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Article ; Online: Serum Metabolomic Characterization of Liver Fibrosis in Rats and Anti-Fibrotic Effects of Yin-Chen-Hao-Tang.

Zhang, Hongyang / Wang, Xiaoning / Hu, Ping / Zhou, Wenjun / Zhang, Min / Liu, Jia / Wang, Yuerong / Liu, Ping / Luo, Guoan

Molecules (Basel, Switzerland)

2016 Volume 21, Issue 1, Page(s) E126

Abstract: Yin-Chen-Hao-Tang (YCHT) is a famous Chinese medicine formula which has long been used in clinical ...

Abstract	Yin-Chen-Hao-Tang (YCHT) is a famous Chinese medicine formula which has long been used in clinical practice for treating various liver diseases, such as liver fibrosis. However, to date, the mechanism for its anti-fibrotic effects remains unclear. In this paper, an ultra-performance liquid chromatography-time-of-flight mass spectrometry (UPLC-TOF-MS)-based metabolomic study was performed to characterize dimethylnitrosamine (DMN)-induced liver fibrosis in rats and evaluate the therapeutic effects of YCHT. Partial least squares-discriminant analysis (PLS-DA) showed that the model group was well separated from the control group, whereas the YCHT-treated group exhibited a tendency to restore to the controls. Seven significantly changed fibrosis-related metabolites, including unsaturated fatty acids and lysophosphatidylcholines (Lyso-PCs), were identified. Moreover, statistical analysis demonstrated that YCHT treatment could reverse the levels of most metabolites close to the normal levels. These results, along with histological and biochemical examinations, indicate that YCHT has anti-fibrotic effects, which may be due to the suppression of oxidative stress and resulting lipid peroxidation involved in hepatic fibrogenesis. This study offers new opportunities to improve our understanding of liver fibrosis and the anti-fibrotic mechanisms of YCHT.
MeSH term(s)	Animals ; Biomarkers ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis/blood ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/pathology ; Liver Function Tests ; Metabolome ; Metabolomics/methods ; Rats ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Chemical Substances	Biomarkers ; Drugs, Chinese Herbal ; yin-chen-hao-tang
Language	English
Publishing date	2016-01-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules21010126
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Article ; Online: Serum Metabolomic Characterization of Liver Fibrosis in Rats and Anti-Fibrotic Effects of Yin-Chen-Hao-Tang

Hongyang Zhang / Xiaoning Wang / Ping Hu / Wenjun Zhou / Min Zhang / Jia Liu / Yuerong Wang / Ping Liu / Guoan Luo

Molecules, Vol 21, Iss 1, p

2016 Volume 126

Abstract: Yin-Chen-Hao-Tang (YCHT) is a famous Chinese medicine formula which has long been used in clinical ...

Abstract	Yin-Chen-Hao-Tang (YCHT) is a famous Chinese medicine formula which has long been used in clinical practice for treating various liver diseases, such as liver fibrosis. However, to date, the mechanism for its anti-fibrotic effects remains unclear. In this paper, an ultra-performance liquid chromatography-time-of-flight mass spectrometry (UPLC-TOF-MS)-based metabolomic study was performed to characterize dimethylnitrosamine (DMN)-induced liver fibrosis in rats and evaluate the therapeutic effects of YCHT. Partial least squares-discriminant analysis (PLS-DA) showed that the model group was well separated from the control group, whereas the YCHT-treated group exhibited a tendency to restore to the controls. Seven significantly changed fibrosis-related metabolites, including unsaturated fatty acids and lysophosphatidylcholines (Lyso-PCs), were identified. Moreover, statistical analysis demonstrated that YCHT treatment could reverse the levels of most metabolites close to the normal levels. These results, along with histological and biochemical examinations, indicate that YCHT has anti-fibrotic effects, which may be due to the suppression of oxidative stress and resulting lipid peroxidation involved in hepatic fibrogenesis. This study offers new opportunities to improve our understanding of liver fibrosis and the anti-fibrotic mechanisms of YCHT.
Keywords	serum metabolomics ; liver fibrosis ; Yin-Chen-Hao-Tang ; anti-fibrotic effects ; oxidative stress ; lipid peroxidation ; ultra-performance liquid chromatography-time-of-flight mass spectrometry ; partial least squares-discriminant analysis ; Organic chemistry ; QD241-441
Subject code	500
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reply to Peng He, Xiaohui Wang, and Hao Li's Letter to the Editor re: Yu Xiao, Kaiyu Qian, Yongwen Luo, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Renal Failure Patients: A Potential Covert Source of Infection. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.025.

