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Article: Use of glucocorticoids and azithromycin in the therapy of COVID-19.

de Lemos Neto, Miguel / Alexandre, Rafael Costa Vieira / Morra, Rafaela Oliveira Gallart / da Paz, Juliana Aparecida Souza / Barroso, Shana Priscila Coutinho / Resende, Angela Castro / de Medeiros-Lima, Daniel J M / Alexandre, Pedro Celso Braga

Pharmacological reports : PR

2021 Volume 73, Issue 6, Page(s) 1513–1519

Abstract: In December 2019, a new variant coronavirus, SARS-CoV-2, emerged in China, which was initially described as a pneumonia of an unknown agent. The new coronavirus spreads mainly by person-to-person transmission through close contact. The pathophysiology of ...

Abstract	In December 2019, a new variant coronavirus, SARS-CoV-2, emerged in China, which was initially described as a pneumonia of an unknown agent. The new coronavirus spreads mainly by person-to-person transmission through close contact. The pathophysiology of COVID-19 is related to a complex immune system response that varies between people and, in severe cases of the disease, is characterized by excessive responses called "cytokine storms," which are associated with complications that can lead to a state of hypercoagulation and death. Glucocorticoids and azithromycin are drugs that may be effective in the treatment. This review aims to highlight the clinical findings that demonstrate the effectiveness of glucocorticoid and azithromycin therapy in the treatment of COVID-19. To date, many drugs have been studied for use in combination therapy, and the rapid expansion of knowledge about the virology of SARS-CoV-2 generates a more accurate direction in therapy.
MeSH term(s)	Azithromycin/therapeutic use ; COVID-19/drug therapy ; COVID-19/physiopathology ; Drug Combinations ; Glucocorticoids/therapeutic use ; Humans ; SARS-CoV-2
Chemical Substances	Drug Combinations ; Glucocorticoids ; Azithromycin (83905-01-5)
Language	English
Publishing date	2021-06-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2186248-5
ISSN	1734-1140
ISSN	1734-1140
DOI	10.1007/s43440-021-00286-4
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Article ; Online: Telemedicine in the National Immunization Program (Brazil): A promising tool.

Brandão, Luciana Gomes Pedro / da Costa, Marcellus Dias / Martins, Pedro Silva / de Jesus-Junior, Sergio Carlos Assis / de Aguiar, Daniele Fernandes / de Lemos, Alberto Santos / Dias, Diogo Vicente Bittencourt Sacramento / Kury, Charbell Miguel Haddad / de Oliveira, Lauro Amaral / de Almeida, Valter Montes / de Carvalho, Flavio / da Silva Santos, Ananza Tainá / Cerbino-Neto, José / Varela, Margareth Catoia

Vaccine: X

2022 Volume 11, Page(s) 100188

Abstract: The coronavirus disease 2019 pandemic abruptly changed the dynamics of basic health care, with the consequent need for adjustments in essential services. The objective of this study was to evaluate the acceptance and impact of telemedicine at a Reference ...

Abstract	The coronavirus disease 2019 pandemic abruptly changed the dynamics of basic health care, with the consequent need for adjustments in essential services. The objective of this study was to evaluate the acceptance and impact of telemedicine at a Reference Center for Special Immunobiologicals (CRIE). Methods: Patients aged 18 years or older who had a medical referral to CRIE and agreed to have a telemedicine consultation were included. After the medical appointments, participants answered a satisfaction survey. Results: From April 2021 to February 2022, 702 telemedicine consultation were conducted. Over 3,380 vaccines were prescribed via telemedicine. Of all the participants who answered the satisfaction questionnaire, 99.8% stated that they would recommend the service to other people. Conclusions: Telemedicine proved to be promising tool for healthcare at CRIE and had good acceptance by users, potentially improving access and extending the reach of the National Immunization Program.
Language	English
Publishing date	2022-06-27
Publishing country	England
Document type	Journal Article
ISSN	2590-1362
ISSN (online)	2590-1362
DOI	10.1016/j.jvacx.2022.100188
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Article ; Online: Histerocele gravídica intratorácica e hérnia diafragmática em cadela

Miguel Felix de Souza Neto / Luana Cristina Correia Gonçalves / Talisson de Jesus Costa Conceição / Beatriz Filgueira Bezerra / Sayenne Ferreira Silva / Nayara Salazar Vieira / Tamires Ferreira de Melo / Vinícius Corrêa Oliveira / Daniel Silva de Araújo / Nathália Lima Dörner / Júlia Lemos Brito / Janielson da Conceição de Moura / Karina de Souza Lobo Borralho / Pedro Agnel Dias Miranda Neto

Pubvet, Vol 15, Iss 8, Pp 1-

Relato de caso

2021 Volume 6

Abstract: No presente trabalho relata-se um caso de atendimento a animal, cadela SRD, de 3 anos e 7 meses de idade, pesando 15 Kg, com suspeita clínica de distocia fetal. Foi atendido no setor de emergência do Hospital Veterinário Universitário (HVU/UFPI), há dois ...

