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  1. Article ; Online: First year medical students’ learning style preferences and their correlation with performance in different subjects within the medical course

    Daniel Hernández-Torrano / Syed Ali / Chee-Kai Chan

    BMC Medical Education, Vol 17, Iss 1, Pp 1-

    2017  Volume 7

    Abstract: Abstract Background Students commencing their medical training arrive with different educational backgrounds and a diverse range of learning experiences. Consequently, students would have developed preferred approaches to acquiring and processing ... ...

    Abstract Abstract Background Students commencing their medical training arrive with different educational backgrounds and a diverse range of learning experiences. Consequently, students would have developed preferred approaches to acquiring and processing information or learning style preferences. Understanding first-year students’ learning style preferences is important to success in learning. However, little is understood about how learning styles impact learning and performance across different subjects within the medical curriculum. Greater understanding of the relationship between students’ learning style preferences and academic performance in specific medical subjects would be valuable. Methods This cross-sectional study examined the learning style preferences of first-year medical students and how they differ across gender. This research also analyzed the effect of learning styles on academic performance across different subjects within a medical education program in a Central Asian university. A total of 52 students (57.7% females) from two batches of first-year medical school completed the Index of Learning Styles Questionnaire, which measures four dimensions of learning styles: sensing-intuitive; visual-verbal; active-reflective; sequential-global. Results First-year medical students reported preferences for visual (80.8%) and sequential (60.5%) learning styles, suggesting that these students preferred to learn through demonstrations and diagrams and in a linear and sequential way. Our results indicate that male medical students have higher preference for visual learning style over verbal, while females seemed to have a higher preference for sequential learning style over global. Significant associations were found between sensing-intuitive learning styles and performance in Genetics [β = −0.46, B = −0.44, p < 0.01] and Anatomy [β = −0.41, B = −0.61, p < 0.05] and between sequential-global styles and performance in Genetics [β = 0.36, B = 0.43, p < 0.05]. More specifically, sensing learners were more ...
    Keywords Learning styles ; Academic performance ; First-year ; Medical education ; Medical subject ; Special aspects of education ; LC8-6691 ; Medicine ; R
    Subject code 370
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Genetic factors associated with obesity risks in a Kazakhstani population.

    Razbekova, Madina / Issanov, Alpamys / Chan, Mei-Yen / Chan, Robbie / Yerezhepov, Dauren / Kozhamkulov, Ulan / Akilzhanova, Ainur / Chan, Chee-Kai

    BMJ nutrition, prevention & health

    2021  Volume 4, Issue 1, Page(s) 90–101

    Abstract: Objectives: There is limited published literature on the genetic risks of chronic inflammatory related disease (eg, obesity and cardiovascular disease) among the Central Asia population. The aim is to determine potential genetic loci as risk factors for ...

    Abstract Objectives: There is limited published literature on the genetic risks of chronic inflammatory related disease (eg, obesity and cardiovascular disease) among the Central Asia population. The aim is to determine potential genetic loci as risk factors for obesity for the Kazakhstani population.
    Setting: Kazakhstan.
    Participants: One hundred and sixty-three Kazakhstani nationals (ethnic groups: both Russians and Kazakhs) were recruited for the cross-sectional study. Linear regression models, adjusted for confounding factors, were used to examine the genetic associations of single nucleotide polymorphisms (SNPs) in 19 genetic loci with obesity (73 obese/overweight individuals and 90 controls).
    Results: Overall, logistic regression analyses revealed genotypes C/T in CRP (rs1205), A/C in AGTR1 (rs5186), A/G in CBS (rs234706), G/G in FUT2 (rs602662), A/G in PAI-1 (rs1799889), G/T (rs1801131) and A/G (rs1801133) in MTHFR genes significantly decrease risk of overweight/obesity. After stratification for ethnicity, rs234706 was significantly associated with overweight/obesity in both Russians and Kazakhs, while rs1800871 was significant in Kazakhs only.
    Conclusions: This study revealed that variations in SNPs known to be associated with cardiovascular health can also contribute to the risks of developing obesity in the population of Kazakhstan.
    Language English
    Publishing date 2021-02-05
    Publishing country England
    Document type Journal Article
    ISSN 2516-5542
    ISSN (online) 2516-5542
    DOI 10.1136/bmjnph-2020-000139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: First year medical students' learning style preferences and their correlation with performance in different subjects within the medical course.

