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  1. Article ; Online: Challenges with need to improve the reference standard in diagnosis paper 4: response to reed.

    Mustafa, Reem A / Schünemann, Holger J

    Journal of clinical epidemiology

    2022  Volume 154, Page(s) 218

    Language English
    Publishing date 2022-12-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2022.11.018
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  2. Article ; Online: The construct of certainty of evidence has not been disseminated to systematic reviews and clinical practice guidelines: author's reply.

    Schünemann, Holger J / Neumann, Ignacio

    Journal of clinical epidemiology

    2022  Volume 147, Page(s) 173

    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2022.03.015
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  3. Article ; Online: Letter: Potassium-competitive acid blockers may increase the risk of gastric cancer after Helicobacter pylori eradication-a retrospective multicentre-cohort analysis. Authors' reply.

    Piovani, Daniele / Tsantes, Andreas G / Schünemann, Holger J / Bonovas, Stefanos

    Alimentary pharmacology & therapeutics

    2023  Volume 57, Issue 10, Page(s) 1199–1200

    MeSH term(s) Humans ; Stomach Neoplasms ; Helicobacter pylori ; Cohort Studies ; Anti-Bacterial Agents/therapeutic use ; Retrospective Studies ; Helicobacter Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-22
    Publishing country England
    Document type Multicenter Study ; Letter ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17480
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  4. Article ; Online: Update of the agency for healthcare research and quality guidance on using nonrandomized studies in evidence syntheses.

    Cuello-Garcia, Carlos A / Schünemann, Holger J

    Journal of clinical epidemiology

    2022  Volume 152, Page(s) 307–308

    Abstract: ...

    Abstract ▪.
    MeSH term(s) United States ; Humans ; United States Agency for Healthcare Research and Quality ; Health Services Research
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2022.10.010
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  5. Article ; Online: The impact of climate change on health needs structured evidence assessment and an evidence to action framework to make decisions: a proposal to adopt the GRADE approach.

    Neumann, Ignacio / Antó, Josep M / Bousquet, Jean / Schünemann, Holger J

    Journal of clinical epidemiology

    2023  Volume 157, Page(s) 146–153

    Abstract: Objectives: To highlight how using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach to understand the certainty in the evidence about the impact of climate change in health outcomes increases transparency. Also, ... ...

    Abstract Objectives: To highlight how using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach to understand the certainty in the evidence about the impact of climate change in health outcomes increases transparency. Also, how GRADE can enhance communication and decisions about adaptation and mitigation strategies.
    Study design and setting: We developed a narrative review based on an assessment of exiting systematic reviews addressing the effect of climate change on health outcomes and the impact of mitigation and adaptation strategies.
    Results: Adopting structured approaches such as GRADE to tackle the impact of climate change on health may help to (1) define the specific question to be addressed; (2) summarize the evidence in a structured way and assess uncertainty; (3) provide a systematic framework to move from evidence to action and to offer recommendations of different strength; (4) provide a systematic way to adapt recommendations to specific settings; and (5) provide a framework to assess the certainty of modeled evidence.
    Conclusion: In this article, we describe epidemiologic principles that could be used to move decision-making in climate change forward.
    MeSH term(s) Humans ; Climate Change ; GRADE Approach ; Communication
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2023.01.006
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  6. Article ; Online: Guideline groups should make recommendations even if the evidence is considered insufficient.

    Neumann, Ignacio / Schünemann, Holger J

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2020  Volume 192, Issue 2, Page(s) E23–E24

    MeSH term(s) Evidence-Based Medicine ; Humans ; Practice Guidelines as Topic
    Language English
    Publishing date 2020-01-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.190144
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  7. Article ; Online: Prospective collaborative recommendation development: a novel model for more timely and trustworthy guidelines.

    Akl, Elie A / Cuker, Adam / Mustafa, Reem A / Nieuwlaat, Robby / Stevens, Adrienne / Schünemann, Holger J

    Journal of clinical epidemiology

    2023  Volume 162, Page(s) 156–159

    MeSH term(s) Humans ; Prospective Studies ; Evidence-Based Medicine
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2023.08.015
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  8. Article ; Online: Next generation health guidelines: The role of real-life data in evidence-based medicine.

    Canonica, G Walter / Agache, Ioana / Schünemann, Holger J / Roche, Nicolas / Price, David / Del Giacco, Stefano

    Allergy

    2023  Volume 79, Issue 1, Page(s) 12–14

    MeSH term(s) Humans ; Evidence-Based Medicine ; Practice Guidelines as Topic
    Language English
    Publishing date 2023-09-07
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15887
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  9. Article ; Online: Interpreting GRADE's levels of certainty or quality of the evidence: GRADE for statisticians, considering review information size or less emphasis on imprecision?

