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  1. Article ; Online: Use of Bookwalter Retractor to Create a Working Space for Tracheostomy During the Coronavirus Disease 2019 Pandemic-Reply.

    Bertroche, J Tyler

    JAMA otolaryngology-- head & neck surgery

    2020  

    Keywords covid19
    Language English
    Publishing date 2020-10-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2020.3593
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  3. Article ; Online: Prominent Cervical Heterotopic Calcification Following Supraclavicular Island Flap Reconstruction.

    Bertroche, J Tyler / Pipkorn, Patrik / Massa, Sean T

    Ear, nose, & throat journal

    2020  Volume 101, Issue 1, Page(s) NP8–NP9

    MeSH term(s) Calcinosis/etiology ; Calcinosis/pathology ; Clavicle/pathology ; Clavicle/surgery ; Heterotrophic Processes ; Humans ; Male ; Medical Illustration ; Middle Aged ; Neck/pathology ; Neck/surgery ; Postoperative Complications/etiology ; Postoperative Complications/pathology ; Reconstructive Surgical Procedures/adverse effects ; Surgical Flaps/adverse effects
    Language English
    Publishing date 2020-07-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/0145561320943346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Negative-Pressure Aerosol Cover for COVID-19 Tracheostomy.

    Bertroche, J Tyler / Pipkorn, Patrik / Zolkind, Paul / Buchman, Craig A / Zevallos, Jose P

    JAMA otolaryngology-- head & neck surgery

    2020  Volume 146, Issue 7, Page(s) 672–674

    MeSH term(s) Aerosols/administration & dosage ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Humans ; Intraoperative Period ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission ; Pressure ; Quality Improvement ; SARS-CoV-2 ; Tracheostomy/methods
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-05-13
    Publishing country United States
    Document type Letter
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2020.1081
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  5. Article ; Online: Patient-defined duration of benefit from juvederm (hyaluronic acid) used in injection laryngoplasty.

    Bertroche, J Tyler / Radder, Megan / Kallogjeri, Dorina / Paniello, Randal C / Bradley, Joseph P

    The Laryngoscope

    2019  Volume 129, Issue 12, Page(s) 2744–2747

    Abstract: Objectives/hypothesis: Injection laryngoplasty has become valuable in treating laryngologic disorders including vocal cord atrophy, paralysis, and paresis. Although materials such as carboxymethylcellulose and calcium hydroxylapatite are Food and Drug ... ...

    Abstract Objectives/hypothesis: Injection laryngoplasty has become valuable in treating laryngologic disorders including vocal cord atrophy, paralysis, and paresis. Although materials such as carboxymethylcellulose and calcium hydroxylapatite are Food and Drug Administration (FDA) approved, they are not without limitations. Juvederm (hyaluronic acid) is an alternative treatment that is not FDA approved. Although studies have examined Juvederm's longevity in cutaneous injections, there are limited data examining durability of Juvederm used in laryngoplasty. We aimed to determine the longevity and effectiveness of Juvederm used in injection laryngoplasty.
    Study design: Retrospective cohort study.
    Methods: Subjects who underwent injection laryngoplasty using Juvederm were reviewed. Longevity was defined as the time between injection and the date that a patient first noted subjective deterioration of their voice. All subjects were subsequently followed using videostroboscopy to evaluate for Juvederm resorption. Longevity was analyzed using a Kaplan-Meier survival model, and effectiveness of laryngoplasty was determined using the Voice-Related Quality of Life index scores and analyzed using a Wilcoxon signed ranks test.
    Results: Fifty-nine subjects met inclusion criteria and underwent Juvederm injection laryngoplasty. Kaplan-Meier survival analysis revealed a mean longevity of 10.6 months (95% confidence interval: 9.1-12.0 months). Wilcoxon signed ranks analysis of the pre- and postinjection Voice Related Quality of Life (VRQOL) scores revealed improvement, with a mean preinjection VRQOL of 49.2 (standard deviation [SD] = 25.8) and mean postinjection VRQOL of 68.2 (SD = 27.5) (P < .001).
    Conclusions: Injection laryngoplasty using Juvederm is an effective treatment for vocal cord atrophy, paralysis, and paresis. Knowledge of the patient-defined duration of benefit following laryngoplasty using Juvederm plays an important role in counseling patients as well as in the planning of future interventions.
    Level of evidence: 4 Laryngoscope, 129:2744-2747, 2019.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Humans ; Hyaluronic Acid/administration & dosage ; Hyaluronic Acid/analogs & derivatives ; Injections ; Laryngoplasty/methods ; Male ; Middle Aged ; Quality of Life ; Retrospective Studies ; Treatment Outcome ; Viscosupplements ; Vocal Cord Paralysis/physiopathology ; Vocal Cord Paralysis/surgery ; Voice Quality/physiology ; Young Adult
    Chemical Substances Juvéderm ; Viscosupplements ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2019-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.27842
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  7. Article ; Online: Negative-Pressure Aerosol Cover for COVID-19 Tracheostomy

    Bertroche, J. Tyler / Pipkorn, Patrik / Zolkind, Paul / Buchman, Craig A. / Zevallos, Jose P.

