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  1. Article ; Online: Jan Tack awardee of the 2023 UEG Lifetime Achievement Award.

    Simrén, Magnus

    United European gastroenterology journal

    2023  Volume 11, Issue 7, Page(s) 708–709

    MeSH term(s) Humans ; Irritable Bowel Syndrome ; Constipation
    Language English
    Publishing date 2023-08-13
    Publishing country England
    Document type News
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12451
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  2. Article ; Online: Targeting the gut microenvironment in IBS to improve symptoms.

    Simrén, Magnus

    Nature reviews. Gastroenterology & hepatology

    2023  Volume 20, Issue 2, Page(s) 69–70

    MeSH term(s) Humans ; Irritable Bowel Syndrome ; Anti-Bacterial Agents/therapeutic use ; Gastrointestinal Microbiome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-022-00718-3
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    Zs.A 6020: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 97: Show issues

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  3. Article ; Online: Manipulating the Gut Microbiome as a Treatment Strategy for Functional Gastrointestinal Disorders.

    Simrén, Magnus

    Gastroenterology

    2018  Volume 155, Issue 4, Page(s) 960–962

    MeSH term(s) Gastrointestinal Diseases ; Gastrointestinal Microbiome ; Gastrointestinal Tract ; Humans
    Language English
    Publishing date 2018-09-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2018.09.008
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    Zs.MO 572: Show issues

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  4. Article ; Online: Comments on the use of confocal laser endomicroscopy in diagnosing protein-losing enteropathy.

    Balsiger, Lukas Michaja / Tack, Jan / Simrén, Magnus / van Gils, Tom

    Endoscopy

    2024  Volume 56, Issue 2, Page(s) 158

    MeSH term(s) Humans ; Protein-Losing Enteropathies/diagnosis ; Protein-Losing Enteropathies/etiology ; Endoscopy ; Contrast Media ; Lasers ; Microscopy, Confocal
    Chemical Substances Contrast Media
    Language English
    Publishing date 2024-01-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2205-3037
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    Zs.A 669: Show issues Location:
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    Zs.MO 162: Show issues

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  5. Article ; Online: Natural history of symptoms and prognostic information of the rapid drink challenge and solid bolus swallows in esophagogastric junction outflow obstruction defined by manometry.

    Josefsson, Axel / Simrén, Magnus / Smolak, Adam / Sabbagh, Nour / Törnblom, Hans

    Neurogastroenterology and motility

    2023  Volume 36, Issue 2, Page(s) e14720

    Abstract: Background/introduction: Esophagogastric junction outflow obstruction (EGJOO) is a condition characterized by poor relaxation of the lower esophageal sphincter (LES), which can manifest as dysphagia and chest pain. The best treatment of EGJOO is unknown ...

    Abstract Background/introduction: Esophagogastric junction outflow obstruction (EGJOO) is a condition characterized by poor relaxation of the lower esophageal sphincter (LES), which can manifest as dysphagia and chest pain. The best treatment of EGJOO is unknown as some patients improve without any specific therapy, whereas some patients undergo invasive therapy. Currently, prognostic factors are lacking. We aimed to assess the long-term prognosis and predictors of dysphagia and chest pain by the rapid drink challenge and solid bolus swallows in EGJOO.
    Methods: We retrospectively assessed high-resolution esophageal manometries (HRM) performed at our center between 2015 and 2018. The patients completed a dysphagia and chest pain questionnaire a median of 34 months after the HRM/baseline assessment, including the Impaction dysphagia questionnaire-10 (IDQ-10) complemented with questions regarding chest pain and esophageal treatments. Symptoms were compared with HRM findings.
    Results: In all, 980 HRMs were analyzed and 66 (6.5%) were identified as having HRM findings compatible with EGJOO. Of these, 27 patients with EGJOO (41%) completed the follow-up questionnaires and had no exclusion criteria, and 70% of these patients had dysphagia and 44% chest pain at least once a week. Dysphagia at follow-up was more common in patients with elevated integrated relaxation pressure (IRP) on all three HRM metrics (water swallows, solid bolus swallows, and rapid drink challenge) (p = 0.03, odds ratio: 8.4 (95% CI: 1.2-56.0)), but this was not seen for chest pain (p = 0.45). Abnormal motility patterns on rapid drink challenge or solid bolus swallows were not associated with dysphagia or chest pain at follow-up.
    Conclusions: Having a high IRP on three HRM metrics-water swallows, solid bolus swallows, and rapid drink challenge-is associated with a worse prognosis in patients with EGJOO and could potentially be used to select candidates suitable for invasive procedures.
    MeSH term(s) Humans ; Deglutition Disorders/diagnosis ; Retrospective Studies ; Esophagogastric Junction ; Prognosis ; Esophageal Motility Disorders/diagnosis ; Manometry/methods ; Esophageal Sphincter, Lower ; Stomach Diseases/complications ; Chest Pain/complications ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1186328-6
    ISSN 1365-2982 ; 1350-1925
    ISSN (online) 1365-2982
    ISSN 1350-1925
    DOI 10.1111/nmo.14720
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2979: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Health-related quality of life in patients with long-standing ulcerative colitis in remission.

