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  1. Article ; Online: Epidemiology of tobacco use in dialysis patients in France and survey of nephrologists' involvement in counseling on tobacco discontinuation.

    Haussaire, Delphine / Couchoud, Cécile / Elharrar, Xavier / Rostoker, Guy

    Journal of nephrology

    2024  Volume 37, Issue 2, Page(s) 451–459

    Abstract: Background: Tobacco smoking is an independent risk factor for chronic kidney disease (CKD) and increases morbidity and mortality in CKD patients. The primary objective of the study was to investigate the epidemiology of smoking in patients undergoing ... ...

    Abstract Background: Tobacco smoking is an independent risk factor for chronic kidney disease (CKD) and increases morbidity and mortality in CKD patients. The primary objective of the study was to investigate the epidemiology of smoking in patients undergoing maintenance dialysis in France. A second objective was to assess the involvement of nephrologists in supporting patients for smoking cessation.
    Methods: Data on the smoking history of prevalent patients on maintenance dialysis in France between 2010 and 2020 were obtained from the REIN database (Renal Epidemiology and Information Network), updated by all French nephrology and dialysis centers. As for the support to smoking discontinuation, a questionnaire on smoking cessation assistance was sent to all members of the French Society of Nephrology, Dialysis and Transplantation (SFNDT).
    Results: The proportion of current smokers among patients on maintenance dialysis was 10.4% in 2010, 11.2% in 2015 and 11.6% in 2020. A total of 228 nephrologists among the 790 members of the SFNDT participated in the survey (28.9%). Most respondents were women (57.3%), worked at a public hospital (61.1%), were under 40 years of age (51.3%) and had no history of smoking (60.8%). The majority reported asking patients about their smoking status and offering brief advice. Among respondents, 72.8% offered help with smoking cessation, 46.3% referred their smoking patients to a tobacco specialist, 51.8% reported prescribing drugs to quit tobacco, and 81.6% requested further training in how to support patients for smoking cessation.
    Conclusion: Smoking cessation training for nephrologists and dedicated programs for patients in nephrology units could improve our practices and decrease the high prevalence of smoking in patients with ESKD.
    MeSH term(s) Humans ; France/epidemiology ; Female ; Male ; Renal Dialysis ; Smoking Cessation/statistics & numerical data ; Adult ; Middle Aged ; Nephrologists ; Counseling ; Surveys and Questionnaires ; Prevalence ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy ; Aged ; Practice Patterns, Physicians'/trends ; Practice Patterns, Physicians'/statistics & numerical data
    Language English
    Publishing date 2024-01-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01842-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pour qu’acheter du tabac ne soit plus un jeu d’enfant !

    Elharrar, Xavier / Béguinot, Emmanuelle / Gallopel-Morvan, Karine / Ben Lakhdar, Christian / Martinet, Yves

    La Revue du praticien

    2021  Volume 70, Issue 2, Page(s) 191–194

    Abstract: Preventing tobacco sales to minors. Since 2009, selling tobacco products in France to minors less than 18 years of age is forbidden by law, but this law is poorly enforced even though tobacco use mainly begins at adolescence. The aim of this study was to ...

    Title translation Preventing tobacco sales to minors.
    Abstract Preventing tobacco sales to minors. Since 2009, selling tobacco products in France to minors less than 18 years of age is forbidden by law, but this law is poorly enforced even though tobacco use mainly begins at adolescence. The aim of this study was to identify measures implemented by foreign countries leading to a better enforcement of tobacco sale ban to minors. The main measures are: organizing tobacco retailers training programs; using automated age-verification systems; requiring a valid photo ID from anyone who looks under the age of 25; developing communication campaigns directed to the general public in order to explain and promote age control for customers. Furthermore, in all studied countries, the only effective controls rely on "mystery shopping" with underage shoppers accompanied by dedicated inspectors, attempting to purchase tobacco products. In case of non-compliance with the law, these controls must lead to dissuasive financial as well as administrative penalties. In all studied countries, an efficient implementation of these measures has led to reduced tobacco sales to minors, and thus contributed to bring down underage smoking.
    MeSH term(s) Adolescent ; Commerce ; France ; Humans ; Minors ; Smoking ; Smoking Prevention ; Nicotiana
    Language French
    Publishing date 2021-02-09
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure.

    Elharrar, Xavier / Trigui, Youssef / Dols, Anne-Marie / Touchon, François / Martinez, Stéphanie / Prud'homme, Eloi / Papazian, Laurent

    JAMA

    2020  Volume 323, Issue 22, Page(s) 2336–2338

    MeSH term(s) Acute Disease ; Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Female ; Humans ; Hypoxia/etiology ; Male ; Middle Aged ; Organ Dysfunction Scores ; Oxygen/blood ; Oxygen Inhalation Therapy ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Prone Position/physiology ; Prospective Studies ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; SARS-CoV-2
    Chemical Substances Oxygen (S88TT14065)
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.8255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of Prone Positioning on the Respiratory Support of Nonintubated Patients With COVID-19 and Acute Hypoxemic Respiratory Failure: A Retrospective Matching Cohort Study.

