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  1. Article ; Online: The

    Suchanecka, Aleksandra / Boroń, Agnieszka / Chmielowiec, Krzysztof / Strońska-Pluta, Aleksandra / Masiak, Jolanta / Lachowicz, Milena / Chmielowiec, Jolanta / Janiszewska-Olszowska, Joanna / Grzywacz, Anna

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: The development of a substance use disorder (SUD) is a multifaceted process influenced by both genetic and environmental factors. Recent research has suggested the potential involvement of ... ...

    Abstract The development of a substance use disorder (SUD) is a multifaceted process influenced by both genetic and environmental factors. Recent research has suggested the potential involvement of the
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Adult ; Smokers ; Polymorphism, Genetic ; Personality Inventory ; Personality/genetics ; Substance-Related Disorders/genetics ; Tobacco Products ; Nerve Tissue Proteins/genetics
    Chemical Substances HINT1 protein, human ; Nerve Tissue Proteins
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: OPRM1 Gene Polymorphism in Women with Alcohol Use Disorder.

    Boroń, Agnieszka / Suchanecka, Aleksandra / Chmielowiec, Krzysztof / Śmiarowska, Małgorzata / Chmielowiec, Jolanta / Strońska-Pluta, Aleksandra / Recław, Remigiusz / Grzywacz, Anna

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: The main aims of the present study were to explore the relationship of the OPRM1 gene rs1074287 polymorphism in alcohol-dependent women with their personality traits and to try to find out whether any specific features may influence alcohol cravings and ... ...

    Abstract The main aims of the present study were to explore the relationship of the OPRM1 gene rs1074287 polymorphism in alcohol-dependent women with their personality traits and to try to find out whether any specific features may influence alcohol cravings and be a prognostic for alcohol dependency and treatment in AUD women. Our study found a notable correlation between openness and the interaction of the ORIM1 gene and AUD. The alcohol use disorder subjects with genotype AG showed a higher level of openness compared to the control group with genotypes AG (
    MeSH term(s) Female ; Humans ; Alcoholism/genetics ; Alcoholism/psychology ; Ethanol ; Genetic Predisposition to Disease ; Genotype ; Polymorphism, Single Nucleotide ; Receptors, Opioid, mu/genetics ; Personality
    Chemical Substances Ethanol (3K9958V90M) ; OPRM1 protein, human ; Receptors, Opioid, mu
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25053067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Congenital Anterior Dislocation of the Sacrococcygeal Bone in a Newborn.

    Fabijan, Artur / Polis, Bartosz / Zakrzewski, Krzysztof / Zawadzka-Fabijan, Agnieszka / Korabiewska-Pluta, Sara / Nowosławska, Emilia

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 12

    Abstract: We present a case of a child who was transported to the Neurosurgery Clinic from another hospital for the purpose of performing a surgical procedure of the spinal myelomeningocele. On the first day of the stay, a set of tests was performed, including an ... ...

    Abstract We present a case of a child who was transported to the Neurosurgery Clinic from another hospital for the purpose of performing a surgical procedure of the spinal myelomeningocele. On the first day of the stay, a set of tests was performed, including an anterior-posterior (AP) projection X-ray, which clearly showed a developmental defect in the lumbar-sacral section of the spine. In the follow-up physical examination, there was a depression of the skin on the right side of the surgical scar after closing the open myelomeningocele. In the follow-up MRI of the lumbar-sacral section, an extremely rare congenital anterior dislocation of the sacrococcygeal bone was unexpectedly visualized. Despite recommendations for further diagnostics, the patient did not attend the required follow-up examinations. In the final section, we provide a general summary of the literature on rare developmental defects of the spine in children.
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13122108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Relationship between the Brain-Derived Neurotrophic Factor Gene Polymorphism (Val66Met) and Substance Use Disorder and Relapse.

    Strońska-Pluta, Aleksandra / Suchanecka, Aleksandra / Chmielowiec, Krzysztof / Chmielowiec, Jolanta / Boroń, Agnieszka / Masiak, Jolanta / Sipak-Szmigiel, Olimpia / Recław, Remigiusz / Grzywacz, Anna

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Substance addiction is a neuropsychiatric disorder characterized by a recurring desire to continue using a substance despite harmful consequences. Brain-derived neurotrophic factor (BDNF) is a protein that plays a role in the activity-dependent ... ...

