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  1. Article: Insight into Recent Advances in Degrading Androgen Receptor for Castration-Resistant Prostate Cancer.

    Chen, Qiao-Hong / Munoz, Erick / Ashong, Dennis

    Cancers

    2024  Volume 16, Issue 3

    Abstract: Induced protein degradation has emerged as an innovative drug discovery approach, complementary to the classical method of suppressing protein function. The androgen receptor signaling pathway has been identified as the primary driving force in the ... ...

    Abstract Induced protein degradation has emerged as an innovative drug discovery approach, complementary to the classical method of suppressing protein function. The androgen receptor signaling pathway has been identified as the primary driving force in the development and progression of lethal castration-resistant prostate cancer. Since androgen receptor degraders function differently from androgen receptor antagonists, they hold the promise to overcome the drug resistance challenges faced by current therapeutics. Proteolysis-targeting chimeras (PROTACs), monomeric degraders, hydrophobic tagging, molecular glues, and autophagic degradation have demonstrated their capability in downregulating intracellular androgen receptor concentrations. The potential of these androgen receptor degraders to treat castration-resistant prostate cancer is substantiated by the advancement of six PROTACs and two monomeric androgen receptor degraders into phase I or II clinical trials. Although the chemical structures, in vitro and in vivo data, and degradation mechanisms of androgen receptor degraders have been reviewed, it is crucial to stay updated on recent advances in this field as novel androgen receptor degraders and new strategies continue to emerge. This review thus provides insight into recent advancements in this paradigm, offering an overview of the progress made since 2020.
    Language English
    Publishing date 2024-02-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Impact of Visual Abstracts Compared to Automated Tweets on Social Media in Otology & Neurotology.

    Fan, Caleb J / Hong, Alyssa C / Bojrab, Dennis I / Lustig, Lawrence R / Hong, Robert S

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2024  

    Abstract: Objective: To analyze the effect of visual abstracts versus automated tweets on social media participation in Otology & Neurotology.: Patients: N/A.: Interventions: Introduction of visual abstracts developed by the social media editorial team to ... ...

    Abstract Objective: To analyze the effect of visual abstracts versus automated tweets on social media participation in Otology & Neurotology.
    Patients: N/A.
    Interventions: Introduction of visual abstracts developed by the social media editorial team to established automated tweets created by the dlvr.it computer program on the Otology & Neurotology Twitter account.
    Main outcome measures: Twitter analytics including the number of new followers per month, impressions per tweet, and engagements per tweet. The Kruskal-Wallis analysis of variance test was used to compare means.
    Results: From October 2016 to October 2017 (average of 20 new followers per month), 101 automated tweets averaged 536 impressions and 16 engagements per tweet. The visual abstract was introduced in November 2017. From November 2017 to November 2020 (average of 39 new followers per month), 447 automated tweets averaged 747 impressions and 22 engagements per tweet, whereas 157 visual abstracts averaged 1977 impressions and 78 engagements per tweet. Automated tweets were discontinued in December 2020. From December 2020 to December 2022 (average of 44 new followers per month), 95 visual abstracts averaged 1893 impressions and 103 engagements per tweet. With the introduction of the visual abstract, the average number of followers, impressions per tweet, and engagements per tweet significantly increased (all p-values <0.01; all large effect sizes of 0.16, 0.47, and 0.47, respectively).
    Conclusions: Visual abstracts created by a social media editorial team have a positive impact on social media participation in the field of otology and neurotology. The impact is greater than that of social media content generated by Twitter automation tools.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000004186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1554: Show issues Location:
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  3. Article: Phylotranscriptomics Shed Light on Intrageneric Relationships and Historical Biogeography of

    Habib, Sadaf / Gong, Yiqing / Dong, Shanshan / Lindstrom, Anders / Stevenson, Dennis William / Wu, Hong / Zhang, Shouzhou

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: ... ...

    Abstract Ceratozamia
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12030478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Extra-syndesmotic interposition of osteochondral fragment causing malreduced ankle syndesmosis.

    Chua, Chen Xi Kasia / Hey, Hwee Weng Dennis / Chua, Xin Ying Jasline / Tan, Ken Jin / Hong, Choon Chiet

    Singapore medical journal

    2023  

    Language English
    Publishing date 2023-05-12
    Publishing country India
    Document type Letter
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.4103/singaporemedj.SMJ-2021-110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Superior Mesenteric Artery Syndrome.

