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  1. Article ; Online: QRS morphology in lead V

    Briceño, David F / Santangeli, Pasquale / Frankel, David S / Liang, Jackson J / Shirai, Yasuhiro / Markman, Timothy / Enriquez, Andres / Walsh, Katie / Riley, Michael P / Nazarian, Saman / Lin, David / Kumareswaran, Ramanan / Arkles, Jeffrey S / Hyman, Matthew C / Deo, Rajat / Supple, Gregory E / Garcia, Fermin C / Dixit, Sanjay / Epstein, Andrew E /
    Callans, David J / Marchlinski, Francis E / Schaller, Robert D

    Heart rhythm

    2020  Volume 17, Issue 10, Page(s) 1711–1718

    Abstract: ... criteria for accurate localization of LV PAP VAs using lead V: Methods: Consecutive patients undergoing ... were reviewed (study group). The QRS morphology in lead V: Results: One hundred eleven patients ... 12), and apex (5). PAP VAs showed 3 distinct QRS morphologies in lead V: Conclusion: VAs ...

    Abstract Background: Twelve-lead electrocardiogram (ECG) criteria have been developed to identify idiopathic ventricular arrhythmias (VAs) from the left ventricular (LV) papillary muscles (PAPs), but accurate localization remains a challenge.
    Objective: The purpose of this study was to develop ECG criteria for accurate localization of LV PAP VAs using lead V
    Methods: Consecutive patients undergoing mapping and ablation of VAs from the LV PAPs guided by intracardiac echocardiography from 2007 to 2018 were reviewed (study group). The QRS morphology in lead V
    Results: One hundred eleven patients with LV PAP VAs (mean age 54 ± 16 years; 65% men) were identified, including 64 (55%) from the posteromedial PAP and 47 (42%) from the anterolateral PAP. The reference group included patients with VAs from the following LV locations: fascicles (n = 21), outflow tract (n = 36), ostium (n = 37), inferobasal segment (n = 12), and apex (5). PAP VAs showed 3 distinct QRS morphologies in lead V
    Conclusion: VAs originating from the LV PAPs manifest unique QRS morphologies in lead V
    MeSH term(s) Arrhythmias, Cardiac/physiopathology ; Arrhythmias, Cardiac/surgery ; Catheter Ablation/methods ; Electrocardiography ; Female ; Follow-Up Studies ; Heart Ventricles/physiopathology ; Humans ; Male ; Middle Aged ; Papillary Muscles/physiopathology ; Predictive Value of Tests ; Retrospective Studies
    Language English
    Publishing date 2020-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2020.05.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6278: Show issues Location:
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  2. Book: Rheumatic and musculoskeltal problems and conditions in children

    Ramanan, Athimalaipet V.

    (Best practice & research. Clinical rheumatology ; volume 31, number 4 (August 2017))

    2017  

    Title variant Rheumatic and musculoskeletal problems and conditions in children
    Author's details Athimalaipet V. Ramanan, Michael W. Beresford, guest editors
    Series title Best practice & research. Clinical rheumatology ; volume 31, number 4 (August 2017)
    Best practice & research
    Collection Best practice & research
    Language English
    Size Seite 440-609, Illustrationen
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    Note Der Haupttitel sollte lauten: Rheumatic and musculoskeletal problems and conditions in children
    HBZ-ID HT019722711
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Secukinumab for children and adolescents with enthesitis-related arthritis and psoriatic arthritis:

    Bagri, Narendra Kumar / King, Hayley / Ramanan, A V

    Expert review of clinical immunology

    2024  Volume 20, Issue 5, Page(s) 435–440

    Abstract: Introduction: Targeting IL-17A using Secukinumab, a humanized monoclonal immunoglobulin G1 (IgG1)/κ against IL-17A is a therapeutic option for immune-mediated disorders such as psoriasis and ankylosing spondylitis. The US Food and Drug Administration ... ...

    Abstract Introduction: Targeting IL-17A using Secukinumab, a humanized monoclonal immunoglobulin G1 (IgG1)/κ against IL-17A is a therapeutic option for immune-mediated disorders such as psoriasis and ankylosing spondylitis. The US Food and Drug Administration and the European Medicines Agency have approved it for the treatment of moderate to severe plaque psoriasis, active psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondylarthritis. Recently it has also been approved for use in children with severe plaque psoriasis, active psoriatic arthritis, and enthesitis-related arthritis.
    Areas covered: This review focuses on the role of Secukinumab in the management of children and adolescents with enthesitis-related arthritis and psoriatic arthritis. We discuss the salient findings of pivotal RCTs and other studies supporting the use of Secukinumab in adults and children, in particular, focusing on its safety and efficacy.
    Expert opinion: Secukinumab is a therapeutic target for psoriasis, psoriatic arthritis, and spondyloarthropathies in both adults and children. No major safety signals are observed with its use in short-term follow-up. Thus far, Secukinumab has not been found to significantly increase the risk of tuberculosis (TB).
    MeSH term(s) Adult ; Child ; Adolescent ; Humans ; Arthritis, Psoriatic/drug therapy ; Interleukin-17/therapeutic use ; Spondylitis, Ankylosing/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Psoriasis/drug therapy ; Arthritis, Juvenile/drug therapy ; Antibodies, Monoclonal, Humanized
    Chemical Substances secukinumab (DLG4EML025) ; Interleukin-17 ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2024.2303340
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  4. Article ; Online: Dr Yellapragada SubbaRow: the forgotten figure in the history of methotrexate.

