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Article ; Online: Crystal storing histiocytosis forming a mass lesion in temporal lobe.

Özşen, Mine / Tolunay, Şahsine / Kocaeli, Hasan / Parlak, Müfit

Indian journal of pathology & microbiology

2023 Volume 66, Issue 3, Page(s) 655–658

Abstract: Crystal storing histiocytosis is a disorder characterized by local or diffuse infiltration of histiocytes containing crystalline inclusions. This entity has been reported in several organs, however the involvement of the central nervous system (CNS) is ... ...

Abstract	Crystal storing histiocytosis is a disorder characterized by local or diffuse infiltration of histiocytes containing crystalline inclusions. This entity has been reported in several organs, however the involvement of the central nervous system (CNS) is extremely rare and to date only 7 cases of crystal storing histiocytosis (CSH) of CNS have been reported in the English literature. More than 90% patients with CSH had an underlying lymphoproliferative or plasma cell disorders, especially multiple myeloma, lymphoplasmacytic lymphoma or monoclonal gammopathy. Radiologically and intraoperatively, CSH may mimic an infectious process or neoplasm, hence its histopathological confirmation is important to facilitate appropriate treatment. In this report, we describe an additional case of crystal storing histiocytosis in a 48 year old female who presented with a mass lesion in the right temporal lobe of the cerebrum.
MeSH term(s)	Female ; Humans ; Middle Aged ; Histiocytosis/diagnosis ; Histiocytosis/pathology ; Multiple Myeloma ; Paraproteinemias ; Monoclonal Gammopathy of Undetermined Significance ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/pathology
Language	English
Publishing date	2023-08-24
Publishing country	India
Document type	Case Reports
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/ijpm.ijpm_373_21
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Article ; Online: Targeting Mfsd2a in hemorrhagic cerebrovascular diseases.

Eser, Pinar / Taskapilioglu, Mevlut Ozgur / Kocaeli, Hasan

Translational stroke research

2022 Volume 13, Issue 6, Page(s) 861–862

MeSH term(s)	Humans ; Membrane Transport Proteins ; Cerebrovascular Disorders/therapy ; Symporters
Chemical Substances	Membrane Transport Proteins ; MFSD2A protein, human ; Symporters
Language	English
Publishing date	2022-03-29
Publishing country	United States
Document type	Letter
ZDB-ID	2541897-X
ISSN	1868-601X ; 1868-4483
ISSN (online)	1868-601X
ISSN	1868-4483
DOI	10.1007/s12975-022-01015-6
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Article ; Online: Variations of perforating arteries of anterior communicating artery in cases with anterior communicating artery aneurysms: a cadaveric anatomical study.

Kuytu, Turgut / Kocaeli, Hasan / Korfali, Ender

Acta neurochirurgica

2022 Volume 164, Issue 8, Page(s) 2127–2139

Abstract: Purpose: In terms of postoperative morbidity and mortality, preservation of the perforating arteries branching from the anterior communicating artery (ACoA) during clipping is particularly imperative in patients with ACoA aneurysm. In the present study, ...

Abstract	Purpose: In terms of postoperative morbidity and mortality, preservation of the perforating arteries branching from the anterior communicating artery (ACoA) during clipping is particularly imperative in patients with ACoA aneurysm. In the present study, we aimed to investigate whether perforating arteries originated from ACoA were pushed away in a different location in patients with ACoA aneurysm. Furthermore, if they did so, we aimed to identify the direction in which they were dislocated and how the perforating arteries could be preserved during clipping. Methods: Herein, we categorized 40 brains obtained from cadavers into two groups. The first (n = 26) and second (n = 14) groups included cases without and with ACoA aneurysms, respectively. After completing the preparation procedure, the brains were dissected using surgical microscope and the relevant anatomical region was examined and photographed. Finally, statistical analyses were performed on the data and the results were documented. Results: In the aneurysms with posterior and superior projections, the perforators appeared to be pushed away inferiorly and were frequently noted at the anteroinferior part of the aneurysm neck. Most of the cases, where one of the A1s was larger at one side, the perforating arteries arose from the larger A1 side. Conclusion: The mortality and morbidity associated with damage to the perforators can be reduced by approaching the patient from the dominant A1 side and pursuing the perforators primarily at the anteroinferior part of the aneurysm neck in the aneurysms with superior and posterior projections.
MeSH term(s)	Adult ; Anterior Cerebral Artery/surgery ; Arteries ; Cadaver ; Child ; Circle of Willis/diagnostic imaging ; Circle of Willis/surgery ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery
Language	English
Publishing date	2022-05-26
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-022-05253-3
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Article ; Online: Microsurgical Clipping of Giant P3 Segment Posterior Cerebral Artery Aneurysm: 2-Dimensional Operative Video.

