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  1. Book ; Online ; E-Book: Cognitive functioning in schizophrenia: Leveraging the RDoC framework

    Barch, Deanna M. / Young, Jared W.

    (Current topics in behavioral neurosciences ; 63)

    2023  

    Abstract: MATRICS – an update -- Cognitive [Computational] Neuroscience Test Reliability and Clinical Applications for Serious mental illness (CNTRaCS) Consortium: Progress and Future Directions -- Attention in Schizophrenia -- Perceptual Functioning -- Episodic ... ...

    Author's details Deanna M. Barch, Jared W. Young editors
    Series title Current topics in behavioral neurosciences ; 63
    Collection
    Abstract MATRICS – an update -- Cognitive [Computational] Neuroscience Test Reliability and Clinical Applications for Serious mental illness (CNTRaCS) Consortium: Progress and Future Directions -- Attention in Schizophrenia -- Perceptual Functioning -- Episodic Memory and Schizophrenia: From Characterization of Relational Memory Impairments to Neuroimaging Biomarkers -- Working Memory in People with Schizophrenia -- "Targeting Frontal Gamma Activity with Neurofeedback to Improve Working Memory in Schizophrenia" -- Cognitive Dysfunction as a Risk Factor for Psychosis -- Environmental Risk Factors and Cognitive Outcomes in Psychosis: Pre-, Perinatal, and Early Life Adversity -- Developmental manipulation-induced changes in cognitive functioning -- Genetic underpinnings of cognitive dysfunction in schizophrenia -- Primate models of cognitive deficit re schizophrenia -- Olfactory cognitive deficits -- Medication/Anticholinergic burden impacting cognition in schizophrenia An Update on Treatment of Cognitive Impairment Associated with Schizophrenia -- Cannabis & cognition -- Sex/gender differences -- Neuroinflammation linked to cognition.

    This book highlights recent research investigating psychological and neural mechanisms contributing to dysfunctional cognition in people with schizophrenia. The work on cognition in schizophrenia from the past 20 years is highlighted, and emphasis throughout the book is placed on utilizing the Research Domain Criterion framework. Thus, the book also covers animals work relevant to schizophrenia that assesses behaviors utilizing the same framework, enabling mechanistic studies and highlighting potential biomarkers of function. The book also includes important areas of research in the field of cognitive function in schizophrenia that have received less attention, such as cognitive side-effects of current treatments and olfactory-based cognition. Altogether, the book provides a translational perspective of the most-up-to-date research on cognition in schizophrenia to-date, but with identification of novel directions for research initiatives.
    Keywords Medicine—Research ; Biology—Research ; Medical sciences ; Drug development ; Pharmacology ; Genetics—Research ; Clinical medicine—Research ; Biochemical markers
    Language English
    Size 1 Online-Ressource (XII, 497 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021732091
    ISBN 978-3-031-26441-2 ; 9783031264405 ; 3-031-26441-X ; 3031264401
    DOI 10.1007/978-3-031-26441-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Conference proceedings: Proceedings of the 2014 Annual Meeting of the International Behavioral Neuroscience Society

    Young, Jared W.

    (Neuroscience & biobehavioral reviews ; volume 58 (November 2015))

    2015  

    Event/congress International Behavioral Neuroscience Society (2014, LasVegasNev., Annual Meeting)
    Author's details guest editors Jared W Young, F Scott Hall, Mikhail Pletnikov, Stephen Kent
    Series title Neuroscience & biobehavioral reviews ; volume 58 (November 2015)
    Collection
    Language English
    Size 210 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    Note Tagungsdaten: Las Vegas, Nevada, June 10-15, 2014
    HBZ-ID HT018851353
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1371 -58- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: 30 years of the International Behavioral Neuroscience Society: Perspectives on progress from Past Presidents.

