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  1. Article ; Online: Deep learning COVID-19 detection bias: accuracy through artificial intelligence.

    Vaid, Shashank / Kalantar, Reza / Bhandari, Mohit

    International orthopaedics

    2020  Volume 44, Issue 8, Page(s) 1539–1542

    Abstract: Background: Detection of COVID-19 cases' accuracy is posing a conundrum for scientists, physicians, and policy-makers. As of April 23, 2020, 2.7 million cases have been confirmed, over 190,000 people are dead, and about 750,000 people are reported ... ...

    Abstract Background: Detection of COVID-19 cases' accuracy is posing a conundrum for scientists, physicians, and policy-makers. As of April 23, 2020, 2.7 million cases have been confirmed, over 190,000 people are dead, and about 750,000 people are reported recovered. Yet, there is no publicly available data on tests that could be missing infections. Complicating matters and furthering anxiety are specific instances of false-negative tests.
    Methods: We developed a deep learning model to improve accuracy of reported cases and to precisely predict the disease from chest X-ray scans. Our model relied on convolutional neural networks (CNNs) to detect structural abnormalities and disease categorization that were keys to uncovering hidden patterns. To do so, a transfer learning approach was deployed to perform detections from the chest anterior-posterior radiographs of patients. We used publicly available datasets to achieve this.
    Results: Our results offer very high accuracy (96.3%) and loss (0.151 binary cross-entropy) using the public dataset consisting of patients from different countries worldwide. As the confusion matrix indicates, our model is able to accurately identify true negatives (74) and true positives (32); this deep learning model identified three cases of false-positive and one false-negative finding from the healthy patient scans.
    Conclusions: Our COVID-19 detection model minimizes manual interaction dependent on radiologists as it automates identification of structural abnormalities in patient's CXRs, and our deep learning model is likely to detect true positives and true negatives and weed out false positive and false negatives with > 96.3% accuracy.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; Bias ; COVID-19 ; Child ; Coronavirus Infections ; Deep Learning ; Female ; Humans ; Male ; Middle Aged ; Neural Networks, Computer ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-020-04609-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Using Machine Learning to Estimate Unobserved COVID-19 Infections in North America.

    Vaid, Shashank / Cakan, Caglar / Bhandari, Mohit

    The Journal of bone and joint surgery. American volume

    2020  Volume 102, Issue 13, Page(s) e70

    Abstract: Background: The detection of coronavirus disease 2019 (COVID-19) cases remains a huge challenge. As of April 22, 2020, the COVID-19 pandemic continues to take its toll, with >2.6 million confirmed infections and >183,000 deaths. Dire projections are ... ...

    Abstract Background: The detection of coronavirus disease 2019 (COVID-19) cases remains a huge challenge. As of April 22, 2020, the COVID-19 pandemic continues to take its toll, with >2.6 million confirmed infections and >183,000 deaths. Dire projections are surfacing almost every day, and policymakers worldwide are using projections for critical decisions. Given this background, we modeled unobserved infections to examine the extent to which we might be grossly underestimating COVID-19 infections in North America.
    Methods: We developed a machine-learning model to uncover hidden patterns based on reported cases and to predict potential infections. First, our model relied on dimensionality reduction to identify parameters that were key to uncovering hidden patterns. Next, our predictive analysis used an unbiased hierarchical Bayesian estimator approach to infer past infections from current fatalities.
    Results: Our analysis indicates that, when we assumed a 13-day lag time from infection to death, the United States, as of April 22, 2020, likely had at least 1.3 million undetected infections. With a longer lag time-for example, 23 days-there could have been at least 1.7 million undetected infections. Given these assumptions, the number of undetected infections in Canada could have ranged from 60,000 to 80,000. Duarte's elegant unbiased estimator approach suggested that, as of April 22, 2020, the United States had up to >1.6 million undetected infections and Canada had at least 60,000 to 86,000 undetected infections. However, the Johns Hopkins University Center for Systems Science and Engineering data feed on April 22, 2020, reported only 840,476 and 41,650 confirmed cases for the United States and Canada, respectively.
    Conclusions: We have identified 2 key findings: (1) as of April 22, 2020, the United States may have had 1.5 to 2.029 times the number of reported infections and Canada may have had 1.44 to 2.06 times the number of reported infections and (2) even if we assume that the fatality and growth rates in the unobservable population (undetected infections) are similar to those in the observable population (confirmed infections), the number of undetected infections may be within ranges similar to those described above. In summary, 2 different approaches indicated similar ranges of undetected infections in North America.
    Level of evidence: Prognostic Level V. See Instructions for Authors for a complete description of levels of evidence.
    MeSH term(s) Bayes Theorem ; Betacoronavirus ; COVID-19 ; Canada/epidemiology ; Computer Simulation ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Forecasting ; Humans ; Machine Learning ; North America/epidemiology ; Pandemics/statistics & numerical data ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.20.00715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Deep learning COVID-19 detection bias

