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  1. Article ; Online: Using the prone position could help to combat the development of fast hypoxia in some patients with COVID-19.

    Lindahl, Sten G E

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 109, Issue 8, Page(s) 1539–1544

    Abstract: The world is facing an explosive COVID-19 pandemic. Some cases rapidly develop deteriorating lung function, which causes deep hypoxaemia and requires urgent treatment. Many centres have started treating patients in the prone position, and oxygenation has ...

    Abstract The world is facing an explosive COVID-19 pandemic. Some cases rapidly develop deteriorating lung function, which causes deep hypoxaemia and requires urgent treatment. Many centres have started treating patients in the prone position, and oxygenation has improved considerably in some cases. Questions have been raised regarding the mechanisms behind this. The mini review provides some insights into the role of supine and prone body positions and summarises the latest understanding of the responsible mechanisms. The scope for discussion is outside the neonatal period and entirely based on experimental and clinical experiences related to adults. The human respiratory system is a complex interplay of many different variables. Therefore, this mini review has prioritised previous and ongoing research to find explanations based on three scientific areas: gravity, lung structure and fractal geometry and vascular regulation. It concludes that gravity is one of the variables responsible for ventilation/perfusion matching but in concert with lung structure and fractal geometry, ventilation and regulation of lung vascular tone. Since ventilation distribution does not change between supine and prone positions, the higher expression of nitric oxide in dorsal lung vessels than in ventral vessels is likely to be the most important mechanism behind enhanced oxygenation in the prone position.
    MeSH term(s) COVID-19 ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Humans ; Hypoxia/prevention & control ; Pandemics ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; Prone Position/physiology
    Keywords covid19
    Language English
    Publishing date 2020-06-17
    Publishing country Norway
    Document type Journal Article ; Review
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15382
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  2. Article ; Online: Using the prone position could help to combat the development of fast hypoxia in some patients with COVID‐19

    Lindahl, Sten G. E.

    Acta Paediatrica

    2020  Volume 109, Issue 8, Page(s) 1539–1544

    Keywords Pediatrics, Perinatology, and Child Health ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ISSN 0803-5253
    DOI 10.1111/apa.15382
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Using the prone position could help to combat the development of fast hypoxia in some patients with COVID-19

    Lindahl, Sten G E

    Acta Paediatr

    Abstract: The world is facing an explosive COVID-19 pandemic. Some cases rapidly develop deteriorating lung function, which causes deep hypoxaemia and requires urgent treatment. Many centres have started treating patients in the prone position, and oxygenation has ...

    Abstract The world is facing an explosive COVID-19 pandemic. Some cases rapidly develop deteriorating lung function, which causes deep hypoxaemia and requires urgent treatment. Many centres have started treating patients in the prone position, and oxygenation has improved considerably in some cases. Questions have been raised regarding the mechanisms behind this. The mini review provides some insights into the role of supine and prone body positions and summarises the latest understanding of the responsible mechanisms. The scope for discussion is outside the neonatal period and entirely based on experimental and clinical experiences related to adults. The human respiratory system is a complex interplay of many different variables. Therefore, this mini review has prioritised previous and ongoing research to find explanations based on three scientific areas: gravity, lung structure and fractal geometry and vascular regulation. It concludes that gravity is one of the variables responsible for ventilation/perfusion matching but in concert with lung structure and fractal geometry, ventilation and regulation of lung vascular tone. Since ventilation distribution does not change between supine and prone positions, the higher expression of nitric oxide in dorsal lung vessels than in ventral vessels is likely to be the most important mechanism behind enhanced oxygenation in the prone position.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #458994
    Database COVID19

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  4. Book: Paediatric anaesthesia

    Lindahl, Sten G. E.

    (Baillière's clinical anaesthesiology ; 10,4)

    1996  

    Author's details S. G. E. Lindahl, guest ed
    Series title Baillière's clinical anaesthesiology ; 10,4
    Collection
    Keywords Anesthesia / in infancy & childhood ; Kind ; Anästhesiologie ; Anästhesie
    Subject Kindheit ; Kindesalter ; Kindschaft ; Kinder
    Language English
    Size IX S., S. 605 - 776 : graph. Darst.
    Publisher Baillière Tindall
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007428335
    ISBN 0-7020-2185-7 ; 978-0-7020-2185-5
    Database Catalogue ZB MED Medicine, Health

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    Se 1117 -10,4- verfügbar in Königswinter Königswinter

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  5. Book ; Conference proceedings: Nitrates in anaesthesia and intensive care

    Lindahl, Sten G. E.