    Schünemann, Holger J

    Journal of clinical epidemiology

    2016  Volume 75, Page(s) 6–15

    Abstract: This article responds to issues raised by Antilla et al. in the Journal of Clinical Epidemiology about the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group's approach to rating imprecision and GRADE's use of ... ...

    Abstract This article responds to issues raised by Antilla et al. in the Journal of Clinical Epidemiology about the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group's approach to rating imprecision and GRADE's use of statistics. They argue that GRADE confuses statistical terms and should provide a stepwise rating of imprecision for making decisions. Here, a clarification of those perceptions is provided. GRADE's ratings of imprecision and other quality of evidence domains is an iterative process that may or may not consider people important thresholds of effects when systematic review authors rate imprecision. Regardless of ratings in systematic reviews, those suggesting decisions such as guideline panels, should consider if they agree or need to revise these suggested thresholds to make informed ratings about imprecision. Decision relevant thresholds are the result of a complex interplay between critical outcomes for a decision-making. The certainty in the evidence of one critical outcome and the resulting possible certainty range, which I conceptualize in this article, may influence ratings of other outcomes. To relieve systematic review authors of the often challenging burden of defining worthwhile or important effects for judging precision based on the optimal information size (OIS), a modified OIS or review information size (RIS) could be used to rate imprecision at the systematic review stage. The RIS focuses only on plausible rather plausible and worthwhile effects. The advantages of using the RIS include avoiding the reliance on statistical significance alone and the varying thresholds resulting from the importance and the baseline risk of the outcome on which the OIS relies. Finally, I argue that GRADE's certainty in the evidence is related to the statistical definition of accuracy but given GRADE's broad application to other ratings of certainty such as qualitative evidence, statistical accuracy does not serve as a definition for GRADE's quality or certainty in the evidence.
    MeSH term(s) Epidemiologic Research Design ; Evidence-Based Medicine/standards ; Evidence-Based Medicine/statistics & numerical data ; Humans ; Reproducibility of Results ; Review Literature as Topic ; Uncertainty
    Language English
    Publishing date 2016-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2016.03.018
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  10. Article ; Online: Participatory development of a target policy profile to support soil-transmitted helminth elimination.

    Means, Arianna Rubin / List, Kellie / Roll, Amy / Gwayi-Chore, Marie-Claire / Dolley, Shawn / Schünemann, Holger J / Norman, Thea C / Walson, Judd L

    Frontiers in health services

    2024  Volume 3, Page(s) 1310694

    Abstract: Introduction: Soil-transmitted helminths (STH) are parasitic worms that infect nearly a quarter of the world's population, particularly those living in communities without access to adequate water, sanitation, and housing. Emerging evidence suggests ... ...

    Abstract Introduction: Soil-transmitted helminths (STH) are parasitic worms that infect nearly a quarter of the world's population, particularly those living in communities without access to adequate water, sanitation, and housing. Emerging evidence suggests that it may be possible to interrupt transmission of STH by deworming individuals of all ages via community-wide MDA (cMDA), as opposed to only treating children and other focal populations. Transitioning from a policy of STH control to STH elimination in targeted areas would require a fundamental shift in STH policy and programming. This policy change would require updated guidance to support countries as they adapt their current approaches for STH surveillance, supply chain management, community mobilization, and core programmatic activities in pursuit of STH elimination. There is an opportunity to engage with key stakeholders, such as program implementers and implementation partners, to understand what evidence they need to confidently adopt a new policy guideline and to deliver guideline adherent management at scale.
    Methods: We aimed to engage with STH stakeholders to develop a Target Policy Profile (TPoP), a single document that describes optimal characteristics and evidence requirements that STH stakeholders prioritized in future potential STH transmission interruption efforts. Steps in TPoP development included a scoping review and key informant interviews (KIIs), which were used to design a two-stage Delphi technique to identify and verify TPoP components.
    Results: The scoping review resulted in 25 articles, and 8 experts participated in KII's. Twenty respondents completed the first Delphi survey and 10 respondents completed the second. This systematic effort resulted in a net of 3 key information domains (background/context, clinical considerations, and implementation considerations) encompassing 24 evidence categories (examples include evidence regarding safety and adverse events, implementation feasibility, or evidence dissemination). For each evidence category, STH stakeholders reviewed, endorsed, or revised a range of options for how the evidence could be presented.
    Discussion: This information can be used by guideline committees or global policy makers prior to convening guideline advisory groups. The TPoP tool may also speed the process of stakeholder consensus building around guidelines, accelerating progress towards implementing evidence-based policy at scale.
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2813-0146
    ISSN (online) 2813-0146
    DOI 10.3389/frhs.2023.1310694
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