    Hernández-Torrano, Daniel / Ali, Syed / Chan, Chee-Kai

    BMC medical education

    2017  Volume 17, Issue 1, Page(s) 131

    Abstract: Background: Students commencing their medical training arrive with different educational backgrounds and a diverse range of learning experiences. Consequently, students would have developed preferred approaches to acquiring and processing information or ...

    Abstract Background: Students commencing their medical training arrive with different educational backgrounds and a diverse range of learning experiences. Consequently, students would have developed preferred approaches to acquiring and processing information or learning style preferences. Understanding first-year students' learning style preferences is important to success in learning. However, little is understood about how learning styles impact learning and performance across different subjects within the medical curriculum. Greater understanding of the relationship between students' learning style preferences and academic performance in specific medical subjects would be valuable.
    Methods: This cross-sectional study examined the learning style preferences of first-year medical students and how they differ across gender. This research also analyzed the effect of learning styles on academic performance across different subjects within a medical education program in a Central Asian university. A total of 52 students (57.7% females) from two batches of first-year medical school completed the Index of Learning Styles Questionnaire, which measures four dimensions of learning styles: sensing-intuitive; visual-verbal; active-reflective; sequential-global.
    Results: First-year medical students reported preferences for visual (80.8%) and sequential (60.5%) learning styles, suggesting that these students preferred to learn through demonstrations and diagrams and in a linear and sequential way. Our results indicate that male medical students have higher preference for visual learning style over verbal, while females seemed to have a higher preference for sequential learning style over global. Significant associations were found between sensing-intuitive learning styles and performance in Genetics [β = -0.46, B = -0.44, p < 0.01] and Anatomy [β = -0.41, B = -0.61, p < 0.05] and between sequential-global styles and performance in Genetics [β = 0.36, B = 0.43, p < 0.05]. More specifically, sensing learners were more likely to perform better than intuitive learners in the two subjects and global learners were more likely to perform better than sequential learners in Genetics.
    Conclusion: This knowledge will be helpful to individual students to improve their performance in these subjects by adopting new sensing learning techniques. Instructors can also benefit by modifying and adapting more appropriate teaching approaches in these subjects. Future studies to validate this observation will be valuable.
    MeSH term(s) Academic Success ; Adult ; Anatomy/education ; Clinical Competence/standards ; Cross-Sectional Studies ; Curriculum ; Education, Medical, Undergraduate ; Educational Measurement ; Female ; Genetics/education ; Humans ; Kazakhstan ; Learning ; Linear Models ; Male ; Students, Medical ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2017-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-017-0965-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Past, Present, and Future of Noninvasive Test in Chronic Liver Diseases.

    Chee, Douglas / Ng, Cheng Han / Chan, Kai En / Huang, Daniel Q / Teng, Margaret / Muthiah, Mark

    The Medical clinics of North America

    2023  Volume 107, Issue 3, Page(s) 397–421

    Abstract: Chronic liver disease is a major global health threat and is the 11th leading cause of death globally. A liver biopsy is frequently required in assessing the degree of steatosis and fibrosis, information that is important in diagnosis, management, and ... ...

    Abstract Chronic liver disease is a major global health threat and is the 11th leading cause of death globally. A liver biopsy is frequently required in assessing the degree of steatosis and fibrosis, information that is important in diagnosis, management, and prognostication. However, liver biopsies have limitations and carry a considerable risk, leading to the development of various modalities of noninvasive testing tools. These tools have been developed in recent years and have improved markedly in diagnostic accuracy. Moving forward, they may change the practice of hepatology.
    MeSH term(s) Humans ; Liver/pathology ; Liver Cirrhosis/diagnosis ; Elasticity Imaging Techniques/adverse effects ; Biopsy/adverse effects ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/complications ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215710-x
    ISSN 1557-9859 ; 0025-7125
    ISSN (online) 1557-9859
    ISSN 0025-7125
    DOI 10.1016/j.mcna.2022.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Preparation and Preliminary Structure-Activity Relationship Studies of Schwarzinicine A Analogs as Vasorelaxant Agents.

    Lee, Fong-Kai / Chan, Nathaniel Jia-Yoong / Krishnan, Premanand / Datu Abdul Salam, Dayang Sharyati / Chee, Xavier Wezen / Muhamad, Azira / Low, Yun-Yee / Ting, Kang-Nee / Lim, Kuan-Hon

    Journal of natural products

    2024  Volume 87, Issue 4, Page(s) 675–691

    Abstract: Schwarzinicines A-D, a series of alkaloids recently discovered ... ...

