Article ; Online: Sympathetic Nerve Activation in Acute Kidney Injury and Cardiorenal Syndrome.
2023 Volume 147, Issue 12, Page(s) 717–720
Abstract: The interactions between the kidney and heart are well studied and frequently lumped together as cardiorenal syndrome. It is believed that the sympathetic nervous system is involved in the mechanism of kidney injury caused by heart failure, but direct ... ...
Abstract | The interactions between the kidney and heart are well studied and frequently lumped together as cardiorenal syndrome. It is believed that the sympathetic nervous system is involved in the mechanism of kidney injury caused by heart failure, but direct evidence is still lacking. In chronic renal fibrosis, sympathetic nerve activation was demonstrated to be harmful by unilateral ureteral obstruction and post-ischemia reperfusion injury models. On the other hand, sympathetic nerve activation seemed protective in acute kidney injury models such as ischemia reperfusion injury and lipopolysaccharide injection. Our recent investigation showed that post-ischemic renal fibrosis was attenuated when preexisting heart failure was induced by transverse aortic constriction surgery and renal denervation canceled this protection. These findings suggest sympathetic nerve activation in cardiorenal syndrome may be protective on chronic renal fibrosis development caused by ischemic an insult. |
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MeSH term(s) | Rats ; Animals ; Humans ; Cardio-Renal Syndrome ; Rats, Sprague-Dawley ; Acute Kidney Injury ; Kidney/pathology ; Sympathetic Nervous System/physiology ; Ischemia ; Reperfusion Injury/pathology ; Heart Failure/complications ; Fibrosis |
Language | English |
Publishing date | 2023-09-27 |
Publishing country | Switzerland |
Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
ZDB-ID | 207121-6 |
ISSN | 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766 |
ISSN (online) | 2235-3186 ; 1423-0186 |
ISSN | 1660-8151 ; 0028-2766 |
DOI | 10.1159/000534217 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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