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Article: GC-MS Profile of Hua-Feng-Dan and RNA-Seq Analysis of Induced Adaptive Responses in the Liver.

Liu, Jia-Jia / Liang, Yan / Zhang, Ya / Wu, Rui-Xia / Song, Ying-Lian / Zhang, Feng / Shi, Jing-Shan / Liu, Jie / Xu, Shang-Fu / Wang, Zhang

Frontiers in pharmacology

2022 Volume 13, Page(s) 730318

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.730318
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: The essence of Liu Feng-wu's gynecology

Liu, Feng-Wu / Shuai, Xuezhong

1998

Title translation	Liu-Feng-Wu-fu-ke-jing-yan
Author's details	by Liu Feng-wu. Transl. by Shuai Xue-zhong
Keywords	Frauenkrankheit ; Chinesische Medizin
Subject	Traditionelle chinesische Medizin ; TCM ; Frauenleiden
Language	English
Size	XI, 326 S.
Edition	1. ed.
Publisher	Blue Poppy Press
Publishing place	Boulder, Colo
Publishing country	United States
Document type	Book
HBZ-ID	HT012964222
ISBN	0-936185-88-0 ; 978-0-936185-88-0
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Sustainable biochar effects on the remediation of contaminated soil: A 2-crop season site practice near a lead-zinc smelter in Feng County, China.

Wang, Ping / Shen, Feng / Xu, Yaqiong / Wang, Xuejia / Huang, Hui / Li, Ronghua / Liu, Tao / Guo, Di / Du, Juan / Guo, Zhanyu / Zhang, Zengqiang

Environmental pollution (Barking, Essex : 1987)

2022 Volume 302, Page(s) 119095

Abstract: ... smelter in Feng County, China, under the rotation condition of different crops. This kind of cultivation ...

Abstract	It is of great significance to explore the remediation pattern in actual heavy metal (HM) contaminated sites. The field trial was carried out to research the remediation effect of biochar near a lead-zinc smelter in Feng County, China, under the rotation condition of different crops. This kind of cultivation mode is very representative in northern of China. And the pattern of production and restoration is suitable for scarce land resources and large food demand in China. The changes of soil physiochemical properties with the biochar addition, crop growth and the accumulated HMs by crops were focused on. The results showed the biochar application was excellent in improving soil nutrient elements and crop growth. The contents of TK were more obvious than those of TN and TP, with an increase of 2.6%-28.2% compared with the controls (without the addition of biochar). The yield of first season crops, i.e., soybean and corn, increased by 30%-42% and 34%-61%, respectively, and the second season crops, i.e., rape and wheat, with the increment of 25%-41% and 9%-29%, respectively. The availability forms of Cd and Pb decreased by 1.07-10.0% and 2.92-8.35%, respectively. While the improvement on the status of the HMs accumulated by crops was disappointing. The contents of HMs accumulated by crops increased to varying degrees (e.g., Pb and Zn in root, Cu and Pb in grain, and Cd in stems and leaves). Moreover, the concentrations of HMs in seeds of crops were higher than the limited levels given by the Chinese directive. Considering the results of the study and food safety, it is suggested to change the nature of the land around the smelter into woodland or construction land to prohibit the cultivation of food crops in this area.
MeSH term(s)	Cadmium/analysis ; Charcoal/chemistry ; China ; Metals, Heavy/analysis ; Seasons ; Soil/chemistry ; Soil Pollutants/analysis ; Zinc/analysis
Chemical Substances	Metals, Heavy ; Soil ; Soil Pollutants ; biochar ; Cadmium (00BH33GNGH) ; Charcoal (16291-96-6) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2022-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119095
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Article ; Online: Cinnabar-containing Chinese medicine Hua-Feng-Dan differs from mercury sulfide and mercury chloride in affecting gut microbiota in mice

Yong-Mei Liu / Bo Liu / Jie Liu / Shang-Fu Xu / Feng Zhang / Ming-Liang Cheng / Jing-Shan Shi

Pharmacological Research - Modern Chinese Medicine, Vol 8, Iss , Pp 100279- (2023)

2023

Abstract: Introduction: Cinnabar (96% HgS) is included in Chinese medicines, including Hua-Feng-Dan. We have ... shown the protective effects of Hua-Feng-Dan against LPS plus rotenone-induced neurotoxicity in rats and ... However, the effects of HgS-containing Hua-Feng-Dan in comparison to HgS and HgCl2 are unknown. Methods: Mice were ...