    JAMA Otolaryngology–Head & Neck Surgery

    2020  Volume 146, Issue 7, Page(s) 672

    Keywords Surgery ; Otorhinolaryngology ; covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 632721-7
    ISSN 1538-361X ; 0886-4470 ; 2168-6181
    ISSN (online) 1538-361X
    ISSN 0886-4470 ; 2168-6181
    DOI 10.1001/jamaoto.2020.1081
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Nf2 Mutation in Schwann Cells Delays Functional Neural Recovery Following Injury.

    Truong, Kristy / Ahmad, Iram / Jason Clark, J / Seline, Alison / Bertroche, Tyler / Mostaert, Brian / Van Daele, Douglas J / Hansen, Marlan R

    Neuroscience

    2018  Volume 374, Page(s) 205–213

    Abstract: Merlin is the protein product of the NF2 tumor suppressor gene. Germline NF2 mutation leads to neurofibromatosis type 2 (NF2), characterized by multiple intracranial and spinal schwannomas. Patients with NF2 also frequently develop peripheral ... ...

    Abstract Merlin is the protein product of the NF2 tumor suppressor gene. Germline NF2 mutation leads to neurofibromatosis type 2 (NF2), characterized by multiple intracranial and spinal schwannomas. Patients with NF2 also frequently develop peripheral neuropathies. While the role of merlin in SC neoplasia is well established, its role in SC homeostasis is less defined. Here we explore the role of merlin in SC responses to nerve injury and their ability to support axon regeneration. We performed sciatic nerve crush in wild-type (WT) and in P0SchΔ39-121 transgenic mice that express a dominant negative Nf2 isoform in SCs. Recovery of nerve function was assessed by measuring mean contact paw area on a pressure pad 7, 21, 60, and 90 days following nerve injury and by nerve conduction assays at 90 days following injury. After 90 days, the nerves were harvested and axon regeneration was quantified stereologically. Myelin ultrastructure was analyzed by electron microscopy. Functional studies showed delayed nerve regeneration in Nf2 mutant mice compared to the WT mice. Delayed neural recovery correlated with a reduced density of regenerated axons and increased endoneurial space in mutants compared to WT mice. Nevertheless, functional and nerve conduction measures ultimately recovered to similar levels in WT and Nf2 mutant mice, while there was a small (∼17%) reduction in the percent of regenerated axons in the Nf2 mutant mice. The data suggest that merlin function in SCs regulates neural ultrastructure and facilitates neural regeneration, in addition to its role in SC neoplasia.
    MeSH term(s) Animals ; Axons/metabolism ; Axons/pathology ; Mice, Transgenic ; Motor Activity/physiology ; Mutation ; Nerve Regeneration/physiology ; Neural Conduction/physiology ; Neurofibromin 2/genetics ; Neurofibromin 2/metabolism ; Protein Isoforms ; Recovery of Function/physiology ; Schwann Cells/metabolism ; Schwann Cells/pathology ; Sciatic Nerve/injuries ; Sciatic Nerve/metabolism ; Sciatic Nerve/pathology ; Time Factors
    Chemical Substances Neurofibromin 2 ; Protein Isoforms
    Language English
    Publishing date 2018-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2018.01.054
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    Zs.A 1215: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Hearing Loss After Activation of Hearing Preservation Cochlear Implants Might Be Related to Afferent Cochlear Innervation Injury.

    Kopelovich, Jonathan C / Reiss, Lina A J / Etler, Christine P / Xu, Linjing / Bertroche, J Tyler / Gantz, Bruce J / Hansen, Marlan R

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2015  Volume 36, Issue 6, Page(s) 1035–1044

    Abstract: Objective: Characterize hearing loss (HL) after hearing preservation cochlear implantation and determine the association between high charge electrical stimulation (ES) and late loss of acoustic hearing.: Methods: A retrospective cohort analysis of ... ...

