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  1. Article ; Online: Web Exclusive. Annals On Call - Procalcitonin in the Diagnosis of Bacterial Infection.

    Centor, Robert M / Gilbert, David N

    Annals of internal medicine

    2022  Volume 175, Issue 3, Page(s) OC1

    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/A21-0006
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  2. Article ; Online: Neglected Variables in the Interpretation of Serum Procalcitonin Levels in Patients With Septic Shock.

    Gilbert, David N

    The Journal of infectious diseases

    2020  Volume 222, Issue Suppl 2, Page(s) S96–S102

    Abstract: The interpretation of serum procalcitonin (PCT) levels in septic patients is facilitated by reviewing the known stimuli that activate the PCT family of genes. Herein we describe 7 pathways that, alone or in combination, can increase serum PCT levels. As ... ...

    Abstract The interpretation of serum procalcitonin (PCT) levels in septic patients is facilitated by reviewing the known stimuli that activate the PCT family of genes. Herein we describe 7 pathways that, alone or in combination, can increase serum PCT levels. As a marker of activation of innate immunity, high PCT levels affect clinical diagnosis, can be trended as a measure of "source" control, and can guide duration of antibacterial therapy in septic patients. Low PCT levels reflect little to no activation of an innate immune response, influence the differential diagnosis, and support the discontinuation of empiric antibiotic therapy. Understanding the pathways that result in elevated serum PCT levels is necessary for interpretation and subsequent clinical management.
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Biomarkers ; Diagnosis, Differential ; Humans ; Procalcitonin/blood ; Procalcitonin/immunology ; Shock, Septic/diagnosis ; Shock, Septic/drug therapy ; Shock, Septic/immunology
    Chemical Substances Anti-Bacterial Agents ; Biomarkers ; Procalcitonin
    Language English
    Publishing date 2020-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiaa204
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  3. Article ; Online: Nebulized Antibiotics for Multidrug-Resistant Ventilator-Associated Pseudomonas aeruginosa Pneumonia.

    Gilbert, David N

    Critical care medicine

    2019  Volume 47, Issue 6, Page(s) 880–881

    MeSH term(s) Amikacin ; Anti-Bacterial Agents ; Fosfomycin ; Humans ; Pneumonia, Ventilator-Associated ; Pseudomonas Infections ; Pseudomonas aeruginosa
    Chemical Substances Anti-Bacterial Agents ; Fosfomycin (2N81MY12TE) ; Amikacin (84319SGC3C)
    Language English
    Publishing date 2019-05-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000003751
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  4. Book ; Conference proceedings: Workshop on Molecular Diagnostics for Respiratory Tract Infections

    Gilbert, David N. / Bartlett, John G.

    12 - 13 November 2009

    (Clinical infectious diseases ; 52, Suppl. 4)

    2011  

    Event/congress Workshop on Molecular Diagnostics for Respiratory Tract Infections (2009)
    Author's details guest ed.: David N. Gilbert ; John G. Bartlett
    Series title Clinical infectious diseases ; 52, Suppl. 4
    Collection
    Language English
    Size S. S277 - S395
    Publisher Oxford Univ. Press
    Publishing place Cary, NC
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016877812
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1505 -52,Suppl.4- not available for loan Zeitschriften-Lesesaal

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  5. Article ; Online: Role of Procalcitonin in the Management of Infected Patients in the Intensive Care Unit.

    Gilbert, David N

    Infectious disease clinics of North America

    2017  Volume 31, Issue 3, Page(s) 435–453

    Abstract: The combination of molecular pathogen diagnostics and the biomarker procalcitonin (PCT) are changing the use of antimicrobials in patients admitted to critical care units with severe community-acquired pneumonia, possible septic shock, or other clinical ... ...

    Abstract The combination of molecular pathogen diagnostics and the biomarker procalcitonin (PCT) are changing the use of antimicrobials in patients admitted to critical care units with severe community-acquired pneumonia, possible septic shock, or other clinical syndromes. An elevated serum PCT level is good supportive evidence of a bacterial pneumonia, whereas a low serum PCT level virtually eliminates an etiologic role for bacteria even if the culture for a potential bacterial pathogen is positive. Serum PCT levels can be increased in any shocklike state; a low PCT level eliminates invasive bacterial infection as an etiology in more than 90% of patients.
    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1077676-x
    ISSN 1557-9824 ; 0891-5520
    ISSN (online) 1557-9824
    ISSN 0891-5520
    DOI 10.1016/j.idc.2017.05.003
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  6. Book: The potential etiologic role of Chlamydia pneumoniae in atherosclerosis

    Gilbert, David N.

    a multidisciplinary meeting to promote collaborative research ; Seattle, Washington, 22 - 25 September 1999

    (The journal of infectious diseases ; 181, Suppl. 3)

    2000  

    Institution Infectious Diseases Society of America
    Author's details organized by the Infectious Diseases Society of America. Guest ed.: David N. Gilbert
    Series title The journal of infectious diseases ; 181, Suppl. 3
    Collection
    Language English
    Size S. S393 - S586 : Ill., graph. Darst.
    Publisher Univ. of Chicago Press
    Publishing place Chicago, Ill
    Publishing country United States
    Document type Book
    HBZ-ID HT012775141
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Uh II Zs 50 -181,Suppl.3- verfügbar in Königswinter Königswinter

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  7. Article ; Online: Where Do We Go From Here?

