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  1. Article: Assessing the impacts of recreation on the spatial and temporal activity of mammals in an isolated alpine protected area.

    Fennell, Mitchell J E / Ford, Adam T / Martin, Tara G / Burton, A Cole

    Ecology and evolution

    2023  Volume 13, Issue 11, Page(s) e10733

    Abstract: The management objectives of many protected areas must meet the dual mandates of protecting biodiversity while providing recreational opportunities. It is difficult to balance these mandates because it takes considerable effort to monitor both the status ...

    Abstract The management objectives of many protected areas must meet the dual mandates of protecting biodiversity while providing recreational opportunities. It is difficult to balance these mandates because it takes considerable effort to monitor both the status of biodiversity and impacts of recreation. Using detections from 45 camera traps deployed between July 2019 and September 2021, we assessed the potential impacts of recreation on spatial and temporal activity for 8 medium- and large-bodied terrestrial mammals in an isolated alpine protected area: Cathedral Provincial Park, British Columbia, Canada. We hypothesised that some wildlife perceive a level of threat from people, such that they avoid 'risky times' or 'risky places' associated with human activity. Other species may benefit from associating with people, be it through access to anthropogenic resource subsidies or filtering of competitors/predators that are more human-averse (i.e., human shield hypothesis). Specifically, we predicted that large carnivores would show the greatest segregation from people while mesocarnivores and ungulates would associate spatially with people. We found spatial co-occurrence between ungulates and recreation, consistent with the human shield hypothesis, but did not see the predicted negative relationship between larger carnivores and humans, except for coyotes (
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Social media community groups support proactive mitigation of human-carnivore conflict in the wildland-urban interface

    Martin, Alexander J.F. / Cole Burton, A.

    Trees, forests and people. 2022 Dec., v. 10

    2022  

    Abstract: Understanding human reactions to potentially dangerous wildlife at the wildland-urban interface is central to mitigating human-wildlife conflicts. Social media is increasingly used to share information about wildlife among residents living in the ... ...

    Abstract Understanding human reactions to potentially dangerous wildlife at the wildland-urban interface is central to mitigating human-wildlife conflicts. Social media is increasingly used to share information about wildlife among residents living in the interface. We used an online survey distributed on community Facebook groups in Victoria Beach, Manitoba — an area experiencing increasing wildlife sightings — to examine whether posts to the groups resulted in people using avoidance tactics to reduce human-wildlife interactions or conflicts. The results indicate that the majority of respondents used Facebook posts to change their behavior to avoid potential encounters with black bears, wolves, and coyotes. Despite few respondents having wildlife safety training, most respondents taught their children wildlife safety. Most respondents would not phone the local conservation authority, for reasons including distrust and concerns about lethal control. Coexistence attitudes towards wildlife management were dominant and respondents recognized the importance of protecting wildlife in the community.
    Keywords humans ; people ; surveys ; wildland-urban interface ; wildlife ; wildlife management ; Manitoba
    Language English
    Dates of publication 2022-12
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2666-7193
    DOI 10.1016/j.tfp.2022.100332
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Social media community groups support proactive mitigation of human-carnivore conflict in the wildland-urban interface

    Alexander J.F. Martin / A. Cole Burton

    Trees, Forests and People, Vol 10, Iss , Pp 100332- (2022)

    2022  

    Abstract: Understanding human reactions to potentially dangerous wildlife at the wildland-urban interface is central to mitigating human-wildlife conflicts. Social media is increasingly used to share information about wildlife among residents living in the ... ...