    Abstract Substance addiction is a neuropsychiatric disorder characterized by a recurring desire to continue using a substance despite harmful consequences. Brain-derived neurotrophic factor (BDNF) is a protein that plays a role in the activity-dependent remodeling of neural function in adult nervous systems. This study analyzed the association of the rs6265 polymorphism of the BDNF gene in a group of patients addicted to psychoactive substances who were participating in addiction treatment for the first time, in a group of post-relapse psychoactive substance abusers and in a control group. The study also assessed personality and anxiety in all study groups. Statistically significant differences in the frequency of genotypes and alleles were found between all study groups. Compared to the control, both study groups had statistically significantly higher scores for trait and state anxiety. Addicted patients in both groups also had higher scores on the Neuroticism and Openness scales and lower scores on the Extraversion and Agreeableness scales. The results of this study provide further evidence that personality traits, anxiety and the rs6265 polymorphism of the BDNF gene may be risk factors for susceptibility to addiction to psychoactive substances. In addition, they can be a predictor of addiction relapse, but further extensive studies are required to confirm these findings.
    MeSH term(s) Adult ; Humans ; Alleles ; Behavior, Addictive ; Brain-Derived Neurotrophic Factor/genetics ; Chronic Disease ; Polymorphism, Genetic ; Substance-Related Disorders/genetics
    Chemical Substances Brain-Derived Neurotrophic Factor ; BDNF protein, human (7171WSG8A2)
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Clinical applications of liver support systems

    Ciężkowska, Małgorzata / Pluta, Krzysztof

    Postepy biochemii

    2019  Volume 65, Issue 3, Page(s) 193–201

    Abstract: Liver diseases that lead to its failure are one of the most frequent causes of death worldwide. Taking into account liver’s complexity, there are no drug for acute or acute on chronic liver failure treatment. So far the only effective therapy is the ... ...

    Title translation Kliniczne metody wspomagania niewydolnej wątroby.
    Abstract Liver diseases that lead to its failure are one of the most frequent causes of death worldwide. Taking into account liver’s complexity, there are no drug for acute or acute on chronic liver failure treatment. So far the only effective therapy is the liver transplantation. Unfortunately donor shortage is a main problem of this therapy. Due to this fact scientists have been looking for a new alternatives. The most promising are cell transplantation and bioartificial support systems. Without doubt hepatocytes are the best source of cells to use. But isolated human hepatocytes dedifferentiate very quickly and lose their functions ex vivo. Therefore, the new sources of cells, which could replace hepatocytes, are highly sought after. It is believed that, in order to help patients suffering from liver disease, the approach to solve this problem should be considered on different levels.
    MeSH term(s) End Stage Liver Disease/pathology ; End Stage Liver Disease/physiopathology ; End Stage Liver Disease/therapy ; Hepatocytes/cytology ; Hepatocytes/pathology ; Hepatocytes/transplantation ; Humans ; Liver, Artificial
    Language Polish
    Publishing date 2019-10-01
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 414019-9
    ISSN 0032-5422
    ISSN 0032-5422
    DOI 10.18388/pb.2019_269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Congenital Anterior Dislocation of the Sacrococcygeal Bone in a Newborn

    Artur Fabijan / Bartosz Polis / Krzysztof Zakrzewski / Agnieszka Zawadzka-Fabijan / Sara Korabiewska-Pluta / Emilia Nowosławska

    Diagnostics, Vol 13, Iss 2108, p

    2023  Volume 2108

    Abstract: We present a case of a child who was transported to the Neurosurgery Clinic from another hospital for the purpose of performing a surgical procedure of the spinal myelomeningocele. On the first day of the stay, a set of tests was performed, including an ... ...

    Abstract We present a case of a child who was transported to the Neurosurgery Clinic from another hospital for the purpose of performing a surgical procedure of the spinal myelomeningocele. On the first day of the stay, a set of tests was performed, including an anterior-posterior (AP) projection X-ray, which clearly showed a developmental defect in the lumbar-sacral section of the spine. In the follow-up physical examination, there was a depression of the skin on the right side of the surgical scar after closing the open myelomeningocele. In the follow-up MRI of the lumbar-sacral section, an extremely rare congenital anterior dislocation of the sacrococcygeal bone was unexpectedly visualized. Despite recommendations for further diagnostics, the patient did not attend the required follow-up examinations. In the final section, we provide a general summary of the literature on rare developmental defects of the spine in children.
    Keywords congenital anomalies ; myelomeningocele ; lumbosacrococcygeal agenesis ; caudal regression syndrome ; Medicine (General) ; R5-920
    Subject code 900
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Effect of Simulated Gastrointestinal Tract Conditions on Survivability of Probiotic Bacteria Present in Commercial Preparations.

    Stasiak-Różańska, Lidia / Berthold-Pluta, Anna / Pluta, Antoni Stanisław / Dasiewicz, Krzysztof / Garbowska, Monika

    International journal of environmental research and public health

    2021  Volume 18, Issue 3

    Abstract: Probiotics are recommended, among others, in the diet of children who are under antibiotic therapy, or that suffer from food allergies or travel diarrhea, etc. In the case of toddlers taking probiotic preparations, it is highly recommended to first ... ...

