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Article ; Online: Anesthetic Management for Combined Anterior Cervical Spinal Decompression and Fusion and Cesarean Delivery: A Case Report.

Keil, Dayley S / Murphy, Bryant A / Cobb, Benjamin G

A&A practice

2022 Volume 16, Issue 5, Page(s) e01595

Abstract: A 31-year-old G2P1 (gravida 2 para 1) woman at 34 weeks of gestation presented after a motor vehicle collision with an incomplete cervical spinal cord injury. The patient underwent emergent anterior cervical decompression and fusion (ACDF), immediately ... ...

Abstract	A 31-year-old G2P1 (gravida 2 para 1) woman at 34 weeks of gestation presented after a motor vehicle collision with an incomplete cervical spinal cord injury. The patient underwent emergent anterior cervical decompression and fusion (ACDF), immediately followed by cesarean delivery. We discuss the clinical decision making to perform ACDF first, weighing risks and benefits to both mother and baby. We also address important anesthetic considerations for this pregnant patient having emergent spine surgery, including positioning with left uterine displacement, rapid sequence intubation to minimize aspiration risk, choice of vasopressor, implications of total intravenous maintenance anesthetic, and the medical teams involved in this care.
MeSH term(s)	Adult ; Anesthetics ; Cervical Vertebrae/injuries ; Cervical Vertebrae/surgery ; Decompression, Surgical ; Female ; Humans ; Infant ; Pregnancy ; Spinal Cord Injuries ; Spinal Fusion
Chemical Substances	Anesthetics
Language	English
Publishing date	2022-05-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2575-3126
ISSN (online)	2575-3126
DOI	10.1213/XAA.0000000000001595
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Anesthesia for Global General Thoracic Surgery.

Phelps, Janey R / Lizi, Henry / Murphy, Bryant A

Thoracic surgery clinics

2022 Volume 32, Issue 3, Page(s) 307–315

Abstract: Anesthesia in low-to-middle income countries (LMICs) is often provided by nonphysician anesthetists. The training and resources for anesthesia in LMICs are limited, and this must be evaluated when starting or expanding a thoracic surgery program in LMICs. ...

Abstract	Anesthesia in low-to-middle income countries (LMICs) is often provided by nonphysician anesthetists. The training and resources for anesthesia in LMICs are limited, and this must be evaluated when starting or expanding a thoracic surgery program in LMICs. The ability to access a patient's baseline pulmonary and cardiovascular status is often based on rudimentary studies and a thorough history and physical. Advance studies, such as echocardiograms, cardiovascular stress test, cardiac catherizations, pulmonary function tests, and MRIs, are often not available. Careful assessment of both preoperative patient selection, intraoperative ability to provide one-lung ventilation, and postoperative critical care management must be considered when surgical planning is occurring.
MeSH term(s)	Anesthesia ; Anesthesia, General ; Anesthesiology ; Humans ; One-Lung Ventilation ; Thoracic Surgery ; Thoracic Surgical Procedures
Language	English
Publishing date	2022-03-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2149218-9
ISSN	1558-5069 ; 1547-4127
ISSN (online)	1558-5069
ISSN	1547-4127
DOI	10.1016/j.thorsurg.2022.04.001
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Article: No Consensus on AID, But We Can Agree on Palliative Care.

Murphy, Bryant A / Kilpatrick, Michaux R / Edwards, Palmer / Caprio, Anthony J

North Carolina medical journal

2020 Volume 81, Issue 3, Page(s) 213

MeSH term(s)	Consensus ; Humans ; Palliative Care
Language	English
Publishing date	2020-05-04
Publishing country	United States
Document type	Letter
ZDB-ID	422795-5
ISSN	0029-2559
ISSN	0029-2559
DOI	10.18043/ncm.81.3.213
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Article ; Online: The multiple effects of aspirin in prostate cancer patients.

Joshi, S N / Murphy, E A / Olaniyi, P / Bryant, R J

Cancer treatment and research communications

2020 Volume 26, Page(s) 100267

Abstract: Aspirin is a commonly used medication with anti-inflammatory and analgesic properties, and it is widely used to reduce the risk of ischaemic heart disease-related events and/or cerebrovascular accidents. However, there is also evidence from ... ...