    Abstract Understanding human reactions to potentially dangerous wildlife at the wildland-urban interface is central to mitigating human-wildlife conflicts. Social media is increasingly used to share information about wildlife among residents living in the interface. We used an online survey distributed on community Facebook groups in Victoria Beach, Manitoba — an area experiencing increasing wildlife sightings — to examine whether posts to the groups resulted in people using avoidance tactics to reduce human-wildlife interactions or conflicts. The results indicate that the majority of respondents used Facebook posts to change their behavior to avoid potential encounters with black bears, wolves, and coyotes. Despite few respondents having wildlife safety training, most respondents taught their children wildlife safety. Most respondents would not phone the local conservation authority, for reasons including distrust and concerns about lethal control. Coexistence attitudes towards wildlife management were dominant and respondents recognized the importance of protecting wildlife in the community.
    Keywords Conservation officer ; Natural resource officer ; Social media ; wildlife avoidance ; Forestry ; SD1-669.5 ; Plant ecology ; QK900-989
    Subject code 333
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Gendered racial microaggressions and black college women: A cross-sectional study of depression and psychological distress.

    Burton, Wanda Martin / Paschal, Angelia M / Jaiswal, Jessica / Leeper, James D / Birch, David A

    Journal of American college health : J of ACH

    2022  , Page(s) 1–8

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604907-2
    ISSN 1940-3208 ; 0744-8481
    ISSN (online) 1940-3208
    ISSN 0744-8481
    DOI 10.1080/07448481.2022.2133567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ensemble-based classification using microRNA expression identifies a breast cancer patient subgroup with an ultralow long-term risk of metastases.

    Block, Ines / Burton, Mark / Sørensen, Kristina P / Larsen, Martin J / Do, Thi T N / Bak, Martin / Cold, Søren / Thomassen, Mads / Tan, Qihua / Kruse, Torben A

    Cancer medicine

    2024  Volume 13, Issue 9, Page(s) e7089

    Abstract: Background: Current clinical markers overestimate the recurrence risk in many lymph node negative (LNN) breast cancer (BC) patients such that a majority of these low-risk patients unnecessarily receive systemic treatments. We tested if differential ... ...

    Abstract Background: Current clinical markers overestimate the recurrence risk in many lymph node negative (LNN) breast cancer (BC) patients such that a majority of these low-risk patients unnecessarily receive systemic treatments. We tested if differential microRNA expression in primary tumors allows reliable identification of indolent LNN BC patients to provide an improved classification tool for overtreatment reduction in this patient group.
    Methods: We collected freshly frozen primary tumors of 80 LNN BC patients with recurrence and 80 recurrence-free patients (mean follow-up: 20.9 years). The study comprises solely systemically untreated patients to exclude that administered treatments confound the metastasis status. Samples were pairwise matched for clinical-pathological characteristics to minimize dependence of current markers. Patients were classified into risk-subgroups according to the differential microRNA expression of their tumors via classification model building with cross-validation using seven classification methods and a voting scheme. The methodology was validated using available data of two independent cohorts (n = 123, n = 339).
    Results: Of the 80 indolent patients (who would all likely receive systemic treatments today) our ultralow-risk classifier correctly identified 37 while keeping a sensitivity of 100% in the recurrence group. Multivariable logistic regression analysis confirmed independence of voting results from current clinical markers. Application of the method in two validation cohorts confirmed successful classification of ultralow-risk BC patients with significantly prolonged recurrence-free survival.
    Conclusion: Profiles of differential microRNAs expression can identify LNN BC patients who could spare systemic treatments demanded by currently applied classifications. However, further validation studies are required for clinical implementation of the applied methodology.
    MeSH term(s) Humans ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Breast Neoplasms/metabolism ; Female ; MicroRNAs/genetics ; Middle Aged ; Biomarkers, Tumor/genetics ; Aged ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Adult ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Risk Assessment/methods ; Neoplasm Metastasis ; Prognosis
    Chemical Substances MicroRNAs ; Biomarkers, Tumor
    Language English
    Publishing date 2024-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.7089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Control of stereogenic oxygen in a helically chiral oxonium ion.

    Smith, Owen / Popescu, Mihai V / Hindson, Madeleine J / Paton, Robert S / Burton, Jonathan W / Smith, Martin D

    Nature

    2023  Volume 615, Issue 7952, Page(s) 430–435

    Abstract: The control of tetrahedral carbon stereocentres remains a focus of modern synthetic chemistry and is enabled by their configurational stability. By contrast, trisubstituted ... ...