Abstract	Introduction: Cinnabar (96% HgS) is included in Chinese medicines, including Hua-Feng-Dan. We have shown the protective effects of Hua-Feng-Dan against LPS plus rotenone-induced neurotoxicity in rats and against LPS plus MPTP-induced neuroinflammation in mice by modulation of gut microbiota. However, the effects of HgS-containing Hua-Feng-Dan in comparison to HgS and HgCl2 are unknown. Methods: Mice were given orally with Hua-Feng-Dan at clinical doses (0.6 and 1.5 g/kg), approximate Hg as HgS or HgCl2 for 7 days. Intestinal histology and Hg accumulation were examined. Bacterial DNA from the colon contents was extracted and subjected to DNA sequencing and qPCR verification with 16S rRNA probes. Results: Hua-Feng-Dan and HgS did not affect animal body weight gain, intestinal histology, nor produce overt intestinal Hg accumulation (2-fold). In contrast, HgCl2 reduced body weight gain, produced spotted mild inflammation, and produced 20-fold Hg accumulation in the duodenum. Operational taxonomic unit (OTU) from DNA sequencing showed that at phyla levels, HgS increased Firmicutes and decreased Bacteroidetes, while HgCl2 produced opposite effects; at the family levels, Hua-Feng-Dan increased Streptococcaceae and Dehalobacteriaceae, HgS had similar effects; at the genus levels, Hua-Feng-Dan and HgS increased Streptococcaceae__garvieae and Paraprevotellaceae__Prevotella, while HgCl2 increased Dehalobacteriaceae__Dehalobacterium and Odoribacteraceae__Odoribacter. HgS also increased Verrucomicrobiaceae__Akkermansia and produced many other alterations. Discussion: Cinnabar-containing Hua-Feng-Dan had minimal effects on animal health, gut histology and Hg accumulation but produced modulations of gut microbiota. Effects of Hua-Feng-Dan on gut microbiota were different from HgS and HgCl2.
Keywords	Cinnabar-containing Hua-Feng-Dan ; HgS ; HgCl2 ; Intestine histology ; Hg accumulation ; Gut microbiota ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
Subject code	501
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neuroprotective potential of phytochemicals isolated from Paeonia ostii ‘Feng Dan’ stamen

Peng, Xiao-Na / Zhou, Yang / Liu, Yan-Xiang / Huo, Yi-Lin / Ren, Jie-Yi / Bai, Zhang-Zhen / Zhang, Yan-Long / Tang, Jiang-Jiang

Industrial Crops & Products. 2023 Sept., v. 200 p.116808-

2023

Abstract: Paeonia ostii ‘Feng Dan’, traditionally known as an important medicinal and ornamental plant, is ...

Abstract	Paeonia ostii ‘Feng Dan’, traditionally known as an important medicinal and ornamental plant, is an emerging oilseed crop widely cultivated in China. As a byproduct, its stamens showed promising anti-neuroinflammation potential in our previous study. In this work, an in-depth phytochemical investigation was firstly conducted through comprehensive spectra to elucidate the neuroprotective components. Two new compounds (+)-oxylactiflorin (1), (+)-3′′-methoxy-oxylactiflorin (2), and twenty-two known compounds were isolated and identified. In lipopolysaccharides-induced BV-2 cells, compound 2 exhibited excellent inhibitory property in inhibiting nitric oxide (NO) production with the lowest EC₅₀ value of 3.02 ± 1.60 µM among all tested compounds. Western blotting and molecular docking results demonstrated the feasible mechanism that 2 exerted anti-inflammatory activity mainly by binding with the key protein cyclooxygenase-2 (COX-2). Additionally, compound 2 showed potent protective effects on the oxidative damages of H₂O₂ or 6-Hydroxydopamine (6-OHDA)-treated PC12 cells. This work provides a theoretical basis of P. ostii stamens for developing into a promising functional tea or neuroprotective drug.
Keywords	Paeonia ostii ; anti-inflammatory activity ; byproducts ; drugs ; neuroprotective effect ; nitric oxide ; oilseed crops ; ornamental plants ; phytochemicals ; prostaglandin synthase ; tea ; China ; Paeonia ostii stamen ; Anti-neuroinflammation ; Cyclooxygenase-2 ; Neuroprotection
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1132158-1
ISSN	1872-633X ; 0926-6690
ISSN (online)	1872-633X
ISSN	0926-6690
DOI	10.1016/j.indcrop.2023.116808
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A mini review of Yu-Ping-Feng polysaccharides

