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Article ; Online: Diagnostic Accuracy of Abdominal Point of Care Ultrasound in Primary Care: Study Design and Protocol.

Calvo Cebrián, Antonio / Alonso Roca, Rafael / Sánchez Barrancos, Ignacio Manuel

POCUS journal

2024 Volume 9, Issue 1, Page(s) 63–70

Abstract: The aim of this study is to estimate the diagnostic accuracy of abdominal point of care ultrasound (POCUS) performed by family physicians (FPs) in primary care (PC), in comparison with the findings in the medical record (MR) at 12 months of follow-up. ... ...

Abstract	The aim of this study is to estimate the diagnostic accuracy of abdominal point of care ultrasound (POCUS) performed by family physicians (FPs) in primary care (PC), in comparison with the findings in the medical record (MR) at 12 months of follow-up. This study is conducted entirely in PC healthcare centers in Spain. Abdominal ultrasound scans performed by FPs (selected on the basis of their ultrasound knowledge and experience) are compared with the findings, or not, in the patient's MR after a 12-month follow-up period. The study will involve 100 FPs in Spain and an estimated sample size of 1334 patients who are to undergo abdominal POCUS at the indication of their physician. The results of the abdominal POCUS will be collected and compared with the findings of the MR. This comparison will be performed by another physician of the research team, different from their FP after one year of follow-up. The diagnostic accuracy of abdominal POCUS has been addressed in the hospital setting but not in PC. This lack of evidence can begin to be resolved with studies such as the one we present, designed for unselected populations such as those treated in PC and taking the patient's MR as the gold standard, which will allow us to make comparisons with the patient's clinical course.
Language	English
Publishing date	2024-04-22
Publishing country	Canada
Document type	Journal Article
ISSN	2369-8543
ISSN (online)	2369-8543
DOI	10.24908/pocus.v9i1.16987
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Article ; Online: Usefulness of Lung Ultrasound Examinations Performed by Primary Care Physicians in Patients With Suspected COVID-19.

Calvo-Cebrián, Antonio / Alonso-Roca, Rafael / Rodriguez-Contreras, Francisco Javier / Rodríguez-Pascual, Maria de Las Nieves / Calderín-Morales, Maria Del Pino

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2020 Volume 40, Issue 4, Page(s) 741–750

Abstract: Objectives: In patients with suspected coronavirus disease 2019 (COVID-19) consulting primary care (PC) centers, clinical criteria may not be sensitive enough to detect many cases in which complications first occur. We intended to assess whether lung ... ...

Abstract	Objectives: In patients with suspected coronavirus disease 2019 (COVID-19) consulting primary care (PC) centers, clinical criteria may not be sensitive enough to detect many cases in which complications first occur. We intended to assess whether lung ultrasound (LUS) examinations performed by PC physicians are a useful tool to detect lung injury and may help in decisions about hospital referral. Methods: This study included 61 patients with moderate symptoms suggesting COVID-19 who were evaluated with LUS by PC physicians and then referred to a hospital during the current pandemic peak in Madrid. We analyzed association of a simple self-designed LUS severity scale (grade 0, normal; grade 1, multiple separated B-lines, pleural irregularity, or both; and grade 2, coalescent B-lines, consolidations, pleural effusion, or a combination thereof) with the main outcome indicating adequacy of hospital referral, and also with chest x-ray (CXR) findings. Results: The proposed LUS severity scale was significantly associated with the main outcome of appropriate referral (P = 0.001): the higher the scale, the higher the percentage of adequate referrals. The LUS scale was also associated with a CXR severity scale (P = 0.034). The presence of coalescent B-lines was the only independent LUS finding significantly associated with the appropriate-referral outcome (P =0 .008) and also with a higher probability of hospital admission (P = 0.02) and with several CXR findings. Conclusions: This study supports the use of LUS in PC as a tool to assess patients with suspected COVID-19. Its use can reduce uncertainty during clinical evaluations of moderate patients, facilitate early detection of lung involvement, allow early appropriate referral, and avoid unnecessary referral.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/diagnostic imaging ; Female ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Physicians, Primary Care ; Ultrasonography
Keywords	covid19
Language	English
Publishing date	2020-08-27
Publishing country	England
Document type	Journal Article
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.1002/jum.15444
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Article ; Online: Lung Ultrasound Performed by Primary Care Physicians for Clinically Suspected Community-Acquired Pneumonia: A Multicenter Prospective Study.

