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Article ; Online: Robot-Assisted Treatment of Symptomatic Lymphocele Postradical Prostatectomy and Lymphadenectomy in the Era or Robotic Surgery:

Di Gianfrancesco, Luca / Alessandro, Crestani / Paolo, Corsi / Davide, De Marchi / Eugenio, Miglioranza / Angelo, Porreca

Technology in cancer research & treatment

2023 Volume 22, Page(s) 15330338221145248

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Male ; Humans ; Robotic Surgical Procedures/adverse effects ; Robotics ; Prostatic Neoplasms/surgery ; Prostatic Neoplasms/complications ; Pelvis/surgery ; Lymph Node Excision/adverse effects ; Lymphocele/etiology ; Lymphocele/surgery ; Prostatectomy/adverse effects
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2146365-7
ISSN	1533-0338 ; 1533-0346
ISSN (online)	1533-0338
ISSN	1533-0346
DOI	10.1177/15330338221145248
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Article: MRI and Active Surveillance for Prostate Cancer.

Porreca, Angelo / Colicchia, Michele / Busetto, Gian Maria / Ferro, Matteo

Diagnostics (Basel, Switzerland)

2020 Volume 10, Issue 8

Abstract: Since the introduction of Prostate-Specific Antigen (PSA) screening, prostate cancer mortality has decreased [ ... ]. ...

Abstract	Since the introduction of Prostate-Specific Antigen (PSA) screening, prostate cancer mortality has decreased [...].
Language	English
Publishing date	2020-08-14
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics10080590
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Article: Paratesticular fibrous pseudotumor with histological features of IgG4-related disease: two case reports and review of the literature.

Crestani, Alessandro / Vassallo, Loretta / Amodeo, Antonio / Diminutto, Alberto / Miglioranza, Eugenio / Di Gianfrancesco, Luca / Corsi, Paolo / Porreca, Angelo / Scapinello, Antonio

Gland surgery

2023 Volume 12, Issue 3, Page(s) 426–431

Abstract: Background: Paratesticular fibrous pseudotumor (PFP) is a rare intrascrotal benign fibrous mass of uncertain aetiology, usually arising between testicular tunica layers and is supposed to be related to inflammatory reactive conditions. Because of ... ...

Abstract	Background: Paratesticular fibrous pseudotumor (PFP) is a rare intrascrotal benign fibrous mass of uncertain aetiology, usually arising between testicular tunica layers and is supposed to be related to inflammatory reactive conditions. Because of morphological similarities to IgG4-related sclerosing fibro-inflammatory lesions, some authors recently postulated that PFP might belong to the IgG4-related disease (IgG4-RD) family. Considering the rarity of this lesion, only few cases have been reported in literature about the correlation between IgG4-RD and PFP. Management of PFP could be extremely challenging: due to the lack of typical clinical signs and the non-specific radiological characteristics, misapprehension does occur in the majority of cases, mainly because these intrascrotal mass may mimic testicular neoplasm, therefore leading to radical orchidectomy rather than a desirable testis-sparing surgery. Case description: Herein we report two cases of young males treated for PFP with histological feature of IgG4-RD. Patients underwent testicular sparing surgery. At 2-year follow-up no evidence of local or distant relapse nor testicular disorder was observed in both patients. An up-to-date review of the literature about the correlation between PFP and the IgG4-RD was carried out. Conclusions: PFP is an extremely rare condition with uncertain etiology being part of IgG4-RD family. Preoperative imaging mimics malignancy hence diagnosis is usually made by specimen analysis. Intraoperative frozen section is fundamental in order to guarantee conservative treatment that is feasible and safe after mid-term follow-up.
Language	English
Publishing date	2023-03-03
Publishing country	China (Republic : 1949- )
Document type	Case Reports
ZDB-ID	3016969-0
ISSN	2227-8575 ; 2227-684X
ISSN (online)	2227-8575
ISSN	2227-684X
DOI	10.21037/gs-22-290
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Article ; Online: A matched-analysis on short-term and long-term (up to 5 years of follow-up) urinary incontinence outcomes after robot-assisted radical prostatectomy with and without anterior and posterior reconstruction: data on 1358 patients.

Rinaldi, Marco / Porreca, Angelo / Di Lena, Sebastiano / Di Gianfrancesco, Luca / Zazzara, Michele / Scarcia, Marcello / Ludovico, Giuseppe Mario

International urology and nephrology

2023 Volume 56, Issue 1, Page(s) 121–127

Abstract: Purpose: We report a comparative monocentric study with a short and long-term follow-up with the aim to assess differences about urinary continence outcomes in patients treated with Robot-Assisted Radical Prostatectomy (RARP) with two different ... ...