    Gibson, Dennis / Hong, Michael / Mehler, Philip S

    Mayo Clinic proceedings

    2021  Volume 96, Issue 12, Page(s) 2945–2946

    MeSH term(s) Female ; Humans ; Superior Mesenteric Artery Syndrome/diagnosis ; Superior Mesenteric Artery Syndrome/diagnostic imaging ; Superior Mesenteric Artery Syndrome/therapy ; Tomography, X-Ray Computed ; Young Adult
    Language English
    Publishing date 2021-12-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.09.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The case for cochlear implantation in unilateral and asymmetric sensorineural hearing loss.

    Bojrab, Dennis / Hong, Robert S

    Current opinion in otolaryngology & head and neck surgery

    2020  Volume 28, Issue 5, Page(s) 329–334

    Abstract: Purpose of review: Cochlear implants have been used to treat bilateral deafness for over 40 years. A more recent development has been the application of this technology toward single-sided deafness (SSD) and asymmetric hearing loss (AHL), culminating in ...

    Abstract Purpose of review: Cochlear implants have been used to treat bilateral deafness for over 40 years. A more recent development has been the application of this technology toward single-sided deafness (SSD) and asymmetric hearing loss (AHL), culminating in the Food and Drug Administration (FDA) approval in the United States for this indication in July of 2019. This review examines the recent literature on cochlear implants for SSD and AHL, focusing on speech perception, sound localization, tinnitus, and quality of life.
    Recent findings: There is an expanding body of literature supporting the use of cochlear implant in SSD/AHL patients. The cochlear implant offers a unique rehabilitation option for this subset of patients as it potentially restores binaural hearing (direct stimulation of both ears). A review of the literature reveals significant improvements with the cochlear implant in speech perception in quiet and noise, sound localization, tinnitus, and quality of life. In addition, these improvements appear to be greater than what conventional options such as a contralateral routing of signal (CROS) hearing aid and bone conduction device (BCD) are able to achieve.
    Summary: Cochlear implants offer additional benefits over previously available options of CROS and BCDs and have recently been approved by the FDA for use in patient with SSD/AHL. Given the growing body of literature demonstrating the benefit of cochlear implant over other devices, it is important to offer cochlear implant as an option to these patients.
    MeSH term(s) Cochlear Implantation ; Cochlear Implants ; Hearing Loss, Sensorineural/therapy ; Hearing Loss, Unilateral/therapy ; Humans ; Patient Selection
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4814: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: The role of warmed-humidified carbon dioxide insufflation in colorectal surgery: A systematic review and meta-analysis.

    Sharma, Sahil / McKechnie, Tyler / Khamar, Jigish / Wu, Kathy / Hong, Dennis / Eskicioglu, Cagla

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2023  Volume 26, Issue 1, Page(s) 7–21

    Abstract: Background: Maintenance of normothermia is a crucial part of enhanced recovery after colorectal surgery. Dry-cold carbon dioxide (CO: Methods: A search of Medline, EMBASE, and CENTRAL was performed. Randomised controlled trials (RCTs) that compared ... ...

    Abstract Background: Maintenance of normothermia is a crucial part of enhanced recovery after colorectal surgery. Dry-cold carbon dioxide (CO
    Methods: A search of Medline, EMBASE, and CENTRAL was performed. Randomised controlled trials (RCTs) that compared patients receiving warmed-humidified CO
    Results: Among the six RCTs included, 208 patients received warmed-humidified CO
    Conclusion: Patients undergoing colorectal surgery receiving warmed-humidified CO
    MeSH term(s) Aged ; Female ; Humans ; Male ; Carbon Dioxide ; Colorectal Surgery/methods ; Humidity ; Insufflation/methods ; Laparoscopy/methods ; Pain, Postoperative/etiology
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5799: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Postoperative Gastrointestinal Dysfunction After Neuromuscular Blockade Reversal With Sugammadex Versus Cholinesterase Inhibitors in Patients Undergoing Gastrointestinal Surgery: A Systematic Review and Meta-Analysis.

    Sharma, Sahil / McKechnie, Tyler / Talwar, Gaurav / Patel, Janhavi / Heimann, Luke / Doumouras, Aristithes / Hong, Dennis / Eskicioglu, Cagla

    The American surgeon

    2024  , Page(s) 31348241227200

    Abstract: Background: Postoperative gastrointestinal dysfunction (POGD) commonly occurs following gastrointestinal (GI) surgery and is associated with specific anesthetic agents. Cholinesterase inhibitors employed for reversing neuromuscular blockade have been ... ...