Eser Ocak, Pinar / Kocaeli, Hasan

World neurosurgery

2020 Volume 139, Page(s) 148

Abstract: Posterior cerebral artery (PCA) aneurysms comprise <2% of all intracranial aneurysms and are usually located on the P1 and P2 segments. Aneurysms of the P3 segment of the PCA are even rarer, and despite their proximity to the cerebral aqueduct, ... ...

Abstract	Posterior cerebral artery (PCA) aneurysms comprise <2% of all intracranial aneurysms and are usually located on the P1 and P2 segments. Aneurysms of the P3 segment of the PCA are even rarer, and despite their proximity to the cerebral aqueduct, presentation with hydrocephalus is exceptional. This video demonstrates the case of a 28-year-old female patient who presented acute hydrocephalus due to a partially thrombosed, giant P3 segment PCA aneurysm. The patient was operated on in the semisitting position, and a right frontal ventricular drain was placed for brain relaxation. A U-shaped skin incision was made, and a left-sided, 6 cm × 6 cm parietooccipital craniotomy crossing the midline was performed. An interhemispheric approach was used to reach the aneurysm. The aneurysm was trapped via temporary clipping of the inflow and outflow arteries, thrombectomized, and then clipped using a right-angled fenestrated aneurysm clip. Postoperative computed tomography and magnetic resonance imaging revealed resolution of the hydrocephalus, and cerebral angiography confirmed total exclusion of the aneurysm from the circulation and occlusion of the P4 segment of the PCA, which was considered embolic. The patient made an excellent recovery, and she was discharged on postoperative day 3 (Video 1). This case demonstrates the efficacy of microsurgical clipping for a giant thrombotic P3 segment PCA aneurysm that caused a mass effect. Surgery excluded the aneurysm from the circulation and decompressed the cerebral aqueduct, obviating the need for a permanent ventriculoperitoneal shunt.
MeSH term(s)	Adult ; Female ; Humans ; Hydrocephalus/etiology ; Hydrocephalus/surgery ; Intracranial Aneurysm/complications ; Intracranial Aneurysm/surgery ; Intracranial Thrombosis/complications ; Intracranial Thrombosis/surgery ; Magnetic Resonance Imaging ; Microsurgery/methods ; Neurosurgical Procedures/methods ; Posterior Cerebral Artery/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-04-18
Publishing country	United States
Document type	Case Reports ; Video-Audio Media
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2020.04.035
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Article ; Online: Investigation of topographical anatomy of Broca's area: an anatomic cadaveric study.

Eser Ocak, Pınar / Kocaelı, Hasan

Surgical and radiologic anatomy : SRA

2017 Volume 39, Issue 4, Page(s) 357–365

Abstract: Purpose: The sulci constituting the structure of the pars triangularis and opercularis, considered as 'Broca's area', present wide anatomical and morphological variations between different hemispheres. The boundaries are described differently from one ... ...

Abstract	Purpose: The sulci constituting the structure of the pars triangularis and opercularis, considered as 'Broca's area', present wide anatomical and morphological variations between different hemispheres. The boundaries are described differently from one another in various studies. The aim of this study was to explore the topographical anatomy, confirm the morphological asymmetry and highlight anatomical variations in Broca's area. Methods: This study was performed with 100 hemispheres to investigate the presence, continuity, patterns and connections of the sulcal structures that constitute the morphological asymmetry of Broca's area. Results: Considerable individual anatomical and morphological variations between the inferior frontal gyrus and related sulcal structures were detected. Rare bilateralism findings supported the morphological asymmetry. The inferior frontal sulcus was identified as a single segment in 54 % of the right and two separate segments in 52 % of the left hemispheres, which was the most common pattern. The diagonal sulcus was present in 48 % of the right and 54 % of the left hemispheres. It was most frequently connected to the ascending ramus on both sides. A 'V' shape was observed in 42.5 % of the right hemispheres and a 'Y' shape in 38.3 % of the left hemispheres, which was the most common shape of the pars triangularis. Moreover, the full results are specified in detail. Conclusions: Knowledge of the anatomical variations in this region is indispensable for understanding the functional structure and performing safe surgery. However, most previously published studies have aimed to determine the anatomical asymmetry of the motor speech area without illuminating the topographical anatomy encountered during surgery.
MeSH term(s)	Adult ; Aged ; Anatomic Variation ; Broca Area/anatomy & histology ; Cadaver ; Female ; Humans ; Male ; Middle Aged ; Young Adult
Language	English
Publishing date	2017-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	632839-8
ISSN	1279-8517 ; 0930-312X ; 0930-1038
ISSN (online)	1279-8517
ISSN	0930-312X ; 0930-1038
DOI	10.1007/s00276-016-1748-0
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Article: Olea europaea