Abstract	No presente trabalho relata-se um caso de atendimento a animal, cadela SRD, de 3 anos e 7 meses de idade, pesando 15 Kg, com suspeita clínica de distocia fetal. Foi atendido no setor de emergência do Hospital Veterinário Universitário (HVU/UFPI), há dois dias estava em trabalho de parto, sem expulsão de nenhum produto, com secreção vaginal sanguinolenta, prostrada e sem se alimentar. Porém, antes que o exame físico se completasse a paciente apresentou uma parada cardiorrespiratória e veio a óbito. Assim, optou-se pela necropsia, que o diagnóstico post-mortem revelou hérnia diafragmática, insuficiência respiratória e septicemia. Este relato ressalta a importância de um minucioso exame clínico/físico para se estabelecer a mais correta terapêutica em animais prenhes que chegam para atendimento emergencial devido a complicações no momento do parto, e sem esquecer a importância do acompanhamento pré-natal em animais de companhia, o qual não ocorre com frequência na rotina clínica veterinária.
Keywords	cirurgia ; fetos ; gestação ; útero ; Veterinary medicine ; SF600-1100
Language	Portuguese
Publishing date	2021-08-01T00:00:00Z
Publisher	Editora MV Valero
Document type	Article ; Online
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Article ; Online: Growth and biomass production of prickly pear in the second cycle irrigated with treated domestic sewage

Manoel Simões de Azevedo Junior / Miguel Ferreira Neto / José Francismar de Medeiros / Francisco Vanies da Silva Sá / Yuri Bezerra de Lima / Marcírio de Lemos / Jorge Luís Fabrício de Queiroz / Rafael Oliveira Batista

Bioscience Journal, Vol 36, Iss

2020 Volume 1

Abstract: This study aimed to evaluate, in the second cycle, the growth and production of ‘Orelha-de-elefante ... production of ‘Orelha-de-elefante Mexicana’ prickly pear; without irrigation, its development was ... de-elefante Mexicana’ prickly pear. ...

Abstract	This study aimed to evaluate, in the second cycle, the growth and production of ‘Orelha-de-elefante Mexicana’ prickly pear (Opuntia sp.) under complementary irrigation with treated domestic sewage. The experiment was carried out in the Milagre Settlement, municipality of Apodi-RN, Brazil, from June 2016 to February 2017. Five treatments were evaluated, corresponding to four irrigation frequencies (2.3, 7.0, 14.0 and 21.0 days) to apply an effluent depth of 3.5 mm, and the control, rainfed cultivation (without irrigation). The experimental design was randomized blocks, with four replicates. After preliminary-primary treatment, the domestic sewage showed acceptable chemical and physical characteristics for fertigation under the conditions adopted in the prickly pear cultivation. 234 days after the 1st cut in the plants, the following morphometric characteristics were measured: plant height and length, width, perimeter, thickness and number of primary and secondary cladodes, and biomass accumulation. Complementary irrigation with treated domestic sewage effluent applied at intervals of 2.3, 7.0, 14.0 and 21.0 days allowed satisfactory growth and production of ‘Orelha-de-elefante Mexicana’ prickly pear; without irrigation, its development was substantially hampered during the dry period. Complementary irrigation with 3.5 mm of domestic sewage effluent applied at intervals of 2.3, 7.0 and 14.0 days led to highest growth and biomass accumulation in ‘Orelha-de-elefante Mexicana’ prickly pear.
Keywords	irrigation ; forage ; opuntia sp ; water reuse ; Agriculture ; S ; Biology (General) ; QH301-705.5
Subject code	571
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Universidade Federal de Uberlândia
Document type	Article ; Online
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Article: PSEUDARTHROSIS OF THE SCAPHOID IN IMMATURE SKELETONS.

de Lemos, Marcelo Barreto / Bentes, Ádria Simone Ferreira / Neto, Miguel Flores do Amaral / Spinelli, Leandro de Freitas / Severo, Antônio Lourenço / Lech, Osvandré

Revista brasileira de ortopedia

2015 Volume 47, Issue 3, Page(s) 292–296

Abstract: This paper presents a review of the literature on pseudarthrosis of the scaphoid in skeletally immature individuals, taking into consideration its epidemiology, diagnosis and treatment, as well as its controversies. Knowledge of this subject makes it ... ...