Rodríguez-Contreras, Francisco Javier / Calvo-Cebrián, Antonio / Díaz-Lázaro, Juncal / Cruz-Arnés, Miguel / León-Vázquez, Fernando / Del Carmen Lobón-Agúndez, María / Palau-Cuevas, Francisco Javier / Henares-García, Paloma / Gavilán-Martínez, Fernando / Fernández-Plaza, Sandra / Prieto-Zancudo, Carmelo

Annals of family medicine

2022 Volume 20, Issue 3, Page(s) 227–236

Abstract: Purpose: We investigated whether lung ultrasound (US) performed in primary care is useful and feasible for diagnosing community-acquired pneumonia (CAP) compared with chest radiography, as most previous research has been conducted in hospital settings.!# ...

Abstract	Purpose: We investigated whether lung ultrasound (US) performed in primary care is useful and feasible for diagnosing community-acquired pneumonia (CAP) compared with chest radiography, as most previous research has been conducted in hospital settings. Methods: We undertook a prospective observational cohort study of lung US performed in 12 primary care centers. Patients aged 5 years and older with symptoms suggesting CAP were examined with lung US (by 21 family physicians and 7 primary care pediatricians) and chest radiograph on the same day. We compared lung US findings with the radiologist's chest radiograph report as the reference standard, given that the latter is the most common imaging test performed for suspected CAP in primary care. The physicians had varied previous US experience, but all received a 5-hour lung US training program. Results: The study included 82 patients. Compared with chest radiography, positive lung US findings (consolidation measuring >1 cm or a focal/asymmetrical B-lines pattern) showed a sensitivity of 87.8%, a specificity of 58.5%, a positive likelihood-ratio of 2.12, and a negative likelihood-ratio of 0.21. Findings were similar regardless of the physicians' previous US training or experience. We propose a practical algorithm whereby patients having consolidation measuring greater than 1 cm or normal findings on lung US could skip chest radiography, whereas patients with a B-lines pattern without consolidation (given its low specificity) would need chest radiography to ensure appropriate management. Lung US was generally performed in 10 minutes or less. Conclusion: Point-of-care lung US in primary care could be useful for investigating suspected CAP (avoiding chest radiography in most cases) and is likely feasible in daily practice, as short training programs appear sufficient and little time is needed to perform the scan.
MeSH term(s)	Community-Acquired Infections/diagnostic imaging ; Emergency Service, Hospital ; Humans ; Lung/diagnostic imaging ; Physicians, Primary Care ; Pneumonia/diagnostic imaging ; Point-of-Care Systems ; Prospective Studies ; Radiography, Thoracic ; Sensitivity and Specificity ; Ultrasonography/methods
Language	English
Publishing date	2022-05-23
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2171425-3
ISSN	1544-1717 ; 1544-1709
ISSN (online)	1544-1717
ISSN	1544-1709
DOI	10.1370/afm.2796
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Article ; Online: Usefulness of Lung Ultrasound Examinations Performed by Primary Care Physicians in Patients With Suspected COVID ‐19

Calvo‐Cebrián, Antonio / Alonso‐Roca, Rafael / Rodriguez‐Contreras, Francisco Javier / Rodríguez‐Pascual, Maria de las Nieves / Calderín‐Morales, Maria del Pino

Journal of Ultrasound in Medicine ; ISSN 0278-4297 1550-9613

2020

Keywords	Radiological and Ultrasound Technology ; Radiology Nuclear Medicine and imaging ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1002/jum.15444
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Article: Usefulness of Lung Ultrasound Examinations Performed by Primary Care Physicians in Patients With Suspected COVID-19

Calvo-Cebrián, Antonio / Alonso-Roca, Rafael / Rodriguez-Contreras, Francisco Javier / Rodríguez-Pascual, Maria de Las Nieves / Calderín-Morales, Maria Del Pino

J. ultrasound med

Abstract: OBJECTIVES: In patients with suspected coronavirus disease 2019 (COVID-19) consulting primary care (PC) centers, clinical criteria may not be sensitive enough to detect many cases in which complications first occur. We intended to assess whether lung ... ...