    Mavroudis, Georgios / Simrén, Magnus / Öhman, Lena / Strid, Hans

    Therapeutic advances in gastroenterology

    2022  Volume 15, Page(s) 17562848211062406

    Abstract: Introduction: Ulcerative colitis (UC) contributes to impaired health-related quality of life (HRQoL). Although disease activity is the most important factor, reduced HRQoL has been reported even in quiescent UC. We aimed to determine HRQoL, and identify ...

    Abstract Introduction: Ulcerative colitis (UC) contributes to impaired health-related quality of life (HRQoL). Although disease activity is the most important factor, reduced HRQoL has been reported even in quiescent UC. We aimed to determine HRQoL, and identify predictors thereof, in patients with long-standing UC in remission.
    Methods: In total, 66 patients with inactive UC were included 10 years after the disease onset. Clinical assessment including rigid sigmoidoscopy was performed to ensure remission. Data on demographic, clinical, treatment-related, and psychological determinants of HRQoL were obtained with a structured interview and self-assessment questionnaires measuring gastrointestinal (GI) and psychological symptoms and fatigue. HRQoL was measured with the Short Form Health Survey (SF-36).
    Results: The SF-36 domains were comparable to the general Swedish population, except for Vitality, where UC patients scored lower. Gender, smoking, comorbidity, or disease phenotype had no impact on HRQoL. In contrast, corticosteroid use and sick leave during the previous year were independently associated with Physical Functioning and Bodily Pain domains of SF-36; persisting GI symptoms during remission with Bodily Pain; and fatigue with Role Physical, General Health and Vitality. For all other SF-36 domains reflecting mental HRQoL (Social Function, Role Emotional, Mental Health), only psychological distress contributed uniquely.
    Conclusions: Although overall HRQoL in long-standing UC in remission is comparable to the general population, previous disease activity as well as persisting GI symptoms, fatigue, and psychological distress are associated with a lower HRQoL among these patients. Improved HRQoL may allow for better UC patient health and reduced costs for health care.
    Language English
    Publishing date 2022-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/17562848211062406
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  7. Article: Type of Rectal Barostat Protocol Affects Classification of Hypersensitivity and Prediction of Symptom Severity in Irritable Bowel Syndrome.

    Josefsson, Axel / Törnblom, Hans / Simrén, Magnus

    Journal of neurogastroenterology and motility

    2022  Volume 28, Issue 4, Page(s) 630–641

    Abstract: Background/aims: Visceral hypersensitivity is an important pathophysiologic mechanism in irritable bowel syndrome (IBS). We compared 2 barostat distension protocols and their ability to distinguish between IBS patients and healthy controls, identify ... ...

    Abstract Background/aims: Visceral hypersensitivity is an important pathophysiologic mechanism in irritable bowel syndrome (IBS). We compared 2 barostat distension protocols and their ability to distinguish between IBS patients and healthy controls, identify subjects with rectal hypersensitivity, and their associations with gastrointestinal symptom severity.
    Methods: We retrospectively reviewed all patients at our unit that had undergone barostat investigations 2002-2014. Protocol 1 (n = 369) used phasic isobaric distensions with stepwise increments in pressure and protocol 2 (n = 153) used pressure controlled ramp inflations. Both protocols terminated when subjects reported pain or maximum pressure was reached. Thresholds for first sensation, urgency, discomfort and pain were established. Age- and gender-matched controls were used for comparison. The gastrointestinal symptom rating scale-IBS, and the hospital anxiety and depression scale were used for symptom reports.
    Results: A significantly higher proportion of patients was classified as having hypersensitivity in protocol 1 vs protocol 2 for all thresholds (
    Conclusion: Our study indicates that a rectal barostat protocol using phasic isobaric distensions with stepwise pressure increments is more sensitive in IBS patients with respect to identifying subjects with rectal hypersensitivity and a link with IBS symptoms.
    Language English
    Publishing date 2022-10-17
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2573719-3
    ISSN 2093-0887 ; 2093-0879
    ISSN (online) 2093-0887
    ISSN 2093-0879
    DOI 10.5056/jnm21214
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  8. Article ; Online: Maintaining work life under threat of symptoms: a grounded theory study of work life experiences in persons with Irritable Bowel Syndrome.

