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  1. Article ; Online: Use of in situ simulation to evaluate the operational readiness of a high-consequence infectious disease intensive care unit.

    Fregene, T E / Nadarajah, P / Buckley, J F / Bigham, S / Nangalia, V

    Anaesthesia

    2020  Volume 75, Issue 6, Page(s) 733–738

    Abstract: On 30 January 2020, the World Health Organization (WHO) declared that the outbreak of a coronavirus disease-2019 (COVID-19) was a public health emergency of international concern. The WHO guidance states that patients with (COVID-19) should be managed by ...

    Abstract On 30 January 2020, the World Health Organization (WHO) declared that the outbreak of a coronavirus disease-2019 (COVID-19) was a public health emergency of international concern. The WHO guidance states that patients with (COVID-19) should be managed by staff wearing appropriate personal protective equipment; however, working whilst wearing personal protective equipment is unfamiliar to many healthcare professionals. We ran high-fidelity, in-situ simulation of high-risk procedures on patients with COVID-19 in a negative-pressure side room on our intensive care unit (ICU). Our aim was to identify potential problems, test the robustness of our systems and inform modification of our standard operating procedures for any patients with COVID-19 admitted to our ICU. The simulations revealed several important latent risks and allowed us to put corrective measures in place before the admission of patients with COVID-19. We recommend that staff working in clinical areas expected to receive patients with COVID-19 conduct in-situ simulation in order to detect their own unique risks and aid in the creation of local guidelines of management of patients with COVID-19.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Coronavirus Infections/transmission ; Humans ; Intensive Care Units ; Pandemics/prevention & control ; Patient Admission ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Space Simulation
    Keywords covid19
    Language English
    Publishing date 2020-03-30
    Publishing country England
    Document type Evaluation Study ; Journal Article
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.15048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Use of in situ simulation to evaluate the operational readiness of a high-consequence infectious disease intensive care unit

    Fregene, T E / Nadarajah, P / Buckley, J F / Bigham, S / Nangalia, V

    Anaesthesia

    Abstract: On 30 January 2020, the World Health Organization (WHO) declared that the outbreak of a coronavirus disease-2019 (COVID-19) was a public health emergency of international concern. The WHO guidance states that patients with (COVID-19) should be managed by ...

    Abstract On 30 January 2020, the World Health Organization (WHO) declared that the outbreak of a coronavirus disease-2019 (COVID-19) was a public health emergency of international concern. The WHO guidance states that patients with (COVID-19) should be managed by staff wearing appropriate personal protective equipment; however, working whilst wearing personal protective equipment is unfamiliar to many healthcare professionals. We ran high-fidelity, in-situ simulation of high-risk procedures on patients with COVID-19 in a negative-pressure side room on our intensive care unit (ICU). Our aim was to identify potential problems, test the robustness of our systems and inform modification of our standard operating procedures for any patients with COVID-19 admitted to our ICU. The simulations revealed several important latent risks and allowed us to put corrective measures in place before the admission of patients with COVID-19. We recommend that staff working in clinical areas expected to receive patients with COVID-19 conduct in-situ simulation in order to detect their own unique risks and aid in the creation of local guidelines of management of patients with COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #18108
    Database COVID19

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  3. Book ; Online: Characterization of desired catfish products and related challenges faced by farmer producers in Oyo, Ogun, and Delta states, Nigeria

    Komugisha, Basiita Rose / Manyise, Timothy / Mwema, Catherine / Cole, Steven M. / Oyesola, Olutokunbo / Akuwa, Elizabeth / Fregene, Bernadette / Siriwardena, Sunil / Rossignoli, Cristiano M. / Benzie, John A.H.

    2023  

    Abstract: The dataset includes transcripts of focus groups discussion conducted with catfish farmers in Oyo, Delta and Ogun State, with the project goal of characterizing catfish products desired by farmers in Nigeria in view of a catfish genetic improvement ... ...

    Abstract The dataset includes transcripts of focus groups discussion conducted with catfish farmers in Oyo, Delta and Ogun State, with the project goal of characterizing catfish products desired by farmers in Nigeria in view of a catfish genetic improvement program.
    Keywords africa ; farmers ; genetic improvement ; nigeria ; fish ; challenges ; opportunities ; characterization ; catfish ; focus group discussion ; product expectation
    Language English
    Publishing date 2023-03-09T05:37:45Z
    Publishing country fr
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Developing Cassava Mosaic Disease resistant cassava varieties in Ghana using a marker assisted selection approach

    Parkes, E. / Fregene, Martin A. / Dixon, A. / Okogbenin, Emmanuel / Boakye-Peprah, B. / Labuschagne, Maryke T.

