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Article ; Online: Clinical Images: Hydrangea-like nephrocalcinosis in Sjögren's syndrome.

Morishita, Shigemi / Sada, Ken-Ei

Arthritis & rheumatology (Hoboken, N.J.)

2023 Volume 76, Issue 2, Page(s) 318

MeSH term(s)	Humans ; Nephrocalcinosis/diagnostic imaging ; Nephrocalcinosis/etiology ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/diagnostic imaging ; Hydrangea
Language	English
Publishing date	2023-11-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42693
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Article ; Online: Pulmonary alveolar proteinosis during treatment of immune-mediated necrotizing myopathy.

Dobashi, Naofumi / Sada, Ken-Ei / Kanemori, Gen / Okada, Takuya / Tarutani, Yusuke / Yamamoto, Mako / Yabe, Moemi / Inoue, Kenshi / Imaizumi, Yasuhiko / Nishii, Masahiko / Katsurada, Masahiro / Misaki, Kenta

International journal of rheumatic diseases

2024 Volume 27, Issue 2, Page(s) e15080

MeSH term(s)	Humans ; Pulmonary Alveolar Proteinosis/diagnosis ; Pulmonary Alveolar Proteinosis/drug therapy ; Lung ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy ; Myositis
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Letter
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.15080
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Zs.A 6098: Show issues

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Article ; Online: Multicentric Reticulohistiocytosis in a Patient with Hand Contracture.

Kawabata, Tomoko / Sada, Ken-Ei / Watanabe, Haruki / Wada, Jun

Internal medicine (Tokyo, Japan)

2020 Volume 59, Issue 18, Page(s) 2337–2338

Language	English
Publishing date	2020-06-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.4934-20
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Zs.A 240: Show issues

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Article ; Online: Small Intestinal Perforation Caused by Enteric-coated Low-dose Aspirin.

Matsubara, Shohei / Sada, Ken-Ei / Sawada, Haruo / Oida, Jiro / Tanaka, Kimiaki

Internal medicine (Tokyo, Japan)

2022 Volume 62, Issue 2, Page(s) 233–235

Abstract: A 77-year-old man presented with abdominal pain for 1 week. He was taking enteric-coated low-dose aspirin (LDA) to prevent secondary cardiovascular events and a proton pump inhibitor (PPI). Computed tomography indicated a small intestinal perforation; ... ...

Abstract	A 77-year-old man presented with abdominal pain for 1 week. He was taking enteric-coated low-dose aspirin (LDA) to prevent secondary cardiovascular events and a proton pump inhibitor (PPI). Computed tomography indicated a small intestinal perforation; thus, small intestine resection was performed. Two months after surgery, he experienced a recurrence of the perforation. Since his repeated perforation was suspected to be due to LDA, LDA was discontinued. He has experienced no further recurrence since then. This is the first case of small intestinal perforation caused by enteric-coated LDA. Enteric-coated LDA may cause small intestinal perforation in patients with severe atherosclerosis under PPI administration.
MeSH term(s)	Male ; Humans ; Aged ; Intestinal Perforation/chemically induced ; Intestinal Perforation/diagnostic imaging ; Intestinal Perforation/surgery ; Aspirin/adverse effects ; Proton Pump Inhibitors/adverse effects ; Abdominal Pain
Chemical Substances	Aspirin (R16CO5Y76E) ; Proton Pump Inhibitors
Language	English
Publishing date	2022-06-21
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.9681-22
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Article: Withdrawal from Hemodialysis in a Patient with IgD Type Multiple Myeloma: A Case-based Review.

Iriyoshi, Hiroki / Sada, Ken-Ei / Miyauchi, Atsushi / Yamamoto, Hirotaka / Hashimoto, Daisuke / Nojima, Shigeru / Yamanaka, Shingo / Kawamura, Masafumi / Oka, Satoshi

Acta medica Okayama

2023 Volume 77, Issue 2, Page(s) 221–225

Abstract: Several previous case reports have shown that patients with immunoglobulin D (IgD) multiple myeloma (MM) can be withdrawn from hemodialysis, however, the characteristics that can predict withdrawal in these patients have not yet been elucidated. A 57- ... ...