Abstract	This paper presents a review of the literature on pseudarthrosis of the scaphoid in skeletally immature individuals, taking into consideration its epidemiology, diagnosis and treatment, as well as its controversies. Knowledge of this subject makes it possible for patients to be given appropriate treatment immediately. Pseudarthrosis of the scaphoid in skeletally immature patients is a rare condition that results from error or lack of diagnosis of a fracture. Thus, careful clinical and radiographic examination should be performed in order to confirm or rule out this diagnosis. Several treatment methods have been reported and have shown good results. These include conservative plaster cast treatment, bone graft without osteosynthesis, bone graft with Kirschner wires, percutaneous screws and bone graft with compression screws. The treatment performed depends on the characteristics of the pseudarthrosis and the surgeon's experience.
Language	English
Publishing date	2015-12-06
Publishing country	Brazil
Document type	Journal Article
ISSN	2255-4971
ISSN	2255-4971
DOI	10.1016/S2255-4971(15)30101-4
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Article ; Online: Fatores que afetam a qualidade do pescado na pesca artesanal de municípios da costa sul de São Paulo, Brasil

Thaís Moron MACHADO / Érika Fabiane FURLAN / Cristiane Rodrigues Pinheiro NEIVA / Luiz Miguel CASARINI / Agar Costa ALEXANDRINO DE PÉREZ / Marildes Josefina LEMOS NETO / Rúbia Yuri TOMITA

Boletim do Instituto de Pesca, Vol 36, Iss

2018 Volume 3

Abstract: Pescadores artesanais dos municípios de São Vicente e Itanhaém - estado de São Paulo, Brasil, foram avaliados entre os meses de agosto de 2007 e julho de 2008, através de entrevista composta por questões objetivas e subjetivas distribuídas em módulos ...

Abstract	Pescadores artesanais dos municípios de São Vicente e Itanhaém - estado de São Paulo, Brasil, foram avaliados entre os meses de agosto de 2007 e julho de 2008, através de entrevista composta por questões objetivas e subjetivas distribuídas em módulos envolvendo fatores sanitários, sociais e econômicos. Em Itanhaém também foram realizadas visitas técnicas aos pontos de manipulação e comercialização de pescado. Os resultados indicaram falhas na utilização de práticas higiênico-sanitárias, desde a captura até a comercialização do pescado. Recomenda-se, para a inversão desse cenário, a implantação de programas de políticas públicas na pesca artesanal. Esses programas devem prever ações específicas para a melhoria da qualidade do pescado que resultem na segurança de consumo.
Keywords	boas práticas ; segurança alimentar ; capacitação ; Aquaculture. Fisheries. Angling ; SH1-691 ; Environmental sciences ; GE1-350 ; Oceanography ; GC1-1581
Language	English
Publishing date	2018-11-01T00:00:00Z
Publisher	Instituto de Pesca
Document type	Article ; Online
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Article ; Online: Sazonalidade e variabilidade espacial da qualidade da água na Lagoa do Apodi, RN Spatial variability and seasonality of the water quality in the Lagoa do Apodi Lagoon, RN, Brazil

Marcírio de Lemos / Miguel Ferreira Neto / Nildo da S. Dias

Revista Brasileira de Engenharia Agrícola e Ambiental - Agriambi, Vol 14, Iss 2, Pp 155-

2010 Volume 164

Abstract: ... urbana da cidade de Apodi e do aporte de materiais trazidos pelas águas continentais que adentram e ... eutrofizam a lagoa, em períodos extremos de temperatura e de precipitação. Amostras sistemáticas no espelho ... da lagoa foram coletadas seguindo-se seu formato ou ao longo de seu leito. A condutividade elétrica ...

