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  1. Article ; Online: Inclusion of cryoprecipitate, pathogen-reduced, in the WHO model lists of essential medicines for adults and children: a call for action.

    Epstein, Jay S / Maryuningsih, Yuyun / Faber, Jean-Claude / Smid, W Martin / Burnouf, Thierry

    Blood transfusion = Trasfusione del sangue

    2024  

    Language English
    Publishing date 2024-01-31
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2135732-8
    ISSN 2385-2070 ; 0041-1787 ; 1723-2007
    ISSN (online) 2385-2070
    ISSN 0041-1787 ; 1723-2007
    DOI 10.2450/BloodTransfus.687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 798: Show issues Location:
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  2. Article ; Online: Points to consider in the preparation and transfusion of COVID-19 convalescent plasma.

    Epstein, Jay / Burnouf, Thierry

    Vox sanguinis

    2020  Volume 115, Issue 6, Page(s) 485–487

    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12939
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    Zs.A 74: Show issues Location:
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  3. Article ; Online: Stepwise options for preparing therapeutic plasma proteins from domestic plasma in low- and middle-income countries.

    Burnouf, Thierry / Epstein, Jay / Faber, Jean-Claude / Smid, W Martin

    Vox sanguinis

    2023  Volume 119, Issue 2, Page(s) 102–109

    Abstract: Industrial plasma fractionation, a complex and highly regulated technology, remains largely inaccessible to many low- and middle-income countries (LMICs). This, combined with the limited availability and high cost of plasma-derived medicinal products ( ... ...

    Abstract Industrial plasma fractionation, a complex and highly regulated technology, remains largely inaccessible to many low- and middle-income countries (LMICs). This, combined with the limited availability and high cost of plasma-derived medicinal products (PDMPs), creates deficiency of access to adequate treatment for patients in resource-limited countries, and leads to their suffering. Meanwhile, an increasing number of LMICs produce surplus plasma, as a by-product of red blood cell preparation from whole blood, that is discarded because of the lack of suitability for fractionation. This article reviews pragmatic technological options for processing plasma collected from LMICs into therapies and supports a realistic stepwise approach aligned with recent World Health Organization guidance and initiatives launched by the Working Party for Global Blood Safety of the International Society of Blood Transfusion. When industrial options based on contract or toll plasma fractionation programme and, even more, domestic fractionation facilities require larger volumes of quality plasma than is produced, alternative methods should be considered. In-bag minipool or small-scale production procedures implementable in blood establishments or national service centres are the only realistic options available to gradually reduce plasma wastage, provide safer treatments for patients currently treated with non-pathogen-reduced blood products and concurrently improve Good Manufacturing Practice (GMP) levels with minimum capital investment. As a next step, when the available volume of quality-assured plasma reaches the necessary thresholds, LMICs could consider engaging with an established fractionator in a fractionation agreement or a contract in support of a domestic fractionation facility to improve the domestic PDMP supply and patients' treatment.
    MeSH term(s) Humans ; Developing Countries ; Blood Proteins/therapeutic use ; Blood Transfusion ; Plasma ; Blood Safety
    Chemical Substances Blood Proteins
    Language English
    Publishing date 2023-10-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13516
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  4. Article ; Online: Recruitment of grid-like responses in human entorhinal and piriform cortices by odor landmark-based navigation.

    Raithel, Clara U / Miller, Alexander J / Epstein, Russell A / Kahnt, Thorsten / Gottfried, Jay A

    Current biology : CB

    2023  Volume 33, Issue 17, Page(s) 3561–3570.e4

    Abstract: Olfactory navigation is universal across the animal kingdom. Humans, however, have rarely been considered in this context. Here, we combined olfactometry techniques, virtual reality (VR) software, and neuroimaging methods to investigate whether humans ... ...

    Abstract Olfactory navigation is universal across the animal kingdom. Humans, however, have rarely been considered in this context. Here, we combined olfactometry techniques, virtual reality (VR) software, and neuroimaging methods to investigate whether humans can navigate an olfactory landscape by learning the spatial relationships among discrete odor cues and integrating this knowledge into a spatial map. Our data show that over time, participants improved their performance on the odor navigation task by taking more direct paths toward targets and completing more trials within a given time period. This suggests that humans can successfully navigate a complex odorous environment, reinforcing the notion of human olfactory navigation. fMRI data collected during the olfactory navigation task revealed the emergence of grid-like responses in entorhinal and piriform cortices that were attuned to the same grid orientation. This result implies the existence of a specialized olfactory grid network tasked with guiding spatial navigation based on odor landmarks.
    MeSH term(s) Animals ; Humans ; Odorants ; Entorhinal Cortex/physiology ; Piriform Cortex ; Smell ; Learning ; Spatial Navigation/physiology
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.06.087
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  6. Article ; Online: Entrapped Leads After Transcatheter Tricuspid Valve Replacement.

