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Article ; Online: Pulmonary functional imaging (PFI): A historical review and perspective.

Bozovic, Gracijela / Schaefer-Prokop, Cornelia M / Bankier, Alexander A

Acta radiologica (Stockholm, Sweden : 1987)

2022 , Page(s) 2841851221076324

Abstract: PFI Pulmonary Functional Imaging (PFI) refers to visualization and measurement of ventilation, perfusion, gas flow and exchange as well as biomechanics. In this review, we will highlight the historical development of PFI, describing recent advances and ... ...

Abstract	PFI Pulmonary Functional Imaging (PFI) refers to visualization and measurement of ventilation, perfusion, gas flow and exchange as well as biomechanics. In this review, we will highlight the historical development of PFI, describing recent advances and listing the various techniques for PFI offered per modality. Challenges PFI is facing and requirements for PFI from a clinical point of view will be pointed out. Hereby the review is meant as an introduction to PFI.
Language	English
Publishing date	2022-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/02841851221076324
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Article ; Online: Elucidating the Complex Oxidation Behavior of Aqueous H

Wibowo, Romualdus Enggar / Garcia-Diez, Raul / Bystron, Tomas / van der Merwe, Marianne / Prokop, Martin / Arce, Mauricio D / Efimenko, Anna / Steigert, Alexander / Bernauer, Milan / Wilks, Regan G / Bouzek, Karel / Bär, Marcus

Journal of the American Chemical Society

2024 Volume 146, Issue 11, Page(s) 7386–7399

Abstract: ... In ... ...

Abstract	In situ
Language	English
Publishing date	2024-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c12381
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Article ; Online: Targeting the Angiotensin Pathway in the Treatment of Cutaneous Fibrosis: A Systematic Review.

Greif, Trenton / Alsawas, Mouaz / Reid, Alexander T / Liu, Vincent / Prokop, Larry / Murad, M Hassan / Powers, Jennifer G

JID innovations : skin science from molecules to population health

2023 Volume 3, Issue 6, Page(s) 100231

Abstract: Acting on the renin-angiotensin-aldosterone system, angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs) are mechanisms of some of the most prescribed medications in the world. In addition to their routine use for ... ...

Abstract	Acting on the renin-angiotensin-aldosterone system, angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs) are mechanisms of some of the most prescribed medications in the world. In addition to their routine use for the treatment of hypertension, such agents have gained attention for their influence on the angiotensin receptor pathway in fibrotic skin disorders, including scars and keloids. To evaluate the current level of evidence supporting the use of these agents, a systematic review related to ACE-Is/ARBs and cutaneous scarring was conducted. We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus from database inception through January 26, 2022. Two independent reviewers identified eligible studies for inclusion and extracted data. Data were insufficient for meta-analysis and are presented narratively. Of 461 citations identified, seven studies were included (199 patients). The studies included two randomized clinical trials, one comparative observation study, and four case reports. All the included studies reported statistically significant improvement in cutaneous scarring in patients using ACE-Is/ARBs compared with that in those treated with placebo/control using various outcome measures such as scar size and scar scales. However, much of the literature on this subject to date is limited by study design.
Language	English
Publishing date	2023-09-12
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2667-0267
ISSN (online)	2667-0267
DOI	10.1016/j.xjidi.2023.100231
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Article ; Online: Disbalanced recruitment of crossed and uncrossed cerebello-thalamic pathways during deep brain stimulation is predictive of delayed therapy escape in essential tremor.

Sajonz, Bastian E A / Frommer, Marvin L / Reisert, Marco / Blazhenets, Ganna / Schröter, Nils / Rau, Alexander / Prokop, Thomas / Reinacher, Peter C / Rijntjes, Michel / Urbach, Horst / Meyer, Philipp T / Coenen, Volker A

NeuroImage. Clinical

2024 Volume 41, Page(s) 103576

Abstract: Background: Thalamic deep brain stimulation (DBS) is an efficacious treatment for drug-resistant essential tremor (ET) and the dentato-rubro-thalamic tract (DRT) constitutes an important target structure. However, up to 40% of patients habituate and ... ...