Abstract	Aspirin is a commonly used medication with anti-inflammatory and analgesic properties, and it is widely used to reduce the risk of ischaemic heart disease-related events and/or cerebrovascular accidents. However, there is also evidence from epidemiological and interventional studies to suggest that regular aspirin use can reduce the risk of prostate cancer development and progression, and can reduce the risk of disease recurrence following anti-prostate cancer therapy. Aspirin use in African-American men is associated with a reduced incidence of advanced PCa and reduced disease recurrence, and there is evidence from other studies of an association between regular aspirin use and decreased PCa-related mortality. The cyclooxygenase-2 enzyme inhibited by Aspirin and other NSAIDs, and which catalyses prostaglandin synthesis and mediates inflammation, is overexpressed in prostate cancer, therefore inhibition of cyclooxygenase-2 may have direct, and indirect, therapeutic effects. This review explores the evidence suggesting that aspirin use can modify prostate cancer biology and disease characteristics, and explores the potential mechanisms underpinning the observed associations between aspirin use and modification of prostate cancer risk. It also summarises the potential for adjuvant aspirin use to combine with other therapeutic approaches such as radical surgery and radiotherapy.
MeSH term(s)	Aspirin/pharmacology ; Aspirin/therapeutic use ; Chemoradiotherapy/methods ; Chemotherapy, Adjuvant/methods ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/pharmacology ; Cyclooxygenase 2 Inhibitors/therapeutic use ; Disease Progression ; Humans ; Male ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/prevention & control ; Progression-Free Survival ; Prostaglandins/metabolism ; Prostatectomy ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy
Chemical Substances	Cyclooxygenase 2 Inhibitors ; Prostaglandins ; Cyclooxygenase 2 (EC 1.14.99.1) ; PTGS2 protein, human (EC 1.14.99.1) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2020-12-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	2468-2942
ISSN (online)	2468-2942
DOI	10.1016/j.ctarc.2020.100267
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Article ; Online: Yarning as a method for building sexual wellbeing among urban Aboriginal young people in Australia.

Bryant, Joanne / Bolt, Reuben / Martin, Kacey / Beadman, Mitchell / Doyle, Michael / Treloar, Carla / Bell, Stephen / Murphy, Dean / Newman, Christy / Browne, Annette / Aggleton, Peter / Beetson, Karen / Brooks, Megan / Wilms, Jessica / Leece, Bronwyn / Stanbury, Linda / Botfield, Jessica / Davis, Ben / Graham, Simon

Culture, health & sexuality

2023 , Page(s) 1–16

Abstract: This paper describes the strategies used by Aboriginal young people to build positive relationships and sexual wellbeing. It does so to counter the risk-focussed narratives present in much existing research and to showcase the resourcefulness of ... ...

Abstract	This paper describes the strategies used by Aboriginal young people to build positive relationships and sexual wellbeing. It does so to counter the risk-focussed narratives present in much existing research and to showcase the resourcefulness of Aboriginal young people. We used peer-interview methods to collect qualitative data from 52 Aboriginal young people living in western Sydney, Australia. Participants reported a strong desire to stay safe and healthy in their sexual relationships and to achieve this they relied heavily on oral communication and
Language	English
Publishing date	2023-09-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2023577-X
ISSN	1464-5351 ; 1369-1058
ISSN (online)	1464-5351
ISSN	1369-1058
DOI	10.1080/13691058.2023.2258948
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Article: Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19.

bioRxiv : the preprint server for biology

2024

Abstract: The variable etiology of persistent breathlessness after COVID-19 have confounded efforts to decipher the immunopathology of lung sequelae. Here, we analyzed hundreds of cellular and molecular features in the context of discrete pulmonary phenotypes to ... ...