Xiao, Yu / Qian, Kaiyu / Luo, Yongwen / Chen, Song / Lu, Mengxin / Wang, Gang / Ju, Lingao / Wang, Xinghuan

European urology

2020 Volume 78, Issue 5, Page(s) e203–e204

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Male ; Pandemics ; Pneumonia, Viral ; Renal Insufficiency ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/diagnosis
Keywords	covid19
Language	English
Publishing date	2020-05-13
Publishing country	Switzerland
Document type	Journal Article ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2020.05.008
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Article: Reply to Peng He, Xiaohui Wang, and Hao Li's Letter to the Editor re: Yu Xiao, Kaiyu Qian, Yongwen Luo, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Renal Failure Patients: A Potential Covert Source of Infection. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.025

Xiao, Yu / Qian, Kaiyu / Luo, Yongwen / Chen, Song / Lu, Mengxin / Wang, Gang / Ju, Lingao / Wang, Xinghuan

Eur Urol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #245729
Database	COVID19

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Article ; Online: Variant histology is associated with more non-urothelial tract recurrence but less intravesical recurrence upper tract urothelial carcinoma after radical nephroureterectomy.

Luo, Hao-Lun

International journal of urology : official journal of the Japanese Urological Association

2024 Volume 31, Issue 4, Page(s) 421

MeSH term(s)	Humans ; Carcinoma, Transitional Cell/surgery ; Carcinoma, Transitional Cell/pathology ; Nephroureterectomy ; Urinary Bladder Neoplasms/surgery ; Urinary Bladder Neoplasms/pathology ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/prevention & control ; Neoplasm Recurrence, Local/pathology ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Ureteral Neoplasms/surgery ; Ureteral Neoplasms/pathology ; Retrospective Studies
Language	English
Publishing date	2024-04-03
Publishing country	Australia
Document type	Letter
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.15455
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Zs.MO 278: Show issues

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Article ; Online: Congenital dual anterior interventricular artery.

Hao, Miao / An, Qi / Luo, Shuhua

Cardiology in the young

2024 , Page(s) 1–2

Abstract: Dual anterior interventricular artery is a rare type of CHD. We reported a fifteen-year-old girl who underwent CT angiography that demonstrated one anterior interventricular artery from aorta and another from pulmonary artery. ...

Abstract	Dual anterior interventricular artery is a rare type of CHD. We reported a fifteen-year-old girl who underwent CT angiography that demonstrated one anterior interventricular artery from aorta and another from pulmonary artery.
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951123003785
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Article ; Online: Chemical characteristics and health risk evaluation of natural waters in the Du River Source National Nature Reserve: A case study in Zhushan County, Hubei Province, China.

Luo, Yingjie / Li, Tongyu / Zhang, Shixi / Hao, Litao / Luo, Kunli

Environmental research

2024 , Page(s) 118656

Abstract: To study the distribution of trace elements in natural water of the Du River Source National Nature Reserve and to assess the water quality and health risks, Zhushan County in Hubei Province was selected as the study area. Element content in 361 natural ... ...

Abstract	To study the distribution of trace elements in natural water of the Du River Source National Nature Reserve and to assess the water quality and health risks, Zhushan County in Hubei Province was selected as the study area. Element content in 361 natural water samples collected from Zhushan County were measured by ICP-MS, ICP-OES, and HG-AFS. The main anions and cations present in water samples from Zhushan County are Ca
Language	English
Publishing date	2024-03-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118656
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Article ; Online: The uncharted territory of NAD

Ma, Quan / Liu, Jianzhao / Hu, Hao / Luo, Zisheng

Trends in cell biology

2024

Abstract: The critical redox cofactor ... ...

Abstract	The critical redox cofactor NAD
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	30122-x
ISSN	1879-3088 ; 0962-8924
ISSN (online)	1879-3088
ISSN	0962-8924
DOI	10.1016/j.tcb.2023.12.005
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Article ; Online: Sleep deprivation affects interference control: A diffusion model analysis.

Luo, Jiaorong / Hao, Chao / Ma, Ning / Wang, Ling

Journal of experimental psychology. Human perception and performance

2024 Volume 50, Issue 2, Page(s) 193–215

Abstract: Previous studies suggest that interference control may be unaffected by sleep deprivation based on the unchanged interference effects (reaction time [RT] differences between incongruent and congruent conditions), while ignoring the overall slower RTs ... ...