Abstract	Several previous case reports have shown that patients with immunoglobulin D (IgD) multiple myeloma (MM) can be withdrawn from hemodialysis, however, the characteristics that can predict withdrawal in these patients have not yet been elucidated. A 57-year-old Japanese woman required hemodialysis because of renal dysfunction due to IgD-λ and Bence Jones protein-λ MM. Bortezomib-based chemotherapy nine days after admission led to her withdrawal from hemodialysis on Day 50. In our case-based review, younger age and early initiation of bortezomib-based chemotherapy emerged as possible predictors of successful hemodialysis withdrawal.
MeSH term(s)	Humans ; Female ; Middle Aged ; Multiple Myeloma/drug therapy ; Bortezomib/therapeutic use ; Immunoglobulin D/therapeutic use ; Renal Dialysis ; Immunoglobulin lambda-Chains
Chemical Substances	Bortezomib (69G8BD63PP) ; Immunoglobulin D ; Immunoglobulin lambda-Chains
Language	English
Publishing date	2023-04-24
Publishing country	Japan
Document type	Case Reports
ZDB-ID	188415-3
ISSN	0386-300X ; 0001-6152
ISSN	0386-300X ; 0001-6152
DOI	10.18926/AMO/65154
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Article ; Online: Bicarbonate concentration as a predictor of prognosis in moderately severe COVID-19 patients

Ken-Ei Sada / Ryohei Yamamoto / Akihiko Yano / Atsushi Miyauchi / Masafumi Kawamura / Hideki Ito

PLoS ONE, Vol 17, Iss 6, p e

A multicenter retrospective study.

2022 Volume 0270141

Abstract: Background Coronavirus disease 2019 (COVID-19) patients reportedly have high bicarbonate concentration. However, its relationship to the disease progression are obscure. Methods In this two-center retrospective study, we included COVID-19 patients with ... ...

Abstract	Background Coronavirus disease 2019 (COVID-19) patients reportedly have high bicarbonate concentration. However, its relationship to the disease progression are obscure. Methods In this two-center retrospective study, we included COVID-19 patients with moderate severity between March 2020 and May 2021. We classified patients into three groups according to bicarbonate concentrations: high (>27 mEq/L), normal (21 to 27 mEq/L), and low (<21 mEq/L). The primary outcome was the time to clinical worsening defined by the requirement of intubation or death during 90 days. We evaluated high or low bicarbonate concentration during the clinical course related to the primary outcome using multivariable Cox proportional hazard models. Results Of the 60 participants (median age 72 years), 60% were men. Participants were classified into high (13 patients), normal (30 patients), and low (17 patients) groups. Clinical worsening occurred in 54% of patients in the high group, 23% in the normal group, and 65% in the low group. Both high and low groups were associated with a higher clinical worsening rate: HR, 3.02 (95% CI, 1.05 to 8.63) in the high group; 3.49 (95% CI: 1.33 to 9.12) in the low group. Conclusion Monitoring of bicarbonate concentrations may be useful to predict the prognosis.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bicarbonate concentration as a predictor of prognosis in moderately severe COVID-19 patients: A multicenter retrospective study.

Sada, Ken-Ei / Yamamoto, Ryohei / Yano, Akihiko / Miyauchi, Atsushi / Kawamura, Masafumi / Ito, Hideki