    Abstract Probiotics are recommended, among others, in the diet of children who are under antibiotic therapy, or that suffer from food allergies or travel diarrhea, etc. In the case of toddlers taking probiotic preparations, it is highly recommended to first remove the special capsule, which normally protects probiotic strains against hard conditions in the gastrointestinal tract. Otherwise, the toddler may choke. This removal can impair probiotic survival and reduce its efficacy in a toddler's organism. The aim of this study was to evaluate the survivability of five strains of lactic acid bacteria from the commercial probiotics available on the Polish market under simulated conditions of the gastrointestinal tract. Five probiotics (each including one of these strains:
    MeSH term(s) Anti-Bacterial Agents ; Bile Acids and Salts ; Gastrointestinal Tract ; Lactobacillus ; Probiotics
    Chemical Substances Anti-Bacterial Agents ; Bile Acids and Salts
    Language English
    Publishing date 2021-01-27
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18031108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Association of the rs3864283 Polymorphism Located in the

    Suchanecka, Aleksandra / Boroń, Agnieszka / Chmielowiec, Krzysztof / Strońska-Pluta, Aleksandra / Masiak, Jolanta / Lachowicz, Milena / Chmielowiec, Jolanta / Grzywacz, Anna

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Nicotine is the major reinforcing component of tobacco and it is believed that the pharmacological effects of nicotine motivate the initiation and maintenance of a smoking habit. HINT1 appears to play a role in the modulation of the effects of drug abuse. ...

    Abstract Nicotine is the major reinforcing component of tobacco and it is believed that the pharmacological effects of nicotine motivate the initiation and maintenance of a smoking habit. HINT1 appears to play a role in the modulation of the effects of drug abuse. Hence, the aim of this study was the analysis of the association between the rs3864283 polymorphism of the
    MeSH term(s) Humans ; Nicotine ; Personality/genetics ; Polymorphism, Genetic ; Anxiety/genetics ; Tobacco Products ; Personality Inventory ; Nerve Tissue Proteins/genetics
    Chemical Substances Nicotine (6M3C89ZY6R) ; HINT1 protein, human ; Nerve Tissue Proteins
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Analysis of the Methylation Level of the

    Recław, Remigiusz / Lachowicz, Milena / Chmielowiec, Krzysztof / Chmielowiec, Jolanta / Strońska-Pluta, Aleksandra / Kowalski, Michał Tomasz / Kudliński, Bartosz / Grzywacz, Anna

    International journal of molecular sciences

    2023  Volume 25, Issue 1

    Abstract: Drug addiction is a chronic biochemical drug use disorder that affects the human brain and behavior and leads to the uncontrolled use of legal or illicit drugs. It has been shown that three factors are involved in the development of addiction: genetic ... ...

    Abstract Drug addiction is a chronic biochemical drug use disorder that affects the human brain and behavior and leads to the uncontrolled use of legal or illicit drugs. It has been shown that three factors are involved in the development of addiction: genetic factors, a diverse environment, and the effect of medication on gene expression. The comprehensive approach and holistic analysis of the problem are due to the multigenic and multifactorial nature of addiction. Dopamine, one of the major neurotransmitters in the brain, is believed to be the "culprit" that leads to a drug abuse-induced "high". That is why, in our research, we focused mainly on the genes related to dopaminergic reuptake. In the present study, we chose methylation of the
    MeSH term(s) Humans ; Dopamine Plasma Membrane Transport Proteins/genetics ; Central Nervous System Stimulants ; DNA Methylation ; Illicit Drugs ; Dopamine ; Personality/genetics
    Chemical Substances Dopamine Plasma Membrane Transport Proteins ; Central Nervous System Stimulants ; Illicit Drugs ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-12-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Influence of Genetic Polymorphic Variability of the Catechol-O-methyltransferase Gene in a Group of Patients with a Diagnosis of Behavioural Addiction, including Personality Traits.

    Recław, Remigiusz / Chmielowiec, Krzysztof / Suchanecka, Aleksandra / Boroń, Agnieszka / Chmielowiec, Jolanta / Strońska-Pluta, Aleksandra / Kowalski, Michał Tomasz / Masiak, Jolanta / Trybek, Grzegorz / Grzywacz, Anna

    Genes

    2024  Volume 15, Issue 3

    Abstract: Gambling Disorder (GD) is characterised by a harmful, enduring, and recurrent involvement in betting-related behaviours. Therefore, GD shares similar biological mechanisms and symptoms to substance use disorders (SUD). Therefore, in this study, we chose ... ...

    Abstract Gambling Disorder (GD) is characterised by a harmful, enduring, and recurrent involvement in betting-related behaviours. Therefore, GD shares similar biological mechanisms and symptoms to substance use disorders (SUD). Therefore, in this study, we chose the behavioural addictions group. During the examination and recruitment to the study, it turned out that all the people undergoing treatment for gambling addiction were also addicted to amphetamines, which is consistent with the biological mechanism related to cerebral neurotransmission. The aim of the study was to investigate the association of the
    MeSH term(s) Adult ; Humans ; Male ; Young Adult ; Amphetamine ; Behavior, Addictive/diagnosis ; Behavior, Addictive/genetics ; Catechol O-Methyltransferase/genetics ; Personality/genetics ; Polymorphism, Genetic/genetics ; Substance-Related Disorders ; Female
    Chemical Substances Amphetamine (CK833KGX7E) ; Catechol O-Methyltransferase (EC 2.1.1.6) ; COMT protein, human (EC 2.1.1.6)
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15030299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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