    Euphytica

    2016  

    Abstract: Cassava is a major staple and food security crop in Africa which can produce a crop under uncertain rainfall and low fertility conditions. How- ever, it suffers from several pests and diseases, with Cassava Mosaic Disease (CMD) being the main biotic ... ...

    Abstract Cassava is a major staple and food security crop in Africa which can produce a crop under uncertain rainfall and low fertility conditions. How- ever, it suffers from several pests and diseases, with Cassava Mosaic Disease (CMD) being the main biotic constraint in production in sub-Saharan Africa. It is caused by cassava mosaic geminiviruses. Plants infected with CMD usually produce a few or no storage roots. Markers associated with resistance genes to CMD have been mapped, including a major dominant gene, CMD2 . Eight CMD resistant geno- types from CIAT were used in crosses with three cassava landraces and one IITA breeding genotype. CMD evaluation was done on the parents and 525 F 1 progenies comprising of individuals pre-selected for CMD resistance based on average severity scores of 1 and 2. Multiple marker analysis was used to screen for the CMD2 gene, where four markers associated with this gene were used. Of the tested genotypes 83 % showed at least one marker allele for the CMD2 gene. Two CIAT genotypes (CR52A-31 and AR14-10) had all four marker alleles. TMEII had three alleles associated with CMD2 while Dabodabo had one marker allele. This suggests that Dababo may have alternative genes than CMD2 for CMD resistance. The F 1 families showed segregation for the CMD2 gene. A total of 88 individuals (17 %) had all four marker alleles associated with the CMD2 gene. A total of 179 individuals had between one to three marker alleles each associated with CMD2 . A total of 91 individuals had no marker allele associated with the CMD2 geneCassava is a major staple and food security crop in Africa which can produce a crop under uncertain rainfall and low fertility conditions. How- ever, it suffers from several pests and diseases, with Cassava Mosaic Disease (CMD) being the main biotic constraint in production in sub-Saharan Africa. It is caused by cassava mosaic geminiviruses. Plants infected with CMD usually produce a few or no storage roots. Markers associated with resistance genes to CMD have been mapped, ...
    Keywords cassava ; geminiviruses ; african cassava mosaic virus
    Language English
    Publishing date 2016-05-25T11:59:34Z
    Publisher Springer
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Combining ability of cassava genotypes for cassava mosaic disease and cassava bacterial blight, yield and its related components in two ecological zones in Ghana

    Parkes, E. / Fregene, Martin A. / Dixon, A. / Boakye-Peprah, B. / Labuschagne, Maryke T.

    Euphytica

    2016  

    Abstract: Breeding for resistant genotypes is the best strategy to offset the destructive effects of cassava mosaic disease (CMD) and cassava bacterial blight (CBB). Two sets of diallel parents were selected for the forest and the savannah ecological zones in ... ...

    Abstract Breeding for resistant genotypes is the best strategy to offset the destructive effects of cassava mosaic disease (CMD) and cassava bacterial blight (CBB). Two sets of diallel parents were selected for the forest and the savannah ecological zones in Ghana based on good levels of resistance to CMD and CBB. Both sets were crossed in a half-diallel design. The first set of seven progenitors and their 21 F1 progenies were planted in a randomised complete block design (RCBD) with three replications in two different locations for two seasons in the forest ecology. The second set of five progenitors and their 10 F1 progenies were planted in a RCBD with three replications in two locations in the coastal savannah ecological zone of Ghana. Both experiments were evaluated for CMD and CBB resistance, fresh root yield, dry root yield, root number, harvest index, dry matter content, plant height at maturity and height at first branching, levels of branching and plant vigour. Results of the combined analysis of variance revealed that the environment effect was significant for all the traits. General combining ability and specific combining ability effects were significant for most of the traits. Narrow sense heritability was significant for plant vigour, root number, CMD and CBB in both the zones. CMD and root number also had a predictability ratio of close to one, indicating the importance of additive gene effects
    Keywords cassava ; diallel ; resistance ; breeding
    Language English
    Publishing date 2016-10-27T08:31:05Z
    Publisher Springer
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Diallel analysis of field resistance to brown streak disease in cassava (Manihot esculenta Crantz) landraces from Tanzania

    Kulembeka, H.P. / Ferguson, M. / Herselman, L. / Kanju, E. / Mkamilo, G.S. / Masumba, E. / Fregene, Martin A. / Labuschagne, Maryke T.

    Euphytica

    2017  

    Abstract: Cassava brown streak disease (CBSD) is an economically important virus disease causing significant losses to cassava root yield and quality in east, central and southern Africa. Breeding for resistance in cassava requires an understanding of the ... ...