PloS one

2022 Volume 17, Issue 6, Page(s) e0270141

Abstract: Background: Coronavirus disease 2019 (COVID-19) patients reportedly have high bicarbonate concentration. However, its relationship to the disease progression are obscure.: Methods: In this two-center retrospective study, we included COVID-19 patients ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) patients reportedly have high bicarbonate concentration. However, its relationship to the disease progression are obscure. Methods: In this two-center retrospective study, we included COVID-19 patients with moderate severity between March 2020 and May 2021. We classified patients into three groups according to bicarbonate concentrations: high (>27 mEq/L), normal (21 to 27 mEq/L), and low (<21 mEq/L). The primary outcome was the time to clinical worsening defined by the requirement of intubation or death during 90 days. We evaluated high or low bicarbonate concentration during the clinical course related to the primary outcome using multivariable Cox proportional hazard models. Results: Of the 60 participants (median age 72 years), 60% were men. Participants were classified into high (13 patients), normal (30 patients), and low (17 patients) groups. Clinical worsening occurred in 54% of patients in the high group, 23% in the normal group, and 65% in the low group. Both high and low groups were associated with a higher clinical worsening rate: HR, 3.02 (95% CI, 1.05 to 8.63) in the high group; 3.49 (95% CI: 1.33 to 9.12) in the low group. Conclusion: Monitoring of bicarbonate concentrations may be useful to predict the prognosis.
MeSH term(s)	Aged ; Bicarbonates ; COVID-19 ; Female ; Humans ; Male ; Prognosis ; Proportional Hazards Models ; Retrospective Studies
Chemical Substances	Bicarbonates
Language	English
Publishing date	2022-06-24
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0270141
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Article: Rhabdomyolysis with Multiple Electrolyte Imbalances under Proton Pump Inhibitor Treatment after Total Thyroidectomy.

Yano, Akihiko / Sada, Ken-Ei / Sawada, Tsutomu / Ito, Hideki / Yano, Hiroko / Ikeda, Tatsuya

Acta medica Okayama

2022 Volume 76, Issue 3, Page(s) 339–342

Abstract: A 90-year-old man presented with muscle weakness, difficulty concentrating, and dysphagia. About eighteen months prior to presentation, lansoprazole had been initiated to prevent stress ulcers; he also had a history of total thyroidectomy due to ... ...

Abstract	A 90-year-old man presented with muscle weakness, difficulty concentrating, and dysphagia. About eighteen months prior to presentation, lansoprazole had been initiated to prevent stress ulcers; he also had a history of total thyroidectomy due to papillary thyroid cancer ten years prior. Laboratory findings were as follows: K 2.4 mEq/L, Ca 3.7 mg/dL, Mg 1.3 mg/dL, CK 5386 U/L, and intact PTH (iPTH) 14 pg/mL. Rhabdomyolysis with multiple electrolyte imbalances under proton pump inhibitor (PPI) treatment was diagnosed. We initiated intravenous hydration and electrolyte supplementation with discontinuation of PPI. After discontinuing PPI, the patient's serum magnesium, potassium, and calcium levels normalised with oral vitamin D and calcium supplementation. PPIs can cause hypocalcaemia and hypokalaemia via hypomagnesemia; hypocalcaemia is also a common postoperative complication of thyroidectomy. Careful monitoring of electrolyte levels is required in patients with long-term PPI treatment, especially in post-thyroidectomy cases.
MeSH term(s)	Aged, 80 and over ; Calcium ; Humans ; Hypocalcemia/drug therapy ; Hypocalcemia/etiology ; Male ; Proton Pump Inhibitors/therapeutic use ; Rhabdomyolysis ; Thyroid Neoplasms ; Thyroidectomy/adverse effects
Chemical Substances	Proton Pump Inhibitors ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-07-05
Publishing country	Japan
Document type	Case Reports
ZDB-ID	188415-3
ISSN	0386-300X ; 0001-6152
ISSN	0386-300X ; 0001-6152
DOI	10.18926/AMO/63745
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Article ; Online: Survey of Japanese nephrologists' use of clinical practice guidelines for rapidly progressive glomerulonephritis.

Takahashi-Kobayashi, Mayumi / Sada, Ken-Ei / Kawashima, Soko / Miyawaki, Yoshia / Nakazawa, Daigo / Furuichi, Kengo / Okada, Hirokazu / Narita, Ichiei / Usui, Joichi

Clinical and experimental nephrology

2023 Volume 28, Issue 4, Page(s) 316–324

Abstract: Background: The guidelines in Japan for the treatment of rapidly progressive glomerulonephritis (RPGN) have been revised; the latest update was released in 2020. We investigated the actual usage of the new guidelines in Japan.: Methods: We ... ...