    Young, Jared W

    Neuroscience and biobehavioral reviews

    2023  Volume 155, Page(s) 105457

    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2023.105457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Decision-making for delaying punishment? A commentary to Minnes et al. (2024).

    Young, Jared W / Roberts, Benjamin Z

    Cognitive, affective & behavioral neuroscience

    2024  Volume 24, Issue 2, Page(s) 322–324

    MeSH term(s) Humans ; Punishment ; Decision Making/physiology
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2029088-3
    ISSN 1531-135X ; 1530-7026
    ISSN (online) 1531-135X
    ISSN 1530-7026
    DOI 10.3758/s13415-024-01173-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5947: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Development of cross-species translational paradigms for psychiatric research in the Research Domain Criteria era.

    Young, Jared W

    Neuroscience and biobehavioral reviews

    2023  Volume 148, Page(s) 105119

    Abstract: The past 30 years of IBNS has included research attempting to treat the cognitive and behavioral deficits observed in people with psychiatric conditions. Early work utilized drugs identified from tests thought to be cognition-relevant, however the high ... ...

    Abstract The past 30 years of IBNS has included research attempting to treat the cognitive and behavioral deficits observed in people with psychiatric conditions. Early work utilized drugs identified from tests thought to be cognition-relevant, however the high failure rate crossing the translational-species barrier led to focus on developing valid cross-species translational tests. The face, predictive, and neurobiological validities used to assess animal models of psychiatry can be used to validate these tests. Clinical sensitivity is another important aspect however, for if the clinical population targeted for treatment does not exhibit task deficits, then why develop treatments? This review covers some work validating cross-species translational tests and suggests future directions. Also covered is the contribution IBNS made to fostering such research and my role in IBNS, making it more available to all including fostering mentor/mentee programs plus spearheading diversity and inclusivity initiatives. All science needs support and IBNS has supported research recreating the behavioral abnormalities that define psychiatric conditions with the aim to improve the lives of people with such conditions.
    MeSH term(s) Animals ; Mental Disorders/therapy ; Cognition ; Disease Models, Animal ; Neurobiology
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2023.105119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Online ; E-Book: Negative affective states and cognitive impairments in nicotine dependence

    Hall, F. Scott / Young, Jared W. / Der-Avakian, Andre

    2017  

    Author's details edited by F. Scott Hall, Jared W. Young, Andre Der-Avakian
    Keywords Tobacco Use Disorder / complications ; Cognition Disorders / etiology ; Tobacco Use Disorder / psychology ; Substance Withdrawal Syndrome / etiology ; Reinforcement (Psychology) ; Comorbidity
    Language English
    Size 1 Online-Ressource (xix, 341 Seiten), Illustrationen
    Publisher Elsevier AP
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019452034
    ISBN 978-0-12-802669-4 ; 9780128025741 ; 0-12-802669-3 ; 0128025743
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  7. Article ; Online: The 2020 International Behavioral Neuroscience Society (IBNS) meeting - Troubles & progress.

    Young, Jared W / Byrnes, Elizabeth M

    Neuroscience and biobehavioral reviews

    2022  Volume 143, Page(s) 104819

    MeSH term(s) Humans ; Neurosciences
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2022.104819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Translational cognitive systems: focus on attention.

    Roberts, Benjamin Z / Young, Jared W

    Emerging topics in life sciences

    2022  Volume 6, Issue 5, Page(s) 529–539

    Abstract: Cognitive dysfunction, particularly attentional impairment, is a core feature of many psychiatric disorders, yet is inadequately addressed by current treatments. Development of targeted therapeutics for the remediation of attentional deficits requires ... ...