    Gilbert, David N

    The Journal of infectious diseases

    2015  Volume 212, Issue 11, Page(s) 1687–1689

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Biomarkers/blood ; Calcitonin/blood ; Female ; Humans ; Male ; Protein Precursors/blood ; Respiratory Tract Infections ; Virus Diseases
    Chemical Substances Anti-Bacterial Agents ; Biomarkers ; Protein Precursors ; Calcitonin (9007-12-9)
    Language English
    Publishing date 2015-12-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiv253
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  8. Article ; Online: Emergence of replication timing during early mammalian development.

    Nakatani, Tsunetoshi / Schauer, Tamas / Altamirano-Pacheco, Luis / Klein, Kyle N / Ettinger, Andreas / Pal, Mrinmoy / Gilbert, David M / Torres-Padilla, Maria-Elena

    Nature

    2023  Volume 625, Issue 7994, Page(s) 401–409

    Abstract: DNA replication enables genetic inheritance across the kingdoms of life. Replication occurs with a defined temporal order known as the replication timing (RT) programme, leading to organization of the genome into early- or late-replicating regions. RT is ...

    Abstract DNA replication enables genetic inheritance across the kingdoms of life. Replication occurs with a defined temporal order known as the replication timing (RT) programme, leading to organization of the genome into early- or late-replicating regions. RT is cell-type specific, is tightly linked to the three-dimensional nuclear organization of the genome
    MeSH term(s) Animals ; Mice ; Blastocyst/cytology ; Blastocyst/metabolism ; Chromatin/genetics ; DNA Replication Timing ; Epigenome/genetics ; Genome/genetics ; RNA Polymerase II/metabolism ; Zygote/cytology ; Zygote/growth & development ; Zygote/metabolism ; Embryo, Mammalian/cytology ; Embryo, Mammalian/embryology ; Embryo, Mammalian/metabolism
    Chemical Substances Chromatin ; RNA Polymerase II (EC 2.7.7.-)
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06872-1
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  9. Article: Influence of an infectious diseases specialist on ICU multidisciplinary rounds.

    Gilbert, David N

    Critical care research and practice

    2014  Volume 2014, Page(s) 307817

    Abstract: Objective. To ascertain the influence of a physician infectious diseases specialist (IDS) on antibiotic use in a medical/surgical intensive care unit. Method. Over a 5-month period, the antibiotic regimens ordered by the ICU multidisciplinary team were ... ...

    Abstract Objective. To ascertain the influence of a physician infectious diseases specialist (IDS) on antibiotic use in a medical/surgical intensive care unit. Method. Over a 5-month period, the antibiotic regimens ordered by the ICU multidisciplinary team were studied. The days of antibiotic therapy (DOT) when management decisions included an IDS were compared to DOT in the absence of an IDS. The associated treatment expense was calculated. Results. Prior to multidisciplinary rounds (MDRs), 79-80% of the patients were receiving one or more antibiotic. IDS participation occurred in 61 multidisciplinary rounding sessions. There were 384 patients who before MDRs had orders for 669 days of antimicrobial therapy (DOT). After MDRs, the antimicrobial DOT were reduced to 511 with a concomitant cost saving of $3772. There were 51 MDR sessions that occurred in the absence of the IDS. There were 352 patients who before MDRs had orders for 593 DOT. After MDRs, the DOT were reduced to 572 with a cost savings of $727. The results were normalized by number of patients evaluated with statistically greater reductions when MDRs included the IDS. In addition, the number of rounding sessions with a reduction in DOT was greater with the participation of the IDS. Conclusion. The addition of an IDS to multidisciplinary ICU patient rounds resulted in a reduction in antibiotic DOT and attendant drug expense.
    Language English
    Publishing date 2014-04-17
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2573849-5
    ISSN 2090-1313 ; 2090-1305
    ISSN (online) 2090-1313
    ISSN 2090-1305
    DOI 10.1155/2014/307817
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  10. Article ; Online: Application of the SLAPNAP statistical learning tool to broadly neutralizing antibody HIV prevention research.

    Williamson, Brian D / Magaret, Craig A / Karuna, Shelly / Carpp, Lindsay N / Gelderblom, Huub C / Huang, Yunda / Benkeser, David / Gilbert, Peter B

    iScience

    2023  Volume 26, Issue 9, Page(s) 107595

    Abstract: Combination monoclonal broadly neutralizing antibody (bnAb) regimens are in clinical development for HIV prevention, necessitating additional knowledge of bnAb neutralization potency/breadth against circulating viruses. Williamson et al. (2021) described ...

    Abstract Combination monoclonal broadly neutralizing antibody (bnAb) regimens are in clinical development for HIV prevention, necessitating additional knowledge of bnAb neutralization potency/breadth against circulating viruses. Williamson et al. (2021) described a software tool, Super LeArner Prediction of NAb Panels (SLAPNAP), with application to any HIV bnAb regimen with sufficient neutralization data against a set of viruses in the Los Alamos National Laboratory's Compile, Neutralize, and Tally Nab Panels repository. SLAPNAP produces a proteomic antibody resistance (PAR) score for Env sequences based on predicted neutralization resistance and estimates variable importance of Env amino acid features. We apply SLAPNAP to compare HIV bnAb regimens undergoing clinical testing, finding improved power for downstream sieve analyses and increased precision for comparing neutralization potency/breadth of bnAb regimens due to the inclusion of PAR scores of Env sequences with much larger sample sizes available than for neutralization outcomes. SLAPNAP substantially improves bnAb regimen characterization, ranking, and down-selection.
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107595
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