Yang Liu / Binbin Tong / Shuangxing Wang / Gen Li / Yuansheng Tan / Hui Yu / Kelin Yang / Yingying Yu

Aquaculture Reports, Vol 20, Iss , Pp 100697- (2021)

Their biological activities and potential applications in aquaculture

2021

Abstract: ... become a focus of attention in many fields, particularly in medical research industry. Yu-Ping-Feng (YPF ... not studied. Under the guidance of the Pharmacological Efficacy Index, we have extracted Yu-Ping-Feng ...

Abstract	Polysaccharides, one of the important active ingredients of traditional Chinese herbal medicine, become a focus of attention in many fields, particularly in medical research industry. Yu-Ping-Feng (YPF) is a primary component of many traditional Chinese medicine prescriptions, and it’s proven to be significantly beneficial to human health. In recent years, polysaccharides from YPF have been well documented after successful isolation and purification, but the polysaccharides from YPF post-processing wastes are not studied. Under the guidance of the Pharmacological Efficacy Index, we have extracted Yu-Ping-Feng polysaccharides (YPF-P) from the wastes of YPF in our previous work. Our previous findings showed that YPF-P promote the growth, enhance immunity and organ structure or function of cultured fish northern snakehead fish (Channa argus) and grass carp (Ctenopharyngodon idellus), and significantly improve the intestinal microflora of fish. This paper reviews the current status of YPF-P and their application in aquaculture, including the development of green feed for aquatic animals and the re-utilization of the YPF wastes. This series of work is a way to have the best of both worlds, not only to realize the rational treatment of medical wastes, but also to effectively use the wastes, to find a green raw material for aquatic feed.
Keywords	Traditional Chinese medicine ; Yu-Ping-Feng polysaccharides ; Feed additive ; Aquaculture. Fisheries. Angling ; SH1-691
Subject code	540
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Sustainable biochar effects on the remediation of contaminated soil: A 2-crop season site practice near a lead-zinc smelter in Feng County, China

Wang, Ping / Shen, Feng / Xu, Yaqiong / Wang, Xuejia / Huang, Hui / Li, Ronghua / Liu, Tao / Guo, Di / Du, Juan / Guo, Zhanyu / Zhang, Zengqiang

Environmental pollution. 2022 June 01, v. 302

2022

Abstract: ... smelter in Feng County, China, under the rotation condition of different crops. This kind of cultivation ...