    Abstract Background: Postoperative gastrointestinal dysfunction (POGD) commonly occurs following gastrointestinal (GI) surgery and is associated with specific anesthetic agents. Cholinesterase inhibitors employed for reversing neuromuscular blockade have been implicated in development of POGD. Sugammadex, a novel reversal agent, is linked with reduced POGD. However, there is a lack of comprehensive comparative review between these agents regarding their impact on POGD following GI surgery. This study aims to systematically review the effects of sugammadex on POGD compared to cholinesterase inhibitors following GI surgery.
    Methods: MEDLINE, EMBASE, and CENTRAL were searched as of July 2022 to identify articles comparing sugammadex with cholinesterase inhibitors in patients undergoing gastrointestinal surgery, specifically in relation to POGD. Secondary endpoints included length of hospital stay, readmission rates, pulmonary complications, and postoperative morbidity.
    Results: From 198 citations, 2 randomized controlled trials (RCTs) and 3 retrospective cohorts with 717 patients receiving sugammadex and 812 patients receiving cholinesterase inhibitors were included. Significantly lower rates of prolonged postoperative ileus (OR .44, 95% CI .25-.77,
    Conclusion: The use of sugammadex following gastrointestinal surgery is associated with significantly lower rates of prolonged postoperative ileus compared to cholinesterase inhibitors. However, these do not translate into a significant reduction in length of stay, morbidity, or postoperative nausea and vomiting. Results are limited by the numer of studies included and missing data, more robust RCTs are needed before recommendations can be made.
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348241227200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.106: Show issues Location:
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  9. Article ; Online: Prucalopride and Bowel Function Post Gastrointestinal Surgery: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    Talwar, Gaurav / Sharma, Sahil / McKechnie, Tyler / Yang, Shuling / Khamar, Jigish / Hong, Dennis / Doumouras, Aristithes / Eskicioglu, Cagla

    The American surgeon

    2024  , Page(s) 31348241241683

    Abstract: Background: Prolonged postoperative ileus (PPOI) contributes to morbidity and prolonged hospitalization. Prucalopride, a selective 5-hydroxytryptamine receptor agonist, may enhance bowel motility. This review assesses whether the perioperative use of ... ...

    Abstract Background: Prolonged postoperative ileus (PPOI) contributes to morbidity and prolonged hospitalization. Prucalopride, a selective 5-hydroxytryptamine receptor agonist, may enhance bowel motility. This review assesses whether the perioperative use of prucalopride compared to placebo is associated with accelerated return of bowel function post gastrointestinal (GI) surgery.
    Methods: OVID, CENTRAL, and EMBASE were searched as of January 2024 to identify randomized controlled trials (RCTs) comparing prucalopride and placebo for prevention of PPOI in adult patients undergoing GI surgery. The primary outcomes were time to stool, time to flatus, and time to oral tolerance. The secondary outcomes were incidence of PPOI, length of stay (LOS), postoperative complications, adverse events, and overall costs. The Cochrane risk of bias tool for randomized trials and the Grading of Recommendations, Assessment, Development, and Evaluations framework were used. An inverse variance random effects model was used.
    Results: From 174 citations, 3 RCTs with 139 patients in each treatment group were included. Patients underwent a variety of GI surgeries. Patients treated with prucalopride had a decreased time to stool (mean difference 36.82 hours, 95% CI 59.4 to 14.24 hours lower, I
    Discussion: Current RCT evidence suggests that prucalopride may enhance postoperative return of bowel function. Larger RCTs assessing patient important outcomes and associated costs are needed before routine use of this agent.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348241241683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Magnetic CAR T cell purification using an anti-G4S linker antibody.

    Harrer, Dennis Christoph / Li, Sin-Syue / Kaljanac, Marcell / Bezler, Valerie / Barden, Markus / Pan, Hong / Herr, Wolfgang / Abken, Hinrich

    Journal of immunological methods

    2024  Volume 528, Page(s) 113667

    Abstract: Chimeric antigen receptor (CAR) redirected T cells are successfully employed in the combat against several hematological malignancies, however, are often compromised by low transduction rates making refinement of the CAR T cell products necessary. Here, ... ...

    Abstract Chimeric antigen receptor (CAR) redirected T cells are successfully employed in the combat against several hematological malignancies, however, are often compromised by low transduction rates making refinement of the CAR T cell products necessary. Here, we report a broadly applicable enrichment protocol relying on marking CAR T cells with an anti-glycine
    MeSH term(s) T-Lymphocytes ; Cytotoxicity, Immunologic ; Receptors, Chimeric Antigen ; Cell Separation ; Magnetic Phenomena ; Immunotherapy, Adoptive/methods
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2024-04-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 120142-6
    ISSN 1872-7905 ; 0022-1759
    ISSN (online) 1872-7905
    ISSN 0022-1759
    DOI 10.1016/j.jim.2024.113667
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