    Abstract Objective: Characterize hearing loss (HL) after hearing preservation cochlear implantation and determine the association between high charge electrical stimulation (ES) and late loss of acoustic hearing.
    Methods: A retrospective cohort analysis of all hearing preservation implantees at our center (n = 42) assayed HL as a function of maximum charge. We analyzed serial audiometry from 85 patients enrolled in the multicenter Hybrid S8 trial to detail the hearing loss greater than 1 month after implantation. Cochleotypic explant cultures were used to assess susceptibility to high levels of ES.
    Results: Early HL after implantation tends to be mild and averages 12.2 dB. After activation of the Hybrid S8 device, 17 (20%) of 85 patients experienced acceleration of HL. Compared with the majority of patients who did not lose significant hearing after activation, these patients experienced more severe HL at 1 year. Five patients implanted at our center experienced acceleration of HL after high charge exposure. In patients implanted at our center, high charge was associated with late HL (Pearson 0.366, p = 0.016). In rat cochleotypic explants, high voltage ES damaged afferent nerve fibers, reflected by blebbing and a 50% reduction in the number of fibers innervating the organ of Corti. In contrast, hair cells displayed only minor differences in cell number and morphology.
    Conclusions: Based on clinical and in vitro data, we theorize that the combination of acoustic amplification and ES in the setting of intact hair cells and neural architecture may contribute, in part, to cochlear toxicity, perhaps by damaging the afferent innervation.
    MeSH term(s) Adolescent ; Adult ; Afferent Pathways/physiopathology ; Animals ; Audiometry ; Audiometry, Pure-Tone ; Cell Count ; Child ; Cochlear Implants/adverse effects ; Cohort Studies ; Electric Stimulation ; Female ; Hair Cells, Auditory/pathology ; Hearing Loss/etiology ; Humans ; Male ; Middle Aged ; Neurites ; Organ Culture Techniques ; Organ of Corti/pathology ; Rats ; Retrospective Studies ; Spiral Ganglion/pathology ; Vestibulocochlear Nerve Diseases/complications ; Vestibulocochlear Nerve Diseases/physiopathology ; Young Adult
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000000754
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    Zs.A 1554: Show issues Location:
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  10. Article ; Online: Protection levels of N95-level respirator substitutes proposed during the COVID-19 pandemic: safety concerns and quantitative evaluation procedures.

    Ballard, David H / Dang, Audrey J / Kumfer, Benjamin M / Weisensee, Patricia B / Meacham, J Mark / Scott, Alex R / Ruppert-Stroescu, Mary / Burke, Broc A / Morris, Jason / Gan, Connie / Hu, Jesse / King, Bradley / Jammalamadaka, Udayabhanu / Sayood, Sena / Liang, Stephen / Choudhary, Shruti / Dhanraj, David / Maranhao, Bruno / Millar, Christine /
    Bertroche, J Tyler / Shomer, Nirah / Woodard, Pamela K / Biswas, Pratim / Axelbaum, Richard / Genin, Guy / Williams, Brent J / Meacham, Kathleen

    BMJ open

    2021  Volume 11, Issue 9, Page(s) e045557

    Abstract: Objective: The COVID-19 pandemic has precipitated widespread shortages of filtering facepiece respirators (FFRs) and the creation and sharing of proposed substitutes (novel designs, repurposed materials) with limited testing against regulatory standards. ...

    Abstract Objective: The COVID-19 pandemic has precipitated widespread shortages of filtering facepiece respirators (FFRs) and the creation and sharing of proposed substitutes (novel designs, repurposed materials) with limited testing against regulatory standards. We aimed to categorically test the efficacy and fit of potential N95 respirator substitutes using protocols that can be replicated in university laboratories.
    Setting: Academic medical centre with occupational health-supervised fit testing along with laboratory studies.
    Participants: Seven adult volunteers who passed quantitative fit testing for small-sized (n=2) and regular-sized (n=5) commercial N95 respirators.
    Methods: Five open-source potential N95 respirator substitutes were evaluated and compared with commercial National Institute for Occupational Safety and Health (NIOSH)-approved N95 respirators as controls. Fit testing using the 7-minute standardised Occupational Safety and Health Administration fit test was performed. In addition, protocols that can be performed in university laboratories for materials testing (filtration efficiency, air resistance and fluid resistance) were developed to evaluate alternate filtration materials.
    Results: Among five open-source, improvised substitutes evaluated in this study, only one (which included a commercial elastomeric mask and commercial HEPA filter) passed a standard quantitative fit test. The four alternative materials evaluated for filtration efficiency (67%-89%) failed to meet the 95% threshold at a face velocity (7.6 cm/s) equivalent to that of a NIOSH particle filtration test for the control N95 FFR. In addition, for all but one material, the small surface area of two 3D-printed substitutes resulted in air resistance that was above the maximum in the NIOSH standard.
    Conclusions: Testing protocols such as those described here are essential to evaluate proposed improvised respiratory protection substitutes, and our testing platform could be replicated by teams with similar cross-disciplinary research capacity. Healthcare professionals should be cautious of claims associated with improvised respirators when suggested as FFR substitutes.
    MeSH term(s) Adult ; COVID-19 ; Equipment Design ; Humans ; N95 Respirators ; Occupational Exposure ; Pandemics/prevention & control ; Respiratory Protective Devices ; SARS-CoV-2 ; United States ; Ventilators, Mechanical
    Language English
    Publishing date 2021-09-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-045557
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