Abstract	Previous studies suggest that interference control may be unaffected by sleep deprivation based on the unchanged interference effects (reaction time [RT] differences between incongruent and congruent conditions), while ignoring the overall slower RTs after sleep deprivation. In the present study, we interpreted these results from a new angle using a variant of diffusion model, diffusion model for conflict tasks (DMC), and investigated whether and how interference control is affected by sleep deprivation. Mathematical derivations and model simulations showed that unchanged task-irrelevant information processing (i.e., unaffected interference control) may not lead to the observed unchanged interference effects when considering the overall slower RTs after sleep deprivation (due to either decreased drift rate of task-relevant information or increased decision boundary). Therefore, the unchanged interference effects do not necessarily indicate unchanged interference control. We then conducted a Simon task following one night of sleep deprivation or normal sleep, and fitted the DMC to the data. Experimental results showed that the Simon effect was reversed when most of the trials were incongruent, indicating that participants used learned spatially incompatible stimulus-response associations to predict responses. However, the Simon effects in both mean RTs and RT distributions were not significantly modulated by sleep deprivation. Model fits showed that the drift rate of task-relevant information decreased and the time-to-peak of task-irrelevant activation increased after sleep deprivation. These results suggest that central information processing was degraded after sleep loss, and most importantly, task-irrelevant activation increased after sleep deprivation as interference control was impaired. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
MeSH term(s)	Humans ; Sleep Deprivation ; Cognition ; Learning
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	189734-2
ISSN	1939-1277 ; 0096-1523
ISSN (online)	1939-1277
ISSN	0096-1523
DOI	10.1037/xhp0001180
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Article ; Online: Investigation of the role of interleukin 27 in the immune regulation of Treg and Th17 cells in neurosyphilis patients.

Zhao, Wei / Luo, Hao

Folia neuropathologica

2024 Volume 61, Issue 4, Page(s) 387–395

Abstract: Introduction: Neurosyphilis (NS) is known as a sexually transmitted disease that is very difficult to diagnose and its diagnosis is delayed. Some studies have suggested that the level of interleukin (IL)-27 decreases in syphilis patients and the level ... ...

Abstract	Introduction: Neurosyphilis (NS) is known as a sexually transmitted disease that is very difficult to diagnose and its diagnosis is delayed. Some studies have suggested that the level of interleukin (IL)-27 decreases in syphilis patients and the level of IL-17 increases in these patients, and these immunological changes can be a therapeutic target for these patients. The present study aims to evaluate IL-27's role in the immune regulation of Treg and Th17 cells in NS patients. Material and methods: 400 documented diagnosed syphilis patients were enrolled to the study and divided into two groups of neurosyphilis (NS) and non-neurosyphilis (S). Also 40 healthy volunteers were enrolled as a healthy control group (C). Peripheral blood mononuclear cells (PBMCs) from peripheral blood and cerebrospinal fluid (CSF) by lumbar puncture were collected as samples. mRNA expression and level of IL-27, IL-17, Th17, IL-17-producing CD4 + T cells and also protein concentration and VDRL of CSF were investigated. To obtain proposed results, flow cytometry, RT-PCR and ELISA were used. Results: The mRNA expression of IL-27 in PBMCs declined significantly in NS patients compared to healthy controls ( p = 0.002) and S patients ( p = 0.005) and decreased significantly in CSF of NS patients in comparison to healthy controls ( p = 0.002) and S patients ( p = 0.003). The frequency of IL-17-producing CD4 + T cells increased significantly in PBMCs of NS patients in comparison to healthy controls ( p = 0.004) and S patients ( p = 0.004). This frequency also increased significantly in CSF of NS patients compared to C ( p = 0.007) and S patients ( p = 0.003). Adding rIL-27 significantly prevented the frequency of IL-17-producing CD4 + T cells from naïve CD4 + T cells under Th17 polarizing conditions from NS patients ( p = 0.043), C ( p = 0.043), and S patients ( p = 0.002) in PBMCs, and also 0.03, 0.02 and 0.03 respectively for NS, S and C of CSF. The results revealed a significant negative relationship between CSF protein and VDRL concentrations and CSF IL-27 levels. Conclusions: This study confirms previous efforts on the critical role of IL-17 in NS. Also, it supports other results on the inhibitory effects of IL-27 on the therapeutic potential of IL-27 in NS and the inflammation process.
MeSH term(s)	Humans ; Interleukin-17/cerebrospinal fluid ; Interleukin-27 ; Leukocytes, Mononuclear ; Neurosyphilis/cerebrospinal fluid ; Neurosyphilis/diagnosis ; RNA, Messenger ; Syphilis ; T-Lymphocytes, Regulatory ; Th17 Cells
Chemical Substances	Interleukin-17 ; Interleukin-27 ; RNA, Messenger ; MYDGF protein, human
Language	English
Publishing date	2024-01-04
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1310363-5
ISSN	1509-572X ; 0028-3894 ; 1641-4640
ISSN (online)	1509-572X
ISSN	0028-3894 ; 1641-4640
DOI	10.5114/fn.2023.132099
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