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  1. Book ; Online ; E-Book: 2024 Nelson's Pediatric Antimicrobial Therapy

    Bradley, John S. / Nelson, John D. / Elizabeth, Barnett / Cantey, Joseph B. / Kimberlin, David W. / Palumbo, Paul E. / Sauberan, Jason / Smart, J. Howard / Steinbach, William J.

    2024  

    Abstract: Completely updated and revised, the 30th edition of this best-selling reference provides instant access to the latest recommendations for treatment of infectious diseases in children. For each disease, the authors provide a commentary to help select ... ...

    Abstract Completely updated and revised, the 30th edition of this best-selling reference provides instant access to the latest recommendations for treatment of infectious diseases in children. For each disease, the authors provide a commentary to help select the best of all antimicrobial choices. Drug descriptions cover all antimicrobial agents available today and include complete information about dosing regimens. Free updates available at aap.org/Nelsons.
    Language English
    Size 1 online resource (403 pages)
    Edition 30th ed.
    Publisher American Academy of Pediatrics
    Publishing place Elk Grove Village
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-61002-697-7 ; 9781610026963 ; 978-1-61002-697-0 ; 1610026969
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Nelson's neonatal antimicrobial therapy

    Cantey, Joseph B. / Nelson, John D. / Elizabeth, Barnett / Bradley, John S. / Kimberlin, David W. / Palumbo, Paul E. / Smart, J. Howard / Steinbach, William J. / Sauberan, Jason

    2024  

    Abstract: Completely updated and revised, Nelson's Neonatal Antimicrobial Therapy, 2nd Edition, provides the most current, practical, and evidence-based recommendations for health care professionals treating neonates. Developed by leading experts in antimicrobial ... ...

    Title variant Neonatal antimicrobial therapy
    Institution American Academy of Pediatrics
    Author's details Joseph B. Cantey, MD, MPH, Jason Sauberan, PharmD Editors in Chief, John D. Nelson, Emeritus
    Abstract Completely updated and revised, Nelson's Neonatal Antimicrobial Therapy, 2nd Edition, provides the most current, practical, and evidence-based recommendations for health care professionals treating neonates. Developed by leading experts in antimicrobial therapy, this resource aims to help clinicians select the right drug, dose, and duration for the treatment of bacterial, viral, fungal, and parasitic infections in neonates.

    Front Matter -- 1. Choosing an Antibiotic for the Neonate -- 2. Antimicrobial Drug Therapy for Neonates -- 3. Bacterial Infections in Neonates -- 4. Viral Infections in Neonates -- 5. Fungal Infections in Neonates -- 6. Parasitic Infections in Neonates -- 7. Antimicrobial Stewardship in the Nursery -- Index.
    Subject code 618.9201
    Language English
    Size 1 Online-Ressource (x, 92 Seiten)
    Edition Second edition
    Publisher American Academy of Pediatrics
    Publishing place Elk Grove Village
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030696544
    ISBN 978-1-61002-699-4 ; 9781610026987 ; 1-61002-699-3 ; 1610026985
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Thesis: Identifizierung prognostischer Faktoren für das rezidivfreie Überleben nach Leberresektion und -transplantation bei hepatozellulärem Karzinom

    Hilt, Alexandra Inge

    2018  

    Institution Goethe-Universität Frankfurt am Main
    Author's details vorgelegt von Alexandra Inge Hilt aus Trier
    Language German
    Size 104 Seiten, Diagramme, 1 Karte, 21 cm
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2019
    Note Zusammenfassung auf Deutsch und Englisch
    HBZ-ID HT020397927
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2020 D 254 order for loan Magazin

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  4. Article ; Conference proceedings: Kalottendefekt bei Amnionbandsyndrom – eine wichtige Differentialdiagnose zum Anencephalus im Ersttrimesterultraschall

    Ruan, V. A. / Königbauer, J. T. / Dressler-Steinbach, I. / Henrich, W. / Verlohren, S.

    Zeitschrift für Geburtshilfe und Neonatologie

    2023  Volume 227, Issue S 01

    Event/congress Abstracts zum 31. Kongress der Deutschen Gesellschaft für perinatale Medizin, Berlin, 2023-11-30
    Language German
    Publishing date 2023-11-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0948-2393 ; 0300-967X ; 1615-5300
    DOI 10.1055/s-0043-1776531
    Database Thieme publisher's database

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  5. Article ; Online: Chitinase dysregulation predicts disease aggressiveness in ALS: Insights from the D50 progression model.

