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Article ; Online: DNA Sequencing in Adults With Acute Myeloid Leukemia to Detect Residual Disease Prior to Hematopoietic Cell Transplant.

Khaire, Niranjan Shiwaji / Kim, Dennis Dong Hwan / Law, Arjun D

2023 Volume 330, Issue 2, Page(s) 190

MeSH term(s)	Adult ; Humans ; Base Sequence ; Hematopoietic Stem Cell Transplantation ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Neoplasm, Residual/diagnosis ; Neoplasm, Residual/genetics ; Sequence Analysis, DNA/methods
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2023.8650
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Article ; Online: "Likely to be missed if unsuspected":

Sharma, Praveen / Khaire, Niranjan Shiwaji / Sreedharanunni, Sreejesh / Malhotra, Pankaj / Varma, Neelam

Journal of cancer research and therapeutics

2022 Volume 18, Issue 1, Page(s) 316–317

MeSH term(s)	Humans ; Imatinib Mesylate ; Oncogene Proteins, Fusion/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; mRNA Cleavage and Polyadenylation Factors/genetics
Chemical Substances	Oncogene Proteins, Fusion ; mRNA Cleavage and Polyadenylation Factors ; Imatinib Mesylate (8A1O1M485B) ; FIP1L1-PDGFRA fusion protein, human (EC 2.7.10.1) ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1)
Language	English
Publishing date	2022-04-06
Publishing country	India
Document type	Case Reports ; Letter
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.JCRT_940_19
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Article ; Online: Hemoglobin Andrew-Minneapolis-Bijnor HBB:c.[413T>C;435G>C] in a complex genotype with β-thalassemia trait: A diagnostic and management conundrum.

Khaire, Niranjan Shiwaji / Jamwal, Manu / Sharma, Prashant / Hira, Jasbir Kaur / Chhabra, Sanjeev / Malhotra, Pankaj / Das, Reena

International journal of laboratory hematology

2022 Volume 44, Issue 4, Page(s) e164–e167

MeSH term(s)	Genotype ; Hemoglobins, Abnormal/genetics ; Humans ; Mutation ; beta-Globins/genetics ; beta-Thalassemia/diagnosis ; beta-Thalassemia/genetics ; beta-Thalassemia/therapy
Chemical Substances	Hemoglobins, Abnormal ; beta-Globins ; hemoglobin Andrew-Minneapolis (53986-72-4)
Language	English
Publishing date	2022-03-09
Publishing country	England
Document type	Letter
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.13821
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Article: Authors' response.

Soni, Shiv Lal / Kajal, Kamal / Yaddanapudi, L N / Malhotra, Pankaj / Puri, Goverdhan Dutt / Bhalla, Ashish / Singh, Mini P / Sehgal, Inderpaul Singh / Koushal, Vipin / Varma, Neelam / Biswal, Manisha / M Lakshmi, P V / Sharma, Sadhna / Suri, Vikas / Deepy, Z / Ram, Sant / Yadav, Jaivinder / Pandey, Navin / Sharma, Prashant /

Malik, Nabhajit / Goyal, Kapil / Mehra, Aseem / Sahoo, Swapnajeet / Mohindra, Ritin / Francis, Jijo / Bhargava, Mudit / Singla, Karan / Babu, Preena / Verma, Amiy / Khaire, Niranjan Shiwaji / Guru, R R

The Indian journal of medical research

2023 Volume 156, Issue 4&5, Page(s) 691–692

Language	English
Publishing date	2023-03-15
Publishing country	India
Document type	Letter ; Comment
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
DOI	10.4103/0971-5916.371296
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Article ; Online: Fibrodysplasia ossificans progressiva--primum non nocere.

Muthu, Valliappan / Khaire, Niranjan Shiwaji / Varma, Subhash

Clinical rheumatology

2014 Volume 33, Issue 4, Page(s) 591–592

MeSH term(s)	Adolescent ; Deglutition Disorders/diagnostic imaging ; Deglutition Disorders/etiology ; Humans ; Kyphosis/diagnostic imaging ; Kyphosis/etiology ; Male ; Myositis Ossificans/complications ; Myositis Ossificans/diagnostic imaging ; Radiography ; Scoliosis/diagnostic imaging ; Scoliosis/etiology
Language	English
Publishing date	2014-02-05
Publishing country	Germany
Document type	Case Reports ; Letter
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-014-2510-9
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Article: Use of convalescent plasma for COVID-19 in India: A review & practical guidelines.