Abstract	Purpose: We report a comparative monocentric study with a short and long-term follow-up with the aim to assess differences about urinary continence outcomes in patients treated with Robot-Assisted Radical Prostatectomy (RARP) with two different techniques: with anterior and posterior reconstruction and without any kind of reconstruction. Materials and methods: From January 2016 to September 2021, at the Department of Urology of the "F. Miulli" Hospital of Acquaviva delle Fonti, in Italy, 850 eligible patients underwent extraperitoneal RARP with anterior and posterior reconstruction and 508 without reconstructions. Results: In patients undergoing RARP with reconstructions 1 month after surgery the urinary continence was preserved in 287/850 patients (33.8%), 3 months after surgery in 688/850 (81%), 6 months in 721/850 (84.8%), 12 months in 734/850 (86.3%), 18 months in 671/754 (89%), 24 months in 696/754 (92.3%), 36 months in 596/662 (90%), 48 months in 394/421 (93.6%), 60 months in 207/212 (97.6%). In patients undergoing RARP without reconstruction 1 month after surgery urinary continence was preserved in 99/508 (19.4%), after 3 months in 276/508 (54.3%), 6 months in 305/508 (60%), 12 months in 329/508 (64.7%), 18 months in 300/456 (65.7%), 24 months in 295/456 (64.7%), 36 months in 268/371 (72.3%), 48 months in 181/224 (81%), 60 months in 93/103 (90.3%). Conclusion: In our case study, the RARP with anterior and posterior reconstruction technique is associated with a statistically significant higher rate (up to 48 months of follow-up) and a faster recovery of urinary continence compared to the technique without reconstructions.
MeSH term(s)	Male ; Humans ; Robotics ; Follow-Up Studies ; Urinary Incontinence/etiology ; Urinary Incontinence/therapy ; Robotic Surgical Procedures/adverse effects ; Robotic Surgical Procedures/methods ; Prostatectomy/adverse effects ; Prostatectomy/methods ; Treatment Outcome
Language	English
Publishing date	2023-08-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-023-03766-z
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Article ; Online: Letter to the Editor: "Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection".

Di Maida, Fabrizio / Antonelli, Alessandro / Porreca, Angelo / Rocco, Bernardo / Mari, Andrea / Minervini, Andrea

EClinicalMedicine

2020 Volume 22, Page(s) 100362

Keywords	covid19
Language	English
Publishing date	2020-04-27
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2020.100362
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Article ; Online: The thin line that made the difference

Ali Forookhi / Marco Bicchetti / Sara Lucciola / Angelo Porreca / Gian Maria Busetto / Maurizio Del Monte

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 53, Iss 1, Pp 1-

a case report on a Bosniak IIF renal cystic mass treated with cyst decortication

2022 Volume 4

Abstract: Abstract Background Among all benign kidney lesions, renal cysts are the most common type. In the proposed update of 2019, the Bosniak classification of cystic renal masses is used to classify renal masses according to their likelihood of malignancy, ... ...

Abstract	Abstract Background Among all benign kidney lesions, renal cysts are the most common type. In the proposed update of 2019, the Bosniak classification of cystic renal masses is used to classify renal masses according to their likelihood of malignancy, both on computed tomography (CT) and on magnetic resonance imaging (MRI). Case presentation A middle-aged Caucasian male presented to our department with chronic right flank pain. Imaging studies revealed a right renal Bosniak IIF cyst, later complicated by traumatic haemorrhage. The patient consequently underwent cyst decortication for symptom relief. Biopsy results from samples taken during the laparoscopic operation revealed ISUP grade 1 cystic clear cell carcinoma. Conclusion The treatment of Bosniak IIF cysts has long been a matter of debate. As a result of scarcity of data on the probability of malignancy in MRI using the new classification, such cysts should be carefully scrutinised and staged before choosing a treatment option. Retroperitoneal seeding should always be considered in interventions involving an incomplete resection margin or cyst drainage.
Keywords	Renal cyst ; Bosniak classification ; Computed tomography ; Magnetic resonance imaging ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	616
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Antioxidant treatment for oligoasthenoteratozoospermia and varicocele: a DBPC trial to evaluate the impact of age and body mass index.

Busetto, Gian Maria / Rodrigues, Bernarde F / Virmani, Ashraf / Checchia, Andrea / Ninivaggi, Antonella / Ricapito, Anna / Barbieri, Giovanni / Fischetti, Piero / Falagario, Ugo G / Annese, Pasquale / d'Altilia, Nicola / Mancini, Vito / Ferro, Matteo / Crocetto, Felice / Porreca, Angelo / Bettocchi, Carlo / Cormio, Luigi / Agarwal, Ashok / Carrieri, Giuseppe

Asian journal of andrology

2024

Abstract: Abstract: Oxidative stress is one of the main mechanisms responsible for male infertility. Various conditions such as varicocele, obesity, advanced age, and lifestyle can lead to an increase in reactive oxygen species, causing an oxidative imbalance in ... ...

