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Book ; Online: Chapter Modelling Neurodegenerative Diseases Using Human Pluripotent Stem Cells

Hall, Vanessa J.

2016

Keywords	Oncology ; biomarker, rare disease, genetic disease, genomics, transcriptomics, proteomics
Size	1 Online-Ressource
Publisher	InTechOpen
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021047801
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Context-dependent effects of a reintroduced ungulate on soil properties are driven by soil texture, moisture, and herbivore activity.

Dodge, Vanessa J / Eviner, Valerie T / Cushman, J Hall

Ecology and evolution

2020 Volume 10, Issue 19, Page(s) 10858–10871

Abstract: Although there is considerable evidence that large mammalian herbivores influence ecosystem-level processes, studies have reported such widely varying results that generalizations have remained elusive. Here, we use an 18-year-old exclosure experiment- ... ...

Abstract	Although there is considerable evidence that large mammalian herbivores influence ecosystem-level processes, studies have reported such widely varying results that generalizations have remained elusive. Here, we use an 18-year-old exclosure experiment-stratified across a landscape heterogeneous with respect to soil texture, moisture and herbivore activity-to understand the variable effects of tule elk (
Language	English
Publishing date	2020-09-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.6743
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Article ; Online: Context‐dependent effects of a reintroduced ungulate on soil properties are driven by soil texture, moisture, and herbivore activity

Vanessa J. Dodge / Valerie T. Eviner / J. Hall Cushman

Ecology and Evolution, Vol 10, Iss 19, Pp 10858-

2020 Volume 10871

Abstract: Abstract Although there is considerable evidence that large mammalian herbivores influence ecosystem‐level processes, studies have reported such widely varying results that generalizations have remained elusive. Here, we use an 18‐year‐old exclosure ... ...

Abstract	Abstract Although there is considerable evidence that large mammalian herbivores influence ecosystem‐level processes, studies have reported such widely varying results that generalizations have remained elusive. Here, we use an 18‐year‐old exclosure experiment—stratified across a landscape heterogeneous with respect to soil texture, moisture and herbivore activity—to understand the variable effects of tule elk (Cervus canadensis nannodes), a native reintroduced herbivore, on soil properties along the coast of northern California. Elk significantly increased soil bulk density and created a compacted layer at shallow soil depth, while decreasing infiltration rate and pH. The effects of elk on bulk density, penetration resistance, and pH varied with soil type, being least pronounced in coarse, sandy loams, and greatest in loose sand. The effects of elk on nutrient availability varied along gradients of soil texture and moisture. In coarser soils, elk decreased ammonium availability, but increased it in finer soils. Elk also decreased soil moisture content, in part through their positive effect on bulk density, and this effect was most pronounced in coarser soils. Through decreasing soil moisture content, elk also decreased nitrate availability in coarser soils. At greater levels of elk activity (as measured by dung deposition), the elk effect on bulk density was amplified, and this had a corresponding negative effect on nitrate and phosphate availability. Our study has demonstrated that a better understanding of spatial variation in the effects of herbivores on ecosystems can emerge by evaluating their influences across gradients of soil texture, soil moisture, and herbivore activity. These data enabled us to evaluate several frameworks that have been developed to understand the variable effects of herbivores on ecosystems, which is a significant step in reconciling the many competing ideas put forth to explain the context‐dependent effects of large herbivores on grazed ecosystems.
Keywords	context‐dependent effects ; ecosystem processes ; environmental heterogeneity ; long‐term effects ; native ungulate herbivore ; reintroduction ; Ecology ; QH540-549.5
Subject code	550
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Medication use and comorbidities in an increasingly younger osteoarthritis population: an 18-year retrospective open-cohort study.

Graham, Jove / Novosat, Tonia / Sun, Haiyan / Piper, Brian J / Boscarino, Joseph A / Kern, Melissa S / Hayduk, Vanessa A / Beck, Craig / Robinson, Rebecca L / Casey, Edward / Hall, Jerry / Dorling, Patricia / Wright, Eric

BMJ open

2023 Volume 13, Issue 5, Page(s) e067211

Abstract: Objectives: As understanding of the pathogenesis and treatment strategies for osteoarthritis (OA) evolves, it is important to understand how patient factors are also changing. Our goal was to examine demographics and known risk factors of patients with ... ...