    Prud'homme, Eloi / Trigui, Youssef / Elharrar, Xavier / Gaune, Marie / Loundou, Anderson / Lehingue, Samuel / Boyer, Arnaud / Lefebvre, Laurent / Dols, Anne-Marie / Chanez, Pascal / Papazian, Laurent / Forel, Jean-Marie

    Chest

    2021  Volume 160, Issue 1, Page(s) 85–88

    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19/therapy ; Female ; France/epidemiology ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Outcome and Process Assessment, Health Care ; Oxygen Inhalation Therapy/methods ; Patient Positioning/methods ; Prone Position/physiology ; Research Design ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; Retrospective Studies ; SARS-CoV-2 ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Letter
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.01.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Awake prone positioning for hypoxaemic respiratory failure: past, COVID-19 and perspectives.

    Touchon, François / Trigui, Youssef / Prud'homme, Eloi / Lefebvre, Laurent / Giraud, Alais / Dols, Anne-Marie / Martinez, Stéphanie / Bernardi, Marie / Begne, Camille / Granier, Pascal / Chanez, Pascal / Forel, Jean-Marie / Papazian, Laurent / Elharrar, Xavier

    European respiratory review : an official journal of the European Respiratory Society

    2021  Volume 30, Issue 160

    Abstract: Prone positioning reduces mortality in the management of intubated patients with moderate-to-severe acute respiratory distress syndrome. It allows improvement in oxygenation by improving ventilation/perfusion ratio mismatching.Because of its positive ... ...

    Abstract Prone positioning reduces mortality in the management of intubated patients with moderate-to-severe acute respiratory distress syndrome. It allows improvement in oxygenation by improving ventilation/perfusion ratio mismatching.Because of its positive physiological effects, prone positioning has also been tested in non-intubated, spontaneously breathing patients, or "awake" prone positioning. This review provides an update on awake prone positioning for hypoxaemic respiratory failure, in both coronavirus disease 2019 (COVID-19) and non-COVID-19 patients. In non-COVID-19 acute respiratory failure, studies are limited to a few small nonrandomised studies and involved patients with different diseases. However, results have been appealing with regard to oxygenation improvement, especially when combined with noninvasive ventilation or high-flow nasal cannula.The recent COVID-19 pandemic has led to a major increase in hospitalisations for acute respiratory failure. Awake prone positioning has been used with the aim to prevent intensive care unit admission and mechanical ventilation. Prone positioning in conscious, non-intubated COVID-19 patients is used in emergency departments, medical wards and intensive care units.Several trials reported an improvement in oxygenation and respiratory rate during prone positioning, but impacts on clinical outcomes, particularly on intubation rates and survival, remain unclear. Tolerance of prolonged prone positioning is an issue. Larger controlled, randomised studies are underway to provide results concerning clinical benefit and define optimised prone positioning regimens.
    MeSH term(s) COVID-19/physiopathology ; COVID-19/therapy ; COVID-19/virology ; Humans ; Lung/physiopathology ; Lung/virology ; Patient Positioning ; Prone Position ; Recovery of Function ; Respiration ; Respiratory Insufficiency/physiopathology ; Respiratory Insufficiency/therapy ; Respiratory Insufficiency/virology ; Treatment Outcome ; Wakefulness
    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0022-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Diagnostic Value of Computed Tomography Imaging Features in Malignant Pleural Mesothelioma.

    Fortin, Marc / Cabon, Emmanuelle / Berbis, Julie / Laroumagne, Sophie / Guinde, Julien / Elharrar, Xavier / Dutau, Hervé / Astoul, Philippe

    Respiration; international review of thoracic diseases

    2019  Volume 99, Issue 1, Page(s) 28–34

    Abstract: Background: Medical history, thoracentesis, and imaging features are usually the first steps in the investigation of a possible malignant pleural effusion (MPE). Unfortunately, the diagnostic yield of thoracentesis in this situation is suboptimal even ... ...