Abstract	The variable etiology of persistent breathlessness after COVID-19 have confounded efforts to decipher the immunopathology of lung sequelae. Here, we analyzed hundreds of cellular and molecular features in the context of discrete pulmonary phenotypes to define the systemic immune landscape of post-COVID lung disease. Cluster analysis of lung physiology measures highlighted two phenotypes of restrictive lung disease that differed by their impaired diffusion and severity of fibrosis. Machine learning revealed marked CCR5+CD95+ CD8+ T-cell perturbations in mild-to-moderate lung disease, but attenuated T-cell responses hallmarked by elevated CXCL13 in more severe disease. Distinct sets of cells, mediators, and autoantibodies distinguished each restrictive phenotype, and differed from those of patients without significant lung involvement. These differences were reflected in divergent T-cell-based type 1 networks according to severity of lung disease. Our findings, which provide an immunological basis for active lung injury versus advanced disease after COVID-19, might offer new targets for treatment.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.03.587929
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Article: Evidence-Based Medicine and Regulatory Oversight: Opioid Prescribing for Treatment of Pain.

Chidgey, Brooke A / Murphy, Bryant A

North Carolina medical journal

2017 Volume 78, Issue 5, Page(s) 310–311

Abstract: It is no secret that our country is in the midst of an opioid crisis. With hundreds of Americans dying everyday due to opioid use, it is hard to ignore. Closely related, though not as often talked about, is another crisis providers are facing: chronic ... ...

Abstract	It is no secret that our country is in the midst of an opioid crisis. With hundreds of Americans dying everyday due to opioid use, it is hard to ignore. Closely related, though not as often talked about, is another crisis providers are facing: chronic pain and its treatment. The treatment approach to this problem is multifaceted. Evidence-based studies are the hallmark of appropriate treatment; however, increasing patient concerns and regulatory oversight have added an additional layer that physicians and other prescribers have to incorporate. Navigating a balance between evidence-based treatment, regulatory pressures, and patient concerns is now at the forefront of pain management and patient care.
MeSH term(s)	Analgesics, Opioid/therapeutic use ; Chronic Pain/drug therapy ; Evidence-Based Medicine ; Humans ; North Carolina ; Opioid-Related Disorders/prevention & control ; Practice Guidelines as Topic
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2017-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	422795-5
ISSN	0029-2559
ISSN	0029-2559
DOI	10.18043/ncm.78.5.310
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Article ; Online: Factors associated with COVID-19 vaccine hesitancy amongst refugees in Australia.

Liddell, Belinda J / Murphy, Stephanie / Mau, Vicki / Bryant, Richard / O'Donnell, Meaghan / McMahon, Tadgh / Nickerson, Angela

European journal of psychotraumatology

2021 Volume 12, Issue 1, Page(s) 1997173

Abstract: Background: Refugees may be especially vulnerable to the adverse effects of COVID-19. Therefore it is critical that refugee communities are supported to access COVID-19 vaccines and for public health responses to address vaccine hesitancy.: Objective!# ...

Abstract	Background: Refugees may be especially vulnerable to the adverse effects of COVID-19. Therefore it is critical that refugee communities are supported to access COVID-19 vaccines and for public health responses to address vaccine hesitancy. Objective: To investigate the key demographic factors, barriers and attitudes associated with vaccine hesitancy in a community sample of refugees. Method: Participants in the Refugee Adjustment Study, a cohort of refugees living in Australia, were invited to complete a survey about their COVID-19 vaccine intentions, barriers to access and attitudes relating to the vaccine. Results: Of the 516 participants, 88% were unvaccinated and 28.1% were classed as vaccine hesitant. Key predictors of vaccine hesitancy were younger age, information and trust barriers, lower logistical barriers, and attitudes relating to low control and risk posed by COVID-19. Conclusions: Findings suggest that public health strategies need to address trust, control and risk perception attitudes to increase COVID-19 vaccine uptake in resettled refugee communities.
MeSH term(s)	Adult ; Australia ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Intention ; Male ; Refugees/psychology ; Refugees/statistics & numerical data ; SARS-CoV-2 ; Surveys and Questionnaires ; Trust ; Vaccination/statistics & numerical data ; Vaccination Hesitancy/psychology ; Vaccination Hesitancy/statistics & numerical data
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-11-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2586642-4
ISSN	2000-8066 ; 2000-8066
ISSN (online)	2000-8066
ISSN	2000-8066
DOI	10.1080/20008198.2021.1997173
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Article ; Online: Building diverse leadership in an academic medical center: The ACCLAIM program.

