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  1. Article ; Online: Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine.

    Dzator, Jemima S A / Smith, Robert A / Coupland, Kirsten G / Howe, Peter R C / Griffiths, Lyn R

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: There is evidence to suggest that hormonal migraine is associated with altered cerebrovascular function. We aimed to investigate whether the expression of genes related to endothelial function in venous blood (1) might influence cerebrovascular function, ...

    Abstract There is evidence to suggest that hormonal migraine is associated with altered cerebrovascular function. We aimed to investigate whether the expression of genes related to endothelial function in venous blood (1) might influence cerebrovascular function, (2) differs between hormonal migraineur and non-migraineur women, and (3) changes following resveratrol supplementation. This study utilised data obtained from 87 women (59 hormonal migraineurs and 28 controls) where RNA from venous blood was used to quantify gene expression and transcranial Doppler ultrasound was used to evaluate cerebrovascular function. Spearman's correlation analyses were performed between gene expression, cerebrovascular function, and migraine-related disability. We compared the expression of genes associated with endothelial function between migraineurs and non-migraineurs, and between resveratrol and placebo. The expression of several genes related to endothelial function was associated with alterations in cerebrovascular function. Notably, the expression of
    MeSH term(s) Humans ; Female ; Resveratrol/pharmacology ; Migraine Disorders/genetics ; Ultrasonography, Doppler, Transcranial ; Neurovascular Coupling ; Cerebrovascular Circulation/genetics
    Chemical Substances Resveratrol (Q369O8926L)
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The event-based influence of incentivizing and physical contexts on daily alcohol initiation and consumption.

    Howe, Lindy K / Finn, Peter R

    Alcohol, clinical & experimental research

    2023  Volume 47, Issue 4, Page(s) 763–771

    Abstract: ... and the contextual factors surrounding each event. The contextual factors included the situation (e.g ... bar setting and pregaming) and incentives (e.g., alcohol, social, and mood enhancement).: Results ...

    Abstract Background: Young adults often decide to engage in heavy drinking. Learning more about the real-time factors that predict decisions to initiate a drinking episode and how much is consumed in any single drinking episode is necessary in developing our understanding of momentary alcohol use and discrete decisions surrounding alcohol use.
    Methods: The current study examined the association between contextual factors and decisions to initiate and consume alcohol in 104 young adult individuals over 2 weeks via mobile daily diary. Participants responded to daily notifications about decisions to drink or not and the contextual factors surrounding each event. The contextual factors included the situation (e.g., bar setting and pregaming) and incentives (e.g., alcohol, social, and mood enhancement).
    Results: Multilevel analyses revealed that incentives predicted both the initiation of drinking and the amount consumed. Event-based alcohol and mood incentives predicted the initiation of drinking, while alcohol, mood, and social/party incentives predicted how much was consumed at a specific event. However, context had a more complex association with drinking outcomes. Being in a bar, alone, or at a residence predicted decisions to initiate drinking, while being in a bar, pregaming situation, or other party situation with others who are drinking predicted how much a person drank.
    Conclusions: The results highlight the importance of studying event-specific predictors of drinking decisions and the complex association between context/location and the type of drinking decision or outcome.
    MeSH term(s) Young Adult ; Humans ; Alcohol Drinking/epidemiology ; Motivation ; Ethanol ; Cognition
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2993-7175
    ISSN (online) 2993-7175
    DOI 10.1111/acer.15027
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  3. Article: Remembering Al Jonsen.

    Howe, Edmund G

    The Journal of clinical ethics

    2020  Volume 31, Issue 4, Page(s) 383

    Abstract: ... R. Jonsen, PhD, one of the founding members of the editorial board of the journal. ...

    Abstract The author, editor-in-chief of The Journal of Clinical Ethics, recalls the contributions of Albert R. Jonsen, PhD, one of the founding members of the editorial board of the journal.
    MeSH term(s) Advisory Committees ; Bioethical Issues ; Editorial Policies ; Ethicists/history ; Ethics, Clinical ; History, 20th Century ; Humans ; Male ; Periodicals as Topic/history ; Publishing/history
    Language English
    Publishing date 2020-12-01
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1122655-9
    ISSN 1046-7890
    ISSN 1046-7890
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3456: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Exploring the effects of resveratrol supplementation on cerebrovascular function in hormonal migraineurs: A pilot study.

