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Article ; Online: Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes.

Zhao, Zhen / Du, Jin-Fa / Wang, Qiao-Lei / Qiu, Fang-Ning / Li, Ping / Jiang, Yan / Li, Hui-Jun

2024 Volume 37, Issue 1, Page(s) 57–71

Abstract: Epimedii Folium (EF) is a botanical dietary supplement to benefit immunity. Baohuoside I (BI), a prenylated flavonoid derived from EF, has exhibited the cholestatic risk before. Here, the mechanism of BI on the stability and membrane localization of ... ...

Abstract	Epimedii Folium (EF) is a botanical dietary supplement to benefit immunity. Baohuoside I (BI), a prenylated flavonoid derived from EF, has exhibited the cholestatic risk before. Here, the mechanism of BI on the stability and membrane localization of liver MRP2, a bile acid exporter in the canalicular membrane of hepatocytes, was investigated. The fluorescent substrate of MRP2, CMFDA was accumulated in sandwich-cultured primary mouse hepatocytes (SCH) under BI stimulation, followed by reduced membrane MRP2 expression. BI triggered MRP2 endocytosis associated with oxidative stress
MeSH term(s)	Mice ; Animals ; Humans ; Sumoylation ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Multidrug Resistance-Associated Protein 2 ; Hepatocytes/metabolism ; Flavonoids/metabolism ; Ubiquitination
Chemical Substances	baohuoside I (113558-15-9) ; Multidrug Resistance-Associated Proteins ; Multidrug Resistance-Associated Protein 2 ; Flavonoids
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639353-6
ISSN	1520-5010 ; 0893-228X
ISSN (online)	1520-5010
ISSN	0893-228X
DOI	10.1021/acs.chemrestox.3c00298
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Zs.A 2320: Show issues

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Article ; Online: Fluoxetine mitigates depressive-like behaviors in mice via anti-inflammation and enhancing neuroplasticity.

Qian, Xu / Zhong, Zuo-Dong / Zhang, Yao / Qiu, Li-Qin / Tan, Hui-Jun

Brain research

2023 Volume 1825, Page(s) 148723

Abstract: Neuroplasticity and inflammation represent a common final pathway for effective antidepressant treatment. SSRIs are the most commonly prescribed medications for depression and have demonstrated efficacy in reducing depressive symptoms. However, the ... ...

Abstract	Neuroplasticity and inflammation represent a common final pathway for effective antidepressant treatment. SSRIs are the most commonly prescribed medications for depression and have demonstrated efficacy in reducing depressive symptoms. However, the precise impact of SSRIs on neuroplasticity and inflammation remains unclear. In this study, we aimed to investigate the influence of long-term treatment with SSRIs on hippocampal neuron, inflammation, synaptic function and morphology. Our findings revealed that fluoxetine treatment significantly alleviated behavioral despair, anhedonia, and anxiety in reserpine-treated mice. Moreover, fluoxetine mitigated hippocampal neuron impairment, inhibited inflammatory release, and increased the expression of synaptic proteins markers (SYP and PSD95) in mice. Notably, fluoxetine also suppressed reserpine-induced synapse loss in the hippocampus. Based on these results, fluoxetine has been demonstrated effectively to ameliorate depressive mood and cognitive dysfunction, possibly through the enhancement of synaptic plasticity. Overall, our study contributes to a further understanding of the mechanisms underlying the therapeutic effects of fluoxetine and its potential role in improving depressive symptoms and cognitive impairments.
MeSH term(s)	Mice ; Animals ; Fluoxetine/pharmacology ; Selective Serotonin Reuptake Inhibitors/pharmacology ; Reserpine/metabolism ; Reserpine/pharmacology ; Depression/drug therapy ; Inflammation/drug therapy ; Inflammation/metabolism ; Neuronal Plasticity ; Hippocampus/metabolism
Chemical Substances	Fluoxetine (01K63SUP8D) ; Selective Serotonin Reuptake Inhibitors ; Reserpine (8B1QWR724A)
Language	English
Publishing date	2023-12-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2023.148723
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Article ; Online: Associations between seasonal ambient air pollution and adverse perinatal outcomes: a retrospective cohort study in Wenzhou, China.