Abstract	Neste trabalho se propõe avaliar a qualidade da água da Lagoa do Apodi, RN, em pontos compreendidos em todo o seu espelho, com ênfase ao monitoramento da qualidade da água sob influência da bacia urbana da cidade de Apodi e do aporte de materiais trazidos pelas águas continentais que adentram e eutrofizam a lagoa, em períodos extremos de temperatura e de precipitação. Amostras sistemáticas no espelho da lagoa foram coletadas seguindo-se seu formato ou ao longo de seu leito. A condutividade elétrica da água da Lagoa varia em todo o seu espelho, principalmente nas extremidades oeste e sudeste, aumentando após o início do período seco e diminuindo após a chegada das chuvas. Há uma grande variabilidade espacial nas características físicas e químicas, sobretudo para pH, CE, RAS e teores de Na e Cl; pode-se inferir, também, que nas águas da lagoa os íons encontrados em maiores níveis foram o cloreto e o sódio, tanto para os pontos de coleta como para a época de coleta. A variação na qualidade bacteriológica da água compromete a balneabilidade da Lagoa do Apodi, principalmente logo após o período das chuvas. The objective of this study was to evaluate the water quality of the Apodi lagoon, in the State of Rio Grande do Norte, Brazil, at points along its surface. The monitoring of the water quality is emphasized as it is under influence of the urban basin of Apodi and due to incorporation of material by the influx of continental waters that lead to eutrophization of the lagoon water in periods of extreme temperatures and precipitation. Systematic samples were collected from the lagoon water surface throughout its length. The electrical conductivity of the Apodi water varies along the surface, mainly in the west and southeast extremities. The water salinity increased with the beginning of the dry period and decreased after the rains. There is a great spatial variability in the physical and chemical characteristics, mainly for pH, CE, RAS and Na and Cl contents. In the lagoon, the most frequent ions were sodium and ...
Keywords	recursos hídricos ; salinidade ; coliformes ; water resources ; salinity ; coliforms ; Agriculture (General) ; S1-972
Language	English
Publishing date	2010-02-01T00:00:00Z
Publisher	Universidade Federal de Campina Grande
Document type	Article ; Online
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Article ; Online: Guideline of the Brazilian Society of Cardiology on Telemedicine in Cardiology - 2019.

Lopes, Marcelo Antônio Cartaxo Queiroga / Oliveira, Gláucia Maria Moraes de / Ribeiro, Antonio Luiz Pinho / Pinto, Fausto J / Rey, Helena Cramer Veiga / Zimerman, Leandro Ioschpe / Rochitte, Carlos Eduardo / Bacal, Fernando / Polanczyk, Carisi Anne / Halperin, Cidio / Araújo, Edson Correia / Mesquita, Evandro Tinoco / Arruda, José Airton / Rohde, Luis Eduardo Paim / Grinberg, Max / Moretti, Miguel / Caramori, Paulo Ricardo Avancini / Botelho, Roberto Vieira / Brandão, Andréa Araújo /

Hajjar, Ludhmila Abrahão / Santos, Alexandre Fonseca / Colafranceschi, Alexandre Siciliano / Etges, Ana Paula Beck da Silva / Marino, Bárbara Campos Abreu / Zanotto, Bruna Stella / Nascimento, Bruno Ramos / Medeiros, Cesar Rocha / Santos, Daniel Vitor de Vasconcelos / Cook, Daniela Matos Arrowsmith / Antoniolli, Eduardo / Souza Filho, Erito Marques de / Fernandes, Fábio / Gandour, Fabio / Fernandez, Francisco / Souza, Germano Emilio Conceição / Weigert, Guilherme de Souza / Castro, Iran / Cade, Jamil Ribeiro / Figueiredo Neto, José Albuquerque de / Fernandes, Juliano de Lara / Hadlich, Marcelo Souza / Oliveira, Marco Antonio Praça / Alkmim, Maria Beatriz / Paixão, Maria Cristina da / Prudente, Maurício Lopes / Aguiar Netto, Miguel A S / Marcolino, Milena Soriano / Oliveira, Monica Amorim de / Simonelli, Osvaldo / Lemos Neto, Pedro A / Rosa, Priscila Raupp da / Figueira, Renato Minelli / Cury, Roberto Caldeira / Almeida, Rodrigo Coelho / Lima, Sandra Regina Franco / Barberato, Silvio Henrique / Constancio, Thiago Inocêncio / Rezende, Wladimir Fernandes de

Arquivos brasileiros de cardiologia

2019 Volume 113, Issue 5, Page(s) 1006–1056

MeSH term(s)	Brazil ; Cardiology/standards ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/therapy ; Humans ; Societies, Medical/standards ; Telemedicine/legislation & jurisprudence ; Telemedicine/organization & administration ; Telemedicine/standards
Language	Portuguese
Publishing date	2019-12-05
Publishing country	Brazil
Document type	Journal Article ; Practice Guideline
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.5935/abc.20190205
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Article ; Online: Relaxant effects of sildenafil on the human isolated bladder neck.