Abstract	OBJECTIVES: In patients with suspected coronavirus disease 2019 (COVID-19) consulting primary care (PC) centers, clinical criteria may not be sensitive enough to detect many cases in which complications first occur. We intended to assess whether lung ultrasound (LUS) examinations performed by PC physicians are a useful tool to detect lung injury and may help in decisions about hospital referral. METHODS: This study included 61 patients with moderate symptoms suggesting COVID-19 who were evaluated with LUS by PC physicians and then referred to a hospital during the current pandemic peak in Madrid. We analyzed association of a simple self-designed LUS severity scale (grade 0, normal; grade 1, multiple separated B-lines, pleural irregularity, or both; and grade 2, coalescent B-lines, consolidations, pleural effusion, or a combination thereof) with the main outcome indicating adequacy of hospital referral, and also with chest x-ray (CXR) findings. RESULTS: The proposed LUS severity scale was significantly associated with the main outcome of appropriate referral (P = 0.001): the higher the scale, the higher the percentage of adequate referrals. The LUS scale was also associated with a CXR severity scale (P = 0.034). The presence of coalescent B-lines was the only independent LUS finding significantly associated with the appropriate-referral outcome (P =0 .008) and also with a higher probability of hospital admission (P = 0.02) and with several CXR findings. CONCLUSIONS: This study supports the use of LUS in PC as a tool to assess patients with suspected COVID-19. Its use can reduce uncertainty during clinical evaluations of moderate patients, facilitate early detection of lung involvement, allow early appropriate referral, and avoid unnecessary referral.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #731596
Database	COVID19

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Article ; Online: Characterization of the invasive macroalgae Rugulopteryx Okamurae for potential biomass valorisation.

Cebrián-Lloret, Vera / Cartan-Moya, Sara / Martínez-Sanz, Marta / Gómez-Cortés, Pilar / Calvo, María Visitación / López-Rubio, Amparo / Martínez-Abad, Antonio

Food chemistry

2023 Volume 440, Page(s) 138241

Abstract: This study aimed to examine the composition and properties of the invasive macroalgae R. okamurae and explore potential applications. The results showed that the seaweed biomass is mainly composed of structural carbohydrates, with alginate being the main ...

Abstract	This study aimed to examine the composition and properties of the invasive macroalgae R. okamurae and explore potential applications. The results showed that the seaweed biomass is mainly composed of structural carbohydrates, with alginate being the main constituent, accounting for 32 % of its total composition and with a mannuronic and guluronic acid ratio (M/G) ratio of 0.93. It also has a relatively high concentration of fucose, related to the presence of fucoidans that have important biological functions. Among the mineral contents, a high magnesium and calcium (7107 and 5504 mg/kg) concentration, and the presence of heavy metals above legislated thresholds, were notable. R. okamurae also contained a high lipid content of 17 %, mainly composed of saturated fatty acids, but with a significant fraction of n3 polyunsaturated fatty acids (18 %) resulting in a low n6/n3 ratio (0.31), that has health benefits. The protein content of R. okamurae was 12 %, with high-quality proteins, as essential amino acids (mainly leucine, phenylalanine and valine) constitute 32 % of the total amino acids. It also showed a high polyphenol content and outstanding antioxidant properties (106.88 mg TE/g). Based on these findings, R. okamurae has significant potential as a sustainable source of bioactive compounds that can add value to different sectors, including food, feed, pharmaceuticals and cosmetics.
MeSH term(s)	Seaweed/chemistry ; Biomass ; Phaeophyceae ; Fatty Acids/metabolism ; Proteins/metabolism
Chemical Substances	Fatty Acids ; Proteins
Language	English
Publishing date	2023-12-22
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.138241
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Article ; Online: Inter-Rater Variability in the Evaluation of Lung Ultrasound in Videos Acquired from COVID-19 Patients

Joaquin L. Herraiz / Clara Freijo / Jorge Camacho / Mario Muñoz / Ricardo González / Rafael Alonso-Roca / Jorge Álvarez-Troncoso / Luis Matías Beltrán-Romero / Máximo Bernabeu-Wittel / Rafael Blancas / Antonio Calvo-Cebrián / Ricardo Campo-Linares / Jaldún Chehayeb-Morán / Jose Chorda-Ribelles / Samuel García-Rubio / Gonzalo García-de-Casasola / Adriana Gil-Rodrigo / César Henríquez-Camacho / Alba Hernandez-Píriz /