Abstract	Abstract: Oxidative stress is one of the main mechanisms responsible for male infertility. Various conditions such as varicocele, obesity, advanced age, and lifestyle can lead to an increase in reactive oxygen species, causing an oxidative imbalance in the reproductive environment. Spermatozoa are sensitive to reactive oxygen species and require energy to carry out their main function of fertilizing the egg. Excessive reactive oxygen species can affect sperm metabolism, leading to immobility, impaired acrosome reaction, and cell death, thereby impairing reproductive success. This double-blind randomized study evaluated the effect of supplementation with L-carnitine, acetyl-L-carnitine, vitamins, and other nutrients on semen quality in 104 infertile patients with or without varicocele, while also investigating the impact of factors such as obesity and advanced age on treatment. Sperm concentration significantly increased in the supplemented group compared to the placebo group (P = 0.0186). Total sperm count also significantly increased in the supplemented group (P = 0.0117), as did sperm motility (P = 0.0120). The treatment had a positive effect on patients up to 35 years of age in terms of sperm concentration (P = 0.0352), while a body mass index (BMI) above 25 kg m-2 had a negative effect on sperm concentration (P = 0.0110). Results were not showing a net benefit in stratifying patients in accordance with their BMI since sperm quality increase was not affected by this parameter. In conclusion, antioxidant supplementation may be beneficial for infertile patients and has a more positive effect on younger patients with a normal weight.
Language	English
Publishing date	2024-02-02
Publishing country	China
Document type	Journal Article
ZDB-ID	2075824-8
ISSN	1745-7262 ; 1008-682X
ISSN (online)	1745-7262
ISSN	1008-682X
DOI	10.4103/aja202381
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Article ; Online: MRI and Active Surveillance for Prostate Cancer

Angelo Porreca / Michele Colicchia / Gian Maria Busetto / Matteo Ferro

Diagnostics, Vol 10, Iss 590, p

2020 Volume 590

Abstract: Since the introduction of Prostate-Specific Antigen (PSA) screening, prostate cancer mortality has decreased [.] ...

Abstract	Since the introduction of Prostate-Specific Antigen (PSA) screening, prostate cancer mortality has decreased [.]
Keywords	active surveillance ; ·prostate cancer ; MRI ; imaging ; Medicine (General) ; R5-920
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Effectiveness of a novel oral combination of D-Mannose, pomegranate extract, prebiotics and probiotics in the treatment of acute cystitis in women.

Pugliese, Dario / Acampora, Anna / Porreca, Angelo / Schips, Luigi / Cindolo, Luca

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2020 Volume 92, Issue 1, Page(s) 34–38

Abstract: Objective: Urinary tract infections (UTIs) are defined as the symptomatic presence of pathogens in the urinary tract that are typically diagnosed by microscopy and culture of urine samples. Over the long-term antibiotic courses, alternative prophylactic ...

Abstract	Objective: Urinary tract infections (UTIs) are defined as the symptomatic presence of pathogens in the urinary tract that are typically diagnosed by microscopy and culture of urine samples. Over the long-term antibiotic courses, alternative prophylactic methods as probiotics, cranberry juices and D-mannose have been introduced for recurrence prevention. The present study aimed to determine whether a new combination of D-Mannose, Pomegranate extract, Prebiotics and Probiotics is effective in modifying symptoms reported by women with acute uncomplicated acute cystitis. Material and methods: This is a pilot study, performed between September 2018 and November 2018 at the Department of Urology of Villa Stuart Private Hospital. A dose of a new combination of agents was administered twice daily for 5 days and then once a day for 10 days. Together with the compound, forced hydration (> 2 liters/day) has been strongly suggested. Antibiotics were permitted only in case of clinical worsening. Changes in patients' symptoms, the therapeutic effects and changes in quality of life (QoL) were evaluated clinically and through a validated questionnaire, the Acute Cystitis Symptom Score (ACSS) at the first visit (T0), 15 (T1) and 30 (T2) days later. Results: Thirty-three patients were enrolled in the study (mean age 38,1 ± 11.2 years) and all completed the treatment protocol. At T1 visit, all symptoms or the majority of symptoms went off in 10 women (30.3%) and at T2 in 30 women (90.9%); some symptoms still remained in 16 women (48.5%) at T1 and in 3 women (9.1%) at T2; the persistence of all symptoms or the worsening of the condition was observed in 7 patients (21.2%) at T1 and in none at T2. The mean score reported at all the ACSS sub-scales significantly decreased between baseline and T1 and T2. Typical symptoms decreased from 11.5 (10.5-12.6) to 4.9 (4.0-5.9) and to 2.7 (2.1-3.3) (p-values < 0.0001); differential symptoms decreased from 3.1 (2.6-3.6) to 0.6 (0.3-0.9) and to 0.3 (0.1-0.5) (p-values 0.009 to < 0.0001); QoL mean score also decrease from 7.2 (6.7- 7.7) to 4.0 (3.3-4.6) and to 1.7 (1.2-2.1) (p-values < 0.0001). Six patients required antibiotics and no adverse events were recorded. Conclusions: Our study suggests that the action of the compounds, administered in this new combination, could help in an effective management of symptoms of acute cystitis in women, without antibiotics, in a wide majority of the cases. Lack of microbiological assessment is a clear limitation of the study. Moreover, lack of a control group is another important limitation. Finally, hyperhydration could have been a confounding factor in interpretation of results.
MeSH term(s)	Acute Disease ; Adult ; Body Mass Index ; Combined Modality Therapy/methods ; Cystitis/therapy ; Drinking ; Drug Combinations ; Female ; Humans ; Mannose/administration & dosage ; Menopause ; Pilot Projects ; Plant Extracts/administration & dosage ; Pomegranate/chemistry ; Prebiotics/administration & dosage ; Probiotics/administration & dosage ; Quality of Life ; Time Factors ; Treatment Outcome ; Urinary Tract Infections/therapy
Chemical Substances	Drug Combinations ; Plant Extracts ; Prebiotics ; Mannose (PHA4727WTP)
Language	English
Publishing date	2020-04-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1120-8538 ; 1124-3562
ISSN (online)	2282-4197
ISSN	1120-8538 ; 1124-3562
DOI	10.4081/aiua.2020.1.34
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Article ; Online: Features of patients referring to the outpatient office due to benign prostatic hyperplasia: analysis of a national prospective cohort of 5815 cases.