Abstract	Background: Thalamic deep brain stimulation (DBS) is an efficacious treatment for drug-resistant essential tremor (ET) and the dentato-rubro-thalamic tract (DRT) constitutes an important target structure. However, up to 40% of patients habituate and lose treatment efficacy over time, frequently accompanied by a stimulation-induced cerebellar syndrome. The phenomenon termed delayed therapy escape (DTE) is insufficiently understood. Our previous work showed that DTE clinically is pronounced on the non-dominant side and suggested that differential involvement of crossed versus uncrossed DRT (DRTx/DRTu) might play a role in DTE development. Methods: We retrospectively enrolled right-handed patients under bilateral thalamic DBS >12 months for ET from a cross-sectional study. They were characterized with the Fahn-Tolosa-Marin Tremor Rating Scale (FTMTRS) and Scale for the Assessment and Rating of Ataxia (SARA) scores at different timepoints. Normative fiber tractographic evaluations of crossed and uncrossed cerebellothalamic pathways and volume of activated tissue (VAT) studies together with [ Results: A total of 29 patients met the inclusion criteria. Favoring DRTu over DRTx in the non-dominant VAT was associated with DTE (R Conclusion: Our results suggest that a disbalanced recruitment of DRTu in the non-dominant VAT induces detrimental stimulation effects on the dominant cerebellar outflow (together with contralateral stimulation) leading to DTE and thus hampering the overall treatment efficacy.
MeSH term(s)	Humans ; Essential Tremor/diagnostic imaging ; Essential Tremor/therapy ; Deep Brain Stimulation/methods ; Cross-Sectional Studies ; Retrospective Studies ; Diffusion Tensor Imaging/methods ; Thalamus/diagnostic imaging ; Thalamus/physiology ; Treatment Outcome ; Ataxia
Language	English
Publishing date	2024-02-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2701571-3
ISSN	2213-1582 ; 2213-1582
ISSN (online)	2213-1582
ISSN	2213-1582
DOI	10.1016/j.nicl.2024.103576
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Article ; Online: HOVE-Wedge-Filtering of Geomorphologic Terrestrial Laser Scan Data

Helmut Panholzer / Alexander Prokop

Applied Sciences, Vol 8, Iss 2, p

2018 Volume 263

Abstract: Terrestrial laser scanning has become an important surveying technique in many fields such as natural hazard assessment. To analyse earth surface processes, it is useful to generate a digital terrain model originated from laser scan point cloud data. To ... ...

Abstract	Terrestrial laser scanning has become an important surveying technique in many fields such as natural hazard assessment. To analyse earth surface processes, it is useful to generate a digital terrain model originated from laser scan point cloud data. To determine the terrain surface as precisely as possible, it is often necessary to filter out points that do not represent the terrain surface. Examples are vegetation, vehicles, and animals. In mountainous terrain with a small-structured topography, filtering is very difficult. Here, automatic filtering solutions usually designed for airborne laser scan data often lead to unsatisfactory results. In this work, we further develop an existing approach for automated filtering of terrestrial laser scan data, which is based on the assumption that no other surface point can be located in the area above a direct line of sight between scanner and another measured point. By taking into account several environmental variables and a repetitive calculation method, the modified method leads to significantly better results. The root-mean-square-error (RSME) for the same test measurement area could be reduced from 5.284 to 1.610. In addition, a new approach for filtering and interpolation of terrestrial laser scanning data is presented using a grid with horizontal and vertical angular data and the measurement length.
Keywords	terrestrial laser scanning ; filtering ; ground points ; digital terrain model (DTM) ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	550
Language	English
Publishing date	2018-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy of Norway Spruce Ointments and Bacterial and Fungal Alterations in the Treatment of Castration Wounds in Piglets.

Prokop, Désirée / Spergser, Joachim / Hagmüller, Werner / Tichy, Alexander / Zitterl-Eglseer, Karin

Planta medica

2021 Volume 88, Issue 3-04, Page(s) 300–312

Abstract: This study aimed to evaluate the efficacy of Norway spruce ointments on wound healing of castration wounds in piglets. This study included 95 male pigs randomly divided into five treatment groups: Norway spruce balm (Vulpuran), Norway spruce resin ( ... ...