    Vaid, Shashank / Kalantar, Reza / Bhandari, Mohit

    International Orthopaedics

    accuracy through artificial intelligence

    2020  Volume 44, Issue 8, Page(s) 1539–1542

    Keywords Orthopedics and Sports Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-020-04609-7
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Using Machine Learning to Estimate Unobserved COVID-19 Infections in North America

    Vaid, Shashank / Cakan, Caglar / Bhandari, Mohit

    Journal of Bone and Joint Surgery

    2020  Volume Publish Ahead of Print

    Keywords Surgery ; Orthopedics and Sports Medicine ; General Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/jbjs.20.00715
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Deep learning COVID-19 detection bias: accuracy through artificial intelligence

    Vaid, Shashank / Kalantar, Reza / Bhandari, Mohit

    Int Orthop

    Abstract: BACKGROUND: Detection of COVID-19 cases' accuracy is posing a conundrum for scientists, physicians, and policy-makers. As of April 23, 2020, 2.7 million cases have been confirmed, over 190,000 people are dead, and about 750,000 people are reported ... ...

    Abstract BACKGROUND: Detection of COVID-19 cases' accuracy is posing a conundrum for scientists, physicians, and policy-makers. As of April 23, 2020, 2.7 million cases have been confirmed, over 190,000 people are dead, and about 750,000 people are reported recovered. Yet, there is no publicly available data on tests that could be missing infections. Complicating matters and furthering anxiety are specific instances of false-negative tests. METHODS: We developed a deep learning model to improve accuracy of reported cases and to precisely predict the disease from chest X-ray scans. Our model relied on convolutional neural networks (CNNs) to detect structural abnormalities and disease categorization that were keys to uncovering hidden patterns. To do so, a transfer learning approach was deployed to perform detections from the chest anterior-posterior radiographs of patients. We used publicly available datasets to achieve this. RESULTS: Our results offer very high accuracy (96.3%) and loss (0.151 binary cross-entropy) using the public dataset consisting of patients from different countries worldwide. As the confusion matrix indicates, our model is able to accurately identify true negatives (74) and true positives (32); this deep learning model identified three cases of false-positive and one false-negative finding from the healthy patient scans. CONCLUSIONS: Our COVID-19 detection model minimizes manual interaction dependent on radiologists as it automates identification of structural abnormalities in patient's CXRs, and our deep learning model is likely to detect true positives and true negatives and weed out false positive and false negatives with > 96.3% accuracy.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #381825
    Database COVID19

    Kategorien

  6. Article: Using Machine Learning to Estimate Unobserved COVID-19 Infections in North America

    Vaid, Shashank / Cakan, Caglar / Bhandari, Mohit

    J Bone Joint Surg Am

    Abstract: BACKGROUND: The detection of coronavirus disease 2019 (COVID-19) cases remains a huge challenge. As of April 22, 2020, the COVID-19 pandemic continues to take its toll, with >2.6 million confirmed infections and >183,000 deaths. Dire projections are ... ...