    [workshop]

    (Acta anaesthesiologica Scandinavica : Supplementum ; 97)

    1992  

    Author's details Sten G. E. Lindahl (ed.)
    Series title Acta anaesthesiologica Scandinavica : Supplementum ; 97
    Acta anaesthesiologica Scandinavica
    Acta anaesthesiologica Scandinavica ; Supplementum
    Collection Acta anaesthesiologica Scandinavica
    Acta anaesthesiologica Scandinavica ; Supplementum
    Keywords Nitric Oxide / pharmacology / congresses ; Nitrates / pharmacology / congresses ; Vasodilation / drug effects / congresses ; Anesthesia / congresses ; Critical Care / congresses ; Nitrattherapie ; Intensivmedizin ; Anästhesiologie ; Anästhesie
    Language English
    Size 36 S. : graph. Darst.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book ; Conference proceedings
    HBZ-ID HT004226292
    ISBN 87-16-14932-7 ; 978-87-16-14932-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 22 -Suppl.97- verfügbar in Königswinter Königswinter

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  6. Book: A salute for Torsten Gordh, 90

    Gordh, Torsten / Lindahl, Sten G. E.

    (Acta anaesthesiologica Scandinavica : Supplement ; 113)

    1998  

    Author's details Sten Lindahl (guest ed.)
    Series title Acta anaesthesiologica Scandinavica : Supplement ; 113
    Acta anaesthesiologica Scandinavica
    Acta anaesthesiologica Scandinavica ; Supplement
    Collection Acta anaesthesiologica Scandinavica
    Acta anaesthesiologica Scandinavica ; Supplement
    Language English
    Size 38 S. : Ill., graph. Darst.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT009716271
    ISBN 87-16-16324-9 ; 978-87-16-16324-0
    Database Catalogue ZB MED Medicine, Health

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    Zs A 22 -Suppl.113- not available for loan Zeitschriften-Lesesaal

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  7. Article ; Online: Atrial natriuretic peptide attenuation of renal ischemia-reperfusion injury after major surgery.

    Moriyama, Takahiro / Kanmura, Yuichi / Lindahl, Sten G E

    The Journal of surgical research

    2015  Volume 201, Issue 1, Page(s) 213–218

    Abstract: Background: Ischemia-reperfusion (I/R) injury is one of the most important pathologic processes causing acute kidney injury. Human atrial natriuretic peptide (hANP) has various effects, including renal protection. The purpose of the present work was to ... ...

    Abstract Background: Ischemia-reperfusion (I/R) injury is one of the most important pathologic processes causing acute kidney injury. Human atrial natriuretic peptide (hANP) has various effects, including renal protection. The purpose of the present work was to study the effects of intrarenal angiotensin II (Ang II) and investigate the potential of hANP to prevent kidney injury.
    Materials and methods: Male Sprague-Dawley rats were divided into three groups as follows: (1) sham; (2) I/R (30 min of bilateral renal ischemia followed by 6 h reperfusion); and (3) I/R + hANP (I/R injury + continuous intravenous infusion of hANP at 0.025 μg/kg/min). After 6 h of reperfusion, both renal and plasma Ang II concentrations were measured. Urinary angiotensinogen and neutrophil gelatinase-associated lipocalin were measured before ischemia and 2, 4, and 6 h after reperfusion. To evaluate the renal-protective effects of hANP, serum creatinine was determined 6 and 24 h after reperfusion. In addition, mitochondrial oxygen consumption in kidney cortex was measured in the presence of Ang II and hANP.
    Results: Renal Ang II concentrations were 24.5 ± 3.9 and 14.2 ± 3.4 pg/mg renal weight in the I/R and I/R + hANP groups, respectively. Urinary angiotensinogen and neutrophil gelatinase-associated lipocalin excretions were elevated after I/R injury. Treatment with hANP significantly attenuated this effect after 4 and 6 h. Oxygen consumption in renal mitochondria increased with the addition of Ang II, which was also attenuated by hANP.
    Conclusions: Production of intrarenal Ang II was attenuated by hANP, indicating a potential to diminish renal I/R injury.
    MeSH term(s) Acute Kidney Injury/metabolism ; Acute Kidney Injury/prevention & control ; Acute-Phase Proteins/urine ; Angiotensin II/metabolism ; Angiotensinogen/urine ; Animals ; Atrial Natriuretic Factor/therapeutic use ; Kidney/metabolism ; Lipocalins/urine ; Male ; Mitochondria/metabolism ; Oxygen Consumption ; Postoperative Complications/metabolism ; Postoperative Complications/prevention & control ; Proto-Oncogene Proteins/urine ; Rats, Sprague-Dawley ; Reperfusion Injury/metabolism ; Reperfusion Injury/prevention & control
    Chemical Substances Acute-Phase Proteins ; Lcn2 protein, rat ; Lipocalins ; Proto-Oncogene Proteins ; Angiotensinogen (11002-13-4) ; Angiotensin II (11128-99-7) ; Atrial Natriuretic Factor (85637-73-6)
    Language English
    Publishing date 2015-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2015.10.036
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    Zs.A 178: Show issues Location:
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  8. Article ; Online: Oxygen and life on earth: an anesthesiologist's views on oxygen evolution, discovery, sensing, and utilization.

    Lindahl, Sten G E

    Anesthesiology

    2008  Volume 109, Issue 1, Page(s) 7–13

    Abstract: The advent of oxygenic photosynthesis and the accumulation of oxygen in our atmosphere opened up new possibilities for the development of life on Earth. The availability of oxygen, the most capable electron acceptor on our planet, allowed the development ...