Abstract	This study aimed to evaluate the efficacy of Norway spruce ointments on wound healing of castration wounds in piglets. This study included 95 male pigs randomly divided into five treatment groups: Norway spruce balm (Vulpuran), Norway spruce resin (Abilar), pork lard (ointment base of Vulpuran), no treatment (negative control) and antibiotic blue spray (Cyclo spray, positive control). Wound healing parameters (such as healing time, wound size, reddening of wound edges and surrounding, swelling, secretion and wound contamination), microbiological status and the haptoglobin level as an inflammation parameter were investigated. In the Norway spruce groups, some positive effects on wound healing parameters were found. In the first 6 days of treatment, Abilar or Vulpuran showed the smallest means of wound areas, and at the end of the study (day 15 + 17), the highest rates of completely closed wounds compared to the other groups. Vulpuran treatment led to significantly lower wound secretion (p = 0.003) and wound contamination (p = 0.015) than the untreated control did. Furthermore, the microbiological status was determined using MALDI-TOF-MS and partial 16S rRNA gene sequencing at different days of treatment. A comparison of the five treatment groups on day 3 revealed that Norway spruce led to the lowest rate of wounds colonised with fungi, mainly classified into genus Candida, (Abilar 77%, Vulpuran 70%) in comparison with blue spray (89%), lard (100%) and untreated control (100%). Fungi could only be detected in one of the 13 samples treated with Vulpuran on day 8, which nearly reached significance (p = 0.055).
MeSH term(s)	Animals ; Castration ; Fungi ; Ointments ; RNA, Ribosomal, 16S ; Swine ; Wound Healing
Chemical Substances	Ointments ; RNA, Ribosomal, 16S
Language	English
Publishing date	2021-10-08
Publishing country	Germany
Document type	Journal Article ; Randomized Controlled Trial, Veterinary
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/a-1646-2959
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Article ; Online: Fleischner Society: Glossary of Terms for Thoracic Imaging.

Bankier, Alexander A / MacMahon, Heber / Colby, Thomas / Gevenois, Pierre Alain / Goo, Jin Mo / Leung, Ann N C / Lynch, David A / Schaefer-Prokop, Cornelia M / Tomiyama, Noriyuki / Travis, William D / Verschakelen, Johny A / White, Charles S / Naidich, David P

Radiology

2024 Volume 310, Issue 2, Page(s) e232558

Abstract: Members of the Fleischner Society have compiled a glossary of terms for thoracic imaging that replaces previous glossaries published in 1984, 1996, and 2008, respectively. The impetus to update the previous version arose from multiple considerations. ... ...

Abstract	Members of the Fleischner Society have compiled a glossary of terms for thoracic imaging that replaces previous glossaries published in 1984, 1996, and 2008, respectively. The impetus to update the previous version arose from multiple considerations. These include an awareness that new terms and concepts have emerged, others have become obsolete, and the usage of some terms has either changed or become inconsistent to a degree that warranted a new definition. This latest glossary is focused on terms of clinical importance and on those whose meaning may be perceived as vague or ambiguous. As with previous versions, the aim of the present glossary is to establish standardization of terminology for thoracic radiology and, thereby, to facilitate communications between radiologists and clinicians. Moreover, the present glossary aims to contribute to a more stringent use of terminology, increasingly required for structured reporting and accurate searches in large databases. Compared with the previous version, the number of images (chest radiography and CT) in the current version has substantially increased. The authors hope that this will enhance its educational and practical value. All definitions and images are hyperlinked throughout the text. Click on each figure callout to view corresponding image. © RSNA, 2024
MeSH term(s)	Humans ; Diagnostic Imaging ; Communication ; Databases, Factual ; Radiologists
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.232558
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Article: An In-Silico Testbed for Fast and Accurate MR Labeling of Orthopaedic Implants.

Noetscher, Gregory M / Serano, Peter J / Horner, Marc / Prokop, Alexander / Hanson, Jonathan / Fujimoto, Kyoko / Brown, James E / Nazarian, Ara / Ackerman, Jerome / Makaroff, Sergey N

bioRxiv : the preprint server for biology

2023

Abstract: One limitation on the ability to monitor health in older adults using Magnetic Resonance (MR) imaging is the presence of implants, where the prevalence of implantable devices (orthopedic, cardiac, neuromodulation) increases in the population, as does the ...

