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  1. Article ; Online: Editorial Comment.

    Ghai, Sangeet

    The Journal of urology

    2020  Volume 204, Issue 4, Page(s) 732–733

    MeSH term(s) Humans ; Male ; Multiparametric Magnetic Resonance Imaging ; Neoplasms ; Prostate ; Ultrasonography ; Ultrasonography, Interventional
    Language English
    Publishing date 2020-07-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001083.02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial Comment.

    Ghai, Sangeet

    The Journal of urology

    2020  Volume 203, Issue 5, Page(s) 923–924

    MeSH term(s) Cognition ; Humans ; Magnetic Resonance Imaging ; Male ; Prostatic Neoplasms ; Robotic Surgical Procedures ; Ultrasonography
    Language English
    Publishing date 2020-02-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000000692.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Editorial Comment.

    Ghai, Sangeet

    The Journal of urology

    2019  Volume 202, Issue 5, Page(s) 957

    MeSH term(s) Humans ; Male ; Patient Selection ; Prostatic Neoplasms ; Social Behavior
    Language English
    Publishing date 2019-10-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/01.JU.0000579304.76406.64
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Beyond the

    Ghai, Sangeet / Perlis, Nathan

    AJR. American journal of roentgenology

    2022  Volume 220, Issue 4, Page(s) 610

    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery ; Magnetic Resonance Imaging
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.22.28413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Magnetic resonance imaging-guided ultrasound ablation for prostate cancer - A contemporary review of performance.

    Alabousi, Mostafa / Ghai, Sangeet

    Frontiers in oncology

    2023  Volume 12, Page(s) 1069518

    Abstract: Prostate cancer (PCa) is one of the most common malignancies in men, but patient outcomes are varied depending on extent of disease. Radical, whole-gland therapies, such as prostatectomy or radiotherapy, are definitive treatments for PCa, but they are ... ...

    Abstract Prostate cancer (PCa) is one of the most common malignancies in men, but patient outcomes are varied depending on extent of disease. Radical, whole-gland therapies, such as prostatectomy or radiotherapy, are definitive treatments for PCa, but they are associated with significant morbidity, including erectile dysfunction and urinary incontinence. Focal therapies for PCa, whereby the part of gland harboring disease is selectively treated, spares the normal surrounding structures, and minimizes the morbidity associated with whole gland treatment. The use of magnetic resonance imaging (MRI) guidance provides advantages over ultrasound guidance, such as better localization and targeting of clinically significant PCa (csPCa), as well as MRI thermometry which optimizes tissue ablation temperatures. This review will discuss two MRI-guided high-intensity focused ultrasound (HIFU) techniques - transrectal MR-guided focused ultrasound (MRgFUS) and TULSA (transurethral ultrasound ablation) ablation for localized PCa. Overall, recent major trials for MRgFUS and TULSA have shown promising oncological and functional results in the treatment of low- to intermediate-risk PCa. Recent Phase II MRgFUS trials have shown better oncologic outcomes than the published results for focal ultrasound guided HIFU and may justify the additional costs associated with MRI guidance. While initial studies on TULSA have focused on subtotal gland ablation, recent trials assessing oncological outcomes for focal treatment of angular sectors have shown promise.
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1069518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Micro-Ultrasound: Current Role in Prostate Cancer Diagnosis and Future Possibilities.

    Basso Dias, Adriano / Ghai, Sangeet

    Cancers

    2023  Volume 15, Issue 4

    Abstract: Prostate Cancer (PCa) is the second most common cancer in men. Population screening using prostate specific antigen (PSA) blood test and digital rectal exam (DRE) is recommended by the NCCN, EAU and other prominent clinical guidelines. While MRI is the ... ...

    Abstract Prostate Cancer (PCa) is the second most common cancer in men. Population screening using prostate specific antigen (PSA) blood test and digital rectal exam (DRE) is recommended by the NCCN, EAU and other prominent clinical guidelines. While MRI is the recommended initial test in men at risk for PCa, micro-Ultrasound (MicroUS) is a novel high resolution ultrasound technology that has shown promise in PCa detection. This article provides a narrative review of the studies to date which have been conducted to evaluate the functionality and efficacy of MicroUS within the patient care pathway for prostate cancer. A total of 13 relevant publications comparing detection of csPCa between MicroUS and mpMRI were selected. An amount of 4 publications referring to use of MicroUS for other indications were found. Each publication was evaluated for risk of bias and applicability using the Quality Assessment of Diagnostic Accuracy (QUADAS-2) tool. The studies reviewed conclude that MicroUS detection rates for clinically significant prostate cancer diagnosis are comparable to the detection rates of mpMRI guided biopsy procedures. While the existing literature indicates that MicroUS should replace conventional TRUS for prostate imaging and biopsy, it is not yet clear whether MicroUS should be used on its own or in conjunction with mpMRI for augmenting prostate cancer detection. The ongoing OPTIMUM trial will provide evidence on how best to utilize this new technology. Early data also suggest this flexible new imaging modality has a place in local staging and active surveillance of prostate cancer as well as in bladder cancer staging.
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prostate Cancer Diagnosis with Micro-ultrasound: What We Know now and New Horizons.