Huang, Hui-Jun / Yu, Qiu-Yan / Zheng, Tian / Wang, Shan-Shan / Yang, Xin-Jun

Environmental science and pollution research international

2022 Volume 29, Issue 39, Page(s) 59903–59914

Abstract: Prenatal exposure to ambient air pollution has been associated with adverse perinatal outcomes in previous studies. However, few studies have examined the interaction between air pollution and the season of conception on term low birth weight (TLBW) or ... ...

Abstract	Prenatal exposure to ambient air pollution has been associated with adverse perinatal outcomes in previous studies. However, few studies have examined the interaction between air pollution and the season of conception on term low birth weight (TLBW) or macrosomia. Birth registry data of singleton live births in Wenzhou, China, between January 2015 and December 2016 were accessed from the Wenzhou Maternal and Child Health Information Management platform, and data on the ambient air pollutants in Wenzhou were obtained from the Chinese Air Quality Online Monitoring and Analysis Platform. Single-/two-pollutant binary logistic regression models were used to assess the associations between ambient air pollutants (PM
MeSH term(s)	Air Pollutants/toxicity ; Air Pollution ; Child ; China/epidemiology ; Female ; Fetal Macrosomia/chemically induced ; Humans ; Infant ; Infant, Newborn ; Maternal Exposure ; Nitrogen Dioxide ; Particulate Matter ; Pregnancy ; Retrospective Studies ; Seasons
Chemical Substances	Air Pollutants ; Particulate Matter ; Nitrogen Dioxide (S7G510RUBH)
Language	English
Publishing date	2022-04-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-20084-6
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Article: Associations between seasonal ambient air pollution and adverse perinatal outcomes: a retrospective cohort study in Wenzhou, China

Huang, Hui-Jun / Yu, Qiu-Yan / Zheng, Tian / Wang, Shan-Shan / Yang, Xin-Jun

Environmental science and pollution research. 2022 Aug., v. 29, no. 39

2022

Abstract	Prenatal exposure to ambient air pollution has been associated with adverse perinatal outcomes in previous studies. However, few studies have examined the interaction between air pollution and the season of conception on term low birth weight (TLBW) or macrosomia. Birth registry data of singleton live births in Wenzhou, China, between January 2015 and December 2016 were accessed from the Wenzhou Maternal and Child Health Information Management platform, and data on the ambient air pollutants in Wenzhou were obtained from the Chinese Air Quality Online Monitoring and Analysis Platform. Single-/two-pollutant binary logistic regression models were used to assess the associations between ambient air pollutants (PM₂.₅, PM₁₀, NO₂, SO₂, and O₃) and TLBW/macrosomia, further exploring whether the season of conception interacts with air pollution to impact birth weight. Finally, 213,959 term newborns were selected, including 2452 (1.1%) infants with TLBW and 13,173 (6.1%) infants with macrosomia. In the single-/two-pollutant models, we observed an increased risk of TLBW associated with maternal exposure to PM₂.₅, PM₁₀, SO₂, and NO₂ during the entire pregnancy, especially in the 2nd trimester. Maternal exposure to O₃ during the 1st trimester was associated with increased macrosomia risk, and O₃ exposure during the 3rd trimester was associated with increased TLBW risk. Pregnant women who conceive in the warm season may experience a more adverse ambient air environment that is related to the risks of TLBW. These findings add to the evidence suggesting that air pollution and the season of conception may have synergistic effects on adverse perinatal outcomes, especially TLBW. Further prospective cohort studies are needed to validate our results.
Keywords	air ; air pollution ; air quality ; child health ; cohort studies ; conception ; fetal macrosomia ; health information ; information management ; low birth weight ; maternal exposure ; pregnancy ; regression analysis ; research ; risk ; warm season ; China
Language	English
Dates of publication	2022-08
Size	p. 59903-59914.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-20084-6
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Article ; Online: Pathological methamphetamine exposure triggers the accumulation of neuropathic protein amyloid-β by inhibiting UCHL1.