Carlos Hernandez-Quiles / Rafael Llamas-Fuentes / Davide Luordo / Raquel Marín-Baselga / María Cristina Martínez-Díaz / María Mateos-González / Manuel Mendez-Bailon / Francisco Miralles-Aguiar / Ramón Nogue / Marta Nogué / Borja Ortiz de Urbina-Antia / Alberto Ángel Oviedo-García / José M. Porcel / Santiago Rodriguez / Diego Aníbal Rodríguez-Serrano / Talía Sainz / Ignacio Manuel Sánchez-Barrancos / Marta Torres-Arrese / Juan Torres-Macho / Angela Trueba Vicente / Tomas Villén-Villegas / Juan José Zafra-Sánchez / Yale Tung-Chen

Applied Sciences, Vol 13, Iss 1321, p

2023 Volume 1321

Abstract: Lung ultrasound (LUS) allows for the detection of a series of manifestations of COVID-19, such as B-lines and consolidations. The objective of this work was to study the inter-rater reliability (IRR) when detecting signs associated with COVID-19 in the ... ...

Abstract	Lung ultrasound (LUS) allows for the detection of a series of manifestations of COVID-19, such as B-lines and consolidations. The objective of this work was to study the inter-rater reliability (IRR) when detecting signs associated with COVID-19 in the LUS, as well as the performance of the test in a longitudinal or transverse orientation. Thirty-three physicians with advanced experience in LUS independently evaluated ultrasound videos previously acquired using the ULTRACOV system on 20 patients with confirmed COVID-19. For each patient, 24 videos of 3 s were acquired (using 12 positions with the probe in longitudinal and transverse orientations). The physicians had no information about the patients or other previous evaluations. The score assigned to each acquisition followed the convention applied in previous studies. A substantial IRR was found in the cases of normal LUS (κ = 0.74), with only a fair IRR for the presence of individual B-lines (κ = 0.36) and for confluent B-lines occupying < 50% (κ = 0.26) and a moderate IRR in consolidations and B-lines > 50% (κ = 0.50). No statistically significant differences between the longitudinal and transverse scans were found. The IRR for LUS of COVID-19 patients may benefit from more standardized clinical protocols.
Keywords	coronavirus disease 2019 ; inter-observer agreement ; inter-rater reliability ; lung ultrasound ; point-of-care ultrasound ; reliability ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Modelo Point-of-Care Ultrasound en Atención Primaria: ¿herramienta de alta resolución?

Calvo Cebrián, Antonio / López García-Franco, Alberto / Short Apellaniz, Jorge

Atencion primaria

2018 Volume 50, Issue 8, Page(s) 500–508

Abstract: Point-of-Care Ultrasound is a method of performing a rapid clinical ultrasound, with the aim of responding to a clinical question immediately. This is not an ultrasound performed systematically as the radiologists do, nor does it pretend to replace it. ... ...

Title translation	Point of Care Ultrasound in Primary Care. Is it a high resolution tool?
Abstract	Point-of-Care Ultrasound is a method of performing a rapid clinical ultrasound, with the aim of responding to a clinical question immediately. This is not an ultrasound performed systematically as the radiologists do, nor does it pretend to replace it. It is useful in some kind of screening (abdominal aortic aneurysm) and is of special interest in ultrasound-guided procedures (joint infiltration by injection). It allows to adapt the derivations, minimising the uncertainty, ruling out certain pathologies due to its high diagnostic precision. It can also lead to overdiagnosis, if the examinations carried out are not limited to the organs on which our clinical suspicion is based. Ultrasound is one tool more in the diagnostic process, but its use must be limited to certain clinical situations. Its use in early detection of prevalent diseases in Primary Care should be properly evaluated. On the other hand with more evidence of a high diagnostic accuracy in a large list of pathological conditions.
MeSH term(s)	Aortic Aneurysm/diagnostic imaging ; Asymptomatic Diseases ; Humans ; Medical Overuse/prevention & control ; Point-of-Care Systems ; Primary Health Care/methods ; Primary Health Care/standards ; Risk Factors ; Ultrasonography/methods ; Ultrasonography/standards
Language	Spanish
Publishing date	2018-03-31
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1200787-0
ISSN	1578-1275 ; 0212-6567
ISSN (online)	1578-1275
ISSN	0212-6567
DOI	10.1016/j.aprim.2017.11.007
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Article: Novel Characterization Techniques for Multifunctional Plasmonic-Magnetic Nanoparticles in Biomedical Applications.