    Dias, Adriano Basso / Ghai, Sangeet

    Radiologic clinics of North America

    2023  Volume 62, Issue 1, Page(s) 189–197

    Abstract: Prostate cancer (PCa) is the most common non-cutaneous cancer diagnosed in males. Multiparametric Magnetic Resonance Imaging (mpMRI) with targeted biopsy can detect PCa and is currently the recommended initial test in men at risk for PCa. Micro- ... ...

    Abstract Prostate cancer (PCa) is the most common non-cutaneous cancer diagnosed in males. Multiparametric Magnetic Resonance Imaging (mpMRI) with targeted biopsy can detect PCa and is currently the recommended initial test in men at risk for PCa. Micro-Ultrasound (MicroUS) is a novel high-resolution 29-MHz ultrasound with ∼three times greater resolution of conventional transrectal ultrasound (TRUS) resolution. Preliminary data suggest improved accuracy of ultrasound for targeted prostate biopsy. A growing body of evidence has become available supporting MicroUS as a potentially time and cost saving modality for PCa detection, with early results suggesting comparable accuracy to mpMRI. Additionally, microUS allows real-time visualization for accurate targeted biopsy. It is not yet clear whether MicroUS should be used on its own or in combination with mpMRI for prostate cancer detection. The ongoing OPTIMUM randomized controlled trial will help to establish the role of MicroUS in the diagnostic algorithm for the detection of clinically significant (cs)-PCa. Early data also indicate this imaging modality may have a role in local staging (eg, extracapsular extension prediction) and active surveillance of PCa. MicroUS has also the potential to add value to biparametric (bp) MRI, and may represent a promising tool for guidance of focal therapy in the near future.
    MeSH term(s) Male ; Humans ; Prostate/diagnostic imaging ; Prostate/pathology ; Image-Guided Biopsy/methods ; Prostatic Neoplasms/pathology ; Prostate-Specific Antigen ; Ultrasonography ; Magnetic Resonance Imaging/methods
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215712-3
    ISSN 1557-8275 ; 0033-8389
    ISSN (online) 1557-8275
    ISSN 0033-8389
    DOI 10.1016/j.rcl.2023.06.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Re: Francesco Giganti, Louise Dickinson, Clement Orczyk, et al. Prostate Imaging After Focal Ablation (PI-FAB): A Proposal for a Scoring System for Multiparametric MRI of the Prostate After Focal Therapy. Eur Urol Oncol. 2023;6:629-634.

    Abreu-Gomez, Jorge / Haider, Masoom / Ghai, Sangeet

    European urology oncology

    2023  Volume 7, Issue 1, Page(s) 169–170

    MeSH term(s) Male ; Humans ; Prostate/diagnostic imaging ; Prostate/surgery ; Multiparametric Magnetic Resonance Imaging ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery ; Diagnostic Imaging
    Language English
    Publishing date 2023-08-22
    Publishing country Netherlands
    Document type Letter
    ISSN 2588-9311
    ISSN (online) 2588-9311
    DOI 10.1016/j.euo.2023.07.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editorial Comment.

    Ghai, Sangeet

    The Journal of urology

    2017  Volume 198, Issue 4, Page(s) 846

    MeSH term(s) Humans ; Laser Coagulation ; Magnetic Resonance Imaging ; Male ; Prostatic Neoplasms ; Ultrasonography
    Language English
    Publishing date 2017-06-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1016/j.juro.2017.04.119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: MRI-guided Minimally Invasive Focal Therapies for Prostate Cancer.

    Alabousi, Mostafa / Ghai, Sangeet / Haider, Masoom A

    Radiology

    2023  Volume 309, Issue 3, Page(s) e230431

    Abstract: Two cases involving patients diagnosed with localized prostate cancer and treated with MRI-guided focal therapies are presented. Patient selection procedures, techniques, outcomes, challenges, and future directions of MRI-guided focal therapies, as well ... ...

    Abstract Two cases involving patients diagnosed with localized prostate cancer and treated with MRI-guided focal therapies are presented. Patient selection procedures, techniques, outcomes, challenges, and future directions of MRI-guided focal therapies, as well as their role in the treatment of low- to intermediate-risk localized prostate cancer, are summarized.
    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery ; Magnetic Resonance Imaging/methods ; Ablation Techniques/methods
    Language English
    Publishing date 2023-09-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.230431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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