Gao, Zheng-Xiang / Zhang, Cui / Lu, Jian-Chong / Zhao, Xu / Qiu, Hai / Wang, Hui-Jun

Neurotoxicology

2021 Volume 86, Page(s) 19–25

Abstract: Methamphetamine (METH), a powerful psychoactive drug, causes damage to the nervous system and leads to degenerative changes similar to Alzheimer's disease (AD), however, the molecular mechanism between the toxicity of METH and AD-related symptoms remains ...

Abstract	Methamphetamine (METH), a powerful psychoactive drug, causes damage to the nervous system and leads to degenerative changes similar to Alzheimer's disease (AD), however, the molecular mechanism between the toxicity of METH and AD-related symptoms remains poorly understood. In this study, we investigated the effect of METH exposure on the accumulation of amyloid-β by establishing the animal and cell models. The results showed that METH exposure increased amyloid precursor protein (APP) and β-secretase (BACE1), contributed to the accumulation of amyloid-β, and which was alleviated with the pretreatment of BACE1 inhibitor. In addition, METH exposure decreased ubiquitin carboxy-terminal hydrolases L1 (UCHL1) which was related to the degradation of BACE1, and therefore led to the up-regulation of BACE1. In summary, the study could provide a new insight into the molecular mechanisms of METH toxicity and new evidence for the link between METH abuse and AD.
MeSH term(s)	Amyloid beta-Peptides/metabolism ; Animals ; Cells, Cultured ; Central Nervous System Stimulants/toxicity ; Dose-Response Relationship, Drug ; Male ; Methamphetamine/toxicity ; Mice ; Mice, Inbred C57BL ; Neurons/drug effects ; Neurons/metabolism ; Peptide Fragments/metabolism ; Ubiquitin Thiolesterase/antagonists & inhibitors ; Ubiquitin Thiolesterase/metabolism
Chemical Substances	Amyloid beta-Peptides ; Central Nervous System Stimulants ; Peptide Fragments ; amyloid beta-protein (1-42) ; Methamphetamine (44RAL3456C) ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; Uchl1 protein, mouse (EC 3.4.19.12)
Language	English
Publishing date	2021-06-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	800820-6
ISSN	1872-9711 ; 0161-813X
ISSN (online)	1872-9711
ISSN	0161-813X
DOI	10.1016/j.neuro.2021.06.004
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Zs.A 1547: Show issues

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Article ; Online: Genetically predicted selenium concentrations and thyroid function: A two-sample Mendelian randomization study.

Huang, Hui-Jun / Wang, Shan-Shan / Jin, Ming-Min / Cheng, Bin-Wei / Liu, Yu / Liu, Xiao-Chen / Yu, Qiu-Yan / Yang, Xin-Jun

Clinical endocrinology

2022 Volume 98, Issue 6, Page(s) 813–822

Abstract: Objective: The impact of selenium (Se) on human thyroid function remains unclear, with inconsistent results from recent epidemiological studies. Moreover, the observed associations are prone to bias due to potential confounding and reverse causation. ... ...

Abstract	Objective: The impact of selenium (Se) on human thyroid function remains unclear, with inconsistent results from recent epidemiological studies. Moreover, the observed associations are prone to bias due to potential confounding and reverse causation. Mendelian randomization (MR) analysis facilitates the large minimization of biases produced by environmental and lifestyle influences, providing unconfounded estimates of causal effects using instrumental variables. We aim to examine the association between Se concentrations and human thyroid function using a two-sample MR analysis. Design and methods: Genetic instruments for Se concentrations, including toenail and blood (TAB) and blood Se concentrations, were identified from a genome-wide association study (GWAS) of blood Se (n = 5477) and toenail Se levels (n = 4162). GWAS summary statistics on thyroid phenotypes were downloaded from the ThyroidOmics consortium, including thyroid-stimulating hormone (TSH) (n = 54,288), free thyroxin (FT4) (n = 49,269), hypo (n = 53,423), and hyperthyroidism (n = 51,823). The MR study was conducted using the inverse-variance weighted (IVW) method, supplemented with the weighted median and the mode-based method. Results: Genetically determined TAB Se was negatively associated with FT4 (β = -.067; 95% confidence interval [CI] = -0.106, -0.028; p = 0.001) using the IVW analyses, as well in the additional analyses using the weighted median and weighted-mode methods. No evidence in heterogeneity, pleiotropy or outlier single-nucleotide polymorphisms was detected (all p > 0.05). Suggestive casual association between increased genetically determined TAB Se concentrations and decreased hypothyroidism risk was found by the IVW method (odds ratio [OR] = 0.847; 95% CI = 0.728, 0.985; p = 0.031). The causal effect of TAB Se on FT4 was observed in women (β = -.076; 95% CI = -0.129, -0.024; p = 0.004). However, the influence of genetically determined higher Se concentrations on TSH levels and hyperthyroidism revealed insignificance in the primary and sensitivity analyses. Conclusions: The present MR study indicated that high Se concentration enable the decreasing of FT4 levels, and the effects of Se concentrations on FT4 remain sex-specific.
MeSH term(s)	Male ; Humans ; Female ; Selenium ; Mendelian Randomization Analysis/methods ; Genome-Wide Association Study ; Thyrotropin ; Hyperthyroidism ; Polymorphism, Single Nucleotide/genetics
Chemical Substances	Selenium (H6241UJ22B) ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2022-12-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.14867
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Article ; Online: Correction to: PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3.