    Abstract The control of tetrahedral carbon stereocentres remains a focus of modern synthetic chemistry and is enabled by their configurational stability. By contrast, trisubstituted nitrogen
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-05719-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Don't forget bovine and porcine surgical products and haemostatic agents.

    Burton, Martin J

    BMJ (Clinical research ed.)

    2013  Volume 346, Page(s) f1192

    MeSH term(s) Animals ; Diet, Vegetarian ; Humans ; Meat Products/analysis ; Pharmaceutical Preparations/chemistry
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2013-02-26
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.f1192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: WITHDRAWN: Ear drops for the removal of ear wax.

    Burton, Martin J / Doree, Carolyn

    The Cochrane database of systematic reviews

    2018  Volume 7, Page(s) CD004326

    Abstract: Background: Problems attributed to the accumulation of wax (cerumen) are among the most common reasons for people to present to their general practitioners with ear trouble. Treatment for this condition often involves use of a wax softening agent ( ... ...

    Abstract Background: Problems attributed to the accumulation of wax (cerumen) are among the most common reasons for people to present to their general practitioners with ear trouble. Treatment for this condition often involves use of a wax softening agent (cerumenolytic) to disperse the cerumen, reduce the need for, or facilitate syringing, but there is no consensus on the effectiveness of the variety of cerumenolytics in use.
    Objectives: To assess the effectiveness of ear drops (cerumenolytics) for the removal of symptomatic ear wax.
    Search methods: We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, 2008 issue 2); MEDLINE; EMBASE; CINAHL; ISI Proceedings; Cambridge Scientific Abstracts; mRCT and additional sources for published and unpublished trials. The date of the most recent search was April 2008.
    Selection criteria: We identified all randomised controlled trials in which a cerumenolytic was compared with no treatment, a placebo, or other cerumenolytics in participants with obstructing or impacted ear wax, and in which the proportion of participants with sufficient clearance of the external canal to make further mechanical clearance unnecessary (primary outcome measure) was stated or calculable.
    Data collection and analysis: The two authors reviewed all the retrieved trials and applied the inclusion criteria independently.
    Main results: Nine trials satisfied the inclusion criteria. In all, 679 participants received one of 11 different cerumenolytics. One trial compared active treatments with no treatment, three compared active treatments with water or a saline 'placebo', and all nine trials compared two or more active treatments. Eight trials included syringing as a secondary intervention.Overall, results were inconclusive. The majority of comparisons showed no difference between treatments.  Meta-analysis of two high quality trials produced a statistical difference in favour of triethanolamine polypeptide over saline in preventing the need for syringing, but no other significant differences between treatments.In three trials of high to moderate quality, no difference was found between the effectiveness of either sodium bicarbonate ear drops, chlorbutanol, triethanolamine polypeptide oleate condensate or docusate sodium liquid versus a sterile water or saline 'placebo'.One trial of moderate methodological quality found all three treatments - sodium bicarbonate ear drops, chlorbutanol and sterile water - to be significantly better than no treatment at preventing the need for syringing.None of the higher quality trials demonstrated superiority of one agent over another in direct comparisons.
    Authors' conclusions: Trials have been heterogeneous and generally of low or moderate quality, making it difficult to offer any definitive recommendations on the effectiveness of cerumenolytics for the removal of symptomatic ear wax. Using drops of any sort appears to be better than no treatment, but it is uncertain if one type of drop is any better than another. Future trials should be of high methodological quality, have large sample sizes, and compare both oil-based and water-based solvents with placebo, no treatment or both.
    MeSH term(s) Cerumen/drug effects ; Detergents/administration & dosage ; Humans ; Randomized Controlled Trials as Topic ; Solvents/administration & dosage ; Syringes
    Chemical Substances Detergents ; Solvents
    Language English
    Publishing date 2018-07-24
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.CD004326.pub3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Seasonal changes in the abundance and activity of bacterial and fungal denitrifying communities associated with different compost amendments.