    Schaller, Robert D / Giri, Jay / Epstein, Andrew E

    JACC. Cardiovascular interventions

    2020  Volume 14, Issue 6, Page(s) 715–716

    MeSH term(s) Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Treatment Outcome ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2021.01.029
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    Zs.A 6669: Show issues Location:
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  7. Article ; Online: Stepwise access to safe plasma proteins in resource-constrained countries: Local production and pathways to fractionation-Report of an International Society of Blood Transfusion Workshop.

    Burnouf, Thierry / Epstein, Jay / Faber, Jean-Claude / Smid, Martin

    Vox sanguinis

    2022  Volume 117, Issue 6, Page(s) 789–795

    Abstract: Background and objectives: Actions are needed to improve access to safe plasma-derived medicinal products (PDMPs) in low- and middle-income countries (LMICs).: Materials and methods: The International Society of Blood Transfusion (ISBT) Working Party ...

    Abstract Background and objectives: Actions are needed to improve access to safe plasma-derived medicinal products (PDMPs) in low- and middle-income countries (LMICs).
    Materials and methods: The International Society of Blood Transfusion (ISBT) Working Party for Global Blood Safety organized an on-line workshop during 21-23 September 2021 to advance access to safe plasma proteins in resource-constrained countries, consistent with recent World Health Organization (WHO) guidance documents.
    Results: The meeting drew attention to the considerable unmet needs for access to essential PDMPs in LMICs, in particular coagulation factors and immunoglobulins, and stepwise actions to address these deficits. First, improved access to safe plasma protein therapies requires blood component separation with prevention of wastage of recovered plasma. Quality and safety of collected blood and plasma must be assured so that plasma in excess of transfusion needs can be processed into safe plasma proteins. Second, local production of safe plasma proteins can be implemented using available technologies to locally obtain pathogen-reduced plasma and prepare pathogen-reduced cryoprecipitate and immunoglobulins from small plasma pools. Third, when a sufficient, stable volume of quality-assured plasma is available (approximately 50,000 L/year), contract or toll fractionation by a foreign plasma fractionator can expand the supply of PDMPs. Fourth, when the national infrastructure supports high-technology industrial production and stable volumes of quality plasma reach at least 200,000 L/year, technology transfer for domestic fractionation can be considered.
    Conclusion: Action is needed including commitments of the organizations that made the workshop possible (WHO, ISBT, World Federation of Haemophilia [WFH], Plasma Protein Therapeutics Association [PPTA], International Plasma Fractionation Association [IPFA], International Patient Organization of Primary Immunodeficiencies [IPOPI] and International Federation of Blood Donor Organizations [FIODS]).
    MeSH term(s) Blood Coagulation Factors ; Blood Component Transfusion ; Blood Proteins ; Blood Transfusion ; Humans ; Plasma/chemistry
    Chemical Substances Blood Coagulation Factors ; Blood Proteins
    Language English
    Publishing date 2022-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13263
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  8. Article ; Online: Points to consider in the preparation and transfusion of COVID‐19 convalescent plasma

    Epstein, Jay / Burnouf, Thierry

    Vox Sanguinis

    2020  Volume 115, Issue 6, Page(s) 485–487

    Keywords Hematology ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12939
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Recovered plasma for fractionation: call for quality standards to end wastage.

    Burnouf, Thierry / Epstein, Jay / Faber, Jean-Claude

    Vox sanguinis

    2019  Volume 115, Issue 2, Page(s) 213–214

    Language English
    Publishing date 2019-11-24
    Publishing country England
    Document type Letter
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12871
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  10. Article ; Online: Improving haemophilia therapy in developing countries: virus-safe cryoprecipitate.

    Faber, Jean-Claude / Epstein, Jay / Burnouf, Thierry

    Vox sanguinis

    2019  Volume 114, Issue 6, Page(s) 635–636

    Language English
    Publishing date 2019-06-10
    Publishing country England
    Document type Letter
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12794
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