    Abstract Background: Medical history, thoracentesis, and imaging features are usually the first steps in the investigation of a possible malignant pleural effusion (MPE). Unfortunately, the diagnostic yield of thoracentesis in this situation is suboptimal even if the procedure is repeated, especially in the context of malignant pleural mesothelioma (MPM). The next step for confirming the diagnosis, if clinically appropriate, is thoracoscopy, but not all patients are fit to undergo this procedure, so the diagnosis is then based on the medical history and imaging features only.
    Objectives: Our objective was to evaluate the diagnostic value of the medical history and imaging features in MPM.
    Methods: We reviewed the imaging and medical charts of 92 patients with a final diagnosis of MPE included in our prospective medical thoracoscopy database. The clinical characteristics and imaging features of patients with primary MPE were compared with those of patients with secondary MPE.
    Results: Male sex (82 vs. 59%, p = 0.02), asbestos exposure (58 vs. 10%, p < 0.001), and mediastinal (68 vs. 33%, p = 0.04), diaphragmatic (75 vs. 31%, p = 0.001) and circumferential pleural thickening (55 vs. 19% p = 0.001) were significantly more frequent in MPM patients. In a multivariate linear regression model, only asbestos exposure (OR 11.2; 95% CI 3.4-36.9) and circumferential pleural thickening (OR 4.7; 95% CI 1.6-13.9) were significantly associated with a diagnosis of MPM.
    Conclusion: In situations where it is impossible to obtain adequate pleural samples to differentiate MPM from a secondary pleural malignancy, the combination of circumferential pleural thickening and a history of asbestos exposure may be sufficient to make a clinical diagnosis.
    MeSH term(s) Aged ; Aged, 80 and over ; Breast Neoplasms/pathology ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/secondary ; Female ; Humans ; Lung Neoplasms/pathology ; Male ; Mesothelioma, Malignant/diagnostic imaging ; Mesothelioma, Malignant/pathology ; Middle Aged ; Neoplasms, Unknown Primary/pathology ; Pleural Effusion, Malignant/diagnostic imaging ; Pleural Effusion, Malignant/pathology ; Pleural Neoplasms/diagnostic imaging ; Pleural Neoplasms/pathology ; Pleural Neoplasms/secondary ; Retrospective Studies ; Thoracentesis ; Thoracoscopy ; Tomography, X-Ray Computed
    Language English
    Publishing date 2019-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000503239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure

    Elharrar, Xavier / Trigui, Youssef / Dols, Anne-Marie / Touchon, François / Martinez, Stéphanie / Prud039, / homme, Eloi / Papazian, Laurent

    JAMA

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32412581
    Database COVID19

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  8. Article ; Online: Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure

    Elharrar, Xavier / Trigui, Youssef / Dols, Anne-Marie / Touchon, François / Martinez, Stéphanie / Prud’homme, Eloi / Papazian, Laurent

    JAMA

    2020  Volume 323, Issue 22, Page(s) 2336

    Keywords General Medicine ; covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.8255
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Safety and Efficacy of a Fully Covered Self-Expandable Metallic Stent in Benign Airway Stenosis.

    Fortin, Marc / Lacasse, Yves / Elharrar, Xavier / Tazi-Mezalek, Rachid / Laroumagne, Sophie / Guinde, Julien / Astoul, Philippe / Dutau, Hervé

    Respiration; international review of thoracic diseases

    2017  Volume 93, Issue 6, Page(s) 430–435

    Abstract: Background: The use of self-expandable metallic stents (SEMS) in benign airway disease was the object of a boxed warning from the United States Food and Drug Administration in 2005 due to the risk of stent-related complications and difficulties ... ...

    Abstract Background: The use of self-expandable metallic stents (SEMS) in benign airway disease was the object of a boxed warning from the United States Food and Drug Administration in 2005 due to the risk of stent-related complications and difficulties associated with their removal. Third-generation fully covered SEMS have been commercialized since this warning and theoretically should not present the same difficulties associated with removal as they cannot become embedded in the airway mucosa.
    Objectives: We aimed to examine the safety and efficacy of a specific third-generation SEMS, the Silmet stent.
    Methods: We reviewed the records of all patients treated for benign airway stenosis with third-generation Silmet SEMS from January 2011 to December 2015 at the North Hospital of Marseilles, France.
    Results: Forty SEMS were inserted in 30 patients over this period. Twenty (50.0%) stents were removed because of stent-related complications after a median of 77.0 ± 96.6 days (migration 32.5%, granulation tissue formation 7.5%, subjective intolerance 5.0%, mucus plugging 2.5%, laryngeal edema 2.5%). There were no cases of stent-related mortality. All complications were managed successfully endoscopically. Thirty-six stents (90.0%) were removed successfully after a median of 122.0 ± 113.2 days without any complications. The clinical success rate of stent treatment was 40.7%.
    Conclusion: Third-generation SEMS are a safe treatment option for complex benign airway stenosis, but complications requiring stent removal are frequent. Further studies are needed to compare the performance of third-generation SEMS and silicone stents in benign airway stenosis.
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000472155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The hypermetabolic mushroom: superior vena cava syndrome.

    Coiffard, Benjamin / Elharrar, Xavier / Vandemoortele, Thomas / Laroumagne, Sophie / Dutau, Hervé / Astoul, Philippe

    The American journal of medicine

    2014  Volume 127, Issue 5, Page(s) 395–397

    MeSH term(s) Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biopsy, Fine-Needle ; Bronchoscopy ; Carcinoma, Small Cell/diagnosis ; Chemoradiotherapy ; Fluorodeoxyglucose F18/metabolism ; Heart Transplantation ; Humans ; Lung Neoplasms/diagnosis ; Male ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/metabolism ; Smoking ; Superior Vena Cava Syndrome/diagnosis ; Superior Vena Cava Syndrome/diagnostic imaging ; Superior Vena Cava Syndrome/metabolism ; Tomography, X-Ray Computed ; Treatment Outcome
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2014-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2014.01.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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