Ercelik, Melis / Tekin, Cagla / Tezcan, Gulcin / Ak Aksoy, Secil / Bekar, Ahmet / Kocaeli, Hasan / Taskapilioglu, Mevlut Ozgur / Eser, Pınar / Tunca, Berrin

Life (Basel, Switzerland)

2023 Volume 13, Issue 2

Abstract: The effects ... ...

Abstract	The effects of
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13020470
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Article ; Online: Diabetes Mellitus-Mediated MALAT1 Expression Induces Glioblastoma Aggressiveness.

Kocaeli, Aysen Akkurt / Aksoy, Secil Ak / Ercelik, Melis / Tezcan, Gulcin / Tekin, Cagla / Kocaeli, Hasan / Bekar, Ahmet / Taskapilioglu, Mevlut Ozgur / Tolunay, Sahsine / Tunca, Berrin

Turkish neurosurgery

2023 Volume 33, Issue 5, Page(s) 821–827

Abstract: Aim: To describe the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in glioblastoma (GB) progression in patients concurrently diagnosed with diabetes mellitus (DM).: Material and methods: Formalin-fixed paraffin-embedded ( ... ...

Abstract	Aim: To describe the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in glioblastoma (GB) progression in patients concurrently diagnosed with diabetes mellitus (DM). Material and methods: Formalin-fixed paraffin-embedded (FFPE) tumor samples of 47 patients diagnosed with GB only and 13 patients diagnosed with GB and DM (GB-DM) were enrolled in this study. Data for p53 and Ki67 immunohistochemical staining of the tumors and blood HbA1c levels of patients with DM were retrospectively collected. MALAT1 expression was assessed using quantitative real-time polymerase chain reaction. Results: The coexistence of GB and DM induced the nuclear expression of p53 and Ki67 compared with GB only. MALAT1 expression was higher in GB-DM tumors than in GB only tumors. The expression of MALAT1 and HbA1c levels were positively correlated. Additionally, MALAT1 was positively correlated with tumoral p53 and Ki67. The disease-free survival of patients with GB-DM with high MALAT1 expression was shorter than that of those diagnosed with GB only and with a lower MALAT1 expression. Conclusion: Our findings suggest that one of the mechanisms of the facilitating effect of DM on GB tumor aggressiveness is via MALAT1 expression.
MeSH term(s)	Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Glioblastoma ; Glycated Hemoglobin ; Ki-67 Antigen ; Retrospective Studies ; Tumor Suppressor Protein p53 ; Diabetes Mellitus
Chemical Substances	RNA, Long Noncoding ; Glycated Hemoglobin ; Ki-67 Antigen ; Tumor Suppressor Protein p53
Language	English
Publishing date	2023-05-12
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1203779-5
ISSN	2651-5032 ; 1019-5149
ISSN (online)	2651-5032
ISSN	1019-5149
DOI	10.5137/1019-5149.JTN.41845-22.2
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Article ; Online: Co-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release.

Ercelik, Melis / Tekin, Cagla / Parin, Fatma Nur / Mutlu, Busra / Dogan, Hazal Yilmaz / Tezcan, Gulcin / Aksoy, Secil Ak / Gurbuz, Melisa / Yildirim, Kenan / Bekar, Ahmet / Kocaeli, Hasan / Taskapilioglu, Mevlut Ozgur / Eser, Pinar / Tunca, Berrin

International journal of biological macromolecules

2023 Volume 253, Issue Pt 2, Page(s) 126722

Abstract: Glioblastoma (GB) has susceptibility to post-surgical recurrence. Therefore, local treatment methods are required against recurrent GB cells in the post-surgical area. In this study, we developed a nanofiber-based local therapy against GB cells using ... ...

