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  1. Article ; Online: The Increasing Incidence of Early-Onset Colorectal Cancer.

    Woloshin, Steven / Kramer, Barnett S

    The New England journal of medicine

    2022  Volume 387, Issue 1, Page(s) 91–93

    MeSH term(s) Colorectal Neoplasms/epidemiology ; Humans ; Incidence ; SEER Program
    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2206652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
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  2. Book: Cancer screening

    Kramer, Barnett S.

    theory and practice

    (Basic and clinical oncology ; 18)

    1999  

    Author's details ed. by Barnett S. Kramer
    Series title Basic and clinical oncology ; 18
    Collection
    Keywords Krebsvorsorgeuntersuchung
    Subject Krebs ; Krebsfrüherkennung
    Language English
    Size XIV, 630 S. : Ill., graph. Darst.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT010740312
    ISBN 0-8247-0200-X ; 978-0-8247-0200-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1999 A 4375 order for loan Magazin

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  3. Article: Simple Methods for Evaluating 4 Types of Biomarkers: Surrogate Endpoint, Prognostic, Predictive, and Cancer Screening.

    Baker, Stuart G / Kramer, Barnett S

    Biomarker insights

    2020  Volume 15, Page(s) 1177271920946715

    Abstract: We review simple methods for evaluating 4 types of biomarkers. First, we discuss the evaluation of surrogate endpoint biomarkers (to shorten a randomized trial) using 2 statistical and 3 biological criteria. Second, we discuss the evaluation of ... ...

    Abstract We review simple methods for evaluating 4 types of biomarkers. First, we discuss the evaluation of surrogate endpoint biomarkers (to shorten a randomized trial) using 2 statistical and 3 biological criteria. Second, we discuss the evaluation of prognostic biomarkers (to predict the risk of disease) by comparing data collection costs with the anticipated net benefit of risk prediction. Third, we discuss the evaluation of predictive markers (to search for a promising subgroup in a randomized trial) using a multivariate subpopulation treatment effect pattern plot involving a risk difference or responders-only benefit function. Fourth, we discuss the evaluation of cancer screening biomarkers (to predict cancer in asymptomatic persons) using methodology to substantially reduce the sample size with stored specimens.
    Language English
    Publishing date 2020-08-04
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1177-2719
    ISSN 1177-2719
    DOI 10.1177/1177271920946715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lung Cancer Screening Websites-Balanced Information vs Advertisement.

    Woloshin, Steven / Black, William C / Kramer, Barnett S

    JAMA internal medicine

    2020  Volume 180, Issue 6, Page(s) 821–823

    MeSH term(s) Advertising ; Early Detection of Cancer ; Humans ; Lung Neoplasms/diagnosis
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2020.0103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.119: Show issues Location:
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  5. Article ; Online: Cancer overdiagnosis: a challenge in the era of screening.

    Dunn, Barbara K / Woloshin, Steven / Xie, Heng / Kramer, Barnett S

    Journal of the National Cancer Center

    2022  Volume 2, Issue 4, Page(s) 235–242

    Abstract: Screening" is a search for preclinical, asymptomatic disease, including cancer. Widespread cancer screening has led to large increases in early-stage cancers and pre-cancers. Ubiquitous public messages emphasize the potential benefits to screening for ... ...

    Abstract "Screening" is a search for preclinical, asymptomatic disease, including cancer. Widespread cancer screening has led to large increases in early-stage cancers and pre-cancers. Ubiquitous public messages emphasize the potential benefits to screening for these lesions based on the underlying assumption that treating cancer at early stages before spread to other organs should make it easier to treat and cure, using more tolerable interventions. The intuition is so strong that public campaigns are sometimes launched without conducting definitive trials directly comparing screening to usual care. An effective cancer screening test should not only increase the incidence of early-stage preclinical disease but should also decrease the incidence of advanced and metastatic cancer, as well as a subsequent decrease in cancer-related mortality. Otherwise, screening efforts may be uncovering a reservoir of non-progressive and very slowly progressive lesions that were not destined to cause symptoms or suffering during the person's remaining natural lifespan: a phenomenon known as "overdiagnosis." We provide here a qualitative review of cancer overdiagnosis and discuss specific examples due to extensive population-based screening, including neuroblastoma, prostate cancer, thyroid cancer, lung cancer, melanoma, and breast cancer. The harms of unnecessary diagnosis and cancer therapy call for a balanced presentation to people considering undergoing screening, even with a test of accepted benefit, with a goal of informed decision-making. We also discuss proposed strategies to mitigate the adverse sequelae of overdiagnosis.
    Language English
    Publishing date 2022-08-21
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-0054
    ISSN (online) 2667-0054
    DOI 10.1016/j.jncc.2022.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Epidemiologic Signatures in Cancer. Reply.

    Welch, H Gilbert / Kramer, Barnett S / Black, William C

    The New England journal of medicine

    2019  Volume 382, Issue 1, Page(s) 96–98

    MeSH term(s) Humans ; Neoplasms
    Language English
    Publishing date 2019-12-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1914747
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
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  7. Article ; Online: Epidemiologic Signatures in Cancer.

    Welch, H Gilbert / Kramer, Barnett S / Black, William C

    The New England journal of medicine

    2019  Volume 381, Issue 14, Page(s) 1378–1386

    MeSH term(s) Female ; Humans ; Incidence ; Male ; Neoplasms/epidemiology ; Neoplasms/mortality ; SEER Program ; United States/epidemiology
    Language English
    Publishing date 2019-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMsr1905447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: Correction to "Latent class instrumental variables: A clinical and biostatistical perspective".

    Baker, Stuart G / Kramer, Barnett S / Lindeman, Karen S

    Statistics in medicine

    2018  Volume 38, Issue 5, Page(s) 901

    Language English
    Publishing date 2018-10-30
    Publishing country England
    Document type Published Erratum
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.8035
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 1756: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Simple Methods for Evaluating 4 Types of Biomarkers

    Stuart G Baker / Barnett S Kramer

    Biomarker Insights, Vol

    Surrogate Endpoint, Prognostic, Predictive, and Cancer Screening

    2020  Volume 15

    Abstract: We review simple methods for evaluating 4 types of biomarkers. First, we discuss the evaluation of surrogate endpoint biomarkers (to shorten a randomized trial) using 2 statistical and 3 biological criteria. Second, we discuss the evaluation of ... ...

    Abstract We review simple methods for evaluating 4 types of biomarkers. First, we discuss the evaluation of surrogate endpoint biomarkers (to shorten a randomized trial) using 2 statistical and 3 biological criteria. Second, we discuss the evaluation of prognostic biomarkers (to predict the risk of disease) by comparing data collection costs with the anticipated net benefit of risk prediction. Third, we discuss the evaluation of predictive markers (to search for a promising subgroup in a randomized trial) using a multivariate subpopulation treatment effect pattern plot involving a risk difference or responders-only benefit function. Fourth, we discuss the evaluation of cancer screening biomarkers (to predict cancer in asymptomatic persons) using methodology to substantially reduce the sample size with stored specimens.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Biomedical research and dissemination: The value of global collaborations.

    Kramer, Barnett S / Dai, Min / Beckwith, Margaret / Hu, Ping / Li, Ni / Ren, Jiansong / Taylor, Martina / He, Jie

    Journal of the National Cancer Center

    2021  Volume 1, Issue 1, Page(s) 12–14

    Language English
    Publishing date 2021-02-24
    Publishing country Netherlands
    Document type Editorial
    ISSN 2667-0054
    ISSN (online) 2667-0054
    DOI 10.1016/j.jncc.2021.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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