Abstract	It is of great significance to explore the remediation pattern in actual heavy metal (HM) contaminated sites. The field trial was carried out to research the remediation effect of biochar near a lead-zinc smelter in Feng County, China, under the rotation condition of different crops. This kind of cultivation mode is very representative in northern of China. And the pattern of production and restoration is suitable for scarce land resources and large food demand in China. The changes of soil physiochemical properties with the biochar addition, crop growth and the accumulated HMs by crops were focused on. The results showed the biochar application was excellent in improving soil nutrient elements and crop growth. The contents of TK were more obvious than those of TN and TP, with an increase of 2.6%–28.2% compared with the controls (without the addition of biochar). The yield of first season crops, i.e., soybean and corn, increased by 30%–42% and 34%–61%, respectively, and the second season crops, i.e., rape and wheat, with the increment of 25%–41% and 9%–29%, respectively. The availability forms of Cd and Pb decreased by 1.07–10.0% and 2.92–8.35%, respectively. While the improvement on the status of the HMs accumulated by crops was disappointing. The contents of HMs accumulated by crops increased to varying degrees (e.g., Pb and Zn in root, Cu and Pb in grain, and Cd in stems and leaves). Moreover, the concentrations of HMs in seeds of crops were higher than the limited levels given by the Chinese directive. Considering the results of the study and food safety, it is suggested to change the nature of the land around the smelter into woodland or construction land to prohibit the cultivation of food crops in this area.
Keywords	biochar ; corn ; field experimentation ; food safety ; heavy metals ; polluted soils ; pollution ; remediation ; soil nutrients ; soybeans ; wheat ; woodlands
Language	English
Dates of publication	2022-0601
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119095
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Endangered but genetically stable—Erythrophleum fordii within Feng Shui woodlands in suburbanized villages

Zheng‐Feng Wang / Hai‐Lin Liu / Se‐Ping Dai / Hong‐Lin Cao / Rui‐Jiang Wang / Zhang‐Ming Wang

Ecology and Evolution, Vol 9, Iss 19, Pp 10950-

2019 Volume 10963

Abstract: Abstract Feng Shui woodlands are naturally or artificially formed green areas in southern China ... of the endangered Erythrophleum fordii in eight Feng Shui woodlands (a total of 1,061 individuals) in Guangzhou ... in genetic variation over generations in Feng Shui populations in the recent past, and the levels of genetic variation ...

Abstract	Abstract Feng Shui woodlands are naturally or artificially formed green areas in southern China. They are precious for maintaining ecosystem balance in modern semiurban environments. However, they are generally small and geographically isolated from each other, and the status of genetic diversity of the plant species within them has been almost neglected. Therefore, we studied the genetic diversity of the endangered Erythrophleum fordii in eight Feng Shui woodlands (a total of 1,061 individuals) in Guangzhou, a large city in southern China, using microsatellites. For comparison, one population with 33 individuals sampled in a nature reserve was also studied. Although our results indicate that significant demographic declines occurred historically in E. fordii, such declines have not resulted in consistent reductions in genetic variation over generations in Feng Shui populations in the recent past, and the levels of genetic variation in these populations were higher than or comparable to the genetic variation of the population in the nature reserve. In addition, our parentage and paternity analyses indicated widespread and potential long‐distance pollen flow within one Feng Shui woodland, indicating the presence of an unbroken pollination network, which would at least partially alleviate the genetic erosion due to habitat fragmentation and the unequal gene contributions of E. fordii parents to their progenies when favorable recruitment habitats are absent under most of the parent trees. Overall, our results suggest that E. fordii in Feng Shui woodlands may not be driven to extinction in the near future. Nevertheless, uncontrolled fast urban development with a lack of awareness of Feng Shui woodlands will cause the local extinction of E. fordii, which has already happened in some Feng Shui woodlands.
Keywords	bottleneck ; demographic history ; genetic diversity ; microsatellites ; parentage analysis ; Ecology ; QH540-549.5
Subject code	333
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mechanisms and molecular targets of the Yu-Ping-Feng powder for allergic rhinitis, based on network pharmacology.

Yang, Shasha / Fu, Qinwei / Deng, Hua / Liu, Zhiqing / Zhong, Juan / Zhu, Xiaoyu / Wang, Qian / Sun, Chuanhui / Wu, Jing

Medicine

2021 Volume 100, Issue 35, Page(s) e26929

Abstract: Abstract: In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat ...