Abstract	One limitation on the ability to monitor health in older adults using Magnetic Resonance (MR) imaging is the presence of implants, where the prevalence of implantable devices (orthopedic, cardiac, neuromodulation) increases in the population, as does the pervasiveness of conditions requiring MRI studies for diagnosis (musculoskeletal diseases, infections, or cancer). The present study describes a novel multiphysics implant modeling testbed using the following approaches with two examples: - an
Language	English
Publishing date	2023-10-02
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.16.549234
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Article ; Online: Guidance on Imaging for Invasive Pulmonary Aspergillosis and Mucormycosis: From the Imaging Working Group for the Revision and Update of the Consensus Definitions of Fungal Disease from the EORTC/MSGERC.

Alexander, Barbara D / Lamoth, Frédéric / Heussel, Claus Peter / Prokop, Cornelia Schaefer / Desai, Sujal R / Morrissey, C Orla / Baddley, John W

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2021 Volume 72, Issue Suppl 2, Page(s) S79–S88

Abstract: Background: Clinical imaging in suspected invasive fungal disease (IFD) has a significant role in early detection of disease and helps direct further testing and treatment. Revised definitions of IFD from the EORTC/MSGERC were recently published and ... ...

Abstract	Background: Clinical imaging in suspected invasive fungal disease (IFD) has a significant role in early detection of disease and helps direct further testing and treatment. Revised definitions of IFD from the EORTC/MSGERC were recently published and provide clarity on the role of imaging for the definition of IFD. Here, we provide evidence to support these revised diagnostic guidelines. Methods: We reviewed data on imaging modalities and techniques used to characterize IFDs. Results: Volumetric high-resolution computed tomography (CT) is the method of choice for lung imaging. Although no CT radiologic pattern is pathognomonic of IFD, the halo sign, in the appropriate clinical setting, is highly suggestive of invasive pulmonary aspergillosis (IPA) and associated with specific stages of the disease. The ACS is not specific for IFD and occurs in the later stages of infection. By contrast, the reversed halo sign and the hypodense sign are typical of pulmonary mucormycosis but occur less frequently. In noncancer populations, both invasive pulmonary aspergillosis and mucormycosis are associated with "atypical" nonnodular presentations, including consolidation and ground-glass opacities. Conclusions: A uniform definition of IFD could improve the quality of clinical studies and aid in differentiating IFD from other pathology in clinical practice. Radiologic assessment of the lung is an important component of the diagnostic work-up and management of IFD. Periodic review of imaging studies that characterize findings in patients with IFD will inform future diagnostic guidelines.
MeSH term(s)	Consensus ; Humans ; Immunocompromised Host ; Invasive Pulmonary Aspergillosis/diagnostic imaging ; Mucormycosis/diagnostic imaging ; Mycoses
Language	English
Publishing date	2021-02-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciaa1855
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Article ; Online: Quantifying the evolution of atomic interaction of a complex surface with a functionalized atomic force microscopy tip

Alexander Liebig / Prokop Hapala / Alfred J. Weymouth / Franz J. Giessibl

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 12

Abstract: Abstract Terminating the tip of an atomic force microscope with a CO molecule allows data to be acquired with a well-known and inert apex. Previous studies have shown conflicting results regarding the electrostatic interaction, indicating in some cases ... ...

Abstract	Abstract Terminating the tip of an atomic force microscope with a CO molecule allows data to be acquired with a well-known and inert apex. Previous studies have shown conflicting results regarding the electrostatic interaction, indicating in some cases that the negative charge at the apex of the CO dominates, whereas in other cases the positive charge at the end of the metal tip dominates. To clarify this, we investigated $$\hbox {CaF}_{2}$$ CaF 2 (111). $$\hbox {CaF}_{2}$$ CaF 2 is an ionic crystal and the (111) surface does not possess charge inversion symmetry. Far from the surface, the interaction is dominated by electrostatics via the negative charge at the apex. Closer to the surface, Pauli repulsion and CO bending dominate, which leads to an unexpected appearance of the complex 3-atom unit cell. We compare simulated data in which the electrostatics are modeled by point particles versus a charge density calculated by DFT. We also compare modeling Pauli repulsion via individual Lennard–Jones potentials versus a total charge density overlap. In doing so, we determine forcefield parameters useful for future investigations of biochemical processes.
Keywords	Medicine ; R ; Science ; Q
Subject code	541
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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