    Dzator, Jemima S A / Coupland, Kirsten G / Howe, Peter R C

    IBRO neuroscience reports

    2023  Volume 15, Page(s) 310–319

    Abstract: Background: Past research suggests that hormonal migraineurs may have poorer cerebrovascular function than women who do not suffer from migraine. Resveratrol, a vasoactive phytoestrogen, has been shown to improve cerebrovascular function in several ... ...

    Abstract Background: Past research suggests that hormonal migraineurs may have poorer cerebrovascular function than women who do not suffer from migraine. Resveratrol, a vasoactive phytoestrogen, has been shown to improve cerebrovascular function in several populations but has never been tested in hormonal migraineurs.
    Aim: To investigate the effects of 3-month resveratrol supplementation on the cerebrovascular function of hormonal migraineurs.
    Methods: We conducted a randomised, double-blind, placebo-controlled, crossover intervention pilot study with resveratrol (150 mg/d for 3 months) in ten hormonal migraineurs (mean age: 37.2 ± 2.6 years). Participants visited the University of Newcastle's Clinical Nutrition Research Centre where quality of life and disability, and cerebrovascular function were assessed. Quality of life and disability were examined using Migraine-Specific Quality of Life, Headache Impact Test-6 and the Migraine Disability Assessment. Cerebrovascular function was determined using transcranial Doppler ultrasound to bilaterally measure blood flow velocity in the middle and posterior cerebral arteries at rest and in response to a hypercapnic stimulus. Cerebrovascular responsiveness to a cognitive task battery was also measured bilaterally in the middle cerebral arteries.
    Results: Compared to placebo, blood flow velocity in the right posterior cerebral artery was significantly higher (P = 0.041) following resveratrol supplementation. No other significant differences in cerebrovascular function between resveratrol and placebo treatments were observed. Baseline correlation analyses revealed higher blood flow velocities in the middle and posterior cerebral arteries were associated with better quality of life and less disability. However, higher cerebrovascular responsiveness to hypercapnia in the posterior circulation was associated with higher migraine-related disability and poorer migraine-related quality of life.
    Conclusion: In this pilot we found evidence that resveratrol may increase blood flow velocity in the right posterior cerebral artery in hormonal migraineurs. Larger cohorts are required confirm this effect and its potential relationship to migraine in premenopausal women.
    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-2421
    ISSN (online) 2667-2421
    DOI 10.1016/j.ibneur.2023.10.005
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  5. Article ; Online: ASO Author Reflections: Endoscopic Management is Reasonable for <2 cm Duodenal Neuroendocrine Tumors.

    Tran, Catherine G / Sherman, Scott K / Howe, James R

    Annals of surgical oncology

    2021  Volume 29, Issue 1, Page(s) 85–86

    Abstract: Optimal management of duodenal neuroendocrine tumors (DNETs) has not been well-defined, especially for DNETs 1-2 cm in size. Recent studies comparing endoscopic mucosal resection (EMR) and surgical resection demonstrate EMR is safe and effective for ... ...

    Abstract Optimal management of duodenal neuroendocrine tumors (DNETs) has not been well-defined, especially for DNETs 1-2 cm in size. Recent studies comparing endoscopic mucosal resection (EMR) and surgical resection demonstrate EMR is safe and effective for these intermediate-sized DNETs. Expert and consensus guidelines could consider updating recommendations to reflect the outcomes of EMR in DNETs and the importance of endoscopic surveillance in these patients to evaluate for local recurrence.
    MeSH term(s) Duodenal Neoplasms/surgery ; Endoscopic Mucosal Resection ; Humans ; Neuroendocrine Tumors/surgery ; Pancreatic Neoplasms ; Stomach Neoplasms
    Language English
    Publishing date 2021-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10859-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The Landmark Series: Management of Small Bowel Neuroendocrine Tumors.

    Tran, Catherine G / Sherman, Scott K / Howe, James R

    Annals of surgical oncology

    2021  Volume 28, Issue 5, Page(s) 2741–2751

    Abstract: Surgical resection is the foundation for treatment of small bowel neuroendocrine tumors (SBNETs). Guidelines for surgical management of SBNETs rely on retrospective data, which suggest that primary tumor resection and cytoreduction improve symptoms, ... ...