Abstract	Glioblastoma (GB) has susceptibility to post-surgical recurrence. Therefore, local treatment methods are required against recurrent GB cells in the post-surgical area. In this study, we developed a nanofiber-based local therapy against GB cells using Oleuropein (OL), and rutin and their combinations with Temozolomide (TMZ). The polylactic acid (PLA) core-shell nanofiber webs were encapsulated with OL (PLA
MeSH term(s)	Humans ; Temozolomide/pharmacology ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Delayed-Action Preparations/pharmacology ; Delayed-Action Preparations/therapeutic use ; Nanofibers/chemistry ; Rutin/pharmacology ; Neoplasm Recurrence, Local ; Polyesters/therapeutic use ; Cell Line, Tumor ; Brain Neoplasms/drug therapy
Chemical Substances	Temozolomide (YF1K15M17Y) ; poly(lactide) (459TN2L5F5) ; oleuropein (2O4553545L) ; Delayed-Action Preparations ; Rutin (5G06TVY3R7) ; Polyesters
Language	English
Publishing date	2023-09-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.126722
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Article ; Online: Reliability of CT angiography scoring systems used for brain death and the effect of cranial interventions on the results.

Ozpar, Rifat / Tonkaz, Mehmet / Girgin, Nermin Kelebek / Bodur, Muhittin / Dinc, Yasemin / Kocaeli, Hasan / Hakyemez, Bahattin

Clinical imaging

2021 Volume 79, Page(s) 142–147

Abstract: Objective: To assess vascular opacifications, the efficiency, and interobserver agreement (IOA) of five different computed tomography angiography (CTA) brain death (BD) scoring systems in patients with and without cranial interventions, for determining ... ...

Abstract	Objective: To assess vascular opacifications, the efficiency, and interobserver agreement (IOA) of five different computed tomography angiography (CTA) brain death (BD) scoring systems in patients with and without cranial interventions, for determining alternative findings correctly supporting BD diagnosis by CTA even in cranial intervention presence. Methods: 45 patients clinically identified with BD and evaluated with CTA were included. IOA of five different scoring systems used for CTA BD diagnosis, the effect of intracranial interventions on scoring systems, and vascular opacification were evaluated. Results: IOA was almost perfect (κ = 0.843-0.911, p < 0.05) and substantial (κ = 0.771-0.776, p < 0.05) in all scoring systems. Significant relationships were observed between craniectomy presence and middle cerebral artery M4 segment and internal cerebral vein (ICV) opacification. No opacification was observed in straight sinus (SS) by observers in any of the craniectomized patients. Conclusion: IOA of CTA scoring systems is adequate. But a significant degree of false-negative results is observed due to ICV filling in craniectomy cases. Opacification presence in SS can give an idea of BD in these cases.
MeSH term(s)	Brain Death/diagnostic imaging ; Cerebral Angiography ; Computed Tomography Angiography ; Humans ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2021.04.012
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Article ; Online: Coexistence of TERT C228T mutation and MALAT1 dysregulation in primary glioblastoma: new prognostic and therapeutic targets.

Ak Aksoy, Secil / Mutlu, Melis / Tunca, Berrin / Kocaeli, Hasan / Taskapilioglu, Mevlut Ozgur / Bekar, Ahmet / Tekin, Cagla / Argadal, Omer Gokay / Civan, Muhammet Nafi / Kaya, İsmail Seckin / Ocak, Pınar Eser / Tolunay, Sahsine

Neurological research

2021 Volume 43, Issue 11, Page(s) 916–925

Abstract: ... ...

Abstract	Objective
MeSH term(s)	Adult ; Aged ; Biomarkers, Tumor/genetics ; Brain Neoplasms/genetics ; Female ; Glioblastoma/genetics ; Humans ; Male ; Middle Aged ; Mutation ; Prognosis ; RNA, Long Noncoding/genetics ; Telomerase/genetics
Chemical Substances	Biomarkers, Tumor ; MALAT1 long non-coding RNA, human ; RNA, Long Noncoding ; TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49)
Language	English
Publishing date	2021-07-01
Publishing country	England
Document type	Journal Article
ZDB-ID	424428-x
ISSN	1743-1328 ; 0161-6412
ISSN (online)	1743-1328
ISSN	0161-6412
DOI	10.1080/01616412.2021.1948738
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