Khaire, Niranjan Shiwaji / Jindal, Nishant / Yaddanapudi, Lakshmi Narayana / Sachdev, Suchet / Hans, Rekha / Sachdeva, Naresh / Singh, Mini P / Agarwal, Anup / Mukherjee, Aparna / Kumar, Gunjan / Sharma, Ratti Ram / Suri, Vikas / Puri, Goverdhan Dutt / Malhotra, Pankaj

The Indian journal of medical research

2021 Volume 153, Issue 1 & 2, Page(s) 64–85

Abstract: Convalescent plasma (CP) therapy is one of the promising therapies being tried for COVID-19 patients. This passive immunity mode involves separating preformed antibodies against SARS-CoV-2 from a recently recovered COVID-19 patient and infusing it into a ...

Abstract	Convalescent plasma (CP) therapy is one of the promising therapies being tried for COVID-19 patients. This passive immunity mode involves separating preformed antibodies against SARS-CoV-2 from a recently recovered COVID-19 patient and infusing it into a patient with active disease or an exposed individual for prophylaxis. Its advantages include ease of production, rapid deployment, specificity against the target infectious agent, and scalability. In the current pandemic, it has been used on a large scale across the globe and also in India. However, unequivocal proof of efficacy and effectiveness in COVID-19 is still not available. Various CP therapy parameters such as donor selection, antibody quantification, timing of use, and dosing need to be considered before its use. The current review attempts to summarize the available evidence and provide recommendations for setting up CP protocols in clinical and research settings.
MeSH term(s)	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/therapy ; Humans ; Immunization, Passive ; India/epidemiology ; COVID-19 Serotherapy
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2021-04-04
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
DOI	10.4103/ijmr.IJMR_3092_20
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Article: Authors' response.

The Indian journal of medical research

2022

Language	English
Publishing date	2022-12-13
Publishing country	India
Document type	Journal Article
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
DOI	10.4103/0971-5916.363264
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Article ; Online: Use of convalescent plasma for COVID-19 in India

Niranjan Shiwaji Khaire / Nishant Jindal / Lakshmi Narayana Yaddanapudi / Suchet Sachdev / Rekha Hans / Naresh Sachdeva / Mini P Singh / Anup Agarwal / Aparna Mukherjee / Gunjan Kumar / Ratti Ram Sharma / Vikas Suri / Goverdhan Dutt Puri / Pankaj Malhotra

Indian Journal of Medical Research, Vol 153, Iss 1, Pp 64-

A review & practical guidelines

2021 Volume 85

Abstract	Convalescent plasma (CP) therapy is one of the promising therapies being tried for COVID-19 patients. This passive immunity mode involves separating preformed antibodies against SARS-CoV-2 from a recently recovered COVID-19 patient and infusing it into a patient with active disease or an exposed individual for prophylaxis. Its advantages include ease of production, rapid deployment, specificity against the target infectious agent, and scalability. In the current pandemic, it has been used on a large scale across the globe and also in India. However, unequivocal proof of efficacy and effectiveness in COVID-19 is still not available. Various CP therapy parameters such as donor selection, antibody quantification, timing of use, and dosing need to be considered before its use. The current review attempts to summarize the available evidence and provide recommendations for setting up CP protocols in clinical and research settings.
Keywords	antibody-dependent enhancement - anti-sars-cov-2 antibodies - convalescent plasma - covid-19 - donor selection - neutralizing antibodies - passive immunization ; Medicine ; R
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Demographic & clinical profile of patients with COVID-19 at a tertiary care hospital in north India.

Soni, Shiv Lal / Kajal, Kamal / Yaddanapudi, L N / Malhotra, Pankaj / Puri, Goverdhan Dutt / Bhalla, Ashish / Singh, Mini P / Sehgal, Inderpaul Singh / Koushal, Vipin / Varma, Neelam / Biswal, Manisha / Lakshmi, P V M / Sharma, Sadhna / Suri, Vikas / Deepy, Z / Ram, Sant / Yadav, Jaivinder / Pandey, Navin / Sharma, Prashant /

The Indian journal of medical research

2021 Volume 153, Issue 1 & 2, Page(s) 115–125

Abstract: Background & objectives: The COVID-19 pandemic emerged as a major public health emergency affecting the healthcare services all over the world. It is essential to analyze the epidemiological and clinical characteristics of patients with COVID-19 in ... ...