Ornaghi, Paola Irene / Porreca, Angelo / Sandri, Marco / Sciarra, Alessandro / Falsaperla, Mario / Ludovico, Giuseppe Mario / Cerruto, Maria Angela / Antonelli, Alessandro

Prostate cancer and prostatic diseases

2022 Volume 26, Issue 4, Page(s) 730–735

Abstract: Background: Evidence on clinical presentation of benign prostatic hyperplasia (BPH) is scarce, and studies involving outpatients are lacking. We aimed to provide an insight into the contemporary Italian scenario of BPH-affected outpatients using symptom ...

Abstract	Background: Evidence on clinical presentation of benign prostatic hyperplasia (BPH) is scarce, and studies involving outpatients are lacking. We aimed to provide an insight into the contemporary Italian scenario of BPH-affected outpatients using symptom scores (International Prostate Symptom Score [IPSS], BPH Impact Index [BII]), and to compare characteristics of patients with known BPH and those first-diagnosed at the visit. Methods: "IMPROVING THE PATH" project working group designed a questionary prospectively administered to BPH-affected outpatients by urologists. A cross-sectional study was performed. Data were adjusted for patient age as a potential confounding factor. Results: Of 5815 patients enrolled, BPH was already diagnosed in 4144 (71.3%), and not in 1671 (28.7%). Patients with known BPH, compared to newly diagnosed, were older (median 68 versus [vs] 55), had more frequent smoking (smoker 27.2 vs 22.6%, and ex-smoker 16.4 vs 12.5%) and drinking habits (55.4 vs 45.1%), were more frequently affected by hypertension (60.0 vs 42.4%), obesity (15.3 vs 9.6%), diabetes (17.9 vs 12.5%), and cardiovascular diseases (14.2 vs 9.5%), p < 0.001. At IPSS, moderate and severe symptoms correlated with already known BPH (56.1 vs 47.3% and 24.8 vs 7.8%), whereas newly diagnosed patients showed milder symptoms (44.9 vs 19.1%), all p < 0.001. At BII, concern for one's health and time lost due to urinary problems were higher in patients with known BPH (p < 0.001). For these patients, the urologist changes at least one of the ongoing medications in 63.5%. For patients newly diagnosed, supplements/phytotherapeutics, alpha-blockers, and 5-alfa reductase inhibitors were prescribed in 54.6%, 21.6%, and 7.1%, respectively. Conclusions: Despite medical treatment, natural history of BPH leads to a progressive deterioration of symptoms. This may reflect the difference between newly diagnosed patients and those with known BPH in lifestyle and associated comorbidities. A healthy lifestyle and treatments including local anti-inflammatory agents may delay worsening of symptoms and improve quality of life.
MeSH term(s)	Male ; Humans ; Prostatic Hyperplasia/complications ; Prostatic Hyperplasia/diagnosis ; Prostatic Hyperplasia/epidemiology ; Quality of Life ; Outpatients ; Prospective Studies ; Cross-Sectional Studies ; Prostatic Neoplasms
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1419277-9
ISSN	1476-5608 ; 1365-7852
ISSN (online)	1476-5608
ISSN	1365-7852
DOI	10.1038/s41391-022-00575-w
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