    Abstract Schwarzinicines A-D, a series of alkaloids recently discovered from
    MeSH term(s) Vasodilator Agents/pharmacology ; Vasodilator Agents/chemistry ; Vasodilator Agents/chemical synthesis ; Animals ; Structure-Activity Relationship ; Rats ; Molecular Structure ; Ficus/chemistry ; Aorta/drug effects ; Alkaloids/pharmacology ; Alkaloids/chemistry ; Male ; Molecular Dynamics Simulation
    Chemical Substances Vasodilator Agents ; Alkaloids
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.3c00707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: FIB-4 Predicts MACE and Cardiovascular Mortality in Patients With Nonalcoholic Fatty Liver Disease.

    Chew, Nicholas W S / Ng, Cheng Han / Chan, Kai En / Chee, Douglas / Syn, Nicholas / Tamaki, Nobuharu / Muthiah, Mark / Noureddin, Mazen

    The Canadian journal of cardiology

    2022  Volume 38, Issue 11, Page(s) 1779–1780

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/diagnosis ; Liver ; ROC Curve ; Cardiovascular System ; Cardiovascular Diseases ; Biopsy
    Language English
    Publishing date 2022-08-03
    Publishing country England
    Document type Letter
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2022.07.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Efficacy of Therapeutic DNA Vaccines Expressing the Human Papillomavirus E6 and E7 Oncoproteins for Treatment of Cervical Cancer

    Ayazhan Akhatova / Chee Kai Chan / Azliyati Azizan / Gulzhanat Aimagambetova

    Vaccines, Vol 10, Iss 53, p

    Systematic Review

    2022  Volume 53

    Abstract: Cervical cancer is recognized as a serious public health problem since it remains one of the most common cancers with a high mortality rate among women despite existing preventative, screening, and treatment approaches. Since Human Papillomavirus (HPV) ... ...

    Abstract Cervical cancer is recognized as a serious public health problem since it remains one of the most common cancers with a high mortality rate among women despite existing preventative, screening, and treatment approaches. Since Human Papillomavirus (HPV) was recognized as the causative agent, the preventative HPV vaccines have made great progress over the last few years. However, people already infected with the virus require an effective treatment that would ensure long-term survival and a cure. Currently, clinical trials investigating HPV therapeutic vaccines show a promising vaccine-induced T-cell mediated immune response, resulting in cervical lesion regression and viral eradication. Among existing vaccine types (live vector, protein-based, nucleic acid-based, etc.), deoxyribonucleic acid (DNA) therapeutic vaccines are the focus of the study, since they are safe, cost-efficient, thermostable, easily produced in high purity and distributed. The aim of this study is to assess and compare existing DNA therapeutic vaccines in phase I and II trials, expressing HPV E6 and E7 oncoproteins for the prospective treatment of cervical cancer based on clinical efficacy, immunogenicity, viral clearance, and side effects. Five different DNA therapeutic vaccines (GX-188E, VGX-3100, pNGVL4a-CRT/E7(detox), pNGVL4a-Sig/E7(detox)/HSP70, MEDI0457) were well-tolerated and clinically effective. Clinical implementation of DNA therapeutic vaccines into treatment regimen as a sole approach or in combination with conservative treatment holds great potential for effective cancer treatment.
    Keywords cervical cancer ; cervical intraepithelial neoplasia ; HPV ; E6 oncoprotein ; E7 oncoprotein ; therapeutic vaccine ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Relating molecular descriptors to frontier orbital energy levels, singlet and triplet excited states of fused tricyclics using machine learning.

    Woon, Kai Lin / Chong, Zhao Xian / Ariffin, Azhar / Chan, Chee Seng

    Journal of molecular graphics & modelling

    2021  Volume 105, Page(s) 107891

    Abstract: Fused tricyclic organic compounds are an important class of organic electronic materials. In designing molecules for organic electronics, knowing what chemical structure that be used to tune the molecular property is one of the keys that can help to ... ...