Calvo, Rodrigo / Rodriguez Mariblanca, Isabel / Pini, Valerio / Dias, Monica / Cebrian, Virginia / Thon, Andreas / Saad, Asis / Salvador-Matar, Antonio / Ahumada, Óscar / Manso Silván, Miguel / Saunders, Aaron E / Wang, Wentao / Stassinopoulos, Adonis

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 22

Abstract: In the rapidly emerging field of biomedical applications, multifunctional nanoparticles, especially those containing magnetic and plasmonic components, have gained significant attention due to their combined properties. These hybrid systems, often ... ...

Abstract	In the rapidly emerging field of biomedical applications, multifunctional nanoparticles, especially those containing magnetic and plasmonic components, have gained significant attention due to their combined properties. These hybrid systems, often composed of iron oxide and gold, provide both magnetic and optical functionalities and offer promising avenues for applications in multimodal bioimaging, hyperthermal therapies, and magnetically driven selective delivery. This paper focuses on the implementation of advanced characterization methods, comparing statistical analyses of individual multifunctional particle properties with macroscopic properties as a way of fine-tuning synthetic methodologies for their fabrication methods. Special emphasis is placed on the size-dependent properties, biocompatibility, and challenges that can arise from this versatile nanometric system. In order to ensure the quality and applicability of these particles, various novel methods for characterizing the magnetic gold particles, including the analysis of their morphology, optical response, and magnetic response, are also discussed, with the overall goal of optimizing the fabrication of this complex system and thus enhancing its potential as a preferred diagnostic agent.
Language	English
Publishing date	2023-11-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13222929
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Article ; Online: Modelo Point-of-Care Ultrasound en Atención Primaria

Antonio Calvo Cebrián / Alberto López García-Franco / Jorge Short Apellaniz

Atención Primaria, Vol 50, Iss 8, Pp 500-

¿herramienta de alta resolución?

2018 Volume 508

Abstract: Resumen: El modelo «Point of Care Ultrasound» es una forma de hacer ecografía clínica rápida con un fin: responder a una cuestión clínica de forma inmediata. No es hacer ecografía de modo sistemático como la que hacen los radiólogos, ni pretende ... ...

Abstract	Resumen: El modelo «Point of Care Ultrasound» es una forma de hacer ecografía clínica rápida con un fin: responder a una cuestión clínica de forma inmediata. No es hacer ecografía de modo sistemático como la que hacen los radiólogos, ni pretende sustituirla. Es útil en alguna forma de cribado (aneurisma de aorta abdominal) y es de especial interés en procedimientos ecoguiados (infiltraciones articulares).Permite adecuar las derivaciones, minimizando la incertidumbre y descartando determinadas enfermedades por su elevada precisión diagnóstica. Pero puede llevarnos al sobrediágnostico si las exploraciones que realizamos son no limitadas a los órganos sobre los que está fundamentada nuestra sospecha clínica.La ecografía es una herramienta más del proceso diagnóstico, pero que debe ser limitada en su utilización a determinadas situaciones clínicas. Su uso en la detección precoz de enfermedades prevalentes en Atención Primaria deberá ser convenientemente evaluado.Y, por otra parte, con gran evidencia de alta precisión diagnóstica en un gran elenco de entidades patológicas. Abstract: Point-of-Care Ultrasound is a method of performing a rapid clinical ultrasound, with the aim of responding to a clinical question immediately. This is not an ultrasound performed systematically as the radiologists do, nor does it pretend to replace it. It is useful in some kind of screening (abdominal aortic aneurysm) and is of special interest in ultrasound-guided procedures (joint infiltration by injection).It allows to adapt the derivations, minimising the uncertainty, ruling out certain pathologies due to its high diagnostic precision. It can also lead to overdiagnosis, if the examinations carried out are not limited to the organs on which our clinical suspicion is based.Ultrasound is one tool more in the diagnostic process, but its use must be limited to certain clinical situations. Its use in early detection of prevalent diseases in Primary Care should be properly evaluated. On the other hand with more evidence of a high diagnostic ...
Keywords	Medicine (General) ; R5-920
Language	Spanish
Publishing date	2018-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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