Drake, Amelia F / Sollecito, William A / Horneffer, Kathryn E / Martin, Joy B / Westervelt, Lauren M / Murphy, Bryant A / Schenck, Anna P / Carter-Edwards, Lori

Journal of the National Medical Association

2023 Volume 115, Issue 2, Page(s) 134–143

Abstract: As healthcare systems become more complex, medical education needs to adapt in many ways. There is a growing need for more formal leadership learning for healthcare providers, including greater attention to health disparities. An important challenge in ... ...

Abstract	As healthcare systems become more complex, medical education needs to adapt in many ways. There is a growing need for more formal leadership learning for healthcare providers, including greater attention to health disparities. An important challenge in addressing health disparities is ensuring inclusive excellence in the leadership of healthcare systems and medical education. Women and those who are underrepresented in medicine (URMs) have historically had fewer opportunities for leadership development and are less likely to hold leadership roles and receive promotions. One successful initiative for improved learning of medical leadership-presented as a case example here-is the Academic Career Leadership Academy in Medicine (ACCLAIM) at the University of North Carolina at Chapel Hill School of Medicine. ACCLAIM is uniquely designed for faculty identified as having emerging leadership potential, with an emphasis on women and URMs. Using a leadership learning system approach, annual cohorts of participants (Scholars) interactively participate in a multi-faceted nine-month long learning experience, including group (e.g., guest-speaker weekly presentations and exercises) and individual learning components (e.g., an individual leadership project). Since its initiation in 2012 and through 2021, 111 Scholars have participated in ACCLAIM; included were 57% women and 27% URMs. Two important outcomes described are: short-term impact as illustrated by consistent improvements in quantitively measured leadership knowledge and capabilities; and long-term leadership growth, whereby half of the ACCLAIM graduates have received academic rank promotions and almost two-thirds have achieved new leadership opportunities, with even higher percentages observed for women and URMs; for example, 87% of URMs were either promoted or achieved new leadership positions. Also consistently noted, through qualitative assessments, are broader healthcare system knowledge and shared tactics for addressing common challenges among Scholars. This case example shows that the promotion of leadership equity may jointly enhance professional development while creating opportunities for systems change within academic medical centers. Such an approach can be a potential model for academic medical institutions and other healthcare schools seeking to promote leadership equity and inclusion.
MeSH term(s)	Humans ; Female ; Male ; Faculty, Medical ; Leadership ; Academic Medical Centers ; Education, Medical ; Learning
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	419737-9
ISSN	1943-4693 ; 0027-9684
ISSN (online)	1943-4693
ISSN	0027-9684
DOI	10.1016/j.jnma.2023.01.004
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Article ; Online: Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19

bioRxiv

Abstract	The variable etiology of persistent breathlessness after COVID-19 have confounded efforts to decipher the immunopathology of lung sequelae. Here, we analyzed hundreds of cellular and molecular features in the context of discrete pulmonary phenotypes to define the systemic immune landscape of post-COVID lung disease. Cluster analysis of lung physiology measures highlighted two phenotypes of restrictive lung disease that differed by their impaired diffusion and severity of fibrosis. Machine learning revealed marked CCR5+CD95+ CD8+ T-cell perturbations in mild-to-moderate lung disease, but attenuated T-cell responses hallmarked by elevated CXCL13 in more severe disease. Distinct sets of cells, mediators, and autoantibodies distinguished each restrictive phenotype, and differed from those of patients without significant lung involvement. These differences were reflected in divergent T-cell-based type 1 networks according to severity of lung disease. Our findings, which provide an immunological basis for active lung injury versus advanced disease after COVID-19, might offer new targets for treatment.
Keywords	covid19
Language	English
Publishing date	2024-04-04
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2024.04.03.587929
Database	COVID19

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