    Gaur, Nayana / Steinbach, Robert / Plaas, Mario / Witte, Otto W / Brill, Monika S / Grosskreutz, Julian

    Journal of neurology, neurosurgery, and psychiatry

    2023  Volume 94, Issue 7, Page(s) 585–588

    MeSH term(s) Humans ; Animals ; Amyotrophic Lateral Sclerosis ; Chitinases ; Motor Neurons ; Disease Progression ; Aggression ; Disease Models, Animal
    Chemical Substances Chitinases (EC 3.2.1.14)
    Language English
    Publishing date 2023-04-19
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2022-330318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intrathecal IgM synthesis as a diagnostic marker in patients with suspected CNS lymphoma.

    Reinecke, Raphael / Jahnke, Kolja / Foltyn-Dumitru, Martha / Lachner, Karsten / Armbrust, Moritz / Weber, Katharina J / Zeiner, Pia S / Czabanka, Marcus / Brunnberg, Uta / Hartmann, Sylvia / Steinbach, Joachim P / Ronellenfitsch, Michael W

    Journal of neurochemistry

    2024  

    Abstract: For CNS lymphomas (CNSL), there is a high need for minimally invasive and easily obtainable diagnostic markers. Intrathecal IgM synthesis can easily be determined in routine CSF diagnostics. The aim of this study was to systematically investigate the ... ...

    Abstract For CNS lymphomas (CNSL), there is a high need for minimally invasive and easily obtainable diagnostic markers. Intrathecal IgM synthesis can easily be determined in routine CSF diagnostics. The aim of this study was to systematically investigate the diagnostic potential of intrathecal IgM synthesis in primary and secondary CNSL (PCNSL and SCNSL). In this retrospective study, patients with a biopsy-proven diagnosis of PCNSL or SCNSL were compared with patients with other neurological diseases in whom CNSL was initially the primary radiological differential diagnosis based on MRI. Sensitivity and specificity of intrathecal IgM synthesis were calculated using receiver operating characteristic curves. Seventy patients with CNSL were included (49 PCNSL and 21 SCNSL) and compared to 70 control patients. The sensitivity and specificity for the diagnosis of CNSL were 49% and 87%, respectively, for the entire patient population and 66% and 91% after selection for cases with tumor access to the CSF system and isolated intrathecal IgM synthesis. In cases with MRI-based radiological suspicion of CNSL, intrathecal IgM synthesis has good specificity but limited sensitivity. Because of its low-threshold availability, analysis of intrathecal IgM synthesis has the potential to lead to higher diagnostic accuracy, especially in resource-limited settings, and deserves further study.
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.16069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Laterality in Parkinson's disease: a neuropsychological review.

    Steinbach, Marilyn J / Campbell, Ransom W / DeVore, Benjamin B / Harrison, David W

    Applied neuropsychology. Adult

    2021  , Page(s) 1–15

    Abstract: Laterality of motor symptom onset in Parkinson's disease is both well-known and under-appreciated. Treatment of disorders that have asymmetric pathological features, such as stroke and epilepsy, demonstrate the importance of incorporating hemispheric ... ...

    Abstract Laterality of motor symptom onset in Parkinson's disease is both well-known and under-appreciated. Treatment of disorders that have asymmetric pathological features, such as stroke and epilepsy, demonstrate the importance of incorporating hemispheric lateralization and specialization into therapy and care planning. These practices could theoretically extend to Parkinson's disease, providing increased diagnostic accuracy and improved treatment outcomes. Additionally, while motor symptoms have generally received the majority of attention, non-motor features (e.g., autonomic dysfunction) also decrease quality of life and are influenced by asymmetrical neurodegeneration. Due to the laterality of cognitive and behavioral processes in the two brain hemispheres, analysis of hemibody side of onset can potentially give insight into expected symptom profile of the patient and allow for increased predictive accuracy of disease progression and outcome, thus opening the door to personalized and improved therapy in treating Parkinson's disease patients. This review discusses motor and non-motor symptoms (namely autonomic, sensory, emotional, and cognitive dysfunction) of Parkinson's disease in respect to hemispheric lateralization from a theoretical perspective in hopes of providing a framework for future research and personalized treatment.
    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2673736-X
    ISSN 2327-9109 ; 2327-9095
    ISSN (online) 2327-9109
    ISSN 2327-9095
    DOI 10.1080/23279095.2021.1907392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Conference proceedings ; Online: MEASUREMENT OF SUBCUTANEOUS GLUCOSE CONCENTRATION IN SHEEP WITH AN AMPEROMETRIC ENZYME ELECTRODE

    Kerner, W. / Zier, H. / Steinbach, G. / Haas, J. / Warhadpande, R. / Brückel, J. / Pfeiffer, E. F.