    Abstract Fused tricyclic organic compounds are an important class of organic electronic materials. In designing molecules for organic electronics, knowing what chemical structure that be used to tune the molecular property is one of the keys that can help to improve the material performance. In this research, we applied machine learning and data analytic approaches in addressing this problem. The energy states (Lowest Unoccupied Molecular Orbital (HOMO), Highest Occupied Molecular Orbitals (LUMO), singlet (E
    MeSH term(s) Algorithms ; Machine Learning ; Organic Chemicals
    Chemical Substances Organic Chemicals
    Language English
    Publishing date 2021-03-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1396450-1
    ISSN 1873-4243 ; 1093-3263
    ISSN (online) 1873-4243
    ISSN 1093-3263
    DOI 10.1016/j.jmgm.2021.107891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Efficacy of Therapeutic DNA Vaccines Expressing the Human Papillomavirus E6 and E7 Oncoproteins for Treatment of Cervical Cancer: Systematic Review.

    Akhatova, Ayazhan / Chan, Chee Kai / Azizan, Azliyati / Aimagambetova, Gulzhanat

    Vaccines

    2021  Volume 10, Issue 1

    Abstract: Cervical cancer is recognized as a serious public health problem since it remains one of the most common cancers with a high mortality rate among women despite existing preventative, screening, and treatment approaches. Since Human Papillomavirus (HPV) ... ...

    Abstract Cervical cancer is recognized as a serious public health problem since it remains one of the most common cancers with a high mortality rate among women despite existing preventative, screening, and treatment approaches. Since Human Papillomavirus (HPV) was recognized as the causative agent, the preventative HPV vaccines have made great progress over the last few years. However, people already infected with the virus require an effective treatment that would ensure long-term survival and a cure. Currently, clinical trials investigating HPV therapeutic vaccines show a promising vaccine-induced T-cell mediated immune response, resulting in cervical lesion regression and viral eradication. Among existing vaccine types (live vector, protein-based, nucleic acid-based, etc.), deoxyribonucleic acid (DNA) therapeutic vaccines are the focus of the study, since they are safe, cost-efficient, thermostable, easily produced in high purity and distributed. The aim of this study is to assess and compare existing DNA therapeutic vaccines in phase I and II trials, expressing HPV E6 and E7 oncoproteins for the prospective treatment of cervical cancer based on clinical efficacy, immunogenicity, viral clearance, and side effects. Five different DNA therapeutic vaccines (GX-188E, VGX-3100, pNGVL4a-CRT/E7(detox), pNGVL4a-Sig/E7(detox)/HSP70, MEDI0457) were well-tolerated and clinically effective. Clinical implementation of DNA therapeutic vaccines into treatment regimen as a sole approach or in combination with conservative treatment holds great potential for effective cancer treatment.
    Language English
    Publishing date 2021-12-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10010053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Using nuclear targeting signals to enhance non-viral gene transfer.

    Chan, Chee-Kai / Jans, David A

    Immunology and cell biology

    2002  Volume 80, Issue 2, Page(s) 119–130

    Abstract: Summary Gene therapy involves the introduction of DNA-encoding therapeutic gene products into appropriate cells of an affected individual. The limitations of the approach relate largely to the poor efficiency of the delivery of the therapeutic DNA to the ...

    Abstract Summary Gene therapy involves the introduction of DNA-encoding therapeutic gene products into appropriate cells of an affected individual. The limitations of the approach relate largely to the poor efficiency of the delivery of the therapeutic DNA to the nucleus. This review examines recent work in the area of non-viral gene transfer, building on developments in the field of nuclear protein import and their application in the field of non-viral gene transfer. In particular, advances in the area of enhancing DNA targeting to the nucleus are discussed, including the use of modular nuclear targeting signals recognised by the cellular nuclear import machinery and DNA condensing agents to facilitate passage through the nuclear pore. Optimising nuclear DNA delivery through these and other strategies should assist greatly in rendering gene therapy a viable and realistic possibility for treating disease.
    MeSH term(s) Biological Transport ; Cell Nucleus/metabolism ; DNA/metabolism ; DNA-Binding Proteins/physiology ; Fungal Proteins/metabolism ; Gene Expression ; Gene Transfer Techniques ; Genetic Therapy/methods ; Molecular Sequence Data ; Nuclear Localization Signals ; Plasmids ; Polylysine/metabolism ; Saccharomyces cerevisiae Proteins ; Signal Transduction ; Transcription Factors/metabolism
    Chemical Substances DNA-Binding Proteins ; Fungal Proteins ; GAL4 protein, S cerevisiae ; Nuclear Localization Signals ; Saccharomyces cerevisiae Proteins ; Transcription Factors ; Polylysine (25104-18-1) ; DNA (9007-49-2)
    Language English
    Publishing date 2002-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1046/j.1440-1711.2002.01061.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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