Abstract	Objectives: As understanding of the pathogenesis and treatment strategies for osteoarthritis (OA) evolves, it is important to understand how patient factors are also changing. Our goal was to examine demographics and known risk factors of patients with OA over time. Design: Open-cohort retrospective study using electronic health records. Setting: Large US integrated health system with 7 hospitals, 2.6 million outpatient clinic visits and 97 300 hospital admissions annually in a mostly rural geographic region. Participants: Adult patients with at least two encounters and a diagnosis of OA or OA-relevant surgery between 2001 and 2018. Because of geographic region, over 96% of participants were white/Caucasian. Interventions: None. Primary and secondary outcome measures: Descriptive statistics were used to examine age, sex, body mass index (BMI), Charlson Comorbidity Index, major comorbidities and OA-relevant prescribing over time. Results: We identified 290 897 patients with OA. Prevalence of OA increased significantly from 6.7% to 33.5% and incidence increased 37% (from 3772 to 5142 new cases per 100 000 patients per year) (p<0.0001). Percentage of females declined from 65.3% to 60.8%, and percentage of patients with OA in the youngest age bracket (18-45 years) increased significantly (6.2% to 22.7%, p<0.0001). The percentage of patients with OA with BMI ≥30 remained above 50% over the time period. Patients had low comorbidity overall, but anxiety, depression and gastro-oesophageal reflux disease showed the largest increases in prevalence. Opioid use (tramadol and non-tramadol) showed peaks followed by declines, while most other medications increased slightly in use or remained steady. Conclusions: We observe increasing OA prevalence and a greater proportion of younger patients over time. With better understanding of how characteristics of patients with OA are changing over time, we can develop better approaches for managing disease burden in the future.
MeSH term(s)	Adult ; Female ; Humans ; Adolescent ; Young Adult ; Middle Aged ; Retrospective Studies ; Cohort Studies ; Comorbidity ; Osteoarthritis/epidemiology ; Anxiety
Language	English
Publishing date	2023-05-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-067211
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Article: The

Ante, Vanessa M / Farris, Lauren C / Saputra, Elizabeth P / Hall, Allie J / O'Bier, Nathaniel S / Oliva Chávez, Adela S / Marconi, Richard T / Lybecker, Meghan C / Hyde, Jenny A

Frontiers in microbiology

2021 Volume 12, Page(s) 676192

Abstract: ... Borrelia ... ...

Abstract	Borrelia burgdorferi
Language	English
Publishing date	2021-05-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.676192
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Article ; Online: Alternative transmission pathways for guinea worm in dogs: implications for outbreak risk and control.

Vinson, John E / Park, Andrew W / Cleveland, Christopher A / Yabsley, Michael J / Ezenwa, Vanessa O / Hall, Richard J

International journal for parasitology

2021 Volume 51, Issue 12, Page(s) 1027–1034

Abstract: Guinea worm (Dracunculus medinensis) has exerted a high human health burden in parts of Africa. Complete eradication of Guinea worm disease (dracunculiasis) may be delayed by the circulation of the parasite in domestic dogs. As with humans, dogs acquire ... ...

Abstract	Guinea worm (Dracunculus medinensis) has exerted a high human health burden in parts of Africa. Complete eradication of Guinea worm disease (dracunculiasis) may be delayed by the circulation of the parasite in domestic dogs. As with humans, dogs acquire the parasite by directly ingesting infected copepods, and recent evidence suggests that consuming frogs that ingested infected copepods as tadpoles may be a viable transmission route (paratenic route). To understand the relative contributions of direct and paratenic transmission routes, we developed a mathematical model that describes transmission of Guinea worm between dogs, copepods and frogs. We explored how the parasite basic reproductive number (R
MeSH term(s)	Animals ; Anura ; Copepoda ; Disease Outbreaks ; Dogs ; Dracunculiasis/epidemiology ; Dracunculiasis/prevention & control ; Dracunculiasis/veterinary ; Dracunculus Nematode
Language	English
Publishing date	2021-07-08
Publishing country	England
Document type	Journal Article
ZDB-ID	120518-3
ISSN	1879-0135 ; 0020-7519
ISSN (online)	1879-0135
ISSN	0020-7519
DOI	10.1016/j.ijpara.2021.05.005
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Article ; Online: Evolution of Acid-Dependent Am