Abstract	Background: The guidelines in Japan for the treatment of rapidly progressive glomerulonephritis (RPGN) have been revised; the latest update was released in 2020. We investigated the actual usage of the new guidelines in Japan. Methods: We distributed a survey electronically to board-certified nephrologists throughout Japan from December 15, 2021 to January 31, 2022. The survey focused on anti-neutrophil cytoplasmic antibody (ANCA)-associated RPGN and anti-glomerular basement membrane (GBM)-antibody RPGN, plus the treatment strategies and infection-prevention measures used. Results: The survey was completed by 155 certified nephrologists from medical facilities across Japan. Their responses regarding treatment procedures revealed that ANCA-associated RPGN was treated with immunosuppressants and/or biologics by 58.1% of the survey respondents, and with plasma exchange (PE) in combination with corticosteroids by 21.3%. Regarding anti-GBM-antibody RPGN, 78.1% of the respondents used corticosteroids in combination with PE (63.2%), cyclophosphamide (CY) (23.9%), or rituximab (RTX) (8.4%), suggesting a discrepancy between clinical practice and the actual use of the guidelines. Trimethoprim-sulfamethoxazole was prescribed as prophylaxis by 94.8% of the respondents, reflecting the widespread recognition of the need to prevent infectious disease in patients with RPGN. Conclusions: The survey responses revealed how Japan's new RPGN guidelines are used in actual clinical practice. Our findings will contribute to the guidelines' dissemination and implementation.
MeSH term(s)	Humans ; Adrenal Cortex Hormones ; Antibodies, Antineutrophil Cytoplasmic ; Glomerulonephritis/drug therapy ; Japan ; Nephritis ; Nephrologists ; Surveys and Questionnaires ; Practice Guidelines as Topic
Chemical Substances	Adrenal Cortex Hormones ; Antibodies, Antineutrophil Cytoplasmic
Language	English
Publishing date	2023-12-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-023-02441-y
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Article ; Online: Infliximab biosimilar-induced lupus nephritis: A case report.

Shidahara, Kenta / Katsuyama, Takayuki / Hirose, Kei / Matsumoto, Kazuya / Nawachi, Shoichi / Nakadoi, Takato / Asano, Yosuke / Katayama, Yu / Miyawaki, Yoshia / Katsuyama, Eri / Takano-Narazaki, Mariko / Matsumoto, Yoshinori / Sada, Ken-Ei / Wada, Jun

Modern rheumatology case reports

2024 Volume 8, Issue 1, Page(s) 74–76

Abstract: We present a case of microhematuria, proteinuria and hypocomplementemia which developed in a 55-year-old female who was being treated with an infliximab biosimilar for rheumatoid arthritis. Renal biopsy showed lupus nephritis (ISN/RPS classification ... ...

Abstract	We present a case of microhematuria, proteinuria and hypocomplementemia which developed in a 55-year-old female who was being treated with an infliximab biosimilar for rheumatoid arthritis. Renal biopsy showed lupus nephritis (ISN/RPS classification class IV + V). Treatment with the infliximab biosimilar was discontinued, and treatment with prednisolone, hydroxychloroquine and abatacept was started, resulting in clinical remission of lupus nephritis and RA. Although tumour necrosis factor-α α inhibitors are known to induce production of autoantibodies, symptoms are usually limited to skin involvement or arthritis, and renal complications are rare. Physicians should be aware of the risk of lupus nephritis and carefully monitor patients for the development of renal involvement during treatment with tumour necrosis factor-α inhibitors.
MeSH term(s)	Female ; Humans ; Middle Aged ; Infliximab/adverse effects ; Lupus Nephritis/diagnosis ; Lupus Nephritis/drug therapy ; Biosimilar Pharmaceuticals/adverse effects ; Tumor Necrosis Factor-alpha ; Kidney/pathology
Chemical Substances	Infliximab (B72HH48FLU) ; Biosimilar Pharmaceuticals ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	2472-5625
ISSN (online)	2472-5625
DOI	10.1093/mrcr/rxad061
Database	MEDical Literature Analysis and Retrieval System OnLINE

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