    Abstract Cognitive dysfunction, particularly attentional impairment, is a core feature of many psychiatric disorders, yet is inadequately addressed by current treatments. Development of targeted therapeutics for the remediation of attentional deficits requires knowledge of underlying neurocircuit, cellular, and molecular mechanisms that cannot be directly assayed in the clinic. This level of detail can only be acquired by testing animals in cross-species translatable attentional paradigms, in combination with preclinical neuroscience techniques. The 5-choice continuous performance test (5C-CPT) and rodent continuous performance test (rCPT) represent the current state of the art of preclinical assessment of the most commonly studied subtype of attention: sustained attention, or vigilance. These tasks present animals with continuous streams of target stimuli to which they must respond (attention), in addition to non-target stimuli from which they must withhold responses (behavioral inhibition). The 5C-CPT and rCPT utilize the same measures as gold-standard clinical continuous performance tests and predict clinical efficacy of known pro-attentional drugs. They also engage common brain regions across species, although efforts to definitively establish neurophysiological construct validity are ongoing. The validity of these tasks as translational vigilance assessments enables their use in characterizing the neuropathology underlying attentional deficits of animal models of psychiatric disease, and in determining therapeutic potential of drugs ahead of clinical testing. Here, we briefly review the development and validation of such tests of attentional functioning, as well as the data they have generated pertaining to inattention, disinhibition, and impulsivity in psychiatric disorders.
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2882721-1
    ISSN 2397-8554 ; 2397-8554 ; 2397-8562
    ISSN (online) 2397-8554
    ISSN 2397-8554 ; 2397-8562
    DOI 10.1042/ETLS20220009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Preclinical Evaluation of Attention and Impulsivity Relevant to Determining ADHD Mechanisms and Treatments.

    Kenton, Johnny A / Young, Jared W

    Current topics in behavioral neurosciences

    2022  Volume 57, Page(s) 291–320

    Abstract: People with Attention-Deficit Hyperactivity Disorder (ADHD) exhibit inattention, hyperactivity, and/or impulsivity. Symptoms of ADHD emerge in childhood and can continue throughout adulthood. Clinical assessments to diagnose ADHD can include ... ...

    Abstract People with Attention-Deficit Hyperactivity Disorder (ADHD) exhibit inattention, hyperactivity, and/or impulsivity. Symptoms of ADHD emerge in childhood and can continue throughout adulthood. Clinical assessments to diagnose ADHD can include administration of continuous performance tests (CPTs). CPTs provide an objective measure of inattention, requiring individuals to respond to targets (attention), and inhibit response to non-targets (impulsivity). When investigating the mechanisms of, and novel treatments for, ADHD it is important to measure such behavioral domains (attention and impulsivity). Some well-established preclinical tasks purport to assess attention in rodents but, unlike CPTs, do not require non-target inhibition, limiting their ADHD-relevance.Recently developed tasks recreate CPTs for rodents. The 5-Choice CPT (5C-CPT) contains non-target stimuli, enabling use of signal detection theory to evaluate performance, consistent with CPTs. The 5C-CPT has been adapted for use in humans, enabling direct cross-species comparisons of performance. A newer task, the rodent CPT (rCPT), is a touchscreen-based analog of CPTs, utilizing symbols instead of a simple stimulus array. Currently, the rCPT may be more akin to a go/no-go task, equally presenting targets/non-targets, although numerous variants exist - a strength. The 5C-CPT and rCPT emulate human CPTs and provide the most up-to-date information on ADHD-relevant studies for understanding attention/impulsivity.
    MeSH term(s) Adult ; Animals ; Attention ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Cognition ; Humans ; Impulsive Behavior/physiology ; Inhibition, Psychological ; Neuropsychological Tests ; Rodentia
    Language English
    Publishing date 2022-05-23
    Publishing country Germany
    Document type Journal Article
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2022_340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Editorial: Negative valence systems.

    Honeycutt, Jennifer A / Young, Jared W / Porcu, Alessandra / Sabariego, Marta

    Frontiers in systems neuroscience

    2022  Volume 16, Page(s) 1014745

    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2453005-0
    ISSN 1662-5137
    ISSN 1662-5137
    DOI 10.3389/fnsys.2022.1014745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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