    Abstract BACKGROUND: The detection of coronavirus disease 2019 (COVID-19) cases remains a huge challenge. As of April 22, 2020, the COVID-19 pandemic continues to take its toll, with >2.6 million confirmed infections and >183,000 deaths. Dire projections are surfacing almost every day, and policymakers worldwide are using projections for critical decisions. Given this background, we modeled unobserved infections to examine the extent to which we might be grossly underestimating COVID-19 infections in North America. METHODS: We developed a machine-learning model to uncover hidden patterns based on reported cases and to predict potential infections. First, our model relied on dimensionality reduction to identify parameters that were key to uncovering hidden patterns. Next, our predictive analysis used an unbiased hierarchical Bayesian estimator approach to infer past infections from current fatalities. RESULTS: Our analysis indicates that, when we assumed a 13-day lag time from infection to death, the United States, as of April 22, 2020, likely had at least 1.3 million undetected infections. With a longer lag time-for example, 23 days-there could have been at least 1.7 million undetected infections. Given these assumptions, the number of undetected infections in Canada could have ranged from 60,000 to 80,000. Duarte's elegant unbiased estimator approach suggested that, as of April 22, 2020, the United States had up to >1.6 million undetected infections and Canada had at least 60,000 to 86,000 undetected infections. However, the Johns Hopkins University Center for Systems Science and Engineering data feed on April 22, 2020, reported only 840,476 and 41,650 confirmed cases for the United States and Canada, respectively. CONCLUSIONS: We have identified 2 key findings: (1) as of April 22, 2020, the United States may have had 1.5 to 2.029 times the number of reported infections and Canada may have had 1.44 to 2.06 times the number of reported infections and (2) even if we assume that the fatality and growth rates in the unobservable population (undetected infections) are similar to those in the observable population (confirmed infections), the number of undetected infections may be within ranges similar to those described above. In summary, 2 different approaches indicated similar ranges of undetected infections in North America. LEVEL OF EVIDENCE: Prognostic Level V. See Instructions for Authors for a complete description of levels of evidence.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #208772
    Database COVID19

    Kategorien

  7. Article ; Online: Risk of a second wave of Covid-19 infections: using artificial intelligence to investigate stringency of physical distancing policies in North America.

    Vaid, Shashank / McAdie, Aaron / Kremer, Ran / Khanduja, Vikas / Bhandari, Mohit

    International orthopaedics

    2020  Volume 44, Issue 8, Page(s) 1581–1589

    Abstract: Purpose: Accurately forecasting the occurrence of future covid-19-related cases across relaxed (Sweden) and stringent (USA and Canada) policy contexts has a renewed sense of urgency. Moreover, there is a need for a multidimensional county-level approach ...

    Abstract Purpose: Accurately forecasting the occurrence of future covid-19-related cases across relaxed (Sweden) and stringent (USA and Canada) policy contexts has a renewed sense of urgency. Moreover, there is a need for a multidimensional county-level approach to monitor the second wave of covid-19 in the USA.
    Method: We use an artificial intelligence framework based on timeline of policy interventions that triangulated results based on the three approaches-Bayesian susceptible-infected-recovered (SIR), Kalman filter, and machine learning.
    Results: Our findings suggest three important insights. First, the effective growth rate of covid-19 infections dropped in response to the approximate dates of key policy interventions. We find that the change points for spreading rates approximately coincide with the timelines of policy interventions across respective countries. Second, forecasted trend until mid-June in the USA was downward trending, stable, and linear. Sweden is likely to be heading in the other direction. That is, Sweden's forecasted trend until mid-June appears to be non-linear and upward trending. Canada appears to fall somewhere in the middle-the trend for the same period is flat. Third, a Kalman filter based robustness check indicates that by mid-June the USA will likely have close to two million virus cases, while Sweden will likely have over 44,000 covid-19 cases.
    Conclusion: We show that drop in effective growth rate of covid-19 infections was sharper in the case of stringent policies (USA and Canada) but was more gradual in the case of relaxed policy (Sweden). Our study exhorts policy makers to take these results into account as they consider the implications of relaxing lockdown measures.
    MeSH term(s) Artificial Intelligence ; Bayes Theorem ; Betacoronavirus ; COVID-19 ; Canada ; Coronavirus Infections ; Humans ; Pandemics ; Physical Distancing ; Physical Examination ; Pneumonia, Viral ; Risk Factors ; SARS-CoV-2 ; Sweden ; Telemedicine ; United States
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-020-04653-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Diversity, Phylogeny, anticancer and antimicrobial potential of fungal endophytes associated with Monarda citriodora L.

    Katoch, Meenu / Phull, Shipra / Vaid, Shagun / Singh, Shashank

    BMC microbiology

    2017  Volume 17, Issue 1, Page(s) 44

    Abstract: Background: Present study focuses on diversity and distribution analysis of endophytic fungi associated with different tissues of the Monarda citriodora Cerv. ex Lag. (Lamiaceae/Labiatae). Anticancer and antimicrobial potential of isolated endophytes ... ...