    Frändemark, Åsa / Törnblom, Hans / Simrén, Magnus / Jakobsson, Sofie

    BMC gastroenterology

    2022  Volume 22, Issue 1, Page(s) 73

    Abstract: Background: Irritable Bowel Syndrome (IBS) is a highly prevalent functional gastrointestinal disorder. Earlier studies have shown that IBS can limit the ability to perform at work and lead to absenteeism. However, few studies focus on work life ... ...

    Abstract Background: Irritable Bowel Syndrome (IBS) is a highly prevalent functional gastrointestinal disorder. Earlier studies have shown that IBS can limit the ability to perform at work and lead to absenteeism. However, few studies focus on work life experiences based on patients' narratives. The purpose of this study was to construct a theory for how persons with IBS maintain their work life.
    Methods: A qualitative study was performed using constructivist grounded theory. Semi-structured interviews with 15 women and 8 men with IBS (26-64 years of age) were conducted. Fourteen participants worked full-time, six worked part-time and three were on sick leave. The interviews were transcribed verbatim and coded line-by-line, incident-by-incident and thereafter focused coding was done. From the data and codes, categories were generated. Finally, a core category was constructed explaining the process of maintaining work life when living with IBS.
    Results: Balancing work life while being under threat of symptoms constituted of four categories, being prepared, restricting impact, reconciling and adjusting. Persons with IBS restricted the impact of IBS on work by using strategies and upholding daily routines and strived to being prepared by exerting control over work life. These ongoing processes served to limit the influence of IBS on work by symptoms being less intense, perceived as less frequent, or not as bothersome. Reconciling IBS with work life was understood as a successful outcome from being prepared and restricting impact but was also influenced by the individual's outlook on life. Adjusting to other people at work interfered with the strategies of being prepared, restricting impact, and reconciling, leaving persons with IBS more susceptible to symptoms.
    Conclusions: This study deepens the understanding of the work situation for persons with IBS. Health care professionals can use the results of this study in the dialogue with the patient discussing work ability and sick leave. The results imply that although balancing work life under threat of symptoms can be a struggle, there are strategies that persons with IBS and employers together can initiate and use to reduce impact on work on several different levels.
    MeSH term(s) Female ; Grounded Theory ; Humans ; Irritable Bowel Syndrome ; Life Change Events ; Male ; Qualitative Research ; Quality of Life
    Language English
    Publishing date 2022-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-022-02158-4
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  9. Article ; Online: Treatments targeting the luminal gut microbiota in patients with irritable bowel syndrome.

    Algera, Joost P / Törnblom, Hans / Simrén, Magnus

    Current opinion in pharmacology

    2022  Volume 66, Page(s) 102284

    Abstract: Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction affecting 4% of the world's population. Patients with IBS experience chronic or recurrent abdominal pain in combination with altered bowel habits (diarrhea and/or constipation), ...

    Abstract Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction affecting 4% of the world's population. Patients with IBS experience chronic or recurrent abdominal pain in combination with altered bowel habits (diarrhea and/or constipation), and have reduced quality of life. Despite the high prevalence and substantial burden of IBS, its pathophysiology is incompletely understood and remains to be elucidated. The importance of the gut microenvironment has been highlighted in IBS, as there are signs that the gut microbiota of patients differs from healthy controls. Recent studies have aimed to alter the gut microbiota and thereby, attempted to alleviate gastrointestinal symptoms in IBS patients. We highlighted recent advances in common treatments that are targeting the luminal gut microbiota in IBS.
    MeSH term(s) Constipation ; Diarrhea ; Gastrointestinal Diseases ; Gastrointestinal Microbiome/physiology ; Humans ; Irritable Bowel Syndrome/drug therapy ; Quality of Life
    Language English
    Publishing date 2022-09-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2022.102284
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  10. Article: UEG Week in Vienna 2016-advancing science, linking people.

    Simrén, Magnus

    United European gastroenterology journal

    2015  Volume 3, Issue 5, Page(s) 484

    Language English
    Publishing date 2015-10
    Publishing country England
    Document type Journal Article
    ISSN 2050-6406
    ISSN 2050-6406
    DOI 10.1177/2050640615607264
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