    Abstract Surgical resection is the foundation for treatment of small bowel neuroendocrine tumors (SBNETs). Guidelines for surgical management of SBNETs rely on retrospective data, which suggest that primary tumor resection and cytoreduction improve symptoms, prevent future complications, and lengthen survival. In advanced NETs, improvement in progression-free survival has been reported in large, randomized, controlled trials of various medical treatments, including somatostatin analogues, targeted therapy, and peptide receptor radionuclide therapy. This review discusses important studies influencing the management of SBNETs and the limitations of current evidence regarding surgical interventions for SBNETs.
    MeSH term(s) Humans ; Intestinal Neoplasms/therapy ; Intestine, Small ; Neuroendocrine Tumors/therapy ; Pancreatic Neoplasms ; Retrospective Studies
    Language English
    Publishing date 2021-01-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-09566-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: ASO Author Reflections: Indolent Growth and Small Bowel Neuroendocrine Tumor Management.

    Sherman, S K / Tran, C G / Howe, J R

    Annals of surgical oncology

    2021  Volume 28, Issue 5, Page(s) 2752–2753

    Abstract: Surgical treatment is central to management of small bowel neuroendocrine tumors (SBNETs). Current controversies include whether to resect asymptomatic primary tumors in the setting of unresectable metastases, the role of minimally invasive surgery, and ... ...

    Abstract Surgical treatment is central to management of small bowel neuroendocrine tumors (SBNETs). Current controversies include whether to resect asymptomatic primary tumors in the setting of unresectable metastases, the role of minimally invasive surgery, and how best to incorporate/sequence medical treatments. Low SBNET incidence, long event-times, and variability in disease burden, surgical technique, and institutional treatment preferences remain obstacles to conducting randomized surgical trials for SBNETs. With increasing referral of these patients to high-volume centers, cooperation between experienced SBNET clinicians should allow design of high-quality randomized trials to test new treatments and answer key questions.
    MeSH term(s) Humans ; Intestinal Neoplasms/surgery ; Intestine, Small/surgery ; Neuroendocrine Tumors/surgery ; Pancreatic Neoplasms ; Stomach Neoplasms
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-09641-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Biogeographic context is related to local scale tree demography, co-occurrence and functional differentiation.

    Swenson, Nathan G / Zambrano, Jenny / Howe, Robert / Wolf, Amy

    Ecology letters

    2023  Volume 26, Issue 7, Page(s) 1212–1222

    Abstract: Identifying the drivers of community structure and dynamics is a major pursuit in ecology. Emphasis is typically placed on the importance of local scale interactions when attempting to explain these fundamental ecological patterns. However, regional ... ...

    Abstract Identifying the drivers of community structure and dynamics is a major pursuit in ecology. Emphasis is typically placed on the importance of local scale interactions when attempting to explain these fundamental ecological patterns. However, regional scale phenomena are also important predictors. The importance of regional scale context should be more evident in assemblages where multiple species are close to their range margins. Here, we test the importance of regional scale context using data from a temperate forest plot that contains two species groups - one near its northern range limit and one near its southern range limit. We show the proximity of species to their southern or northern range margins is linked to local scale co-occurrence, similarity in gene expression responses to a key environmental driver, demographic performance and inter-specific variation in conspecific negative density dependence. In sum, many of the key local scale patterns and processes of interest to community ecologists are linked to biogeographic context that is frequently ignored.
    MeSH term(s) Trees/physiology ; Forests ; Demography ; Ecosystem
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Letter
    ZDB-ID 1441608-6
    ISSN 1461-0248 ; 1461-023X
    ISSN (online) 1461-0248
    ISSN 1461-023X
    DOI 10.1111/ele.14233
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    In stock of ZB MED Bonn / Germany

    Z 2005/709: Show issues

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  9. Article ; Online: External quality assessment-bringing difficulty, complexity and severity of errors to bear on the assessment of performance in antimicrobial susceptibility testing.

    Kahlmeter, Gunnar / Howe, Robin / Wootton, Mandy

    The Journal of antimicrobial chemotherapy

    2022  Volume 78, Issue 2, Page(s) 321–322

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkac431
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  10. Article ; Online: Small Bowel Neuroendocrine Tumors.

    Tran, Catherine G / Sherman, Scott K / Howe, James R

    Current problems in surgery

    2020  Volume 57, Issue 12, Page(s) 100823

    MeSH term(s) Humans ; Intestinal Neoplasms/diagnosis ; Intestinal Neoplasms/epidemiology ; Intestinal Neoplasms/genetics ; Intestinal Neoplasms/therapy ; Intestine, Small ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/epidemiology ; Neuroendocrine Tumors/genetics ; Neuroendocrine Tumors/therapy
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 753169-2
    ISSN 1535-6337 ; 0011-3840
    ISSN (online) 1535-6337
    ISSN 0011-3840
    DOI 10.1016/j.cpsurg.2020.100823
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