    Abstract The advent of oxygenic photosynthesis and the accumulation of oxygen in our atmosphere opened up new possibilities for the development of life on Earth. The availability of oxygen, the most capable electron acceptor on our planet, allowed the development of highly efficient energy production from oxidative phosphorylation, which shaped the evolutionary development of aerobic life forms from the first multicellular organisms to the vertebrates.
    MeSH term(s) Anesthesiology ; Animals ; Atmosphere/analysis ; Atmosphere/chemistry ; Earth (Planet) ; Evolution, Chemical ; Humans ; Life ; Oxygen/chemistry ; Oxygen/isolation & purification ; Oxygen/metabolism ; Photochemistry ; Physicians
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2008-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0b013e31817b5a7e
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  9. Article: One hundred years of Nobel Prizes and 150 years of anesthesiology.

    Lindahl, Sten G E

    Journal of anesthesia

    2003  Volume 17, Issue 1, Page(s) 42–45

    MeSH term(s) Anesthesiology/history ; History, 19th Century ; History, 20th Century ; Humans ; Nobel Prize
    Language English
    Publishing date 2003-08-05
    Publishing country Japan
    Document type Historical Article ; Journal Article
    ZDB-ID 1107821-2
    ISSN 1438-8359 ; 0913-8668
    ISSN (online) 1438-8359
    ISSN 0913-8668
    DOI 10.1007/s005400300006
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  10. Article: Thermogenesis inhibition in brown adipocytes is a specific property of volatile anesthetics.

    Ohlson, Kerstin B E / Lindahl, Sten G E / Cannon, Barbara / Nedergaard, Jan

    Anesthesiology

    2002  Volume 98, Issue 2, Page(s) 437–448

    Abstract: Background: This investigation examined the possibility that the inhibitory effect of halothane on nonshivering thermogenesis (heat production) in brown adipocytes is not a universal effect of all anesthetic agents but related to the type of anesthetic.! ...

    Abstract Background: This investigation examined the possibility that the inhibitory effect of halothane on nonshivering thermogenesis (heat production) in brown adipocytes is not a universal effect of all anesthetic agents but related to the type of anesthetic.
    Methods: Brown adipocytes from hamster were isolated with a collagenase digestion method and incubated with anesthetic agents. The rate of oxygen consumption was measured with an oxygen electrode. The effect of clinically relevant (and higher) doses of anesthetics of different classes on basal and norepinephrine-induced thermogenesis (oxygen consumption) was tested.
    Results: Two distinct groups of anesthetics could be distinguished: thermogenesis inhibitors and noninhibitors. Thermogenesis inhibitors include volatile anesthetics such as halothane (IC(50), 1.1 mm), ether (IC(50), 20 mm), and chloroform (IC(50), 2.2 mm) (nominal concentrations), but also tribromoethanol (IC(50), 0.6 mm), all inducing inhibition of norepinephrine-induced thermogenesis without affecting the EC for norepinephrine. Thermogenesis noninhibitors include the nonvolatile anesthetics pentobarbital, propofol, ketamine, and urethane, the inhalation anesthetic nitrous oxide, and, notably, also the volatile nonanesthetics (nonimmobilizers) 1,2-dichlorohexafluorocyclobutane and 2,3-dichlorooctafluorobutane; none of these compounds had any effect on norepinephrine-induced thermogenesis at any concentration tested.
    Conclusions: There are two distinct classes of anesthetics with regard to effects on thermogenesis, thermogenesis inhibitors and thermogenesis noninhibitors. The results are important for the interpretation of studies in thermal biology in general; specifically, they indicate that conclusions concerning regulation of nonshivering thermogenesis during anesthesia depend on the type of anesthetic used. Of clinical importance is that the volatile anesthetics are inhibitory for nonshivering thermogenesis and thus for an alternative heat production when myorelaxants prevent shivering. As the distinction between thermogenesis inhibitors and thermogenesis noninhibitors corresponds to the distinction between volatile and nonvolatile anesthetics, it may be related to the mode of action of the volatile anesthetics.
    MeSH term(s) Adipocytes/drug effects ; Adipose Tissue, Brown/cytology ; Adipose Tissue, Brown/drug effects ; Anesthetics, Inhalation/administration & dosage ; Anesthetics, Inhalation/pharmacology ; Animals ; Cell Separation ; Chloroform/pharmacology ; Cricetinae ; Dose-Response Relationship, Drug ; Ethanol/analogs & derivatives ; Ethanol/pharmacology ; Ether/pharmacology ; Female ; Halothane/pharmacology ; In Vitro Techniques ; Male ; Mesocricetus ; Oxygen Consumption/drug effects ; Pharmaceutical Solutions ; Thermogenesis/drug effects
    Chemical Substances Anesthetics, Inhalation ; Pharmaceutical Solutions ; Ether (0F5N573A2Y) ; tribromoethanol (149JI83A44) ; Ethanol (3K9958V90M) ; Chloroform (7V31YC746X) ; Halothane (UQT9G45D1P)
    Language English
    Publishing date 2002-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 269-0
    ISSN 0003-3022
    ISSN 0003-3022
    DOI 10.1097/00000542-200302000-00025
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