    Abstract Cassava brown streak disease (CBSD) is an economically important virus disease causing significant losses to cassava root yield and quality in east, central and southern Africa. Breeding for resistance in cassava requires an understanding of the underlying genetic control of CBSD resistance. Sources of CBSD resistance are available but little is known on the value of those varieties as parents for CBSD resistance breeding. Two resistant and two susceptible varieties were crossed in a half diallel design and 35 F1 progeny from each of the six families, plus parents, were screened at two locations in a randomised complete block design with four replications in warm sub-humid environments of coastal Tanzania in 2008. Screening for CBSD field resistance was done using disease severity scoring on a scale of 1–5. Significant variations in disease severity were observed for crosses, general combining ability (GCA) and specific combining ability (SCA) at both locations. The CBSD shoot symptom severity scores ranged from 1 to 4.4 while root necrosis ranged from 1.3 to 4.5. The contribution of GCA to the total sum of squares of crosses for disease scores ranged from 86.9 to 95.2 % compared to SCA that ranged from 4.8 to 14.2 %. Additive gene effects were more important than non-additive effects indicating that CBSD resistance is genetically determined and that selection should be successful to improve resistance. Selection of parents with good GCA effects will be important for success in CBSD resistance breeding.
    Keywords root ; necrosis ; cassava ; brown ; disease ; infection ; genotypes ; horticulture ; genetics
    Language English
    Publishing date 2017-02-13T13:41:53Z
    Publisher Springer
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Audio / Video ; Online: Assessment of genetic variability of local cassava cultivars in Uganda using simple sequence repeat markers

    Kizito, E.B. / Castelblanco, W.H. / Bua, A. / Egwang, T.G. / Gullberg, U. / Fregene, Martin A.

    2015  

    Keywords manihot esculenta
    Language Spanish
    Publishing date 2015-03-13T08:30:02Z
    Publisher International Center for Tropical Agriculture
    Publishing country fr
    Document type Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: Assessment of cassava diversity in Uganda using SSR markers

    Kizito, E.B. / Castelblanco, WH / Omara, J / Bua, A. / Egwang, T.G. / Fregene, Martin A. / Gullberg, U

    2016  

    Keywords manihot esculenta ; genetic variation ; genetic markers ; variación genética ; marcadores genéticos
    Language English
    Publishing date 2016-02-29T17:14:40Z
    Publisher International Center for Tropical Agriculture
    Publishing country fr
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Audio / Video ; Online: Progress in determining the genetic basis and genetic linkage mapping of cassava brown streak disease tolerance in Tanzania

    Kulembeka, H.P. / Ferguson, Morag E. / Kanju, E.E. / Labuschagne, Maryke T. / Herselman, L. / Mkamilo, G.S. / Fregene, Martin A.

    2015  

    Language English
    Publishing date 2015-03-13T08:30:16Z
    Publisher International Center for Tropical Agriculture
    Publishing country fr
    Document type Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The effect of cassava mosaic disease on the genetic diversity of cassava in Uganda

    Kizito, E.B. / Bua, A. / Fregene, Martin A. / Egwang, T.G. / Gullberg, U

    Euphytica

    2014  

    Abstract: Cassava (Manihot esculenta) is a tropical crop that is grown in Africa, Latin America and Southeast Asia. Cassava was introduced from Latin America into West and East Africa at two independent events. In Uganda a serious threat to cassava's survival is ... ...

    Abstract Cassava (Manihot esculenta) is a tropical crop that is grown in Africa, Latin America and Southeast Asia. Cassava was introduced from Latin America into West and East Africa at two independent events. In Uganda a serious threat to cassava's survival is the cassava mosaic disease (CMD). Uganda has had two notable CMD epidemics since the introduction of cassava in the 1850s causing severe losses. SSR markers were used to study the effect of CMD on the genetic diversity in five agroecologies in Uganda with high and low incidence of CMD. Surprisingly, high gene diversity was detected. Most of the diversity was found within populations, while the diversity was very small among agroecological zones and the high and low CMD incidence areas. The high genetic diversity suggests a mechanism by which diversity is maintained by the active involvement of the Ugandan farmer in continuously testing and adopting new genotypes that will serve their diverse needs. However, in spite of the high genetic diversity we found a loss of rare alleles in areas with high CMD incidence. To study the effect of the introgression history on the gene pool the genetic differentiation between East and West Africa was also studied. Genetic similarities were found between the varieties in Uganda and Tanzania in East Africa and Ghana in West Africa. Thus, there is no evidence for a differentiation of the cassava gene pool into a western and an eastern genetic lineage. However, a possible difference in the genetic constitution of the introduced cassava into East and West Africa may have been diminished by germplasm movement.
    Keywords manihot esculenta ; genetic variation ; african cassava mosaic virus ; genetic markers ; variación genética ; virus del mosaico de la yuca ; marcadores genéticos
    Language English
    Publishing date 2014-10-02T08:33:21Z
    Publisher Springer
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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