metastases in RCC.
    Language English
    Publishing date 2022-05-25
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 2803342-5
    ISSN 2203-5826 ; 2203-5826
    ISSN (online) 2203-5826
    ISSN 2203-5826
    DOI 10.15586/jkcvhl.v9i2.229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chromophobe Renal Cell Carcinoma with Sarcomatoid Differentiation.

    Lichtbroun, Benjamin J / Shinder, Brian / Sara, Tina Gowda / Srivastava, Arnav / Saraiya, Biren / Mayer, Tina M / Cristelli, Ryan / Sadimin, Evita / Weiss, Robert E / Singer, Eric A

    Journal of kidney cancer and VHL

    2023  Volume 10, Issue 3, Page(s) 1–8

    Abstract: Chromophobe renal cell carcinoma (chRCC) is one of the less common types of kidney cancer and generally portends a more favorable prognosis. RCC with sarcomatoid differentiation has a more aggressive clinical course with poor outcomes. Four cases of ... ...

    Abstract Chromophobe renal cell carcinoma (chRCC) is one of the less common types of kidney cancer and generally portends a more favorable prognosis. RCC with sarcomatoid differentiation has a more aggressive clinical course with poor outcomes. Four cases of chRCC with varying degrees of sarcomatoid differentiation were retrospectively reviewed at our institution, and clinicopathologic data as well as clinical courses were reported. Patients with higher degrees of sarcomatoid differentiation and larger tumors at presentation generally had and worse overall survival. chRCC with sarcomatoid differentiation portends a poor prognosis with limited data on systemic treatment options for metastatic disease.
    Language English
    Publishing date 2023-07-08
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 2803342-5
    ISSN 2203-5826 ; 2203-5826
    ISSN (online) 2203-5826
    ISSN 2203-5826
    DOI 10.15586/jkcvhl.v10i3.254
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  4. Article ; Online: Factors associated with clinical trial participation for patients with renal cell carcinoma.

    Shinder, Brian M / Kim, Sinae / Srivastava, Arnav / Patel, Hiren V / Jang, Thomas L / Mayer, Tina M / Saraiya, Biren / Ghodoussipour, Saum B / Singer, Eric A

    Urologic oncology

    2023  Volume 41, Issue 4, Page(s) 208.e1–208.e8

    Abstract: Objective: Recruitment of a diverse and representative study population is critical to the external validity of oncology clinical trials. The primary objective of this study was to characterize the factors associated with clinical trial participation ... ...

    Abstract Objective: Recruitment of a diverse and representative study population is critical to the external validity of oncology clinical trials. The primary objective of this study was to characterize the factors associated with clinical trial participation for patients with renal cell carcinoma and the secondary objective was to examine differences in survival outcomes.
    Materials and methods: We used a matched case-control design by querying the National Cancer Database for patients with renal cell carcinoma who were coded as having enrolled in a clinical trial. Trial patients were matched in a 1:5 ratio to the control cohort based on clinical stage and then sociodemographic variables were compared between the 2 groups. Multivariable conditional logistic regression models evaluated factors associated with clinical trial participation. The trial patient cohort was then matched again in a 1:10 ratio based on age, clinical stage, and comorbidities. Log-rank test was used to compare overall survival (OS) between these groups.
    Results: From 2004 to 2014, 681 patients enrolled in clinical trials were identified. Clinical trial patients were significantly younger and had a lower Charlson-Deyo comorbidity score. On multivariate analysis, male patients and white patients were more likely to participate compared to their Black counterparts. Having Medicaid or Medicare negatively associated with trial participation. Median OS was greater among clinical trial participants.
    Conclusion: Patient sociodemographic factors remain significantly associated with clinical trial participation and trial participants experienced superior OS to their matched counterparts.
    MeSH term(s) Aged ; Humans ; Male ; Carcinoma, Renal Cell ; Kidney Neoplasms ; Logistic Models ; Medicaid ; Medicare ; Retrospective Studies ; United States ; Case-Control Studies
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2023.01.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4817: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Metastatic Prostate Cancer to the Renal Pelvis and Proximal Ureter: A Case Report and Review of the Literature.

    Munshi, Faizanahmed / Shinder, Brian M / Sadimin, Evita / Mayer, Tina M / Singer, Eric A

    Cancer studies and therapeutics

    2019  Volume 4, Issue 4

    Abstract: Prostate cancer metastases are commonly seen in the skeleton, lymph nodes, lungs, or liver, and are associated with a poor five-year survival rate. Renal pelvis and ureteral metastasis are exceedingly uncommon and can present with obstructive symptoms or ...

