Article ; Online: Use of remdesivir in the presence of elevated LFTs for the treatment of severe COVID-19 infection.
BMJ case reports
2020 Volume 13, Issue 10
Abstract: An 82-year-old man with an extensive medical history presented to the emergency room with complaints of generalised weakness and cough. He tested positive for COVID-19 10 days prior to presenting to the emergency room. Although his symptoms started a ... ...
| Abstract | An 82-year-old man with an extensive medical history presented to the emergency room with complaints of generalised weakness and cough. He tested positive for COVID-19 10 days prior to presenting to the emergency room. Although his symptoms started a week prior to diagnosis, his weakness increased, warranting emergency response. A comprehensive metabolic panel was drawn from the patient on admission, indicating markedly high liver function tests (LFTs) ≥20 times above the upper limit of normal. On day 1 of admission, the decision was still made to start remdesivir (5-day course) due to decompensated acute respiratory failure as well as dexamethasone. The patient's LFTs significantly improved throughout his hospital stay. The patient made a full recovery and was discharged on day 10 of hospitalisation. |
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| MeSH term(s) | Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/analogs & derivatives ; Aged, 80 and over ; Alanine/administration & dosage ; Alanine/analogs & derivatives ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Dexamethasone/administration & dosage ; Emergency Service, Hospital ; Humans ; Length of Stay ; Liver Diseases/complications ; Liver Diseases/diagnosis ; Liver Function Tests ; Male ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Patient Discharge ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Respiratory Insufficiency/diagnosis ; Respiratory Insufficiency/therapy ; Severity of Illness Index ; Treatment Outcome ; COVID-19 Drug Treatment |
| Chemical Substances | remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Dexamethasone (7S5I7G3JQL) ; Alanine (OF5P57N2ZX) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-10-31 |
| Publishing country | England |
| Document type | Case Reports ; Journal Article ; Review |
| ISSN | 1757-790X |
| ISSN (online) | 1757-790X |
| DOI | 10.1136/bcr-2020-239210 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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