    2023  

    Abstract: An amperometric enzyme electrode was developped for measurement of glucose in subcutaneous tissue. In vitro, this sensor exhibited an linear range extending to 500 mg/dl and was stable for at least 7 days. The measurement was relatively independent from ... ...

    Abstract An amperometric enzyme electrode was developped for measurement of glucose in subcutaneous tissue. In vitro, this sensor exhibited an linear range extending to 500 mg/dl and was stable for at least 7 days. The measurement was relatively independent from ambient oxygen concentrations and was not significantly influenced by stirring. In short term in vivo experiments this sensor was successfully used for glucose measurement in subcutaneous tissue of sheep.
    Language English
    Publishing date 2023-08-30
    Publisher GBF - Gesellschaft für Biotechnologische Forschung
    Publishing country de
    Document type Article ; Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Single-shot bevacizumab for cerebral radiation injury.

    Voss, Martin / Wenger, Katharina J / Fokas, Emmanouil / Forster, Marie-Thérèse / Steinbach, Joachim P / Ronellenfitsch, Michael W

    BMC neurology

    2021  Volume 21, Issue 1, Page(s) 77

    Abstract: Background: Cerebral radiation injury, including subacute radiation reactions and later stage radiation necrosis, is a severe side effect of brain tumor radiotherapy. A protocol of four infusions of the monoclonal antibody bevacizumab has been shown to ... ...

    Abstract Background: Cerebral radiation injury, including subacute radiation reactions and later stage radiation necrosis, is a severe side effect of brain tumor radiotherapy. A protocol of four infusions of the monoclonal antibody bevacizumab has been shown to be a highly effective treatment. However, bevacizumab is costly and can cause severe complications including thrombosis, bleeding and gastrointestinal perforations.
    Methods: We performed a retrospective analysis of patients treated in our clinic for cerebral radiation injury who received only a singular treatment with bevacizumab. Single-shot was defined as a singular administration of bevacizumab without a second administration during an interval of at least 6 weeks.
    Results: We identified 11 patients who had received a singular administration of bevacizumab to treat cerebral radiation injury. Prior radiation had been administered to treat gliomas (ten patients) or breast cancer brain metastases (one patient). 9 of 10 patients with available MRIs showed a marked reduction of edema at first follow-up. Discontinuation of Dexamethasone was possible in 6 patients and a significant dose reduction could be achieved in all other patients. One patient developed pulmonary artery embolism 2 months after bevacizumab administration. The median time to treatment failure of any cause was 3 months.
    Conclusions: Single-shot bevacizumab therefore has meaningful activity in cerebral radiation injury, but durable control is rarely achieved. In patients where a complete protocol of four infusions with bevacizumab is not feasible due to medical contraindications or lack of reimbursement, single-shot bevacizumab treatment may be considered.
    MeSH term(s) Adult ; Aged ; Angiogenesis Inhibitors/administration & dosage ; Angiogenesis Inhibitors/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Bevacizumab/administration & dosage ; Bevacizumab/therapeutic use ; Brain/pathology ; Brain Edema/diagnostic imaging ; Brain Edema/drug therapy ; Brain Edema/etiology ; Brain Injuries/diagnostic imaging ; Brain Injuries/drug therapy ; Brain Injuries/etiology ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Breast Neoplasms/pathology ; Dexamethasone/therapeutic use ; Dose-Response Relationship, Drug ; Female ; Glioma/radiotherapy ; Glucocorticoids/therapeutic use ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Necrosis ; Radiation Injuries/drug therapy ; Retrospective Studies ; Treatment Outcome ; Young Adult
    Chemical Substances Angiogenesis Inhibitors ; Antibodies, Monoclonal ; Glucocorticoids ; Bevacizumab (2S9ZZM9Q9V) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2021-02-17
    Publishing country England
    Document type Journal Article
    ISSN 1471-2377
    ISSN (online) 1471-2377
    DOI 10.1186/s12883-021-02103-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Funding Pediatric Subspecialty Training: Are T32 Grants the Future?

    Steinbach, William J / Benjamin, Daniel K / Sleasman, John W

    The Journal of pediatrics

    2018  Volume 202, Page(s) 4–7.e1

    MeSH term(s) Biomedical Research/education ; Fellowships and Scholarships/economics ; Humans ; National Institutes of Health (U.S.) ; Pediatrics/education ; Training Support/economics ; United States
    Language English
    Publishing date 2018-10-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2018.08.035
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