Abstract	Abstract: In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat allergic rhinitis (AR) for centuries. However, the mechanisms underlying its effects or its molecular targets in AR treatment are yet to be elucidated. Therefore, the active compounds of YPFP and their targets were collected and identified from the Traditional Chinese Medicine Systems Pharmacology database. Moreover, AR-associated targets were acquired from the GeneCards and Online Mendelian Inheritance in Man database. Proteins interactions network of YPFP presumed targets and AR-associated targets were examined and merged to reveal the candidate YPFP targets against AR.Cytoscape software and BisoGenet Database were employed to perform the Visualization and Integrated Discovery (Cluster Profiler R package, version: 3.8.1). Kyoto Encyclopedia of Genes and Genomes and genome pathway analyses. To identify the key target genes, a gene-pathway network has been constructed.We identified 44 effective active compounds and 622 YPFP targets. Also 1324 target genes related to AR were identified. Twenty pathways, including those of AGE-RAGE signaling, fluid shear stress, atherosclerosis, PI3K-Akt signaling, and tumor necrosis factor signaling was enriched significantly. MAPK1 was identified as the core gene, while others including RELA, AKT1, NFKBIA, IL6, and JUN, were also important in the gene-pathway network. Clearly, network pharmacology can be applied in revealing the molecular targets and mechanisms of action of complex herbal preparations.These findings suggested that YPFP could treat AR by regulating immunological functions, diminishing inflammation, and improving immunity through different pathways.
MeSH term(s)	Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Pharmacology/methods ; Protein Interaction Maps/drug effects ; Rhinitis, Allergic/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; yu ping feng san
Language	English
Publishing date	2021-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000026929
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Article ; Online: Yu ping feng san for pediatric allergic rhinitis: A systematic review and meta-analysis of randomized controlled trials.

Liao, Yong / Zhong, Juan / Liu, Shuqin / Dai, Menglin / Liu, Yang / Li, Xinrong / Yang, Yepeng / Zhang, Dazheng / Lai, Dan / Lu, Tao / Zhang, Qinxiu / Zhao, Yu

Medicine

2021 Volume 100, Issue 13, Page(s) e24534

Abstract: Background: The potential treatment effects and safety of Yu ping feng san (YPFS) for pediatric ...

Abstract	Background: The potential treatment effects and safety of Yu ping feng san (YPFS) for pediatric allergic rhinitis (PAR) patients have yet to be studied systematically. Objectives: To assess the effects and safety of YPFS for treat pediatric patients, allergic rhinitis. Methods: We systematically searched PubMed, EMBASE (Excerpta Medical Database), Cochrane library, Chinese Cochrane Centre's Controlled Trials Register platform, Wanfang Chinese Digital Periodical and Conference Database, China National Knowledge Infrastructure Database, and VIP Chinese Science, from inception dates to November 1, 2019. Randomized controlled trials (RCTs) were included. The risk of bias in the trials was assessed in accordance with the Cochrane Handbook, version 5.1.0. RevMan 5.3 software was used to perform a meta-analysis. Grading of Recommendations Assessment, Development and Evaluation methodology was applied to evaluate the evidence quality for each outcome. The quality of evidence for each outcome measurement was low for 4 outcomes and very low for 5 outcomes. Results: A total of 10 RCTs involving 1069 participants (3-15 years old) fulfilled the inclusion criteria. After exclusion, 8 RCTs were pooled for efficacy assessment. The overall efficacy evaluation result did not show benefit for the experimental group (relative risk 0.32, CI 95% 0.24-0.45; P = .98;) Investigation of variation of serum IgA, immunoglobulin E, IgG in three studies in 2 groups returned no statistical significance. YPFS gave relatively better safety (relative risk 0.29, CI 95% 0.14-0.58; P = .0005; Fig. S8, http://links.lww.com/MD/F751) and lower recurrence rates than did Western medical therapy. Conclusions: Current evidence cannot support the routine use of YPFS for treatment of PAR. This may be due to poor-quality study-design limitations of the included YPFS studies. Our data showed that the use of YPFS for PAR is relatively safe compared to Western medical therapy, but a conclusion could not be drawn because only 5 studies were analyzed. Every study suffered from some methodological limitation. Therefore, further large, rigorously-designed studies are necessary to determine conclusively the utility of YPFS in PAR.
MeSH term(s)	Adolescent ; Child ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Male ; Randomized Controlled Trials as Topic ; Rhinitis, Allergic/drug therapy ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal ; yu ping feng san
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000024534
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