    Novinscak, Amy / Goyer, Claudia / Wilson, Carolyn / Zebarth, Bernie J / Burton, David L / Chantigny, Martin H / Filion, Martin

    Canadian journal of microbiology

    2021  Volume 68, Issue 2, Page(s) 91–102

    Abstract: Composts can be efficient organic amendments in potato culture as they can supply carbon and nutrients to the soil. However, more information is required on the effects of composts on denitrification and nitrous oxide emissions ( ... ...

    Abstract Composts can be efficient organic amendments in potato culture as they can supply carbon and nutrients to the soil. However, more information is required on the effects of composts on denitrification and nitrous oxide emissions (N
    MeSH term(s) Bacteria/genetics ; Composting ; Denitrification ; Nitrous Oxide/analysis ; Seasons ; Soil ; Soil Microbiology
    Chemical Substances Soil ; Nitrous Oxide (K50XQU1029)
    Language English
    Publishing date 2021-11-11
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 280534-0
    ISSN 1480-3275 ; 0008-4166
    ISSN (online) 1480-3275
    ISSN 0008-4166
    DOI 10.1139/cjm-2021-0256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Disease progression joint model predicts time to type 1 diabetes onset: Optimizing future type 1 diabetes prevention studies.

    Morales, Juan Francisco / Muse, Rhoda / Podichetty, Jagdeep T / Burton, Jackson / David, Sarah / Lang, Patrick / Schmidt, Stephan / Romero, Klaus / O'Doherty, Inish / Martin, Frank / Campbell-Thompson, Martha / Haller, Michael J / Atkinson, Mark A / Kim, Sarah

    CPT: pharmacometrics & systems pharmacology

    2023  Volume 12, Issue 7, Page(s) 1016–1028

    Abstract: Clinical trials seeking type 1 diabetes prevention are challenging in terms of identifying patient populations likely to progress to type 1 diabetes within limited (i.e., short-term) trial durations. Hence, we sought to improve such efforts by developing ...

    Abstract Clinical trials seeking type 1 diabetes prevention are challenging in terms of identifying patient populations likely to progress to type 1 diabetes within limited (i.e., short-term) trial durations. Hence, we sought to improve such efforts by developing a quantitative disease progression model for type 1 diabetes. Individual-level data obtained from the TrialNet Pathway to Prevention and The Environmental Determinants of Diabetes in the Young natural history studies were used to develop a joint model that links the longitudinal glycemic measure to the timing of type 1 diabetes diagnosis. Baseline covariates were assessed using a stepwise covariate modeling approach. Our study focused on individuals at risk of developing type 1 diabetes with the presence of two or more diabetes-related autoantibodies (AAbs). The developed model successfully quantified how patient features measured at baseline, including HbA1c and the presence of different AAbs, alter the timing of type 1 diabetes diagnosis with reasonable accuracy and precision (<30% RSE). In addition, selected covariates were statistically significant (p < 0.0001 Wald test). The Weibull model best captured the timing to type 1 diabetes diagnosis. The 2-h oral glucose tolerance values assessed at each visit were included as a time-varying biomarker, which was best quantified using the sigmoid maximum effect function. This model provides a framework to quantitatively predict and simulate the time to type 1 diabetes diagnosis in individuals at risk of developing the disease and thus, aligns with the needs of pharmaceutical companies and scientists seeking to advance therapies aimed at interdicting the disease process.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 1/prevention & control ; Glucose Tolerance Test ; Autoantibodies ; Disease Progression ; Blood Glucose/metabolism
    Chemical Substances Autoantibodies ; Blood Glucose
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697010-7
    ISSN 2163-8306 ; 2163-8306
    ISSN (online) 2163-8306
    ISSN 2163-8306
    DOI 10.1002/psp4.12973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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