Oncogene

2023 Volume 42, Issue 35, Page(s) 2655–2656

Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Published Erratum
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/s41388-023-02735-1
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Article ; Online: Establishment and Verification of UPLC-MS/MS Technique for Pharmacokinetic Drug-Drug Interactions of Selinexor with Posaconazole in Rats.

Zhou, Chen-Jian / Wang, Hui-Jun / Zhou, Chun-Yan / Li, Chao-Fan / Zhu, Ming-Jia / Qiu, Xiang-Jun

Drug design, development and therapy

2021 Volume 15, Page(s) 1561–1568

Abstract: Background: A method for the determination of selinexor by UPLC-MS/MS was established to study the effect of posaconazole on the pharmacokinetics of selinexor in rats.: Methods: The experiment rats were divided into group A (0.5% CMC-Na) and group B ( ...

Abstract	Background: A method for the determination of selinexor by UPLC-MS/MS was established to study the effect of posaconazole on the pharmacokinetics of selinexor in rats. Methods: The experiment rats were divided into group A (0.5% CMC-Na) and group B (posaconazole, 20 mg/kg), 6 rats in each group. 30 minutes after administration of 0.5% CMC-Na or posaconazole, all the rats were given selinexor (8 mg/kg), and plasma samples were collected. The plasma samples underwent acetonitrile protein precipitation, and were separated by UPLC on an Acquity UPLC BEH C18 column with gradient elution. Acetonitrile and 0.1% formic acid were used as the mobile phases. The analyte detection was used a Xevo TQ-S triple quadrupole tandem mass spectrometer and multiple reaction monitoring (MRM) for analyte monitoring. We use acetonitrile for protein precipitation. Results: Selinexor had good linearity (1.0-1000 ng/mL, r Conclusion: This bioanalysis method had been applied to the study of drug interactions in rats. It was found that posaconazole significantly increased the concentration of selinexor in rats. Therefore, when selinexor and posaconazole are combined, we should pay attention to the possible drug-drug interactions to reduce adverse reactions.
MeSH term(s)	Animals ; Chromatography, High Pressure Liquid ; Hydrazines/blood ; Hydrazines/chemistry ; Hydrazines/pharmacokinetics ; Male ; Molecular Structure ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry ; Triazoles/blood ; Triazoles/chemistry ; Triazoles/pharmacokinetics
Chemical Substances	Hydrazines ; Triazoles ; selinexor (31TZ62FO8F) ; posaconazole (6TK1G07BHZ)
Language	English
Publishing date	2021-04-15
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S303928
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Article ; Online: Traumatic carotid-cavernous fistula with perimedullary venous drainage and delayed myelopathy: A case report.

Ding, Chun-Long / Zhang, Chun-Lei / Hua, Feng / Xi, Shao-Dong / Zhou, Qin-Wei / Wang, Hui-Jun / Chen, Jun-Jie / Qiu, Jie

Medicine international

2021 Volume 1, Issue 5, Page(s) 16

Abstract: Traumatic carotid-cavernous fistula (TCCF) with perimedullary venous drainage and delayed myelopathy is a relatively rare clinical lesion. Endovascular embolization using embolic agents is the preferred treatment for patients with a poor collateral ... ...