Abstract	Background & objectives: The COVID-19 pandemic emerged as a major public health emergency affecting the healthcare services all over the world. It is essential to analyze the epidemiological and clinical characteristics of patients with COVID-19 in different parts of our country. This study highlights clinical experience in managing patients with COVID-19 at a tertiary care centre in northern India. Methods: Clinical characteristics and outcomes of consecutive adults patients admitted to a tertiary care hospital at Chandigarh, India, from April 1 to May 25, 2020 were studied. The diagnosis of SARS-CoV-2 infection was confirmed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) on throat and/or nasopharyngeal swabs. All patients were managed according to the institute's consensus protocol and in accordance with Indian Council of Medical Research guidelines. Results: During the study period, 114 patients with SARS-CoV-2 infection were admitted. The history of contact with COVID-19-affected individuals was available in 75 (65.8%) patients. The median age of the patients was 33.5 yr (13-79 yr), and there were 66 (58%) males. Of the total enrolled patients, 48 (42%) were symptomatic. The common presenting complaints were fever (37, 77%), cough (26, 54%) and shortness of breath (10, 20.8%). Nineteen (17%) patients had hypoxia (SpO Interpretation & conclusions: Majority of the patients with COVID-19 infection presenting to our hospital were young and asymptomatic. Fever was noted only in three-fourth of the patients and respiratory symptoms in half of them. Patients with comorbidities were more vulnerable to complications. Triaged classification of patients and protocol-based treatment resulted in good outcomes and low case fatality.
MeSH term(s)	Adolescent ; Adult ; Aged ; COVID-19/epidemiology ; Child ; Demography ; Female ; Humans ; India/epidemiology ; Male ; Middle Aged ; Pandemics ; Tertiary Care Centers/statistics & numerical data ; Young Adult
Language	English
Publishing date	2021-09-01
Publishing country	India
Document type	Journal Article
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
DOI	10.4103/ijmr.IJMR_2311_20
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Article ; Online: Demographic & clinical profile of patients with COVID-19 at a tertiary care hospital in north India

Shiv Lal Soni / Kamal Kajal / L N Yaddanapudi / Pankaj Malhotra / Goverdhan Dutt Puri / Ashish Bhalla / Mini P Singh / Inderpaul Singh Sehgal / Vipin Koushal / Neelam Varma / Manisha Biswal / P.V.M. Lakshmi / Sadhna Sharma / Vikas Suri / Z Deepy / Sant Ram / Jaivinder Yadav / Navin Pandey / Prashant Sharma /

Nabhajit Malik / Kapil Goyal / Aseem Mehra / Swapnajeet Sahoo / Ritin Mohindra / Jijo Francis / Mudit Bhargava / Karan Singla / Preena Babu / Amiy Verma / Niranjan Shiwaji Khaire / R R Guru

Indian Journal of Medical Research, Vol 153, Iss 1, Pp 115-

2021 Volume 125

Abstract	Background & objectives: The COVID-19 pandemic emerged as a major public health emergency affecting the healthcare services all over the world. It is essential to analyze the epidemiological and clinical characteristics of patients with COVID-19 in different parts of our country. This study highlights clinical experience in managing patients with COVID-19 at a tertiary care centre in northern India. Methods: Clinical characteristics and outcomes of consecutive adults patients admitted to a tertiary care hospital at Chandigarh, India, from April 1 to May 25, 2020 were studied. The diagnosis of SARS-CoV-2 infection was confirmed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) on throat and/or nasopharyngeal swabs. All patients were managed according to the institute's consensus protocol and in accordance with Indian Council of Medical Research guidelines. Results: During the study period, 114 patients with SARS-CoV-2 infection were admitted. The history of contact with COVID-19-affected individuals was available in 75 (65.8%) patients. The median age of the patients was 33.5 yr (13-79 yr), and there were 66 (58%) males. Of the total enrolled patients, 48 (42%) were symptomatic. The common presenting complaints were fever (37, 77%), cough (26, 54%) and shortness of breath (10, 20.8%). Nineteen (17%) patients had hypoxia (SpO2<94%) at presentation and 36 (31%) had tachypnoea (RR >24). Thirty four (29.8%) patients had an accompanying comorbid illness. Age more than 60 yr and presence of diabetes and hypertension were significantly associated with severe COVID-19 disease. Admission to the intensive care unit (ICU) was needed in 18 patients (52%), with three (2.6%) patients requiring assisted ventilation. Mortality of 2.6 per cent (3 patients) was observed. Interpretation & conclusions: Majority of the patients with COVID-19 infection presenting to our hospital were young and asymptomatic. Fever was noted only in three-fourth of the patients and respiratory symptoms in half of them. ...
Keywords	acute respiratory distress syndrome - comorbidities - covid-19 - hypoxia - india - pandemic - pneumonia ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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