Bittencourt, José Augusto F / Tano, Tania / Gajar, Sessin A / Resende, Angela C / de Lemos Neto, Miguel / Damião, Ronaldo / Criddle, David N / de Bem, Graziele Freitas / de Moura, Roberto Soares

Urology

2009 Volume 73, Issue 2, Page(s) 427–430

Abstract: Objective: To evaluate potential in vitro relaxant actions of sildenafil on human isolated bladder neck smooth muscle.: Methods: Bladder neck strips were sampled from patients (aged 55-77 years) submitted to prostatic surgery (6 adenomectomies and 1 ... ...

Abstract	Objective: To evaluate potential in vitro relaxant actions of sildenafil on human isolated bladder neck smooth muscle. Methods: Bladder neck strips were sampled from patients (aged 55-77 years) submitted to prostatic surgery (6 adenomectomies and 1 radical prostatectomy). These were carefully dissected into 1-2 x 0.5-cm pieces and suspended in an organ bath containing 30 mL of a modified Krebs Henseleit solution, bubbled with 95% O(2)/5% CO(2). After tissue stabilization and viability test with KCl, the tissue was precontracted with phenylephrine, and a concentration-response relaxant curve to sildenafil was constructed. The effect of sildenafil was also assessed in tissues treated with N(omega)-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one (ODQ) (inhibitors of nitric oxide synthase and guanylyl cyclase, respectively). Result: Sildenafil induced significant bladder neck relaxation at all concentrations tested. The maximum relaxation was 86.97% +/- 6.69%, obtained with a high concentration of sildenafil (5.1 x 10(-4) M). Both L-NAME and ODQ significantly reduced sildenafil-induced relaxation. Conclusions: Sildenafil was effective in inducing bladder neck smooth muscle relaxation in vitro. This effect was almost abolished by L-NAME and ODQ, clearly demonstrating a dependence of the nitric oxide-cyclic guanosine monophosphate pathway. Our in-vitro results suggest that sildenafil might be useful in improving lower urinary tract symptoms due to benign prostatic hyperplasia.
MeSH term(s)	Aged ; Humans ; In Vitro Techniques ; Male ; Middle Aged ; Muscle Relaxation/drug effects ; Phosphodiesterase Inhibitors/pharmacology ; Piperazines/pharmacology ; Purines/pharmacology ; Sildenafil Citrate ; Sulfones/pharmacology ; Urinary Bladder/drug effects ; Urinary Bladder/physiology
Chemical Substances	Phosphodiesterase Inhibitors ; Piperazines ; Purines ; Sulfones ; Sildenafil Citrate (BW9B0ZE037)
Language	English
Publishing date	2009-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2008.06.060
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Article ; Online: Performance of digester decant system with biological filter followed by constructed wetland and solar reactor in the treatment of domestic sewage

Delfran Batista dos Santos / Miguel Ferreira Neto / Luis César de Aquino Lemos Filho / Rafael Oliveira Batista / Paulo César Moura da Silva / Glícia Pinto Barra Reinaldo

Revista Ambiente & Água, Vol 7, Iss 2, Pp 62-

2012 Volume 74

Abstract: This study aimed to analyze the performance of digester decant system with biological filter followed by constructed wetland and solar reactor in the treatment of domestic sewage from Milagres rural community in Apodi-RN. The treatment system was ... ...

Abstract	This study aimed to analyze the performance of digester decant system with biological filter followed by constructed wetland and solar reactor in the treatment of domestic sewage from Milagres rural community in Apodi-RN. The treatment system was monitored for the period of October and November 2010, 48 days after planting Pennisetum purpureum Schumach. Samples of domestic sewage were collected at different stages of treatment, in four replications on time, to determine physicochemical and microbiological characteristics about the system performance. The results indicated significant removal of turbidity, biochemical oxygen demand, chemical oxygen demand, total solids, suspended solids, phosphorus and oil and grease using the set digester decant with biological filter, followed by constructed wetland and solar reactor; the association of average solar radiation of 28.73 MJ m-2 d-1, effluent depth of 0.10 m on reactor and time of sun exposure of 12 hours provided removal of fecal coliform up to 99.99% of domestic sewage in Apodi, RN, the treated effluent met microbiological standard of the Brazilian guidelines for agricultural use with restrictions.
Keywords	sustainability ; sanitation ; wastewater ; Environmental sciences ; GE1-350
Subject code	660
Language	English
Publishing date	2012-08-01T00:00:00Z
Publisher	Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHi)
Document type	Article ; Online
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