    Bagri, Narendra K / Ramanan, Atreya / Ramanan, Athimalaipet V

    Rheumatology (Oxford, England)

    2022  Volume 62, Issue 4, Page(s) 1364–1365

    MeSH term(s) Humans ; History, 20th Century ; Methotrexate/therapeutic use
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pediatric COVID-19 and MIS-C - Lessons Learnt and the Way Forward.

    Balasubramanian, S / Venkataraman, Aishwarya / Ramanan, A V

    Indian pediatrics

    2023  Volume 60, Issue 5, Page(s) 347–349

    MeSH term(s) Humans ; Child ; COVID-19
    Language English
    Publishing date 2023-05-10
    Publishing country India
    Document type Journal Article ; Comment
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Thinking beyond intravenous immunoglobulin for Kawasaki disease.

    Sage, Anne / Jindal, Ankur Kumar / Ramanan, Athimalaipet V

    Archives of disease in childhood

    2023  Volume 108, Issue 10, Page(s) 781–782

    MeSH term(s) Humans ; Infant ; Immunoglobulins, Intravenous/therapeutic use ; Mucocutaneous Lymph Node Syndrome/drug therapy
    Chemical Substances Immunoglobulins, Intravenous
    Language English
    Publishing date 2023-08-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2023-325843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immunoglobulin, glucocorticoid, or combined therapy for multisystem inflammatory syndrome in children.

    Chew, Christine / Ramanan, Athimalaipet V

    The Lancet. Rheumatology

    2023  Volume 5, Issue 4, Page(s) e168–e169

    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(23)00035-8
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  8. Article ; Online: Scope of JAK Inhibitors in Children: Recent Evidence and Way Forward.

    Bagri, Narendra Kumar / Chew, Christine / Ramanan, A V

    Paediatric drugs

    2023  Volume 25, Issue 6, Page(s) 635–647

    Abstract: Over the last decade, there has been an increase in the use of targeted therapy using small molecules such as Janus kinase (JAK) inhibitors. Since the introduction of ruxolitinib, the first non-selective JAK inhibitor approved for use in myelofibrosis, ... ...

    Abstract Over the last decade, there has been an increase in the use of targeted therapy using small molecules such as Janus kinase (JAK) inhibitors. Since the introduction of ruxolitinib, the first non-selective JAK inhibitor approved for use in myelofibrosis, many other JAK inhibitors have been tried in a wide spectrum of immune-mediated disorders. Although various trials have shown the promising efficacy of JAK inhibitors in immune-mediated inflammatory disorders (IMIDs), there is a growing concern over the major cardiovascular events and malignancies associated with the use of these molecules in older adults, particularly those over 65 years of age. In this review, we aim to discuss the immunology of the JAK-STAT pathway, the scope of use of JAK inhibitors, and their safety in paediatric practice. Here, we discuss high-quality evidence favouring the use of JAK inhibitors in children with juvenile idiopathic arthritis (JIA) who are refractory to one or more conventional/biological disease-modifying drugs, demonstrated in two randomised controlled trials (RCTs). In addition to JIA, there are reports favouring the role of JAK inhibitors in other IMIDs such as systemic-onset JIA and interferonopathies. Thus far, the existing literature suggests an acceptable safety profile for JAK inhibitors in children. With the expanding scope of JAK inhibitors in a wide range of IMIDs in children, there is a significant need for long-term close vigilance for any potential harm.
    MeSH term(s) Child ; Humans ; Aged ; Janus Kinase Inhibitors/adverse effects ; Immunomodulating Agents ; Neoplasms/drug therapy
    Chemical Substances Janus Kinase Inhibitors ; Immunomodulating Agents
    Language English
    Publishing date 2023-09-29
    Publishing country Switzerland
    Document type Review ; Journal Article
    ZDB-ID 1492748-2
    ISSN 1179-2019 ; 1174-5878
    ISSN (online) 1179-2019
    ISSN 1174-5878
    DOI 10.1007/s40272-023-00594-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5205: Show issues Location:
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  9. Article ; Online: Hiding in plain sight: how the COVID-19 pandemic unmasked the autoinflammatory PFAPA syndrome lurking in our midst.

    Sinnappurajar, Praisoody / Ramanan, Athimalaipet V / Goenka, Anu

    Archives of disease in childhood

    2022  Volume 108, Issue 7, Page(s) 543–544

    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Syndrome ; Fever/epidemiology ; Pharyngitis/epidemiology
    Language English
    Publishing date 2022-07-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2021-323708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Advancing Transition in Resource-Constrained Settings.

    Sinnappurajar, Praisoody / Ramanan, Athimalaipet V

    Indian journal of pediatrics

    2022  Volume 90, Issue 1, Page(s) 7–8

    MeSH term(s) Humans ; Health Services Accessibility
    Language English
    Publishing date 2022-10-06
    Publishing country India
    Document type Editorial ; Comment
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-022-04362-2
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