Hall, Gabriel B / Holfeltz, Vanessa E / Campbell, Emily L / Boglaienko, Daria / Lumetta, Gregg J / Levitskaia, Tatiana G

Inorganic chemistry

2020 Volume 59, Issue 7, Page(s) 4453–4467

Abstract: Coordination of trivalent lanthanide and actinide metal ions by lipophilic diglycolamides and phosphonic acids has been proposed for their separation through extraction from aqueous nitric acid solutions. However, the nature of ... ...

Abstract	Coordination of trivalent lanthanide and actinide metal ions by lipophilic diglycolamides and phosphonic acids has been proposed for their separation through extraction from aqueous nitric acid solutions. However, the nature of M
Language	English
Publishing date	2020-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.9b03612
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Article ; Online: Chest X-ray in suspected lung cancer is harmful.

Foley, Robert W / Nassour, Vanessa / Oliver, Helen C / Hall, Toby / Masani, Vidan / Robinson, Graham / Rodrigues, Jonathan C L / Hudson, Benjamin J

European radiology

2021 Volume 31, Issue 8, Page(s) 6269–6274

Abstract: Objectives: The aim of this study was to analyse the use of the chest radiograph (CXR) as the first-line investigation in primary care patients with suspected lung cancer.: Methods: Of 16,945 primary care referral CXRs (June 2018 to May 2019), 1,488 ... ...

Abstract	Objectives: The aim of this study was to analyse the use of the chest radiograph (CXR) as the first-line investigation in primary care patients with suspected lung cancer. Methods: Of 16,945 primary care referral CXRs (June 2018 to May 2019), 1,488 were referred for suspected lung cancer. CXRs were coded as follows: CX1, normal but a CT scan is recommended to exclude malignancy; CX2, alternative diagnosis; or CX3, suspicious for cancer. Kaplan-Meier survival analysis was undertaken by stratifying patients according to their CX code. Results: In the study period, there were 101 lung cancer diagnoses via a primary care CXR pathway. Only 10% of patients with a normal CXR (CX1) underwent subsequent CT and there was a significant delay in lung cancer diagnosis in these patients (p < 0.001). Lung cancer was diagnosed at an advanced stage in 50% of CX1 patients, 38% of CX2 patients and 57% of CX3 patients (p = 0.26). There was no survival difference between CX codes (p = 0.42). Conclusion: Chest radiography in the investigation of patients with suspected lung cancer may be harmful. This strategy may falsely reassure in the case of a normal CXR and prioritises resources to advanced disease. Key points: • Half of all lung cancer diagnoses in a 1-year period are first investigated with a chest X-ray. • A normal chest X-ray report leads to a significant delay in the diagnosis of lung cancer. • The majority of patients with a normal or abnormal chest X-ray have advanced disease at diagnosis and there is no difference in survival outcomes based on the chest X-ray findings.
MeSH term(s)	Humans ; Lung ; Lung Neoplasms/diagnostic imaging ; Radiography ; Radiography, Thoracic ; Tomography, X-Ray Computed ; X-Rays
Language	English
Publishing date	2021-01-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-021-07708-0
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Article ; Online: Personal protective equipment use during industrial hog operation work activities and acute lung function changes in a prospective worker cohort, North Carolina 2014-2015.