    Abstract Prostate cancer metastases are commonly seen in the skeleton, lymph nodes, lungs, or liver, and are associated with a poor five-year survival rate. Renal pelvis and ureteral metastasis are exceedingly uncommon and can present with obstructive symptoms or as an asymptomatic mass on imaging. We report the case of a 60-year-old patient who was initially diagnosed with prostate adenocarcinoma and experienced eventual metastasis to the right renal pelvis and proximal ureter. Following the diagnosis, he was started on docetaxel and pembrolizumab as part of a clinical trial protocol. A high index of suspicion and thorough metastatic work-up is necessary when patients with prostate cancer present with symptoms of obstructive uropathy or new visceral disease is identified.
    Language English
    Publishing date 2019-08-11
    Publishing country England
    Document type Journal Article
    ISSN 2002-7184
    ISSN (online) 2002-7184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Factors Associated With Palliative Intervention Utilization for Metastatic Renal Cell Carcinoma.

    Patel, Hiren V / Kim, Sinae / Srivastava, Arnav / Shinder, Brian M / Sterling, Joshua / Saraiya, Biren / Mayer, Tina M / Ghodoussipour, Saum / Jang, Thomas L / Singer, Eric A

    Clinical genitourinary cancer

    2022  Volume 20, Issue 3, Page(s) 296–296.e9

    Abstract: Introduction: Several guidelines have adopted early integration of palliative intervention (PI) into oncologic care to improve quality of life among patients with advanced malignancies. However, PI utilization patterns and factors associated with its ... ...

    Abstract Introduction: Several guidelines have adopted early integration of palliative intervention (PI) into oncologic care to improve quality of life among patients with advanced malignancies. However, PI utilization patterns and factors associated with its use in metastatic renal cell carcinoma are poorly understood.
    Patients and methods: Using the National Cancer Database (NCDB), we abstracted patients diagnosed with Stage IV RCC from 2004 to 2014 and evaluated the utilization of PI within this cohort. Socioeconomic and clinical factors were compared for patients receiving and not receiving PI for metastatic RCC. Multivariable logistic regression (MLR) models identified factors that were associated with receipt of PI within overall cohort and treatment-based cohorts.
    Results: We identified 42,014 patients with Stage IV RCC, of which 7,912 patients received PI. From 2004 to 2014, the use of PI minimally increased from 17% to 20% for Stage IV RCC. MLR analysis demonstrated that increased comorbidities, insurance status, higher education status, facility location, care at a comprehensive cancer program or integrated network, sarcomatoid histology, and treatment type significantly increased the likelihood of PI use. Various socioeconomic, clinical, and geographical factors that are associated with use of PI-based on the treatment received for Stage IV RCC.
    Conclusions: While PI utilization has minimally increased for Stage IV RCC, there are several geographic, socioeconomic, and clinical factors that predict its use among patients with Stage IV RCC in a treatment-specific manner. Taken together, this suggests the need for earlier initiation of PI in a more equitable and systematic fashion among patients with metastatic RCC.
    MeSH term(s) Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/therapy ; Cohort Studies ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/therapy ; Neoplasm Staging ; Quality of Life
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2225121-2
    ISSN 1938-0682 ; 1558-7673
    ISSN (online) 1938-0682
    ISSN 1558-7673
    DOI 10.1016/j.clgc.2022.01.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Urologic oncology surgery during COVID-19: a rapid review of current triage guidance documents.

    Shinder, Brian M / Patel, Hiren V / Sterling, Joshua / Tabakin, Alexandra L / Kim, Isaac Y / Jang, Thomas L / Singer, Eric A

    Urologic oncology

    2020  Volume 38, Issue 7, Page(s) 609–614

    Abstract: The Coronavirus Disease 2019 pandemic placed urologic surgeons, and especially urologic oncologists, in an unprecedented situation. Providers and healthcare systems were forced to rapidly create triage schemas in order to preserve resources and reduce ... ...