    Abstract Background: Present study focuses on diversity and distribution analysis of endophytic fungi associated with different tissues of the Monarda citriodora Cerv. ex Lag. (Lamiaceae/Labiatae). Anticancer and antimicrobial potential of isolated endophytes have also been investigated.
    Results: A total of twenty eight fungal endophytes belonging to 11 different genera were isolated from this plant. All the endophytic fungi belonged to the Ascomycota phylum. The leaves were immensely rich in fungal species, while roots showed the highest tissue specific fungal dominance. Out of 28 fungal species, 72% endophytic extracts were found cytotoxic against one or more human cancer cell lines. The most prominent anticancer activity (IC
    Conclusions: These results indicated that M. citriodora harbors a rich fungal endophytic community with anticancer and antimicrobial activities. The isolated endophyte MC-24 L (C. tenuissimum) has the potential to be a source of novel cytotoxic/antimicrobial compounds. This is the first report of diversity of fungal endophytes isolated from M. citriodora.
    MeSH term(s) Anti-Infective Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Ascomycota/classification ; Ascomycota/metabolism ; Aspergillus fumigatus/metabolism ; Bacteria/drug effects ; Biodiversity ; Cell Line, Tumor/drug effects ; Cladosporium/metabolism ; DNA, Fungal/genetics ; Endophytes/classification ; Endophytes/genetics ; Endophytes/isolation & purification ; Endophytes/metabolism ; Fungi/classification ; Fungi/isolation & purification ; Fungi/metabolism ; Fusarium/metabolism ; HCT116 Cells/drug effects ; Humans ; India ; MCF-7 Cells/drug effects ; Microbial Sensitivity Tests ; Monarda/microbiology ; Phylogeny ; Plant Leaves/microbiology ; Plant Roots/microbiology
    Chemical Substances Anti-Infective Agents ; Antineoplastic Agents ; DNA, Fungal
    Language English
    Publishing date 2017-03-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2180
    ISSN (online) 1471-2180
    DOI 10.1186/s12866-017-0961-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Risk of a second wave of Covid-19 infections

    Vaid, Shashank / McAdie, Aaron / Kremer, Ran / Khanduja, Vikas / Bhandari, Mohit

    International Orthopaedics

    using artificial intelligence to investigate stringency of physical distancing policies in North America

    2020  Volume 44, Issue 8, Page(s) 1581–1589

    Keywords Orthopedics and Sports Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-020-04653-3
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  10. Article: Risk of a second wave of Covid-19 infections: using artificial intelligence to investigate stringency of physical distancing policies in North America

    Vaid, Shashank / McAdie, Aaron / Kremer, Ran / Khanduja, Vikas / Bhandari, Mohit

    Int Orthop

    Abstract: PURPOSE: Accurately forecasting the occurrence of future covid-19-related cases across relaxed (Sweden) and stringent (USA and Canada) policy contexts has a renewed sense of urgency. Moreover, there is a need for a multidimensional county-level approach ... ...

    Abstract PURPOSE: Accurately forecasting the occurrence of future covid-19-related cases across relaxed (Sweden) and stringent (USA and Canada) policy contexts has a renewed sense of urgency. Moreover, there is a need for a multidimensional county-level approach to monitor the second wave of covid-19 in the USA. METHOD: We use an artificial intelligence framework based on timeline of policy interventions that triangulated results based on the three approaches-Bayesian susceptible-infected-recovered (SIR), Kalman filter, and machine learning. RESULTS: Our findings suggest three important insights. First, the effective growth rate of covid-19 infections dropped in response to the approximate dates of key policy interventions. We find that the change points for spreading rates approximately coincide with the timelines of policy interventions across respective countries. Second, forecasted trend until mid-June in the USA was downward trending, stable, and linear. Sweden is likely to be heading in the other direction. That is, Sweden's forecasted trend until mid-June appears to be non-linear and upward trending. Canada appears to fall somewhere in the middle-the trend for the same period is flat. Third, a Kalman filter based robustness check indicates that by mid-June the USA will likely have close to two million virus cases, while Sweden will likely have over 44,000 covid-19 cases. CONCLUSION: We show that drop in effective growth rate of covid-19 infections was sharper in the case of stringent policies (USA and Canada) but was more gradual in the case of relaxed policy (Sweden). Our study exhorts policy makers to take these results into account as they consider the implications of relaxing lockdown measures.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #543202
    Database COVID19

    Kategorien

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