Coffman, Vanessa R / Hall, Devon J / Pisanic, Nora / Nadimpalli, Maya / McCormack, Meredith / Diener-West, Marie / Davis, Meghan F / Heaney, Christopher D

American journal of industrial medicine

2021 Volume 64, Issue 8, Page(s) 688–698

Abstract: Introduction: Occupational activities related to industrial hog operation (IHO) worker lung function are not well defined. Therefore, we aimed to identify IHO work activities associated with diminished respiratory function and the effectiveness, if any, ...

Abstract	Introduction: Occupational activities related to industrial hog operation (IHO) worker lung function are not well defined. Therefore, we aimed to identify IHO work activities associated with diminished respiratory function and the effectiveness, if any, of personal protective equipment (PPE) use on IHOs. Methods: From 2014 to 2015, 103 IHO workers were enrolled and followed for 16 weeks. At each biweekly visit, work activities and PPE use were self-reported via questionnaire and lung function measurements were collected via spirometry. Generalized linear and linear fixed-effects models were fitted to cross-sectional and longitudinal data. Results: Increasing years worked on an IHO were associated with diminished lung function, but baseline and longitudinal work activities were largely inconsistent in direction and magnitude. Unexpectedly, a -0.3 L (95% confidence interval: -0.6, -0.04) difference in forced expiratory volume in the first second (FEV Conclusions: Similar to past studies, baseline estimates were likely obscured by healthy worker effect bias, but showed decrements in worker lung function as years of work increased. A challenge to disentangling the effect of work activities on lung function was the discovery that IHO workers used PPE differently according to the work task. These data suggest that interventions may be targeted toward improving barn conditions so that workers can consistently utilize IHO-provided PPE.
MeSH term(s)	Animals ; Cross-Sectional Studies ; Lung ; North Carolina ; Occupational Exposure ; Personal Protective Equipment ; Prospective Studies ; Swine
Language	English
Publishing date	2021-06-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	604538-8
ISSN	1097-0274 ; 0271-3586
ISSN (online)	1097-0274
ISSN	0271-3586
DOI	10.1002/ajim.23260
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Article: Alternative transmission pathways for guinea worm in dogs: implications for outbreak risk and control

Vinson, John E. / Park, Andrew W. / Cleveland, Christopher A. / Yabsley, Michael J. / Ezenwa, Vanessa O. / Hall, Richard J.

Australian Society for Parasitology International journal for parasitology. 2021 Nov., v. 51, no. 12

2021

Abstract	Guinea worm (Dracunculus medinensis) has exerted a high human health burden in parts of Africa. Complete eradication of Guinea worm disease (dracunculiasis) may be delayed by the circulation of the parasite in domestic dogs. As with humans, dogs acquire the parasite by directly ingesting infected copepods, and recent evidence suggests that consuming frogs that ingested infected copepods as tadpoles may be a viable transmission route (paratenic route). To understand the relative contributions of direct and paratenic transmission routes, we developed a mathematical model that describes transmission of Guinea worm between dogs, copepods and frogs. We explored how the parasite basic reproductive number (R₀) depends on parameters amenable to actionable interventions under three scenarios: frogs/tadpoles do not consume copepods; tadpoles consume copepods but frogs do not contribute to transmission; and frogs are paratenic hosts. We found a non-monotonic relationship between the number of dogs and R₀. Generally, frogs can contribute to disease control by removing infected copepods from the waterbody even when paratenic transmission can occur. However, paratenic transmission could play an important role in maintaining the parasite when direct transmission is reduced by interventions focused on reducing copepod ingestion by dogs. Together, these suggest that the most effective intervention strategies may be those which focus on the reduction of copepods, as this reduces outbreak potential irrespective of the importance of the paratenic route.
Keywords	Copepoda ; Dracunculus medinensis ; disease control ; human health ; ingestion ; mathematical models ; parasites ; parasitology ; risk ; surface water ; Africa
Language	English
Dates of publication	2021-11
Size	p. 1027-1034.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120518-3
ISSN	1879-0135 ; 0020-7519
ISSN (online)	1879-0135
ISSN	0020-7519
DOI	10.1016/j.ijpara.2021.05.005
Database	NAL-Catalogue (AGRICOLA)

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