    Abstract The Coronavirus Disease 2019 pandemic placed urologic surgeons, and especially urologic oncologists, in an unprecedented situation. Providers and healthcare systems were forced to rapidly create triage schemas in order to preserve resources and reduce potential viral transmission while continuing to provide care for patients. We reviewed United States and international triage proposals from professional societies, peer-reviewed publications, and publicly available institutional guidelines to identify common themes and critical differences. To date, there are varying levels of agreement on the optimal triaging of urologic oncology cases. As the need to preserve resources and prevent viral transmission grows, prioritizing only high priority surgical cases is paramount. A similar approach to prioritization will also be needed as nonemergent cases are allowed to proceed in the coming weeks. While these decisions will often be made on a case-by-case basis, more nuanced surgeon-driven consensus guidelines are needed for the near future.
    MeSH term(s) Betacoronavirus/pathogenicity ; COVID-19 ; Clinical Decision-Making ; Consensus ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Humans ; Medical Oncology/standards ; Pandemics/prevention & control ; Patient Selection ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Practice Guidelines as Topic ; SARS-CoV-2 ; Societies, Medical/standards ; Triage/standards ; Urologic Diseases/diagnosis ; Urologic Diseases/surgery ; Urologic Surgical Procedures/standards ; Urology/standards
    Keywords covid19
    Language English
    Publishing date 2020-05-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2020.05.017
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4817: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Primary Renal Ewing Sarcoma: A Case Report and Review of the Literature.

    Findlay, Bridget L / Shinder, Brian M / Fatima, Aisha / Sadimin, Evita / Drachtman, Richard / Parikh, Rahul R / Singer, Eric A

    Journal of renal cancer

    2019  Volume 2, Issue 1, Page(s) 15–19

    Abstract: Primary Ewing sarcoma of the kidney is an extremely rare and aggressive tumor affecting young adults. We present the case of a 22-year-old male with primary Ewing sarcoma/primitive neuroectodermal tumor (EWS/PNET) of the kidney who underwent right ... ...

    Abstract Primary Ewing sarcoma of the kidney is an extremely rare and aggressive tumor affecting young adults. We present the case of a 22-year-old male with primary Ewing sarcoma/primitive neuroectodermal tumor (EWS/PNET) of the kidney who underwent right radical nephrectomy and adjuvant chemo-radiation.
    Language English
    Publishing date 2019-05-04
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The human microbiome and genitourinary malignancies.

    Nicolaro, Michael / Portal, Daniella E / Shinder, Brian / Patel, Hiren V / Singer, Eric A

    Annals of translational medicine

    2020  Volume 8, Issue 19, Page(s) 1245

    Abstract: The human microbiome contains a vast network of understudied organisms that have an intimate role in our health and wellness. These microbiomes differ greatly between individuals, creating what may be thought of as a unique and dynamic microbial ... ...

    Abstract The human microbiome contains a vast network of understudied organisms that have an intimate role in our health and wellness. These microbiomes differ greatly between individuals, creating what may be thought of as a unique and dynamic microbial signature. Microbes have been shown to have various roles in metabolism, local and systemic inflammation, as well as immunity. Recent findings have confirmed the importance of both the gut and urinary microbiomes in genitourinary malignancies. Numerous studies have identified differences in microbial signatures between healthy patients and those with urologic malignancies. The microbiomes have been shown to contain microbes that may contribute to the etiology of disease state as well as yield information in regard to a person's health and their responsiveness to certain drugs such as immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs). Less well understood are the effects of antibiotics on oncologic outcomes in such treatment courses. This review will explore our current understanding and advancements in the field of microbiome research and discuss its intimate association with genitourinary diseases including bladder cancer, prostate cancer, and kidney cancer. With a better understanding of the association between the microbiome and genitourinary malignancy, further investigation may produce reliable predictors of disease, prognostic indicators as well as therapeutic targets.
    Language English
    Publishing date 2020-11-10
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-20-2976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Role of the androgen signaling axis in genitourinary malignancies.

    Shinder, Brian M / Shupe, Adam / Lee, Geun Taek / Stein, Mark N / Kim, Isaac Y / Singer, Eric A

    Translational cancer research

    2019  Volume 7, Issue 4, Page(s) 1135–1142

    Abstract: As we learn more about the molecular biology of genitourinary malignancies, novel therapeutic strategies can be developed. This is especially crucial for prostate, renal, and bladder cancer, where mortality rates remain high especially in advanced ... ...

    Abstract As we learn more about the molecular biology of genitourinary malignancies, novel therapeutic strategies can be developed. This is especially crucial for prostate, renal, and bladder cancer, where mortality rates remain high especially in advanced disease states. The androgen signaling axis and the androgen receptor (AR) are areas that are actively being explored for their role in these diseases. Although long been associated with prostate cancer development and progression, the role of AR in renal cell carcinoma (RCC) and bladder cancer is becoming recognized as well. This review will highlight the current research into the role of the androgen signaling axis in genitourinary malignancies and how this pathway is being used to expand our therapeutic armamentarium.
    Language English
    Publishing date 2019-01-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2018.03.41
    Database MEDical Literature Analysis and Retrieval System OnLINE

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