Abstract	Traumatic carotid-cavernous fistula (TCCF) with perimedullary venous drainage and delayed myelopathy is a relatively rare clinical lesion. Endovascular embolization using embolic agents is the preferred treatment for patients with a poor collateral circulation. The present study describes the case of a 45-year-old male with TCCF, who presented with progressive cervical myelopathy for 1 month. A previous history of the patient included an anterior skull base fracture induced by a traffic accident 2 years prior. Cervical spinal magnetic resonance imaging (MRI) revealed dilated perimedullary veins and cervical spinal cord edema. Cerebral digital subtraction angiography revealed a direct CCF with perimedullary venous drainage. The patient received endovascular treatment with coils and an Onyx liquid embolic system to occlude the fistula, and his symptoms were relieved when he was discharged 3 weeks later. The patient then felt normal and a cervical spinal MRI revealed the disappearance of the perimedullary veins dilation and spinal cord edema at the 6-month follow-up. To the best of our knowledge, only three cases of CCFs with perimedullary venous drainage presenting with myelopathy have been previously reported. The present study also discussed the possible pathological mechanisms for this rare presentation. Moreover, it is suggested that the possibility of CCFs as a cause of cervical myelopathy needs to be taken into consideration.
Language	English
Publishing date	2021-09-17
Publishing country	England
Document type	Case Reports
ISSN	2754-1304
ISSN (online)	2754-1304
DOI	10.3892/mi.2021.16
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Article ; Online: An integrated strategy combining network toxicology and feature-based molecular networking for exploring hepatotoxic constituents and mechanism of Epimedii Folium-induced hepatotoxicity in vitro.

Zhao, Zhen / Du, Jin-Fa / Wang, Qiao-Lei / Qiu, Fang-Ning / Chen, Xu-Yan / Liu, Feng-Jie / Li, Ping / Jiang, Yan / Li, Hui-Jun

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2023 Volume 176, Page(s) 113785

Abstract: Epimedii Folium (EF), a commonly used herbal medicine to treat osteoporosis, has caused serious concern due to potential hepatotoxicity. Until now, its intrinsic hepatotoxic mechanism and hepatotoxic ingredients remain unclear. Here, a novel high- ... ...

Abstract	Epimedii Folium (EF), a commonly used herbal medicine to treat osteoporosis, has caused serious concern due to potential hepatotoxicity. Until now, its intrinsic hepatotoxic mechanism and hepatotoxic ingredients remain unclear. Here, a novel high-throughput approach was designed to investigate the intrinsic hepatotoxic of EF. High-content screen imaging (HCS) and biochemical tests were first performed to obtain the cytotoxicity parameter matrix of 17 batch EF samples. EF-treated alpha mouse liver 12 (AML12) cells showed increased reactive oxygen species (ROS), reduced glutathione (GSH) and mitochondrial membrane potential (MMP), and apoptosis and cholestasis were further observed. Network toxicology predicted that EF-triggered hepatotoxiciy was involved in transcription factor (TF) activity. The FXR expression, screened by a TF PCR array, exhibited down-regulation following EF extract administration. Moreover, EF inhibited bile acid (BA) metabolism pathway in an FXR-dependent manner. Pearson correlation between the cytotoxicity parameter matrix and quantification feature table obtained from UHPLC-QTOF data of EF suggested 7 prenylated flavonoids possessed potent hepatotoxicities and their cytotoxicity order was further summarized. The transcriptional repression effects of them on FXR were also verified. Collectively, our findings indicate that FXR is probably responsible for EF-induced hepatotoxicity and prenylated flavonoids may be a major class of hepatotoxic constituents in EF.
MeSH term(s)	Mice ; Animals ; Drugs, Chinese Herbal/chemistry ; Flavonoids/toxicity ; Plants, Medicinal ; Chemical and Drug Induced Liver Injury
Chemical Substances	epimedii flavone ; Drugs, Chinese Herbal ; Flavonoids
Language	English
Publishing date	2023-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2023.113785
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